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Hedayatollah Shirzad	1 Article
Effects of Toxoplasma gondii and Toxocara canis Antigens on WEHI-164 Fibrosarcoma Growth in a Mouse Model Hossein Yousofi Darani, Hedayatollah Shirzad, Fataneh Mansoori, Nozhat Zabardast, Mahdi Mahmoodzadeh Korean J Parasitol 2009;47(2):175-177. Published online May 27, 2009 DOI: https://doi.org/10.3347/kjp.2009.47.2.175 Abstract PDF Cancer is the main cause of death in developed countries. However, in underdeveloped countries infections and parasitic diseases are the main causes of death. There are raising scientific evidences indicating that parasitic infections induce antitumor activity against certain types of cancers. In this study, the effects of Toxoplasma gondii and Toxocara canis egg antigens in comparison with Bacillus Calmette Guerin (BCG) (known to have anticancer distinctive) on WEHI-164 fibosarcoma transplanted to BALB/c mice was investigated. Groups of 6 male BALB/c mice injected with T. gondii antigen, BCG, or T. canis egg antigen as case groups and alum alone as control groups. All mice were then challenged with WEHI-164 fibrosarcoma cells. The mice were examined for growth of the solid tumor and the tumor sizes were measured every other day up to 4 wk. The mean tumor area in T. gondii, BCG, or alum alone injected mice in 4 different days of measurements was 25 mm², 23 mm², and 186 mm² respectively. Also the mean tumor area in T. canis injected mice in 4 different days was 25.5 mm² compared to the control group (alum treated) which was 155 mm². T. gondii parasites and T. canis egg antigens induced inhibition of the tumor growth in the fibrosarcoma mouse model. We need further study to clarify the mechanisms of anti-cancer effects. Citations Citations to this article as recorded by Bug as a drug: Unveiling anti-cancer properties of Toxoplasma gondii and its therapeutic prospects in cancer immunotherapy Yie Wei Chua, Sek Chuen Chow Acta Tropica.2025; 267: 107684. CrossRef From pathogen to cure: exploring the antitumor potential of Toxoplasma gondii Parisa Alipanahi, Arezou Khosrojerdi, Abdol Satar Pagheh, Kareem Hatam-Nahavandi, Ehsan Ahmadpour Infectious Agents and Cancer.2025;[Epub] CrossRef Effect of Nematodes-Bacteria Complex Metabolites on Cancer and Tumor Progression Aisa Bahar, Malihe Parsa Sefat, Meisam Khazaei, Hamed Tahmasebi, Valentyn Oksenych Biomolecules.2025; 15(8): 1165. CrossRef Evaluation of Antitumor Effects of Toxoplasma gondii Different Antigens on Ehrlich Solid Carcinoma in Mice Salwa S. Younis, Basma M. Elmansory, Hend A. Elrefaey, Nahla A. Nasef, Sara H. Elakshar, Radwa A. Awad, Ghada A. 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CrossRef Toxoplasma gondii-derived antigen modifies tumor microenvironment of Ehrlich solid carcinoma murine model and enhances immunotherapeutic activity of cyclophosphamide Cherine A. Ismail, Maha M. Eissa, Maha R. Gaafar, Layla K. Younis, Nahla El Skhawy Medical Oncology.2023;[Epub] CrossRef Shedding light on a mysterious link between Toxoplasma gondii and cancer: A review Nahla El Skhawy, Maha M. Eissa Experimental Parasitology.2023; 250: 108544. CrossRef Using Helminths to Fight Cancer: An Innovative Approach Nima Ameli, Alireza Masoumi, Mahnaz Kerachi, Niloufar Sheidaeimehneh, Naghmeh Layegh Khavidaki, Melika Zamanian World's Veterinary Journal.2023; 13(4): 606. CrossRef In vitro anti-gastrointestinal cancer activity of Toxocara canis-derived peptide: Analyzing the expression level of factors related to cell proliferation and tumor growth Saeed Bahadory, Javid Sadraei, Mohammad Zibaei, Majid Pirestani, Abdolhossein Dalimi Frontiers in Pharmacology.2022;[Epub] CrossRef Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth Jiating Chen, Wenzhong Liao, HongJuan Peng Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef Effect of Hydatid Cyst Antigens Polyspecific Antisera on Breast Cancer Cells (4T1) Growth in Cell Culture Medium Hossein Yousofi Darani, Seyedeh Maryam Sharafi International Journal of Environmental Health Engineering.2022; 11(1): 15. CrossRef Anti-cancer immunoprotective effects of immunization with hydatid cyst wall antigens in a non-immunogenic and metastatic triple-negative murine mammary carcinoma model Mahshid Shakibapour, Amirhosein Kefayat, Mohammad Reza Mofid, Behrokh Shojaie, Fereshteh Mohamadi, Seydeh Maryam Sharafi, Mahdi Mahmoudzadeh, Hossein Yousofi Darani International Immunopharmacology.2021; 99: 107955. CrossRef Effect of Toxoplasma gondii on colon cancer growth in mouse model Farideh Zavareh, Mahboubeh Hadiipour, Reza Kalantari, Somayeh Mousavi American Journal of BioMedicine.2021; 9(2): 168. CrossRef Gamma Radiation-Attenuated Toxoplasma gondii Provokes Apoptosis in Ehrlich Ascites Carcinoma-Bearing Mice Generating Long-Lasting Immunity Eman N. Hafez, Fatma S. M. Moawed, Gehan R. Abdel-Hamid, Nermeen M. Elbakary Technology in Cancer Research & Treatment.2020;[Epub] CrossRef Immunization with Hydatid Cyst Wall Antigens Can Inhibit Breast Cancer through Changes in Serum Levels of Th1/Th2 Cytokines Mahshid Shakibapour, Behrokh Shojaie, Hossein Yousofi Darani International Journal of Preventive Medicine.2020;[Epub] CrossRef Identifying the Most Effective Hydatid Cyst Fluid Fraction for Anticancer Vaccination of 4T1 Breast Tumor-Bearing Mice Shima Daneshpour, Shahla Rostamirad, Amirhosein Kefayat, MohammadReza Mofid, Ashkan Safavi, Hossein Yousofi Darani International Journal of Preventive Medicine.2019;[Epub] CrossRef Anti-Toxoplasma gondii antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes Fereshteh Mohamadi, Mahshid Shakibapour, Seyedeh Sharafi, Ali Andalib, Sepideh Tolouei, Hossein Yousofi Darani Biomedical Reports.2019;[Epub] CrossRef Plasmodium yoelii infection inhibits murine leukaemia WEHI-3 cell proliferation in vivo by promoting immune responses Zhen-Zhen Tong, Zheng-Ming Fang, Qi Zhang, Yun Zhan, Yue Zhang, Wan-Fang Jiang, Xiao Hou, Yong-Long Li, Ting Wang Infectious Diseases of Poverty.2018;[Epub] CrossRef GADD45β Loss Ablates Innate Immunosuppression in Cancer Daniela Verzella, Jason Bennett, Mariafausta Fischietti, Anil K. Thotakura, Camilla Recordati, Fabio Pasqualini, Daria Capece, Davide Vecchiotti, Daniel D'Andrea, Barbara Di Francesco, Marcella De Maglie, Federica Begalli, Laura Tornatore, Salvatore Papa, Cancer Research.2018; 78(5): 1275. CrossRef Study on the mitochondrial apoptosis pathways of small cell lung cancer H446 cells induced by Trichinella spiralis muscle larvae ESPs JINGMEI LUO, LI YU, GUANGCHENG XIE, DAN LI, MENG SU, XUERONG ZHAO, LUANYING DU Parasitology.2017; 144(6): 793. CrossRef Parasites and immunotherapy: with or against? Hossein Yousofi Darani, Morteza Yousefi, Marzieh Safari, Rasool Jafari Journal of Parasitic Diseases.2016; 40(2): 217. CrossRef Effect of two hydatid cyst antigens on the growth of melanoma cancer in C57/black mice Milad Badri Chookami, Seyedeh Maryam Sharafi, Raheleh Rafiei Sefiddashti, Rasool Jafari, Mehran Bahadoran, Nader Pestechian, Hossein Yousofi Darani Journal of Parasitic Diseases.2016; 40(4): 1170. CrossRef Influence of Toxoplasma gondii on in vitro proliferation and apoptosis of hepatoma carcinoma H7402 cell Gang Wang, Ming Gao Asian Pacific Journal of Tropical Medicine.2016; 9(1): 63. CrossRef A Nonglycosylated 27 KDa Molecule as Common Antigen between Human Breast Cancer and <i>Echinococcus granulosus</i> Hydatid Cyst Wall Seyedeh Maryam Sharafi, Raheleh Rafiei, Raheleh Rafiei, Mahboubeh Hadipour, Hedayat Shirzad, Hossein Khanahmad, Hossein Yousofi Darani Advances in Breast Cancer Research.2016; 05(02): 90. CrossRef Puzzling and ambivalent roles of malarial infections in cancer development and progression ERIC FAURE Parasitology.2016; 143(14): 1811. CrossRef Common antigens between hydatid cyst and cancers Shima Daneshpour, Mehran Bahadoran, Seyed Hossein Hejazi, Abas Ali Eskandarian, Mehdi Mahmoudzadeh, Hossein Yousofi Darani Advanced Biomedical Research.2016;[Epub] CrossRef Preliminary study on association between toxoplasmosis and breast cancer in Iran Narges Kalantari, Salman Ghaffari, Masomeh Bayani, Maryam Mitra Elmi, Daryush Moslemi, Novin Nikbakhsh, Fariedh Ghavipanjeh Asian Pacific Journal of Tropical Biomedicine.2015; 5(1): 44. CrossRef Mutual Action of Anticancer and Antiparasitic Drugs: Are there any Shared Targets? Zahra Dorosti, Morteza Yousefi, Seyedeh Maryam Sharafi, Hossein Yousofi Darani Future Oncology.2014; 10(15): 2529. CrossRef Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines Barbara A. Fox, Kiah L. Sanders, Shan Chen, David J. Bzik Trends in Parasitology.2013; 29(9): 431. CrossRef Trichinella spiralis infection reduces tumor growth and metastasis of B16-F10 melanoma cells Yun-Jeong Kang, Jin-Ok Jo, Min-Kyoung Cho, Hak-Sun Yu, Sun-Hee Leem, Kyoung Seob Song, Mee Sun Ock, Hee-Jae Cha Veterinary Parasitology.2013; 196(1-2): 106. CrossRef Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney FibroblastsIn Vitro Hossein Yousofi Darani, Narges Soozangar, Soliman Khorami, Fatomeh Taji, Mortaza Yousofi, Hedayatollah Shirzad Journal of Parasitology Research.2012; 2012: 1. CrossRef Parasites and Cancers: Parasite Antigens as Possible Targets for Cancer Immunotherapy Hossein Yousofi Darani, Morteza Yousefi Future Oncology.2012; 8(12): 1529. CrossRef <i>Toxoplasma gondii</i> But Not <i>Leishmania major</i> or <i>Trichomonas vaginalis</i> Decreases Cell Proliferation and Increases Cell Death on Fibrosarcoma Cancer Cells in Culture Medium Hedayatollah Shirzad, Soleiman Khorami, Narges Soozangar, Mortaza Yousefi, Hossein Yousofi Darani World Journal of Vaccines.2012; 02(02): 105. CrossRef Natural Cytotoxicity of NC‐2+ Cells Against the Growth and Metastasis of WEHI‐164 Fibrosarcoma H. Shirzad, R. C. Burton, Y. C. Smart, M. Rafieian‐kopaei, M. Shirzad Scandinavian Journal of Immunology.2011; 73(2): 85. CrossRef Suppressed CD31 Expression in Sarcoma-180 Tumors after Injection with Toxoplasma gondii Lysate Antigen in BALB/c Mice Kyoung-Ho Pyo, Bong-Kwang Jung, Jong-Yil Chai, Eun-Hee Shin The Korean Journal of Parasitology.2010; 48(2): 171. CrossRef 9,993 View 145 Download Crossref