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Donghee Kim	1 Article
STAT6 Expression and IL-13 Production in Association with Goblet Cell Hyperplasia and Worm Expulsion of Gymnophalloides seoi from C57BL/6 Mice Jin-Joo Lee, Donghee Kim, Kyoung-Ho Pyo, Min-Ki Kim, Hyo-Jin Kim, Jong-Yil Chai, Eun-Hee Shin Korean J Parasitol 2013;51(5):589-594. Published online October 31, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.5.589 Abstract PDF In intestinal helminth infections, Th2 immune respones are generally associated with mucin secretion for worm expulsion from the host intestine. In particular, IL-4 and IL-13 are the important cytokines related with intestinal mucus production via STAT6 signalling in nematode infections. However, this perspective has never been studied in Gymnophalloides seoi infection. The present study aimed to observe the STAT6 signalling and cytokine responses in C57BL/6 mice, a mouse strain resistant to infection with this trematode. The results showed that worm expulsion occurred actively during days 1-2 post-infection (PI), when goblet cells began to proliferate in the small intestine. The STAT6 gene expression in the mouse spleen became remarkable from day 2 PI. Moreover, G. seoi infection induced a significant increase of IL-13 from day 4 PI in the spleen of infected mice. Our results suggested that goblet cell hyperplasia and worm expulsion in G. seoi-infected mice should be induced by STAT6 signalling, in which IL-13 may be involved as a dominant triggering cytokine. Citations Citations to this article as recorded by Immune Regulation of Goblet Cell and Mucus Functions in Health and Disease Jenny K. Gustafsson, Gunnar C. Hansson Annual Review of Immunology .2025; 43(1): 169. CrossRef The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis Franziska Bayer, Olga Dremova, My Phung Khuu, Könül Mammadova, Giulia Pontarollo, Klytaimnistra Kiouptsi, Natalia Soshnikova, Helen Louise May-Simera, Kristina Endres, Christoph Reinhardt Nutrients.2021; 13(7): 2198. CrossRef Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity Songwei Yang, Min Yu Journal of Inflammation Research.2021; Volume 14: 3171. CrossRef The relationship between intestinal goblet cells and the immune response Mingming Zhang, Chenchen Wu Bioscience Reports.2020;[Epub] CrossRef Developmental expression of STATs, nuclear factor-κB and inflammatory genes in the jejunum of piglets during weaning Hongbo Yi, Denghu Jiang, Lin Zhang, Haitao Xiong, Feifei Han, Yizhen Wang International Immunopharmacology.2016; 36: 199. CrossRef Increased Intestinal Epithelial Cell Turnover and Intestinal Motility in Gymnophalloides seoi-Infected C57BL/6 Mice Sang Hyub Lee, Bong-Kwang Jung, Jae-Hwan Park, Eun-Hee Shin, Jong-Yil Chai The Korean Journal of Parasitology.2014; 52(3): 273. CrossRef 9,335 View 89 Download Crossref