Parasites, Hosts and Diseases

Skip to main navigation Skip to main content

OPEN ACCESS

Page Path

HOME
BROWSE ARTICLES

Author index detail contents
Darambazar Gantulaga	1 Article
Reactivity of German Cockroach Allergen, Bla g 2, Peptide Fragments to IgE Antibodies in Patients' Sera Haeseok Lee, Kyoung Yong Jeong, Kwang Hyun Shin, Myung-hee Yi, Darambazar Gantulaga, Chein-Soo Hong, Tai-Soon Yong Korean J Parasitol 2008;46(4):243-246. Published online December 20, 2008 DOI: https://doi.org/10.3347/kjp.2008.46.4.243 Abstract PDF Bla g 2 is a cockroach allergen of great importance. This study was conducted to identify IgE-binding epitope(s) of Bla g 2 using the recombinant protein technique. Approximately 50% of tested sera showed IgE reactivity to Pichia-expressed Bla g 2 (PrBla g 2) and E. coli-expressed Bla g 2 (ErBla g 2). Only 5.3% of serum samples showed stronger reactivity to PrBla g 2 than ErBla g 2, indicating that serum was reactive to conformational or carbohydrate epitopes. The full-length and 5 peptide fragments of Bla g 2 were produced in E. coli. All fragments showed IgE-binding activity to the cockroach-allergy patients' sera. Specifically, peptide fragments of amino acid residue 1-75 and 146-225 appeared to be important for IgE-binding. The information about the IgE-binding epitope of Bla g 2 can aid in the diagnosis and treatment for cockroach allergies. Citations Citations to this article as recorded by Cross-reactive IgE responses to cockroach, house dust mite, and seafood allergens in patients with allergic rhinitis Sakinah Mohamad, V Sha Kri Eh Dam, Asma Abdullah Nurul, Fook Tim Chew, Baharudin Abdullah Expert Review of Clinical Immunology.2025; 21(9): 1307. CrossRef Edible insects as ingredients in food products: nutrition, functional properties, allergenicity of insect proteins, and processing modifications Jing Yang, Shuling Zhou, Hong Kuang, Chunhong Tang, Jiajia Song Critical Reviews in Food Science and Nutrition.2024; 64(28): 10361. CrossRef Cockroach allergen exposure and risk of asthma D. C. Do, Y. Zhao, P. Gao Allergy.2016; 71(4): 463. CrossRef Pulmonary α-1,3-Glucan–Specific IgA-Secreting B Cells Suppress the Development of Cockroach Allergy Preeyam S Patel, R Glenn King, John F Kearney The Journal of Immunology.2016; 197(8): 3175. CrossRef IgE-Binding Epitope Mapping and Tissue Localization of the Major American Cockroach Allergen Per a 2 Mey-Fann Lee, Chia-Wei Chang, Pei-Pong Song, Guang-Yuh Hwang, Shyh-Jye Lin, Yi-Hsing Chen Allergy, Asthma & Immunology Research.2015; 7(4): 376. CrossRef Different Bla‐g T cell antigens dominate responses in asthma versus rhinitis subjects M. B. C. Dillon, V. Schulten, C. Oseroff, S. Paul, L. M. Dullanty, A. Frazier, X. Belles, M.‐D. Piulachs, C. Visness, L. Bacharier, G. R. Bloomberg, P. Busse, J. Sidney, B. Peters, A. Sette Clinical & Experimental Allergy.2015; 45(12): 1856. CrossRef Preparation and Characterization of an Extract of German Cockroach From a Korean Source Kyoung Yong Jeong, Soo-Young Choi, Jae-Hyun Lee, Joo-Shil Lee, Tai-Soon Yong, Chein-Soo Hong, Jung-Won Park Allergy, Asthma & Immunology Research.2013; 5(2): 102. CrossRef Identification of Novel Allergenic Components from German Cockroach Fecal Extract by a Proteomic Approach Kyoung Yong Jeong, Chung-ryul Kim, Jina Park, In-Soo Han, Jung-Won Park, Tai-Soon Yong International Archives of Allergy and Immunology.2013; 161(4): 315. CrossRef The Cockroach and Allergic Diseases Myung Hyun Sohn, Kyu-Earn Kim Allergy, Asthma & Immunology Research.2012; 4(5): 264. CrossRef Validation of a Phage Display and Computational Algorithm by Mapping a Conformational Epitope of Bla g 2 Ruby Tiwari, Surendra S. Negi, Benjamin Braun, Werner Braun, Anna Pomés, Martin D. Chapman, Randall M. Goldblum, Terumi Midoro-Horiuti International Archives of Allergy and Immunology.2012; 157(4): 323. CrossRef Sensitization to per a 2 of the American cockroach correlates with more clinical severity among airway allergic patients in Taiwan Mey-Fann Lee, Pei-Peng Song, Guang-Yuh Hwang, Shyh-Jye Lin, Yi-Hsing Chen Annals of Allergy, Asthma & Immunology.2012; 108(4): 243. CrossRef Household Arthropod Allergens in Korea Tai-Soon Yong, Kyoung Yong Jeong The Korean Journal of Parasitology.2009; 47(Suppl): S143. CrossRef 9,012 View 87 Download Crossref