The present study was designed to investigate polymorphism in Duffy binding protein (DBP) gene of Plasmodium vivax isolates of Korea. Thirty samples were obtained from P. vivax patients in Yonchon-gun, Kyonggi-do in 1998. The PCR products of the samples were subjected to sequencing and hybridization analyses of the regions II and IV of P. vivax DBP gene. Two genotypes, SK-1 and SK-2, were identified on the basis of amino acid substitution and deletion. The genotype of 10 isolates was SK-1 and that of 20 isolates was SK-2. Most of the predicted amino acids in the region II of DBP gene were conserved between the Korean isolates and Belem strain except for 4-5 amino acid substitutions. In the region IV of DBP, a 6-bp insert that was shown in the Sal-1 allele type was found in SK-1, and a 27-bp insert that was shown in the Papua New Guinea allele type was found in SK-2. In conclusion, the present findings suggest that two genotypes of P. vivax coexist in the endemic area of Korea.
Citations
Citations to this article as recorded by
PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial Francisco J. Martinez, Michael White, Micheline Guillotte-Blisnick, Christèle Huon, Alix Boucharlat, Fabrice Agou, Patrick England, Jean Popovici, Mimi M. Hou, Sarah E. Silk, Jordan R. Barrett, Carolyn M. Nielsen, Jenny M. Reimer, Paushali Mukherjee, Vira npj Vaccines.2024;[Epub] CrossRef
Genetic diversity and natural selection of Plasmodium vivax reticulocyte invasion genes in Ecuador Andrés Núñez, Francis B. Ntumngia, Yasel Guerra, John H. Adams, Fabián E. Sáenz Malaria Journal.2023;[Epub] CrossRef
Plasmodium vivax Duffy Binding Protein-Based Vaccine: a Distant Dream Sonalika Kar, Abhinav Sinha Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Global distribution of single amino acid polymorphisms in
Plasmodium vivax
Duffy-binding-like domain and implications for vaccine development efforts
Payal Mittal, Siddhartha Mishra, Sonalika Kar, Veena Pande, Abhinav Sinha, Amit Sharma Open Biology.2020;[Epub] CrossRef
Paleopathological Considerations on Malaria Infection in Korea before the 20th Century Dong Hoon Shin, Min Seo, Jong Ha Hong, Eunju Lee BioMed Research International.2018; 2018: 1. CrossRef
Genetic diversity in two Plasmodium vivax protein ligands for reticulocyte invasion Camille Roesch, Jean Popovici, Sophalai Bin, Vorleak Run, Saorin Kim, Stéphanie Ramboarina, Emma Rakotomalala, Rado Lalaina Rakotoarison, Tsikiniaina Rasoloharimanana, Zo Andriamanantena, Anuj Kumar, Micheline Guillotte-Blisnick, Christèle Huon, David Ser PLOS Neglected Tropical Diseases.2018; 12(10): e0006555. CrossRef
Genetic Diversity of Plasmodium vivax Causing Epidemic Malaria in the Republic of Korea Young Yil Bahk, Jeonga Kim, Seong Kyu Ahn, Byoung-Kuk Na, Jong-Yil Chai, Tong-Soo Kim The Korean Journal of Parasitology.2018; 56(6): 545. CrossRef
Characteristics of Imported Malaria and Species of Plasmodium Involved in Shandong Province, China (2012-2014) Chao Xu, Qing-Kuan Wei, Jin Li, Ting Xiao, Kun Yin, Chang-Lei Zhao, Yong-Bin Wang, Xiang-Li Kong, Gui-Hua Zhao, Hui Sun, Xin Liu, Bing-Cheng Huang The Korean Journal of Parasitology.2016; 54(4): 407. CrossRef
Strain-Transcending Inhibitory Antibodies against Homologous and Heterologous Strains of Duffy Binding Protein region II Sudarat Wongkidakarn, Amy M. McHenry, Jetsumon Sattabongkot, John H Adams, Patchanee Chootong, Laurent Rénia PLOS ONE.2016; 11(5): e0154577. CrossRef
Diversity and evolutionary genetics of the three major Plasmodium vivax merozoite genes participating in reticulocyte invasion in southern Mexico Lilia González-Cerón, Rene Cerritos, Jordán Corzo-Mancilla, Frida Santillán Parasites & Vectors.2015;[Epub] CrossRef
Population genetics and natural selection in the gene encoding the Duffy binding protein II in Iranian Plasmodium vivax wild isolates Vahideh Valizadeh, Sedigheh Zakeri, Akram Abouie Mehrizi, Navid Dinparast Djadid Infection, Genetics and Evolution.2014; 21: 424. CrossRef
Non-allele specific antibody responses to genetically distinct variant forms of Plasmodium vivax Duffy binding protein (PvDBP-II) in Iranians exposed to seasonal malaria transmission Vahideh Valizadeh, Sedigheh Zakeri, Akram Abouei Mehrizi, Navid Dinparast Djadid Acta Tropica.2014; 136: 89. CrossRef
Genetic diversity, haplotypes and allele groups of Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from Peninsular Malaysia Mun-Yik Fong, Yee-Ling Lau, Phooi-Yee Chang, Claudia Anthony Parasites & Vectors.2014; 7(1): 161. CrossRef
The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon Taís Nóbrega de Sousa, Flora Satiko Kano, Cristiana Ferreira Alves de Brito, Luzia Helena Carvalho Memórias do Instituto Oswaldo Cruz.2014; 109(5): 608. CrossRef
Genetic diversity and natural selection of Duffy binding protein of Plasmodium vivax Korean isolates Hye-Lim Ju, Jung-Mi Kang, Sung-Ung Moon, Young-Yil Bahk, Pyo-Yun Cho, Woon-Mok Sohn, Yun-Kyu Park, Jae-Won Park, Tong-Soo Kim, Byoung-Kuk Na Acta Tropica.2013; 125(1): 67. CrossRef
Microsatellite DNA Analysis Revealed a Drastic Genetic Change of Plasmodium vivax Population in the Republic of Korea During 2002 and 2003 Moritoshi Iwagami, Seung-Young Hwang, So-Hee Kim, So-Jung Park, Ga-Young Lee, Emilie Louise Akiko Matsumoto-Takahashi, Weon-Gyu Kho, Shigeyuki Kano, Shan Lv PLoS Neglected Tropical Diseases.2013; 7(10): e2522. CrossRef
Genetic polymorphism and natural selection of Duffy binding protein of Plasmodium vivax Myanmar isolates Hye-Lim Ju, Jung-Mi Kang, Sung-Ung Moon, Jung-Yeon Kim, Hyeong-Woo Lee, Khin Lin, Woon-Mok Sohn, Jin-Soo Lee, Tong-Soo Kim, Byoung-Kuk Na Malaria Journal.2012;[Epub] CrossRef
Population Structure and Transmission Dynamics of Plasmodium vivax in the Republic of Korea Based on Microsatellite DNA Analysis Moritoshi Iwagami, Megumi Fukumoto, Seung-Young Hwang, So-Hee Kim, Weon-Gyu Kho, Shigeyuki Kano, Mehmet Ali Ozcel PLoS Neglected Tropical Diseases.2012; 6(4): e1592. CrossRef
Characterization of Inhibitory Anti-Duffy Binding Protein II Immunity: Approach to Plasmodium vivax Vaccine Development in Thailand Patchanee Chootong, Tasanee Panichakul, Chongrak Permmongkol, Samantha J. Barnes, Rachanee Udomsangpetch, John H. Adams, Georges Snounou PLoS ONE.2012; 7(4): e35769. CrossRef
Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea Hajime Honma, Jung-Yeon Kim, Nirianne MQ Palacpac, Toshihiro Mita, Wonja Lee, Toshihiro Horii, Kazuyuki Tanabe Malaria Journal.2011;[Epub] CrossRef
Worldwide Genetic Variability of the Duffy Binding Protein: Insights into Plasmodium vivax Vaccine Development Taís Nóbrega de Sousa, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito, Mauricio Martins Rodrigues PLoS ONE.2011; 6(8): e22944. CrossRef
Determination of the Molecular Basis for a Limited Dimorphism, N417K, in the Plasmodium vivax Duffy-Binding Protein Amy M. McHenry, Samantha J. Barnes, Francis B. Ntumngia, Christopher L. King, John H. Adams, Ivo Mueller PLoS ONE.2011; 6(5): e20192. CrossRef
Molecular markers and genetic diversity of Plasmodium vivax Cristiana Ferreira Alves de Brito, Marcelo Urbano Ferreira Memórias do Instituto Oswaldo Cruz.2011; 106(suppl 1): 12. CrossRef
Antibody Responses and Avidity of Naturally Acquired Anti-Plasmodium vivax Duffy Binding Protein (PvDBP) Antibodies in Individuals from an Area with Unstable Malaria Transmission Sedigheh Zakeri, Akram Abouie Mehrizi, Navid Dinparast Djadid, Laleh Babaeekhou, Maryam Abbasi The American Journal of Tropical Medicine and Hygiene.2011; 84(6): 944. CrossRef
Mapping Epitopes of the
Plasmodium vivax
Duffy Binding Protein with Naturally Acquired Inhibitory Antibodies
Patchanee Chootong, Francis B. Ntumngia, Kelley M. VanBuskirk, Jia Xainli, Jennifer L. Cole-Tobian, Christopher O. Campbell, Tresa S. Fraser, Christopher L. King, John H. Adams Infection and Immunity.2010; 78(3): 1089. CrossRef
Genetic variability and natural selection at the ligand domain of the Duffy binding protein in brazilian Plasmodium vivax populations Taís N Sousa, Eduardo M Tarazona-Santos, Daniel J Wilson, Ana P Madureira, Paula RK Falcão, Cor JF Fontes, Luiz HS Gil, Marcelo U Ferreira, Luzia H Carvalho, Cristiana FA Brito Malaria Journal.2010;[Epub] CrossRef
Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivax Seung-Young Hwang, So-Hee Kim, Weon-Gyu Kho The Korean Journal of Parasitology.2009; 47(Suppl): S51. CrossRef
Naturally acquired inhibitory antibodies toPlasmodium vivaxDuffy binding protein are short-lived and allele-specific following a single malaria infection I P Ceravolo, B A M Sanchez, T N Sousa, B M Guerra, I S Soares, E M Braga, A M McHenry, J H Adams, C F A Brito, L H Carvalho Clinical and Experimental Immunology.2009; 156(3): 502. CrossRef
Plasmodium vivax PCR genotyping of the first malaria case imported from South Korea into Japan Moritoshi Iwagami, Shigeyuki Kano, Ichiro Itoda, Seung-Young Hwang, Weon-Gyu Kho Journal of Infection and Chemotherapy.2009; 15(1): 27. CrossRef
Molecular Genetic Characterization of the Merozoite Surface Protein 1 Gene of
Plasmodium vivax
from Reemerging Korean Isolates
So-Hee Kim, Seung-Young Hwang, Jeong Hwan Shin, Chi-Sook Moon, Dong-Wook Kim, Weon-Gyu Kho Clinical and Vaccine Immunology.2009; 16(5): 733. CrossRef
Single-Chain Antibody Fragment Specific forPlasmodium vivaxDuffy Binding Protein So-Hee Kim, Seung-Young Hwang, Yong-Seok Lee, In-Hak Choi, Sae-Gwang Park, Weon-Gyu Kho Clinical and Vaccine Immunology.2007; 14(6): 726. CrossRef
The crystal structure of P. knowlesi DBPα DBL domain and its implications for immune evasion Amy M. McHenry, John H. Adams Trends in Biochemical Sciences.2006; 31(9): 487. CrossRef
Reemerging vivax malaria: changing patterns of annual incidence and control programs in the Republic of Korea Eun-Taek Han, Duk-Hyoung Lee, Ki-Dong Park, Won-Seok Seok, Young-Soo Kim, Takafumi Tsuboi, Eun-Hee Shin, Jong-Yil Chai The Korean Journal of Parasitology.2006; 44(4): 285. CrossRef
The pattern of major polymorphisms in the Duffy binding protein ligand domain among Plasmodium vivax isolates from the Brazilian Amazon area Taís N. Sousa, Isabela P. Cerávolo, Cor Jésus Fernandes Fontes, Álvaro Couto, Luzia H. Carvalho, Cristiana F.A. Brito Molecular and Biochemical Parasitology.2006; 146(2): 251. CrossRef
Plasmodium vivax Duffy binding protein: a modular evolutionary proposal P. MARTINEZ, C. F. SUAREZ, P. P. CARDENAS, M. A. PATARROYO Parasitology.2004; 128(4): 353. CrossRef
Diversity and natural selection in Plasmodium vivax Duffy binding protein gene Jennifer Cole-Tobian, Christopher L. King Molecular and Biochemical Parasitology.2003; 127(2): 121. CrossRef
Analysis of the Plasmodium vivax apical membrane antigen-1 gene from re-emerging Korean isolates Joon-Yong Chung, Eui-Hyun Chun, Jin-Ho Chun, Weon-Gyu Kho Parasitology Research.2003; 90(4): 325. CrossRef
Apical membrane antigen-1 (AMA-1) gene sequences of re-emerging Plasmodium vivax in South Korea Eun-Taek Han, Jae-Hwan Park, Eun-Hee Shin, Min-Ho Choi, Myoung-Don Oh, Jong-Yil Chai The Korean Journal of Parasitology.2002; 40(3): 157. CrossRef
Age-Dependent Cellular Immune Responses toPlasmodium vivaxDuffy Binding Protein in Humans Jia Xainli, Moses Baisor, Will Kastens, Moses Bockarie, John H. Adams, Christopher L. King The Journal of Immunology.2002; 169(6): 3200. CrossRef
Analysis of polymorphic region of GAM-1 gene in Plasmodium vivax Korean isolates Weon-Gyu Kho, Joon-Yong Chung, Ui-Wook Hwang, Jin-Ho Chun, Yeong-Hong Park, Woo-Chul Chung The Korean Journal of Parasitology.2001; 39(4): 313. CrossRef
