For treating Leishmania major infection in BALB/c mice, we used thalidomide in conjunction with glucantime. Groups of mice were challenged with 5 × 103 metacyclic promastigotes of L. major subcutaneously. A week after the challenge, drug treatment was started and continued for 12 days. Thalidomide was orally administrated 30 mg/kg/day and glucantime was administrated intraperitoneally (200 mg/kg/day). It was shown that the combined therapy is more effective than single therapies with each one of the drugs since the foot pad swelling in the group of mice received thalidomide and glucantime was significantly decreased (0.9 ± 0.2 mm) compared to mice treated with either glucantime, thalidomide, or carrier alone (1.2 ± 0.25, 1.4 ± 0.3, and 1.7 ± 0.27 mm, respectively). Cytokine study showed that the effect of thalidomide was not dependent on IL-12; however, it up-regulated IFN-γ and down-regulated IL-10 production. Conclusively, thalidomide seems promising as a conjunctive therapy with antimony in murine model of visceral leishmaniasis.
Citations
Citations to this article as recorded by
Deciphering Molecular Mechanisms of Cutaneous Leishmaniasis, Pathogenesis and Drug Repurposing through Systems Biology Fatemeh Saberi, Zeinab Dehghan, Zahra Taheri, Tayyebeh Pilehchi, Hakimeh Zali Iranian Biomedical Journal.2024; 28(4): 179. CrossRef
A standardized intraperitoneal Glucantime™ for experimental treatment of cutaneous leishmaniasis caused by Leishmania amazonensis in BALB/c mice Aline Ávila Brustolin, Nathália Martins Franzói, Áquila Carolina Fernandes Herculano Ramos-Milaré, Cínthia Akemi Tanoshi, Camila Alves Mota, Izabel Galhardo Demarchi, Maria Valdrinez Campana Lonardoni, Thaís Gomes Verzignassi Silveira Experimental Parasitology.2022; 236-237: 108259. CrossRef
Effect of Synergism of Thalidomide and Liposomal Amphotericin-B on Leishmania tropica and Leishmania donovani Promastigote Nasma I. Al-Mamary, Haitham L. Al-Hayali Bionatura.2022; 7(2): 1. CrossRef
Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice Alexandre C. Santana, Sabrina Degaspari, Sergio Catanozi, Humberto Dellê, Larissa de Sá Lima, Cleonice Silva, Paula Blanco, Kim Solez, Cristoforo Scavone, Irene L. Noronha Nephrology Dialysis Transplantation.2013; 28(5): 1140. CrossRef
Immunomodulation by chemotherapeutic agents against Leishmaniasis Piu Saha, Debanjan Mukhopadhyay, Mitali Chatterjee International Immunopharmacology.2011; 11(11): 1668. CrossRef
Immunomodulatory effect of picroliv on the efficacy of paromomycin and miltefosine in combination in experimental visceral leishmaniasis Shraddha A. Sane, Nishi Shakya, Suman Gupta Experimental Parasitology.2011; 127(2): 376. CrossRef
Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime Diana Copi Ayres, Thiago Antonio Fedele, Maria Cristina Marcucci, Selma Giorgio Revista do Instituto de Medicina Tropical de São Paulo.2011; 53(6): 329. CrossRef
Anni 2.0: a multipurpose text-mining tool for the life sciences Rob Jelier, Martijn J Schuemie, Antoine Veldhoven, Lambert CJ Dorssers, Guido Jenster, Jan A Kors Genome Biology.2008;[Epub] CrossRef
