Parasites, Hosts and Diseases

Skip to main navigation Skip to main content

OPEN ACCESS

Page Path

HOME
BROWSE ARTICLES

Author index detail contents
Hong Shang	1 Article
Age-Related CD4⁺CD25⁺Foxp3⁺ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria Ying Shan, Jun Liu, Yan-Yan Pan, Yong-Jun Jiang, Hong Shang, Ya-Ming Cao Korean J Parasitol 2013;51(3):289-295. Published online June 30, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.3.289 Abstract PDF Different functions have been attributed to CD4⁺CD25⁺Foxp3⁺ regulatory T-cells (Tregs) during malaria infection. Herein, we describe the disparity in Treg response and pro- and anti-inflammatory cytokines during infection with Plasmodium berghei ANKA between young (3-week-old) and middle-aged (8-month-old) C57BL/6 mice. Young mice were susceptible to cerebral malaria (CM), while the middle-aged mice were resistant to CM and succumbed to hyperparasitemia and severe anemia. The levels of pro-inflammatory cytokines, such as TNF-α, in young CM-susceptible mice were markedly higher than in middle-aged CM-resistant mice. An increased absolute number of Tregs 3-5 days post-inoculation, co-occurring with elevated IL-10 levels, was observed in middle-aged CM-resistant mice but not in young CM-susceptible mice. Our findings suggest that Treg proliferation might be associated with the suppression of excessive pro-inflammatory Th1 response during early malaria infection, leading to resistance to CM in the middle-aged mice, possibly in an IL-10-dependent manner. Citations Citations to this article as recorded by Contribution of Magnetic Resonance Imaging Studies to the Understanding of Cerebral Malaria Pathogenesis Alicia Comino Garcia-Munoz, Isabelle Varlet, Georges Emile Grau, Teodora-Adriana Perles-Barbacaru, Angèle Viola Pathogens.2024; 13(12): 1042. CrossRef Mechanistic insights into immunopathogenesis of murine cerebral malaria: Cues from “young” C57BL/6J and BALB/c mice Shweta Rai, Meetali Girdhar, Fouzia Siraj, Sheetal Sharma, Mukesh Kumar, Anju Katyal Immunology Letters.2023; 256-257: 9. CrossRef G6pd-Deficient Mice Are Protected From Experimental Cerebral Malaria and Liver Injury by Suppressing Proinflammatory Response in the Early Stage of Plasmodium berghei Infection Haoan Yi, Weiyang Jiang, Fang Yang, Fan Li, Yirong Li, Wenjing Zhu, Qing Li, Syed Hassam Fakhar, Yaming Cao, Lan Luo, Wen Zhang, Yongshu He Frontiers in Immunology.2021;[Epub] CrossRef The role of regulatory T cells during Plasmodium chabaudi chabaudi AS infection in BALB/c mice W. Pang, X. Sun, H. Feng, J. Wang, L. Cui, Y. Cao Parasite Immunology.2016; 38(7): 439. CrossRef Phenylhydrazine administration accelerates the development of experimental cerebral malaria Xiaotong Zhu, Jun Liu, Yonghui Feng, Wei Pang, Zanmei Qi, Yongjun Jiang, Hong Shang, Yaming Cao Experimental Parasitology.2015; 156: 1. CrossRef Myeloid expression of the AP‐1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections M. F. Fontana, A. Baccarella, D. Kellar, T. K. Oniskey, P. Terinate, S. D. Rosenberg, E. J. Huang, D. R. Herbert, C. C. Kim Parasite Immunology.2015; 37(9): 470. CrossRef Parasite densities modulate susceptibility of mice to cerebral malaria during co-infection with Schistosoma japonicum and Plasmodium berghei Mei-lian Wang, Yong-hui Feng, Wei Pang, Zan-mei Qi, Ying Zhang, Ya-jun Guo, En-jie Luo, Ya-ming Cao Malaria Journal.2014;[Epub] CrossRef 9,138 View 89 Download Crossref