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Feng Meng	2 Articles
Sensitivity of Plasmodium falciparum to Antimalarial Drugs in Hainan Island, China Shan-Qing Wang, Guang-Ze Wang, Yu-Chun Li, Feng Meng, Shi-Gan Lin, Zhen-Hu Zhu, Ding-Wei Sun, Chang-Hua He, Xi-Min Hu, Jian-Wei Du Korean J Parasitol 2015;53(1):35-41. Published online February 27, 2015 DOI: https://doi.org/10.3347/kjp.2015.53.1.35 Abstract PDF Pyronaridine and artesunate have been shown to be effective in falciparum malaria treatment. However, pyronaridine is rarely used in Hainan Island clinically, and artesunate is not widely used as a therapeutic agent. Instead, conventional antimalarial drugs, chloroquine and piperaquine, are used, explaining the emergence of chloroquine-resistant Plasmodium falciparum. In this article, we investigated the sensitivity of P. falciparum to antimalarial drugs used in Hainan Island for rational drug therapy. We performed in vivo (28 days) and in vitro tests to determine the sensitivity of P. falciparum to antimalarial drugs. Total 46 patients with falciparum malaria were treated with dihydroartemisinin/piperaquine phosphate (DUO-COTECXIN) and followed up for 28 day. The cure rate was 97.8%. The mean fever clearance time (22.5±10.6 hr) and the mean parasite clearance time (27.3±12.2 hr) showed no statistical significance with different genders, ages, temperatures, or parasite density (P>0.05). The resistance rates of chloroquine, piperaquine, pyronarididine, and artesunate detected in vitro were 71.9%, 40.6%, 12.5%, and 0%, respectively (P<0.0001). The resistance intensities decreased as follows: chloroquine>piperaquine>pyronarididine>artesunate. The inhibitory dose 50 (IC₅₀) was 3.77×10^-6 mol/L, 2.09×10^-6 mol/L, 0.09×10^-6 mol/L, and 0.05×10^-6 mol/L, and the mean concentrations for complete inhibition (CIMC) of schizont formation were 5.60×10^-6 mol/L, 9.26×10^-6 mol/L, 0.55×10^-6 mol/L, and 0.07×10^-6 mol/L, respectively. Dihydroartemisinin showed a strong therapeutic effect against falciparum malaria with a low toxicity. Citations Citations to this article as recorded by Evaluation Algorithm of Volleyball Players’ Competitive Ability Based on the Random Matrix Model Tailin Wang, Hua Zheng, Fangshu Li, Nian Jia, Zengliang Cai, Ning Cao Mathematical Problems in Engineering.2022; 2022: 1. CrossRef 11,734 View 104 Download 2 Web of Science Crossref A Case of Plasmodium ovale wallikeri Infection in a Chinese Worker Returning from West Africa Yuchun Li, Guangze Wang, Dingwei Sun, Feng Meng, Shigan Lin, Ximin Hu, Shanqing Wang Korean J Parasitol 2013;51(5):557-562. Published online October 31, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.5.557 Abstract PDF In contrast to the gradual reduction in the number of locally transmitted malaria cases in China, the number of imported malaria cases has been increasing since 2008. Here, we report a case of a 39-year-old Chinese man who acquired Plasmodium ovale wallikeri infection while staying in Ghana, West Africa for 6 months in 2012. Microscopic examinations of Giemsa-stained thin and thick blood smears indicated Plasmodium vivax infection. However, the results of rapid diagnostic tests, which were conducted 3 times, were not in agreement with P. vivax. To further check the diagnosis, standard PCR analysis of the small-subunit rRNA gene was conducted, based on which a phylogeny tree was constructed. The results of gene sequencing indicated that this malaria is a variant of P. ovale (P. ovale wallikeri). The infection in this patient was not a new infection, but a relapse of the infection from the one that he had contracted in West Africa. Citations Citations to this article as recorded by Geographical origin of Plasmodium vivax in the Hainan Island, China: insights from mitochondrial genome Yuchun Li, Xiaomin Huang, Ling Qing, Wen Zeng, Xiangjie Zeng, Feng Meng, GuangZe Wang, Yan Chen Malaria Journal.2023;[Epub] CrossRef An innovative three-layer strategy in response to a quartan malaria outbreak among forest goers in Hainan Island, China: a retrospective study Yuchun Li, Yingjuan Huang, Renqiang Chen, Weizhen Huang, Huanzhi Xu, Rongshen Ye, Shaoling Huang, Ji Zhen, Xiaodan Wen, Guoyi Wang, Yong Liu, Haishan Li, Zaichun Zheng, Jian Wang, Guoshen Wang, Chong Chen, Wen Zeng, Feng Meng, Xiaoming Huang, Guangze Wang Infectious Diseases of Poverty.2022;[Epub] CrossRef High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana Charles A. Brown, Prince J. Pappoe-Ashong, Nancy Duah, Anita Ghansah, Harry Asmah, Edwin Afari, Kwadwo A. Koram Malaria Journal.2021;[Epub] CrossRef A comparison of two PCR protocols for the differentiation of Plasmodium ovale species and implications for clinical management in travellers returning to Germany: a 10-year cross-sectional study Hagen Frickmann, Christine Wegner, Stefanie Ruben, Ulrike Loderstädt, Egbert Tannich Malaria Journal.2019;[Epub] CrossRef Indel-informed Bayesian analysis suggests cryptic population structure between Plasmodium knowlesi of humans and long-tailed macaques (Macaca fascicularis) in Malaysian Borneo JustinJ.S. Wilcox, Abigail Kerschner, Hope Hollocher Infection, Genetics and Evolution.2019; 75: 103994. CrossRef Detection of malaria with light microscopy and Nested polymerase chain reaction (Nested PCR) methods in peripheral blood expansions and investigation of the genetic diversity of Plasmodium species by 18S rRNA gene in Southeast of Iran Ahmad Taghdiri, Pooya Ghasemi Nejad Almani, Iraj Sharifi, Mohammad Ali Mohammadi, Samira Salari Microbial Pathogenesis.2019; 137: 103782. CrossRef WITHDRAWN: Indel-informed bayesian analysis suggests cryptic divisions between Plasmodium knowlesi of humans and long-tailed macaques (Macaca fascicularis) in Malaysian Borneo Justin J.S. Wilcox, Abigail Kerschner, Hope Hollocher Infection, Genetics and Evolution.2018;[Epub] CrossRef Diagnosis of an imported Plasmodium ovale wallikeri infection in Malaysia Jonathan Wee Kent Liew, Rohela Mahmud, Lian Huat Tan, Yee Ling Lau Malaria Journal.2016;[Epub] CrossRef Clinical implications of a gradual dormancy concept in malaria Joachim Richter, Gabriele Franken, Martha C. Holtfreter, Susanne Walter, Alfons Labisch, Heinz Mehlhorn Parasitology Research.2016; 115(6): 2139. CrossRef Genetic diversity of Plasmodium vivax population before elimination of malaria in Hainan Province, China Yu-Chun Li, Guang-Ze Wang, Feng Meng, Wen Zeng, Chang-hua He, Xi-Min Hu, Shan-Qing Wang Malaria Journal.2015;[Epub] CrossRef Molecular characterization of misidentified Plasmodium ovale imported cases in Singapore Jean-Marc Chavatte, Sarah Bee Hui Tan, Georges Snounou, Raymond Tzer Pin Valentine Lin Malaria Journal.2015;[Epub] CrossRef Characterization of Plasmodium ovale curtisi and P. ovale wallikeri in Western Kenya Utilizing a Novel Species-specific Real-time PCR Assay Robin H. Miller, Clifford O. Obuya, Elizabeth W. Wanja, Bernhards Ogutu, John Waitumbi, Shirley Luckhart, V. Ann Stewart, Alain Debrabant PLOS Neglected Tropical Diseases.2015; 9(1): e0003469. CrossRef 10,931 View 110 Download Crossref