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Dae-Whan Shin	12 Articles
Kinetics of IL-23 and IL-12 Secretion in Response to Toxoplasma gondii Antigens from THP-1 Monocytic Cells Juan-Hua Quan, Wei Zhou, Guang-Ho Cha, In-Wook Choi, Dae-Whan Shin, Young-Ha Lee Korean J Parasitol 2013;51(1):85-92. Published online February 18, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.1.85 Abstract PDF IL-23 and IL-12 are structurally similar and critical for the generation of efficient cellular immune responses. Toxoplasma gondii induces a strong cell-mediated immune response. However, little is known about IL-23 secretion profiles in T. gondii-infected immune cells in connection with IL-12. We compared the patterns of IL-23 and IL-12 production by THP-1 human monocytic cells in response to stimulation with live or heat-killed T. gondii tachyzoites, or with equivalent quantities of either T. gondii excretory/secretory proteins (ESP) or soluble tachyzoite antigen (STAg). IL-23 and IL-12 were significantly increased from 6 hr after stimulation with T. gondii antigens, and their secretions were increased with parasite dose-dependent manner. IL-23 concentrations were significantly higher than those of IL-12 at the same multiplicity of infection. IL-23 secretion induced by live parasites was significantly higher than that by heat-killed parasites, ESP, or STAg, whereas IL-12 secretion by live parasite was similar to those of ESP or STAg. However, the lowest levels of both cytokines were at stimulation with heat-killed parasites. These data indicate that IL-23 secretion patterns by stimulation with various kinds of T. gondii antigens at THP-1 monocytic cells are similar to those of IL-12, even though the levels of IL-23 induction were significantly higher than those of IL-12. The detailed kinetics induced by each T. gondii antigen were different from each other. Citations Citations to this article as recorded by Differential detection of chicken heterodimeric cytokines, interleukin 12 and 23 using their subunit-specific mouse monoclonal antibodies Youngsub Lee, Woo H. Kim, Hyoyoun Nam, Hyun S. Lillehoj Poultry Science.2024; 103(8): 103872. CrossRef T. gondii excretory proteins promote the osteogenic differentiation of human bone mesenchymal stem cells via the BMP/Smad signaling pathway Mingzhu Deng, Feifei Gao, Tianfeng Liu, Weiqiang Zhan, Juanhua Quan, Ziquan Zhao, Xuyang Wu, Zhuolan Zhong, Hong Zheng, Jiaqi Chu Journal of Orthopaedic Surgery and Research.2024;[Epub] CrossRef IL-12 and IL-23 Production in Toxoplasma gondii- or LPS Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways Hassan Ahmed Hassan Ahmed Ismail, Byung-Hun Kang, Jae-Su Kim, Jae-Hyung Lee, In-Wook Choi, Guang-Ho Cha, Jae-Min Yuk, Young-Ha Lee The Korean Journal of Parasitology.2017; 55(6): 613. CrossRef Cytokine response of human THP-1 macrophages to Trichomonas tenax Emily J. Govro, Melissa K. Stuart Experimental Parasitology.2016; 169: 77. CrossRef Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan ParasitesIn VitroandIn Vivo Liliana M. R. Silva, Tamara Muñoz-Caro, Rafael A. Burgos, Maria A. Hidalgo, Anja Taubert, Carlos Hermosilla Mediators of Inflammation.2016; 2016: 1. CrossRef Eimeria ninakohlyakimovae induces NADPH oxidase-dependent monocyte extracellular trap formation and upregulates IL-12 and TNF-α, IL-6 and CCL2 gene transcription D. Pérez, M.C. Muñoz, J.M. Molina, T. Muñoz-Caro, L.M.R. Silva, A. Taubert, C. Hermosilla, A. Ruiz Veterinary Parasitology.2016; 227: 143. CrossRef Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity Barbara A. Fox, Kiah L. Sanders, Leah M. Rommereim, Rebekah B. Guevara, David J. Bzik, Imtiaz A Khan PLOS Genetics.2016; 12(7): e1006189. CrossRef Levels of Transforming Growth Factor-Beta After Immunization of Mice With Toxoplasma gondii prepared Excretory/Secretory Proteins Seyed Hossein Abdollahi, Fateme Ayoobi, Hossein Khorramdelazad, Behzad Nasiri Ahmadabadi, Mohammadtaghi Rezayati, Mohammad Kazemi Arababadi, Mohammad Zare-Bidaki Jundishapur Journal of Microbiology.2015;[Epub] CrossRef Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells Juan-Hua Quan, Jia-Qi Chu, Jaeyul Kwon, In-Wook Choi, Hassan Ahmed Hassan Ahmed Ismail, Wei Zhou, Guang-Ho Cha, Yu Zhou, Jae-Min Yuk, Eun-Kyeong Jo, Young-Ha Lee, Salvatore V Pizzo PLOS ONE.2015; 10(11): e0141550. CrossRef Besnoitia besnoiti tachyzoites induce monocyte extracellular trap formation Tamara Muñoz-Caro, Liliana M. R. Silva, Christin Ritter, Anja Taubert, Carlos Hermosilla Parasitology Research.2014; 113(11): 4189. CrossRef 12,556 View 112 Download Crossref Gene Expression Profiles in Genetically Different Mice Infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU Hassan Ahmed Hassan Ahmed Ismail, Juan-Hua Quan, Zhou Wei, In-Wook Choi, Guang-Ho Cha, Dae-Whan Shin, Young-Ha Lee, Chang-June Song Korean J Parasitol 2012;50(1):7-13. Published online March 6, 2012 DOI: https://doi.org/10.3347/kjp.2012.50.1.7 Abstract PDF Toxoplasma gondii can modulate host cell gene expression; however, determining gene expression levels in intermediate hosts after T. gondii infection is not known much. We selected 5 genes (ALDH1A2, BEX2, CCL3, EGR2 and PLAU) and compared the mRNA expression levels in the spleen, liver, lung and small intestine of genetically different mice infected with T. gondii. ALDH1A2 mRNA expressions of both mouse strains were markedly increased at day 1-4 postinfection (PI) and then decreased, and its expressions in the spleen and lung were significantly higher in C57BL/6 mice than those of BALB/c mice. BEX2 and CCR3 mRNA expressions of both mouse strains were significantly increased from day 7 PI and peaked at day 15-30 PI (P<0.05), especially high in the spleen liver or small intestine of C57BL/6 mice. EGR2 and PLAU mRNA expressions of both mouse strains were significantly increased after infection, especially high in the spleen and liver. However, their expression patterns were varied depending on the tissue and mouse strain. Taken together, T. gondii-susceptible C57BL/6 mice expressed higher levels of these 5 genes than did T. gondii-resistant BALB/c mice, particularly in the spleen and liver. And ALDH1A2 and PLAU expressions were increased acutely, whereas BEX2, CCL3 and EGR2 expressions were increased lately. Thus, these demonstrate that host genetic factors exert a strong impact on the expression of these 5 genes and their expression patterns were varied depending on the gene or tissue. Citations Citations to this article as recorded by Effect of Puerarin, Baicalin and Berberine Hydrochloride on the Regulation of IPEC-J2 Cells Infected with Enterotoxigenic Escherichia coli Xiaoxi Liu, Fenghua Liu, Yunfei Ma, Huanrong Li, Xianghong Ju, Jianqin Xu Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1. CrossRef Gene Silencing of Porcine MUC13 and ITGB5: Candidate Genes towards Escherichia coli F4ac Adhesion Chuanli Zhou, Zhengzhu Liu, Yang Liu, Weixuan Fu, Xiangdong Ding, Jianfeng Liu, Ying Yu, Qin Zhang, Lucia R. Languino PLoS ONE.2013; 8(7): e70303. CrossRef 10,059 View 86 Download Crossref Proteomic Analysis of Toxoplasma gondii KI-1 Tachyzoites Si-Hwan Choi, Tae Yun Kim, Sung Goo Park, Guang-Ho Cha, Dae-Whan Shin, Jong-Yil Chai, Young-Ha Lee Korean J Parasitol 2010;48(3):195-201. Published online September 16, 2010 DOI: https://doi.org/10.3347/kjp.2010.48.3.195 Abstract PDF We studied on the proteomic characteristics of Toxoplasma gondii KI-1 tachyzoites which were originally isolated from a Korean patient, and compared with those of the well-known virulent RH strain using 2-dimensional electrophoresis (2-DE), mass spectrometry, and quantitative real-time PCR. Two-dimensional separation of the total proteins isolated from KI-1 tachyzoites revealed up to 150 spots, of which 121 were consistent with those of RH tachyzoites. Of the remaining 29 spots, 14 showed greater than 5-fold difference in density between the KI-1 and RH tachyzoites at a pH of 5.0-8.0. Among the 14 spots, 5 from the KI-1 isolate and 7 from the RH strain were identified using MALDI-TOF mass spectrometry and database searches. The spots from the KI-1 tachyzoites were dense granule proteins (GRA 2, 3, 6, and 7), hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGRPTase), and uracil phosphoribosyltransferase (UPRTase). The spots from the RH strain were surface antigen 1 (SAG 1), L-lactate dehydrogenase (LDH), actin, chorismate synthase, peroximal catalase, hexokinase, bifunctional dihydrofolate reductase-thymidylate synthase (DHTR-TS), and nucleoside-triphosphatases (NTPases). Quantitative real-time PCR supported our mass spectrometric results by showing the elevated expression of the genes encoding GRA 2, 3, and 6 and UPRTase in the KI-1 tachyzoites and those encoding GRA 7, SAG 1, NTPase, and chorismate synthase in the RH tachyzoites. These observations demonstrate that the protein compositions of KI-1 and RH tachyzoites are similar but differential protein expression is involved in virulence. Citations Citations to this article as recorded by Prophylactic antineoplastic activity of Toxoplasma gondii RH derived antigen against ehrlich solid carcinoma with evidence of shared antigens by comparative immunoblotting Maha M. Eissa, Maha R. Gaafar, Layla K. Younis, Cherine A. Ismail, Nahla El Skhawy Infectious Agents and Cancer.2023;[Epub] CrossRef Mining the Proteome of Toxoplasma Parasites Seeking Vaccine and Diagnostic Candidates Sajad Rashidi, Javier Sánchez-Montejo, Reza Mansouri, Mohammad Ali-Hassanzadeh, Amir Savardashtaki, Mohammad Saleh Bahreini, Mohammadreza Karimazar, Raúl Manzano-Román, Paul Nguewa Animals.2022; 12(9): 1098. CrossRef Unraveling Toxoplasma gondii GT1 Strain Virulence and New Protein-Coding Genes with Proteogenomic Analyses Neelam Antil, Manish Kumar, Santosh Kumar Behera, Mohammad Arefian, Chinmaya Narayana Kotimoole, Devasahayam Arokia Balaya Rex, Thottethodi Subrahmanya Keshava Prasad OMICS: A Journal of Integrative Biology.2021; 25(9): 591. CrossRef iTRAQ-Based Global Phosphoproteomics Reveals Novel Molecular Differences Between Toxoplasma gondii Strains of Different Genotypes Ze-Xiang Wang, Chun-Xue Zhou, Guillermo Calderón-Mantilla, Evangelia Petsalaki, Jun-Jun He, Hai-Yang Song, Hany M. Elsheikha, Xing-Quan Zhu Frontiers in Cellular and Infection Microbiology.2019;[Epub] CrossRef Immunoproteomic technology offers an extraordinary diagnostic approach for Toxoplasma gondii infection Saeed El-Ashram, Qing Yin, John R. Barta, Jamal Khan, Xianyong Liu, Xun Suo Journal of Microbiological Methods.2015; 119: 18. CrossRef Exploring Early and Late Toxoplasma gondii Strain RH Infection by Two-Dimensional Immunoblots of Chicken Immunoglobulin G and M Profiles Saeed El-Ashram, Ximeng Sun, Qing Yin, Xianyong Liu, Xun Suo, Wei Wang PLOS ONE.2015; 10(3): e0121647. CrossRef From the Macro to the Micro: Gel Mapping to Differentiate between Sporozoites of Two Immunologically Distinct Strains of Eimeria maxima (Strains M6 and Guelph) Saeed El-Ashram, Qing Yin, Hongbin Liu, Ibrahim Al Nasr, Xianyong Liu, Xun Suo, John Barta, Paulo Lee Ho PLOS ONE.2015; 10(12): e0143232. CrossRef Identification of differentially expressed proteins in sulfadiazine resistant and sensitive strains of Toxoplasma gondii using difference-gel electrophoresis (DIGE) Christelle Doliwa, Dong Xia, Sandie Escotte-Binet, Emma L. Newsham, Sanderson Sanya J., Dominique Aubert, Nadine Randle, Jonathan M. Wastling, Isabelle Villena International Journal for Parasitology: Drugs and Drug Resistance.2013; 3: 35. CrossRef Proteome expression changes among virulent and attenuated Neospora caninum isolates Javier Regidor-Cerrillo, Gema Álvarez-García, Iván Pastor-Fernández, Virginia Marugán-Hernández, Mercedes Gómez-Bautista, Luis M. Ortega-Mora Journal of Proteomics.2012; 75(8): 2306. CrossRef Modulation of mouse macrophage proteome induced by Toxoplasma gondii tachyzoites in vivo D. H. Zhou, Z. G. Yuan, F. R. Zhao, H. L. Li, Y. Zhou, R. Q. Lin, F. C. Zou, H. Q. Song, M. J. Xu, X. Q. Zhu Parasitology Research.2011; 109(6): 1637. CrossRef 9,328 View 88 Download Crossref Antigenemia and Specific IgM and IgG Antibody Responses in Rabbits Infected with Toxoplasma gondii Juan Hua Quan, Hassan Ahmed Hassan, Guang-Ho Cha, Dae-Whan Shin, Young-Ha Lee Korean J Parasitol 2009;47(4):409-412. Published online December 1, 2009 DOI: https://doi.org/10.3347/kjp.2009.47.4.409 Abstract PDF In this experiment, the correlation between antigenemia and specific antibody responses in Toxoplasma gondii-infected rabbits was assessed. We injected 1,000 T. gondii tachyzoites (RH) subcutaneously into 5 rabbits. Parasitemia, circulating antigens, and IgM and IgG antibody titers in blood were tested by ELISA and immunoblot. For detection of parasitemia, mice were injected with blood from rabbits infected with T. gondii and mice died between days 2 and 10 post-infection (PI). Circulating antigens were detected early on day 2 PI, and the titers increased from day 4 PI and peaked on day 12 PI. Anti-Toxoplasma IgM antibody titers increased on day 6 PI and peaked on days 14-16 PI. IgG was detected from day 10 PI, and the titers increased continuously during the experiment. The antigenic protein patterns differed during the infection period, and the number of bands increased with ongoing infection by the immunoblot analysis. These result indicated that Toxoplasma circulating antigens during acute toxoplasmosis are closely related to the presence of parasites in blood. Also, the circulating antigen levels were closely correlated with IgM titers, but not with IgG titers. Therefore, co-detection of circulating antigens with IgM antibodies may improve the reliability of the diagnosis of acute toxoplasmosis. Citations Citations to this article as recorded by Effect of fermented Cassava sievate and tiger nut shaft on growth performance, blood profile and immunological parameters in male rabbits C. O. Bamigboye, O. E. Akinola, J. D. Adegboye, I. A. Fadiora, I. O. Omomowo, O. N. Majolagbe, O. R. Oyeleke, A. A. Alarape, T. K. Ojediran, M. D. Shittu, J. K. Oloke Tropical Animal Health and Production.2024;[Epub] CrossRef Isolation and genetic characterization of Toxoplasma gondii from chickens from public markets in Pernambuco State, Brazil Renato Amorim da Silva, Raissa Santana Renovato, Hannah Tsuruzaki Kirzner de Barros e Silva, Maria Luiza Didier Marques, Pollyanne Raysa Fernandes Oliveira, Jéssica de Crasto Souza Carvalho-Reis, Paul M. Bartley, Frank Katzer, Érika Fernanda Torres Samico Current Research in Parasitology & Vector-Borne Diseases.2024; 6: 100207. CrossRef Epidemiological and Public Health Significance of Toxoplasma gondii Infection in Wild Rabbits and Hares: 2010–2020 Sonia Almeria, Fernando H. A. Murata, Camila K. Cerqueira-Cézar, Oliver C. H. Kwok, Alicia Shipley, Jitender P. Dubey Microorganisms.2021; 9(3): 597. CrossRef Assessment of antigenic specificity of polyclonal antisera raised against Avibacterium paragallinarum by ELISA Ajaz Ahmed, Sidhartha Deshmukh, Harmanjit Singh Banga, Sandeep Sodhi, Rajinder Singh Brar Veterinary and Animal Science.2020; 9: 100119. CrossRef Occurrence of Toxoplasma gondii in domestic rabbits of Northeastern Brazil Débora Costa Viegas de Lima, André de Souza Santos, Luana Thamires Rapôso da Silva, Renata Pimentel Bandeira de Melo, José Givanildo da Silva, José Wilton Pinheiro Júnior, Rinaldo Aparecido Mota Acta Parasitologica.2016;[Epub] CrossRef Seroprevalence of Toxoplasma gondii and Encephalitozoon cuniculi in rabbits from different farming systems Helena Neumayerová, Jana Juránková, Edita Jeklová, Hana Kudláčková, Martin Faldyna, Kamil Kovařčík, Eva Jánová, Břetislav Koudela Veterinary Parasitology.2014; 204(3-4): 184. CrossRef *Prevalence of Toxoplasma gondii* Infection in Rabbits of Korea by Serological Tests and Nested Polymerase Chain Reaction** Hyun-Guk SHIN, Sang- Eun LEE, Sung-Hee HONG, Se-Mi KIM, Young-Ki CHOI, Hyung-Jin PARK, Kyoung-Won SEO, Kun-Ho SONG Journal of Veterinary Medical Science.2013; 75(12): 1609. CrossRef Evaluation of automated assays for immunoglobulin G, M, and A measurements in dog and cat serum Asta Tvarijonaviciute, Silvia Martínez‐Subiela, Marco Caldin, Fernando Tecles, Jose J. Ceron Veterinary Clinical Pathology.2013; 42(3): 270. CrossRef Purification of IgG from Sera of Rabbit and Guinea Pig by Flow-Through Mode Ion-Exchange Chromatography using DEAE Sepharose Fast Flow Column Ying Wang, Peiyin Zhang, Shujun Liu, Yongsheng Zhang, Tiesuo Zhao, Wenhui Huang, Chunyan He, Yongli Yu, Liying Wang, Min Wan Chromatographia.2011; 74(3-4): 209. CrossRef Evaluation of Toxoplasma gondii as a live vaccine vector in susceptible and resistant hosts Jun Zou, Xiao-Xi Huang, Guang-Wen Yin, Ye Ding, Xian-Yong Liu, Heng Wang, Qi-Jun Chen, Xun Suo Parasites & Vectors.2011;[Epub] CrossRef 9,042 View 88 Download Crossref Seroprevalence of Toxoplasma gondii Infection and Characteristics of Seropositive Patients in General Hospitals in Daejeon, Korea Dae-Whan Shin, Dong-Yeub Cha, Quan Juan Hua, Guang-Ho Cha, Young-Ha Lee Korean J Parasitol 2009;47(2):125-130. Published online May 27, 2009 DOI: https://doi.org/10.3347/kjp.2009.47.2.125 Abstract PDF To figure out the epidemiological status and relevance with other diseases in toxoplasmosis, we checked serum IgG antibody titers of 1,265 patients and medical records of seropositive patients. Seropositive rates were 6.6% by latex agglutination test (LAT) and 6.7% by ELISA. No significant differences were detected between sexes and age groups. The peak seroprevalence was detected in the 40-49-year-old age group. According to clinical department, Toxoplasma-positive rates were high in patients in psychiatry, ophthalmology, health management, emergency medicine, and thoracic surgery. Major coincidental diseases in seropositive cases were malignant neoplasms, diabetes mellitus, arthritis, chronic hepatitis B, chronic renal diseases, schizophrenia, and acute lymphadenitis, in the order of frequency. In particular, some patients with chronic hepatitis B and malignant neoplasms had high antibody titers. These results revealed that the seroprevalence of toxoplasmosis in a general hospital-based study was similar to that in a community-based study, and T. gondii seropositivity may be associated with neoplasms, diabetes, and other chronic infections. Citations Citations to this article as recorded by Eosinophils Respond to Extracellular Matrix Treated Muscle Injuries but are Not Required for Macrophage Polarization Ravi Lokwani, Daphna Fertil, Devon R. Hartigan, Aditya Josyula, Tran B. Ngo, Kaitlyn Sadtler Advanced Healthcare Materials.2025;[Epub] CrossRef Association of infection with Toxoplasma gondii and arthritis: Insights from a cross-sectional study and genetic epidemiology analysis Dan Zhu, Haining Li, Chu Zhang, Ying Zhou, Jin Yang, Changzhou Feng Microbial Pathogenesis.2025; 209: 108086. CrossRef Automated Machine Learning versus Expert-Designed Models in Ocular Toxoplasmosis: Detection and Lesion Localization Using Fundus Images Daniel Milad, Fares Antaki, Allison Bernstein, Samir Touma, Renaud Duval Ocular Immunology and Inflammation.2024; 32(9): 2061. CrossRef Ally, adversary, or arbitrator? The context-dependent role of eosinophils in vaccination for respiratory viruses and subsequent breakthrough infections Lauren A Chang, Michael Schotsaert Journal of Leukocyte Biology.2024; 116(2): 224. CrossRef Immunization of laboratory animal workers: occupational health and safety aspects Laxit K. Bhatt, Jitendra H. Patel, Chitrang R. Shah, Sudhir R. Patel, Shital D. Patel, Vipul A. Patel, Rajesh Sundar, Mukul R. Jain Pathogens and Global Health.2024; 118(5): 376. CrossRef Risk factors for toxoplasmosis in people living with HIV in the Asia-Pacific region Ki Hyun Lee, Awachana Jiamsakul, Sasisopin Kiertiburanakul, Rohidas Borse, Vohith Khol, Evy Yunihastuti, Iskandar Azwa, I. Ketut Agus Somia, Romanee Chaiwarith, Thach Ngoc Pham, Suwimon Khusuwan, Cuong Duy Do, Nagalingeswaran Kumarasamy, Yasmin Gani, Ross PLOS ONE.2024; 19(7): e0306245. CrossRef Do parasites induce the expression of biochemical markers in the Golden grey mullet Chelon auratus (Risso, 1810)? 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CrossRef Evaluation of Anti-Toxoplasma gondii Antibodies in Hemodialysis Patients with Chronic Kidney Disease in Sari, Iran Seyyed Hosein Seyyedpour, Parvaneh Afshar, Ayoub Barzegarnejad, Shamsi Kalhori, Reza Agah Nephro-Urology Monthly.2016;[Epub] CrossRef Seroepidemiological analysis of toxoplasmosis in college students Jaqueline Polizeli Rodrigues, Fernando Frei, Italmar Teodorico Navarro, Luciana Pereira Silva, Monica Yonashiro Marcelino, Heitor Franco de Andrade-Junior, Carolina Arruda de Faria, Marislene Santos, João Tadeu Ribeiro-Paes Journal of Venomous Animals and Toxins including Tropical Diseases.2015;[Epub] CrossRef Seroprevalence of toxoplasmosis in mentally retarded patients in Iranian rehabilitation centers Behrouz Ezatpour, Mohammad Zibaie, Hessam Rahmati, Yadollah Pournia, Mehdi Azami, Farzad Ebrahimzadeh, Mozhgan Azadpour, Maryam Jamshidian Ghalesefidi Journal of Parasitic Diseases.2015; 39(1): 13. CrossRef Seroprevalence and genetic characterization of Toxoplasma gondii in cancer patients in Anhui Province, Eastern China Lin Wang, Liu-yuan He, De-di Meng, Zhao-wu Chen, He Wen, Gong-si Fang, Qing-li Luo, Kai-quan Huang, Ji-long Shen Parasites & Vectors.2015;[Epub] CrossRef High seroprevalence of echinococossis, schistosomiasis and toxoplasmosis among the populations in Babati and Monduli districts, Tanzania Mohammad Behram Khan, Parthasarathy Sonaimuthu, Yee Ling Lau, Hesham M Al-Mekhlafi, Rohela Mahmud, Nicholas Kavana, Ayub Kassuku, Christopher Kasanga Parasites & Vectors.2014;[Epub] CrossRef Seroprevalence of Toxoplasma gondii in the Iranian general population: A systematic review and meta-analysis Ahmad Daryani, Shahabeddin Sarvi, Mohsen Aarabi, Azadeh Mizani, Ehsan Ahmadpour, Azar Shokri, Mohammad-Taghi Rahimi, Mehdi Sharif Acta Tropica.2014; 137: 185. CrossRef Repurposing the Open Access Malaria Box To Discover Potent Inhibitors of Toxoplasma gondii and Entamoeba histolytica Fabrice F. Boyom, Patrick V. T. Fokou, Lauve R. Y. Tchokouaha, Thomas Spangenberg, Alvine N. Mfopa, Ruffin M. T. Kouipou, Cedric J. Mbouna, Valerie F. Donkeng Donfack, Paul H. A. Zollo Antimicrobial Agents and Chemotherapy.2014; 58(10): 5848. CrossRef Ocular toxoplasmosis I: parasitology, epidemiology and public health Jo?o M Furtado, Kevin L Winthrop, Nicholas J Butler, Justine R Smith Clinical & Experimental Ophthalmology.2013; 41(1): 82. CrossRef Study the Anti-Toxoplasma Antibodies (IgG and IgM) in Hemodialysis Patients of Abadan and Khoramshahr Cities Southwest Iran in 2011 using ELISA Sharif Maraghi, Mohammad Jafar Yadyad, Marjan Sheikhi, Fatemeh Shamakhteh, Seyed Mahmood Latifi Jundishapur Journal of Microbiology.2013;[Epub] CrossRef Prevalence of toxoplasmosis in France in 1998: Is there a difference between men and women? At what age do children become infected? H. Bellali, H. Pelloux, I. Villena, H. Fricker-Hidalgo, Y. Le Strat, V. Goulet Revue d'Épidémiologie et de Santé Publique.2013; 61(4): 311. CrossRef Cerebral Toxoplasmosis Mimicking Subacute Meningitis in HIV-Infected Patients; a Cohort Study from Indonesia A. Rizal Ganiem, Sofiati Dian, Agnes Indriati, Lidya Chaidir, Rudi Wisaksana, Patrick Sturm, Willem Melchers, Andre van der Ven, Ida Parwati, Reinout van Crevel, Judd L. Walson PLoS Neglected Tropical Diseases.2013; 7(1): e1994. CrossRef Antiallergic Effect of Anti–Siglec-F through Reduction of Eosinophilic Inflammation in Murine Allergic Rhinitis Young Hyo Kim, Chang-Shin Park, Dae Hyun Lim, Byong Kwan Son, Jeong Hee Kim, Sung-Hye Ahn, Bruce S. Bochner, Kwangmin Na, Tae Young Jang American Journal of Rhinology & Allergy.2013; 27(3): 187. CrossRef The antioxidant defence mechanisms of parasite and host after chronic Hymenolepis diminuta infestation of the rat H. Czeczot, M. Skrzycki, M. 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CrossRef Spectrum of Intracranial Parenchymal Lesions in Patients with Human Immunodeficiency Virus Infection in the Republic of Korea Pyoeng Gyun Choe, Wan Beom Park, Jin Su Song, Kyoung-Ho Song, Jae Hyun Jeon, Sang-Won Park, Hong Bin Kim, Kee-Hyun Chang, Myoung-don Oh, Kang Won Choe, Nam Joong Kim Journal of Korean Medical Science.2010; 25(7): 1005. CrossRef A Case of Cerebral Toxoplasmosis Following Tandem Autologous Stem Cell Transplantation in a Multiple Myeloma Patient Kye-Hyung Kim, Kyoung-Ho Song, Jae Hyun Jeon, Wan Beom Park, Sang-Won Park, Hong Bin Kim, Nam Joong Kim, Inho Kim, Myoung-don Oh Infection and Chemotherapy.2010; 42(3): 181. CrossRef Seroepidemiology of Toxoplasma gondii Infection in Patients with Vision and Hearing Impairments, Cancer, HIV, or Undergoing Hemodialysis in Durango, Mexico C. Alvarado-Esquivel, O. Liesenfeld, A. Torres-Castorena, S. Estrada-Martínez, J. D. Urbina-Álvarez, M. Ramos-de la Rocha, J. A. Márquez-Conde, J. P. Dubey Journal of Parasitology.2010; 96(3): 505. CrossRef Serodiagnosis of bovine leptospirosis by IgG-Enzyme-Linked Immunosorbent Assay and Latex Agglutination Test T. M. A. Senthilkumar, M. Subathra, P. Ramadass, V. Ramaswamy Tropical Animal Health and Production.2010; 42(2): 217. CrossRef Importance of Nonenteric Protozoan Infections in Immunocompromised People J. L. N. Barratt, J. Harkness, D. Marriott, J. T. Ellis, D. Stark Clinical Microbiology Reviews.2010; 23(4): 795. CrossRef 11,063 View 84 Download Crossref Cytokine and antibody responses of reactivated murine toxoplasmosis upon administration of dexamethasone Ki-Man Kang, In-Uk Choi, Dae-Whan Shin, Young-Ha Lee Korean J Parasitol 2006;44(3):209-219. Published online September 20, 2006 DOI: https://doi.org/10.3347/kjp.2006.44.3.209 Abstract PDF Toxoplasma gondii has been shown to result in life-threatening encephalitis in immunocompromised patients after reactivation of dormant parasites. In order to obtain information on immune responses related to this phenomenon, BALB/c mice were infected with 25 cysts of the 76K strain of T. gondii, then, treated orally with dexamethasone (Toxo/Dexa-treated group) in order to reactivate the chronic toxoplasmosis. None of the T. gondii-infected mice died during the experimental periods, whereas the Toxo/Dexa-treated mice evidenced a significant attenuation of survival periods. Toxoplasma-specific IgG2a, IgA and IgM titers in sera were significantly depressed in the Toxo/Dexa-treated mice; however, the IgG1 sera titers were similar to those seen in the Toxoplasma-infected mice. The percentages of CD4+ and CD8α+ T cells in the Toxo/Dexa-treated mice were significantly reduced 2 weeks after dexamethasone treatment. IFN-γ and IL-10 production levels in the Toxo/Dexa-treated mice were depressed significantly, whereas IL-4 production was increased temporarily. The expression levels of the Toxoplasma-specific P30 and B1 genes were found to have been increased in the Toxo/Dexa-treated mice in comparison with the Toxoplasma-infected mice. Collectively, the findings of this study demonstrate that reactivation of murine toxoplasmosis as the result of dexamethasone treatment induced a depression in Th1 immune responses, whereas Th2 immune responses were not significantly influenced. 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José Antonio Vargas-Villavicencio, Irma Cañedo-Solares, Dolores Correa Microorganisms.2022; 10(8): 1659. CrossRef Immunological, histopathological, and ultrastructural evidence of steroid-induced reactivation of chronic murine toxoplasmosis Aida A. Abdel-Magied, Doaa S. Ghorab, Abeer A. Elhenawy, Nora I. Aboulfotouh Ultrastructural Pathology.2021; 45(1): 28. CrossRef Development of Neurological Mouse Model for Toxoplasmosis Using Toxoplasma gondii Isolated from Chicken in Kenya John Mokua Mose, David Muchina Kamau, John Maina Kagira, Naomi Maina, Maina Ngotho, Adele Njuguna, Simon Muturi Karanja Pathology Research International.2017; 2017: 1. CrossRef Strength and Aerobic Physical Exercises Are Able to Increase Survival of Toxoplasma gondii-Infected C57BL/6 Mice by Interfering in the IFN-γ Expression Miguel J. S. Bortolini, Murilo V. Silva, Fábio M. Alonso, Luciana A. Medeiros, Fernando R. Carvalho, Lourenço F. Costa, Neide M. Silva, Nilson Penha-Silva, Tiago W. P. Mineo, José R. 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CrossRef Evaluation of the immunosuppressive effect of cyclophosphamide and dexamethasone in mice with visceral toxocariasis Luciana Farias da Costa de Avila, Juliana Santos Vieira da Fonseca, Gisele Ferreira Dutra, Paula de Lima Telmo, Ana Maria Wolkmer Azambuja Silva, Maria Elisabeth Aires Berne, Pedro Eduardo Almeida da Silva, Fabricio Rochedo Conceição, Carlos James Scaini Parasitology Research.2012; 110(1): 443. CrossRef Real-Time RT-PCR on SAG1 and BAG1 Gene Expression during Stage Conversion in Immunosuppressed Mice Infected with Toxoplasma gondii Tehran Strain Monavar Selseleh, Mohammad Hossein Modarressi, Mehdi Mohebali, Saeedeh Shojaee, Mohammad Reza Eshragian, Mina Selseleh, Ebrahim Azizi, Hossein Keshavarz The Korean Journal of Parasitology.2012; 50(3): 199. CrossRef Toxoplasma gondii: Simple duplex RT-PCR assay for detecting SAG1 and BAG1 genes during stage conversion in immunosuppressed mice Aongart Mahittikorn, Hannes Wickert, Yaowalark Sukthana Experimental Parasitology.2010; 124(2): 225. CrossRef Autism spectrum disorders may be due to cerebral toxoplasmosis associated with chronic neuroinflammation causing persistent hypercytokinemia that resulted in an increased lipid peroxidation, oxidative stress, and depressed metabolism of endogenous and exo Joseph Prandota Research in Autism Spectrum Disorders.2010; 4(2): 119. CrossRef Migraine Associated with Patent Foramen Ovale May Be Caused by Reactivation of Cerebral Toxoplasmosis Triggered by Arterial Blood Oxygen Desaturation Joseph Prandota International Journal of Neuroscience.2010; 120(2): 81. CrossRef DoesToxoplasma gondiiInfection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)? Joanna Matowicka-Karna, Violetta Dymicka-Piekarska, Halina Kemona Clinical and Developmental Immunology.2009; 2009: 1. CrossRef Idiopatyczne nadciśnienie śródczaszkowe, guz rzekomy czaszki oraz aseptyczne zapalenie opon mogą być spowodowane reaktywacją latentnej toksoplazmozy mózgowej Józef Prandota Pediatria Polska.2009; 84(5): 453. CrossRef THE IMPORTANCE OF TOXOPLASMA GONDII INFECTION IN DISEASES PRESENTING WITH HEADACHES. HEADACHES AND ASEPTIC MENINGITIS MAY BE MANIFESTATIONS OF THE JARISCH-HERXHEIMER REACTION JOSEPH PRANDOTA International Journal of Neuroscience.2009; 119(12): 2144. CrossRef Antiallergic Effects of Lactobacillus pentosus Strain S-PT84 Mediated by Modulation of Th1/Th2 Immunobalance and Induction of IL-10 Production Yuji Nonaka, Takayuki Izumo, Fumi Izumi, Toshihiro Maekawa, Hiroshi Shibata, Aoi Nakano, Atsuko Kishi, Kaoru Akatani, Yoshinobu Kiso International Archives of Allergy and Immunology.2008; 145(3): 249. CrossRef Recurrent Headache as the Main Symptom of Acquired Cerebral Toxoplasmosis in Nonhuman Immunodeficiency Virus-infected Subjects With no Lymphadenopathy Joseph Prandota American Journal of Therapeutics.2007; 14(1): 63. CrossRef 9,479 View 77 Download Crossref Effects of iNOS inhibitor on IFN-γ production and apoptosis of splenocytes in genetically different strains of mice infected with Toxoplasma gondii Ki-Man Kang, Gye-Sung Lee, Jae-Ho Lee, In-Wook Choi, Dae-Whan Shin, Young-Ha Lee Korean J Parasitol 2004;42(4):175-183. Published online December 20, 2004 DOI: https://doi.org/10.3347/kjp.2004.42.4.175 Abstract PDF To evaluate the role of nitric oxide (NO) in IFN-γ production and apoptosis of splenocytes in genetically different strains of mice with toxoplasmosis, BALB/c (a toxoplasmosis resistant strain) and C57BL/6 (a toxoplasmosis susceptible strain) mice were infected with Toxoplasma gondii cysts orally and subsequently injected intraperitoneally with aminoguanidine, an iNOS inhibitor (AG; 35 mg/kg per mouse daily for 14 days). When BALB/c or C57BL/6 mice were infected with T. gondii without AG treatment, number of brain cysts, NO and IFN-γ production by splenocytes, and percentages of apoptotic splenocytes were increased compared to uninfected control mice without AG treatment. AG treatment increased the number of brain cysts, and reduced NO and IFN-γ production in T. gondii-infected C57BL/6 mice. In contrast, in T. gondii-infected BABL/c mice, the number of brain cysts, and NO and IFN-γ production of splenocytes was not altered by treatment with AG. However, the percentages of apoptotic splenocytes in T. gondii-infected BALB/c or C57BL/6 mice were not affected by AG treatment. These results suggest that NO modulates IFN-γ production in T. gondii-infected C57BL/6 mice, and that NO is involved in mediating a protective response in toxoplasmosis susceptible, but not resistant, mice strain during acute infection. Citations Citations to this article as recorded by Effect of spiramycin versus aminoguanidine and their combined use in experimental toxoplasmosis Marwa Omar, Beessa E. Abaza, Esraa Mousa, Shereen M. Ibrahim, Hayam E. Rashed, Tahani I. Farag Journal of Parasitic Diseases.2021; 45(4): 1014. CrossRef Recombinant TgHSP70 Immunization Protects against Toxoplasma gondii Brain Cyst Formation by Enhancing Inducible Nitric Oxide Expression Paulo Czarnewski, Ester C. B. Araújo, Mário C. Oliveira, Tiago W. P. Mineo, Neide M. Silva Frontiers in Cellular and Infection Microbiology.2017;[Epub] CrossRef Pathophysiological mechanisms of diarrhea caused by theVibrio choleraeO1 El Tor variant: anin vivostudy in mice Saravut Satitsri, Pawin Pongkorpsakol, Potjanee Srimanote, Varanuj Chatsudthipong, Chatchai Muanprasat Virulence.2016; 7(7): 789. CrossRef Oxidative stress and tryptophan degradation pattern of acute Toxoplasma gondii infection in mice Ayse Basak Engin, Funda Dogruman-Al, Ugur Ercin, Bekir Celebi, Cahit Babur, Neslihan Bukan Parasitology Research.2012; 111(4): 1725. CrossRef Distinct roles for nitric oxide in resistant C57BL/6 and susceptible BALB/c mice to control Burkholderia pseudomallei infection Katrin Breitbach, Patimaporn Wongprompitak, Ivo Steinmetz BMC Immunology.2011;[Epub] CrossRef MMHD [(S,E)-2-Methyl-1-(2-methylthiazol-4-yl) hexa-1,5-dien-ol], a Novel Synthetic Compound Derived From Epothilone, Suppresses Nuclear Factor-κB–Mediated Cytokine Expression in Lipopolysaccharide-Stimulated BV-2 Microglia Na-Ra Jeon, Sushruta Koppula, Byung-Wook Kim, Su-Ho Park, Hyo-Won Lee, Dong-Kug Choi Journal of Pharmacological Sciences.2010; 112(2): 158. CrossRef The immunobiology of the innate response to Toxoplasma gondii Catherine M. Miller, Nicola R. Boulter, Rowan J. Ikin, Nicholas C. Smith International Journal for Parasitology.2009; 39(1): 23. CrossRef Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients Ulku Karaman, Tuncay Celik, Tugba Raika Kiran, Cemil Colak, Nilgun Ulfet Daldal The Korean Journal of Parasitology.2008; 46(4): 293. CrossRef Toxoplasma gondii infection induces apoptosis in noninfected macrophages: role of nitric oxide and other soluble factors Y. NISHIKAWA, O. KAWASE, O. VIELEMEYER, H. SUZUKI, K. A. JOINER, X. XUAN, H. NAGASAWA Parasite Immunology.2007; 29(7): 375. CrossRef 8,884 View 114 Download Crossref T cell phenotype and intracellular IFN-γ production in peritoneal exudate cells and gut intraepithelial lymphocytes during acute Toxoplasma gondii infection in mice Young-Ha Lee, Dae-Whan Shin Korean J Parasitol 2002;40(3):119-129. Published online September 30, 2002 DOI: https://doi.org/10.3347/kjp.2002.40.3.119 Abstract PDF Although there are many reports on the splenic (systemic) T cell response after Toxoplasma gondii infection, little information is available regarding the local T cell responses of peritoneal exudate cells (PEC) and gut intraepithelial lymphocytes (IEL) following peroral infection with bradyzoites. Mice were infected with 40 cysts of the 76K strain of T. gondii, and then sacrificed at days 0, 1, 4, 7 and 10 postinfection (PI). The cellular composition and T cell responses of PEC and IEL were analyzed. The total number of PEC and IEL per mouse increased after infection, but the ratio of increase was higher in IEL. Lymphocytes were the major component of both PEC and IEL. The relative percentages of PEC macrophages and neutrophils/eosinophils increased significantly at day 1 and 4 PI, whereas those of IEL did not change significantly. The percentage of PEC NK1.1 and γδ T cells peaked at day 4 PI (p < 0.0001), and CD4 and CD8α T cells increased continuously after infection. The percentages of IEL CD8α and γδ T cells decreased slightly at first, and then increased. CD4 and NK1.1 T cells of IEL did not change significantly after infection. IFN-γ-producing PEC NK1.1 T cells increased significantly from day 1 PI, but the other T cell subsets produced IFN-γ abundantly thereafter. The proportion of IEL IFN-γ-producing CD8α and γδ T cells increased significantly after infection, while IEL NK1.1 T cells had similar IFN-γ production patterns. Taken together, CD4 T cells were the major phenotype and the important IFN-γ-producing T cell subsets in PEC after oral infection with T. gondii, whereas CD8α T cells had these roles in IEL. These results suggest that PEC and IEL comprise different cell differentials and T cell responses, and according to infection route these factors may contribute to the different cellular immune responses. Citations Citations to this article as recorded by Apicomplexan infections in the gut C. L. Wilhelm, F. Yarovinsky Parasite Immunology.2014; 36(9): 409. CrossRef Mucosal and systemic T cell response in mice intragastrically infected with Neospora caninum tachyzoites Alexandra Correia, Pedro Ferreirinha, Amanda A Costa, Joana Dias, Joana Melo, Rita Costa, Adília Ribeiro, Augusto Faustino, Luzia Teixeira, António Rocha, Manuel Vilanova Veterinary Research.2013;[Epub] CrossRef Intraepithelial γδ+ Lymphocytes Maintain the Integrity of Intestinal Epithelial Tight Junctions in Response to Infection Jane E. Dalton, Sheena M. Cruickshank, Charlotte E. Egan, Rainy Mears, Darren J. Newton, Elizabeth M. Andrew, Beth Lawrence, Gareth Howell, Kathryn J. Else, Marc–Jan Gubbels, Boris Striepen, Judith E. Smith, Stanley J. White, Simon R. Carding Gastroenterology.2006; 131(3): 818. CrossRef A Requirement for the Vγ1+ Subset of Peripheral γδ T Cells in the Control of the Systemic Growth of Toxoplasma gondii and Infection-Induced Pathology Charlotte E. Egan, Jane E. Dalton, Elizabeth M. Andrew, Judith E. Smith, Marc-Jan Gubbels, Boris Striepen, Simon R. Carding The Journal of Immunology.2005; 175(12): 8191. CrossRef 8,353 View 88 Download Crossref Epidemiological study of clonorchiasis and metagonimiasis along the Geum-gang (River) in Okcheon-gun (County), Korea Gye-Sung Lee, In-Sung Cho, Young-Ha Lee, Hyung-Jun Noh, Dae-Whan Shin, Sok-Goo Lee, Tae-Yong Lee Korean J Parasitol 2002;40(1):9-16. Published online March 31, 2002 DOI: https://doi.org/10.3347/kjp.2002.40.1.9 Abstract PDF The endemic status of clonorchiasis and metagonimiasis along the Geum-gang (River) in Okcheon-gun (County) in Korea was examined. From February to December 2000, stools of total 1,081 inhabitants living in 5 villages were examined. Each stool specimen was examined by both the cellophane thick smear method and the formalin-ether sedimentation technique. Egg-positive cases were further analyzed by Stoll's egg-counting technique, and praziquantel was administered to positive cases. The egg-positive rates for Clonorchis sinensis and Metagonimus species were 9.3% and 5.5%, respectively, and the double infection rate was 3.5%. The numbers of eggs per gram (EPG) of feces of C. sinensis and Metagonimus sp. were 918±1,463 and 711±947, respectively. The egg-positive rates for C. sinensis and Metagonimus sp. in the riverside area were 14.2% and 8.4%, respectively, which were significantly higher than those of the inland area (3.2% and 1.7%, respectively). The egg-positive rates of C. sinensis and Metagonimus sp. in males (16.7% and 10.0%) were significantly higher than those of females (3.5% and 1.8%). However, there were no significant differences of EPG values between localities and sexes. The prevalence of clonorchiasis and metagonimiasis in this survey was significantly lower than that in the previous reports. However, there is still a high prevalence of infection with C. sinensis and Metagonimus sp. in this region, especially in the riverside area. Citations Citations to this article as recorded by Infection characteristics of Metagonimus species (Digenea: Heterophyidae) metacercariae in fish from major rivers of Korea Woon-Mok Sohn Parasites, Hosts and Diseases.2024; 62(1): 1. CrossRef Age, period, and cohort effects of Clonorchis sinensis infection prevalence in the Republic of Korea: Insights and projections Sung-mok Jung, Heewon Kang, Bong-Kwang Jung, Sejin Ju, Jung-Won Ju, Myoung-Ro Lee, Jong-hun Kim, Sung Hye Kim, Ran Wang PLOS Neglected Tropical Diseases.2024; 18(10): e0012574. 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CrossRef 9,691 View 100 Download Crossref Effects of specific monoclonal antibodies to dense granular proteins on the invasion of Toxoplasma gondii in vitro and in vivo Dong Yeob Cha, In Kwan Song, Gye Sung Lee, Ok-Sun Hwang, Hyung-Jun Noh, Seung-Dong Yeo, Dae-Whan Shin, Young-Ha Lee Korean J Parasitol 2001;39(3):233-240. Published online September 30, 2001 DOI: https://doi.org/10.3347/kjp.2001.39.3.233 Abstract PDF Although some reports have been published on the protective effect of antibodies to Toxoplasma gondii surface membrane proteins, few address the inhibitory activity of antibodies to dense granular proteins (GRA proteins). Therefore, we performed a series of experiments to evaluate the inhibitory effects of monoclonal antibodies (mAbs) to GRA proteins (GRA2, 28 kDa; GRA6, 32 kDa) and surface membrane protein (SAG1, 30 kDa) on the invasion of T. gondii tachyzoites. Passive immunization of mice with one of three mAbs following challenge with a lethal dose of tachyzoites significantly increased survival compared with results for mice treated with control ascites. The survival times of mice challenged with tachyzoites pretreated with anti-GRA6 or anti-SAG1 mAb were significantly increased. Mice that received tachyzoites pretreated with both mAb and complement had longer survival times than those that received tachyzoites pretreated with mAb alone. Invasion of tachyzoites into fibroblasts and macrophages was significantly inhibited in the anti-GRA2, anti-GRA6 or anti-SAG1 mAb pretreated group. Pretreatment with mAb and complement inhibited invasion of tachyzoites in both fibroblasts and macrophages. These results suggest that specific antibodies to dense-granule molecules may be useful for controlling infection with T. gondii. 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CrossRef Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid A (MPL) adjuvant against Toxoplasma chronic infection in mice Majid Golkar, Mohammad-Ali Shokrgozar, Sima Rafati, Karine Musset, Mehdi Assmar, Reza Sadaie, Marie-France Cesbron-Delauw, Corinne Mercier Vaccine.2007; 25(21): 4301. CrossRef 9,175 View 83 Download Crossref Seroepidemiological study of Toxoplasma gondii infection in the rural area Okcheon-gun, Korea Young-Ha Lee, Hyung-Jun Noh, Ok-Sun Hwang, Sang-Keol Lee, Dae-Whan Shin Korean J Parasitol 2000;38(4):251-256. Published online December 31, 2000 DOI: https://doi.org/10.3347/kjp.2000.38.4.251 Abstract PDF There have been some reports about the prevalence of anti-Toxoplasma gondii antibody among Koreans, and most of all data were taken from patients visiting hospitals. However, the epidemiological data of the community-based study in Korea are rare. This study was performed to evaluate the seroprevalence of toxoplasmosis among the inhabitants of the rural area Okcheon-gun, Korea. A total of 1,109 serum samples (499 males, 610 females) were examined for the IgG antibodies by ELISA. To set up the cut-off point for ELISA, we used a commercial latex agglutination (LA) kit. The sensitivity and specificity of ELISA against LA test were 89.5%, and 98.6% respectively. Among 1,109 sera, 6.9% showed seropositivity by ELISA. The positive rates of males and females were 6.0% and 7.2%, respectively. However, there were no significant differences between sexes. Comparing the age groups, the highest seropositive rate showed in the seventies or higher, and their rates had a tendency to increase with age (0.05 < p < 0.3). 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CrossRef A Case of Cerebral Toxoplasmosis Following Tandem Autologous Stem Cell Transplantation in a Multiple Myeloma Patient Kye-Hyung Kim, Kyoung-Ho Song, Jae Hyun Jeon, Wan Beom Park, Sang-Won Park, Hong Bin Kim, Nam Joong Kim, Inho Kim, Myoung-don Oh Infection and Chemotherapy.2010; 42(3): 181. CrossRef Review of Zoonotic Parasites in Medical and Veterinary Fields in the Republic of Korea Heejeong Youn The Korean Journal of Parasitology.2009; 47(Suppl): S133. CrossRef Seroprevalence of Toxoplasma gondii Infection and Characteristics of Seropositive Patients in General Hospitals in Daejeon, Korea Dae-Whan Shin, Dong-Yeub Cha, Quan Juan Hua, Guang-Ho Cha, Young-Ha Lee The Korean Journal of Parasitology.2009; 47(2): 125. CrossRef Genotyping of a Korean isolate of Toxoplasma gondii by multilocus PCR-RFLP and microsatellite analysis Juan-Hua Quan, Tae Yun Kim, In-Uk Choi, Young-Ha Lee The Korean Journal of Parasitology.2008; 46(2): 105. CrossRef Seroepidemiological study of toxoplasmosis in intellectual disability children in rehabilitation centers of northern Iran M. Sharif, H. Ziaei, A. Daryani, A. Ajami Research in Developmental Disabilities.2007; 28(3): 219. CrossRef Serological evidence for remarkably variable prevalence rates of Toxoplasma gondii in children of major residential areas in United Arab Emirates Y.A Abu-Zeid Acta Tropica.2002; 83(1): 63. CrossRef 9,246 View 93 Download Crossref Sequential analysis of cell differentials and IFN-γ production of splenocytes from mice infected with Toxoplasma gondii Young-Ha Lee, Dae-Whan Shin, Lloyd H. Kasper Korean J Parasitol 2000;38(2):85-90. Published online June 30, 2000 DOI: https://doi.org/10.3347/kjp.2000.38.2.85 Abstract PDF To assess the relationship between the changes of cellular components and the production of Th1 cytokine in the immune tissue, inbred C57BL/6 mice were orally infected with 40 cysts of 76K strain of Toxoplasma gondii. The sequential change of cell differentials and IFN-γ production of splenocytes were analyzed by Diff-Quik stain and RT-PCR. There were no significant proportional changes of cellular components of splenocytes until day 4 postinfection (PI) as compared to those of day 0, and the relative percentage of macrophages and neutrophils/eosinophils increased significantly (p<0.01) thereafter. The expression of IFN-γ mRNA of CD3^- cells was observed from day 1 PI at a low level. However, IFN-γ production of CD3⁺ cells increased significantly from day 4 PI (p<0.01) which progressively increased thereafter. These findings provide the relative percentages of granulocytes and macrophages were increased in conjunction with increase of total number of splenocytes after oral infection with T. gondii in the susceptible murine hosts, and lymphocytes were the major cellular components and the important source of IFN-γ. Citations Citations to this article as recorded by Oral Tolerization with Cardiac Myosin Peptide (614–629) Ameliorates Experimental Autoimmune Myocarditis: Role of Stat 6 Genes in BALB/CJ Mice Patricia A. Gonnella, Pedro J. Del Nido, Francis X. McGowan Journal of Clinical Immunology.2009; 29(4): 434. CrossRef T cell phenotype and intracellular IFN-γ production in peritoneal exudate cells and gut intraepithelial lymphocytes during acute Toxoplasma gondii infection in mice Young-Ha Lee, Dae-Whan Shin The Korean Journal of Parasitology.2002; 40(3): 119. CrossRef 8,175 View 82 Download Crossref