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Jetsumon Sattabongkot	2 Articles
Prevalence of Drug Resistance-Associated Gene Mutations in Plasmodium vivax in Central China Feng Lu, Bo Wang, Jun Cao, Jetsumon Sattabongkot, Huayun Zhou, Guoding Zhu, Kwonkee Kim, Qi Gao, Eun-Taek Han Korean J Parasitol 2012;50(4):379-384. Published online November 26, 2012 DOI: https://doi.org/10.3347/kjp.2012.50.4.379 Abstract PDF Resistance of Plasmodium spp. to anti-malarial drugs is the primary obstacle in the fight against malaria, and molecular markers for the drug resistance have been applied as an adjunct in the surveillance of the resistance. In this study, we investigated the prevalence of mutations in pvmdr1, pvcrt-o, pvdhfr, and pvdhps genes in temperate-zone P. vivax parasites from central China. A total of 26 isolates were selected, including 8 which were previously shown to have a lower susceptibility to chloroquine in vitro. For pvmdr1, pvcrt-o, and pvdhps genes, no resistance-conferring mutations were discovered. However, a highly prevalent (69.2%), single-point mutation (S117N) was found in pvdhfr gene. In addition, tandem repeat polymorphisms existed in pvdhfr and pvdhps genes, which warranted further studies in relation to the parasite resistance to antifolate drugs. The study further suggests that P. vivax populations in central China may still be relatively susceptible to chloroquine and sulfadoxine-pyrimethamine. Citations Citations to this article as recorded by Genetic Diversity of Potential Drug Resistance Markers in Plasmodium vivax Isolates from Panama, Mesoamerica Vanessa Vásquez, Ana María Santamaría, Dianik Moreno, Fergie Ruíz, Chystrie A. Rigg, Luis F. Chaves, José E. Calzada Pathogens.2025; 14(3): 231. CrossRef Are pvcrt-o and pvmdr1 Gene Mutations Associated with Plasmodium vivax Chloroquine-Resistant Parasites? Rebecca de Abreu-Fernandes, Natália Ketrin Almeida-de-Oliveira, Aline Rosa de Lavigne Mello, Lucas Tavares de Queiroz, Jacqueline de Aguiar Barros, Bárbara de Oliveira Baptista, Joseli Oliveira-Ferreira, Rodrigo Medeiros de Souza, Lilian Rose Pratt-Riccio Biomedicines.2024; 12(1): 141. CrossRef Polymorphisms of potential drug resistant molecular markers in Plasmodium vivax from China–Myanmar border during 2008‒2017 Zhensheng Wang, Chunyan Wei, Yunchun Pan, Zhihua Wang, Xin Ji, Qianqian Chen, Lianhui Zhang, Zenglei Wang, Heng Wang Infectious Diseases of Poverty.2022;[Epub] CrossRef Prevalence of pvmrp1 Polymorphisms and Its Contribution to Antimalarial Response Yi Yin, Gangcheng Chen, Myat Htut Nyunt, Meihua Zhang, Yaobao Liu, Guoding Zhu, Xinlong He, Fang Tian, Jun Cao, Eun-taek Han, Feng Lu Microorganisms.2022; 10(8): 1482. CrossRef Assessing the in vitro sensitivity with associated drug resistance polymorphisms in Plasmodium vivax clinical isolates from Delhi, India Monika Matlani, Amit Kumar, Vineeta Singh Experimental Parasitology.2021; 220: 108047. CrossRef Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions Marcelo U. Ferreira, Tais Nobrega de Sousa, Gabriel W. Rangel, Igor C. Johansen, Rodrigo M. Corder, Simone Ladeia-Andrade, José Pedro Gil International Journal for Parasitology: Drugs and Drug Resistance.2021; 15: 9. CrossRef Phylogenetic analysis suggests single and multiple origins of dihydrofolate reductase mutations in Plasmodium vivax Ayaz Shaukat, Qasim Ali, Lucy Raud, Abdul Wahab, Taj Ali Khan, Imran Rashid, Muhammad Rashid, Mubashir Hussain, Mushtaq A. Saleem, Neil D. Sargison, Umer Chaudhry Acta Tropica.2021; 215: 105821. CrossRef Antimalarial Drug Resistance and Implications for the WHO Global Technical Strategy Matthew M. Ippolito, Kara A. Moser, Jean-Bertin Bukasa Kabuya, Clark Cunningham, Jonathan J. Juliano Current Epidemiology Reports.2021; 8(2): 46. CrossRef Polymorphism of Antifolate Drug Resistance in Plasmodium vivax From Local Residents and Migrant Workers Returned From the China-Myanmar Border Weilin Zeng, Siqi Wang, Shi Feng, Daibin Zhong, Yue Hu, Yao Bai, Yonghua Ruan, Yu Si, Hui Zhao, Qi Yang, Xinxin Li, Xi Chen, Yanmei Zhang, Cuiying Li, Zheng Xiang, Yanrui Wu, Fang Chen, Pincan Su, Benjamin M. Rosenthal, Zhaoqing Yang Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef Molecular Surveillance and Ex Vivo Drug Susceptibilities of Plasmodium vivax Isolates From the China–Myanmar Border Weilin Zeng, Hui Zhao, Wei Zhao, Qi Yang, Xinxin Li, Xiaosong Li, Mengxi Duan, Xun Wang, Cuiying Li, Zheng Xiang, Xi Chen, Liwang Cui, Zhaoqing Yang Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef Molecular Detection of Antimalarial Drug Resistance in Plasmodium vivax from Returned Travellers to NSW, Australia during 2008–2018 Chaturong Noisang, Wieland Meyer, Nongyao Sawangjaroen, John Ellis, Rogan Lee Pathogens.2020; 9(2): 101. CrossRef Plasmodium vivax drug resistance markers: Genetic polymorphisms and mutation patterns in isolates from Malaysia Fei-Wen Cheong, Shairah Dzul, Mun-Yik Fong, Yee-Ling Lau, Sasheela Ponnampalavanar Acta Tropica.2020; 206: 105454. CrossRef Ex vivo susceptibilities of Plasmodium vivax isolates from the China-Myanmar border to antimalarial drugs and association with polymorphisms in Pvmdr1 and Pvcrt-o genes Jiangyan Li, Jie Zhang, Qian Li, Yue Hu, Yonghua Ruan, Zhiyong Tao, Hui Xia, Jichen Qiao, Lingwen Meng, Weilin Zeng, Cuiying Li, Xi He, Luyi Zhao, Faiza A. Siddiqui, Jun Miao, Zhaoqing Yang, Qiang Fang, Liwang Cui, Kamala Thriemer PLOS Neglected Tropical Diseases.2020; 14(6): e0008255. CrossRef An unlabelled probe-based real time PCR and modified semi-nested PCR as molecular tools for analysis of chloroquine resistant Plasmodium vivax isolates from Afghanistan Sayed Hussain Mosawi, Abdolhossein Dalimi, Najibullah Safi, Reza Fotouhi-Ardakani, Fatemeh Ghaffarifar, Javid Sadraei Malaria Journal.2020;[Epub] CrossRef Molecular surveillance for drug resistance markers in Plasmodium vivax isolates from symptomatic and asymptomatic infections at the China–Myanmar border Yan Zhao, Lin Wang, Myat Thu Soe, Pyae Linn Aung, Haichao Wei, Ziling Liu, Tongyu Ma, Yuanyuan Huang, Lynette J. Menezes, Qinghui Wang, Myat Phone Kyaw, Myat Htut Nyunt, Liwang Cui, Yaming Cao Malaria Journal.2020;[Epub] CrossRef Selective sweep and phylogenetic models for the emergence and spread of pyrimethamine resistance mutations in Plasmodium vivax Ayaz Shaukat, Qasim Ali, Timothy Connelley, Muhammad Azmat Ullah Khan, Mushtaq A. Saleem, Mike Evans, Imran Rashid, Neil D. Sargison, Umer Chaudhry Infection, Genetics and Evolution.2019; 68: 221. CrossRef Polymorphisms in genes associated with drug resistance of Plasmodium vivax in India Vamsi Mohan Anantabotla, Hiasindh Ashmi Antony, Subhash Chandra Parija, Nonika Rajkumari, Jyoti R. Kini, Radhakrishna Manipura, Vijaya Lakshmi Nag, R. Gadepalli, Nirupama Chayani, Somi Patro Parasitology International.2019; 70: 92. CrossRef Molecular detection of drug resistant malaria in Southern Thailand Chaturong Noisang, Christiane Prosser, Wieland Meyer, Waenurama Chemoh, John Ellis, Nongyao Sawangjaroen, Rogan Lee Malaria Journal.2019;[Epub] CrossRef Drug resistance genes: pvcrt-o and pvmdr-1 polymorphism in patients from malaria endemic South Western Coastal Region of India Shiny Joy, Benudhar Mukhi, Susanta K. Ghosh, Rajeshwara N. Achur, D. Channe Gowda, Namita Surolia Malaria Journal.2018;[Epub] CrossRef Presence of novel triple mutations in the pvdhfr from Plasmodium vivax in Mangaluru city area in the southwestern coastal region of India Shiny Joy, Susanta K. Ghosh, Rajeshwara N. Achur, D. Channe Gowda, Namita Surolia Malaria Journal.2018;[Epub] CrossRef The prevalence of molecular markers of drug resistance in Plasmodium vivax from the border regions of Thailand in 2008 and 2014 Kritpaphat Tantiamornkul, Tepanata Pumpaibool, Jittima Piriyapongsa, Richard Culleton, Usa Lek-Uthai International Journal for Parasitology: Drugs and Drug Resistance.2018; 8(2): 229. CrossRef Simultaneous detection of Plasmodium vivax dhfr, dhps, mdr1 and crt-o resistance-associated mutations in the Colombian Amazonian region Juan Ricardo Cubides, Paola Andrea Camargo-Ayala, Carlos Hernando Niño, Diego Garzón-Ospina, Anggie Ortega-Ortegón, Estefany Ospina-Cantillo, María Fernanda Orduz-Durán, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo Malaria Journal.2018;[Epub] CrossRef Molecular Evidence of Drug Resistance in Asymptomatic Malaria Infections, Myanmar, 2015 Myat Htut Nyunt, Thinzar Shein, Ni Ni Zaw, Soe Soe Han, Fauzi Muh, Seong-Kyun Lee, Jin-Hee Han, Kyaw Zin Thant, Eun-Taek Han, Myat Phone Kyaw Emerging Infectious Diseases.2017; 23(3): 517. CrossRef Clinical and molecular surveillance of drug resistant vivax malaria in Myanmar (2009–2016) Myat Htut Nyunt, Jin-Hee Han, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Seong-Kyun Lee, Ye Htut, Myat Phone Kyaw, Kay Thwe Han, Eun-Taek Han Malaria Journal.2017;[Epub] CrossRef Low prevalence of dihydro folate reductase (dhfr) and dihydropteroate synthase (dhps) quadruple and quintuple mutant alleles associated with SP resistance in Plasmodium vivax isolates of West Bengal, India Sabyasachi Das, Abhijit Banik, Amiya Kumar Hati, Somenath Roy Malaria Journal.2016;[Epub] CrossRef Polymorphisms in chloroquine resistance-associated genes in Plasmodium vivax in Ethiopia Lemu Golassa, Berhanu Erko, Frederick N Baliraine, Abraham Aseffa, Göte Swedberg Malaria Journal.2015;[Epub] CrossRef Amplification of pfmdr1 , pfcrt , pvmdr1 , and K13 Propeller Polymorphisms Associated with Plasmodium falciparum and Plasmodium vivax Isolates from the China-Myanmar Bord Jun Feng, Daili Zhou, Yingxue Lin, Huihui Xiao, He Yan, Zhigui Xia Antimicrobial Agents and Chemotherapy.2015; 59(5): 2554. CrossRef Molecular surveillance of pvdhfr, pvdhps, and pvmdr-1 mutations in Plasmodium vivax isolates from Yunnan and Anhui provinces of China Bo Huang, Shiguang Huang, Xin-zhuan Su, Xinxin Tong, Junping Yan, Hongbin Li, Fangli Lu Malaria Journal.2014;[Epub] CrossRef Prevalence and patterns of antifolate and chloroquine drug resistance markers in Plasmodium vivax across Pakistan Aamer A Khattak, Meera Venkatesan, Lubna Khatoon, Amed Ouattara, Leo J Kenefic, Muhammad F Nadeem, Farida Nighat, Salman A Malik, Christopher V Plowe Malaria Journal.2013;[Epub] CrossRef N-TerminalPlasmodium vivaxMerozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine Fernanda G. Versiani, Maria E. Almeida, Luis A. Mariuba, Patricia P. Orlandi, Paulo A. Nogueira Clinical and Developmental Immunology.2013; 2013: 1. CrossRef In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon Yonne F Chehuan, Monica RF Costa, Jacqueline S Costa, Maria GC Alecrim, Fátima Nogueira, Henrique Silveira, Larissa W Brasil, Gisely C Melo, Wuelton M Monteiro, Marcus VG Lacerda Malaria Journal.2013;[Epub] CrossRef High levels of IgG3 anti ICB2-5 in Plasmodium vivax-infected individuals who did not develop symptoms Fernanda G Versiani, Maria EM Almeida, Gisely C Melo, Francivaldo OL Versiani, Patrícia P Orlandi, Luís André M Mariúba, Leidiane A Soares, Luciana P Souza, Antonio A da Silva Balieiro, Wuelton M Monteiro, Fabio TM Costa, Hernando A del Portillo, Marcus V Malaria Journal.2013;[Epub] CrossRef Prevalence of drug resistance associated mutations in Plasmodium vivax against sulphadoxine-pyrimethamine in southern Pakistan Afsheen Raza, Najia K Ghanchi, Muhammad Shahzeb Khan, Mohammad Asim Beg Malaria Journal.2013;[Epub] CrossRef Blood Stage of Plasmodium vivax in Central China Is Still Susceptible to Chloroquine Plus Primaquine Combination Therapy Eun-Taek Han, Yaobao Liu, Feng Lu, Qi Gao, Jun Cao, Guoding Zhu, Huayun Zhou The American Journal of Tropical Medicine and Hygiene.2013; 89(1): 184. CrossRef 10,564 View 98 Download Crossref Molecular Cloning of Plasmodium vivax Calcium-Dependent Protein Kinase 4 Kyung-Mi Choi, Jung-Yeon Kim, Sung-Ung Moon, Hyeong-Woo Lee, Jetsumon Sattabongkot, Byoung-Kuk Na, Dae-Won Kim, Eun-Jung Suh, Yeon-Joo Kim, Shin-Hyeong Cho, Ho-Sa Lee, Ho-Gun Rhie, Tong-Soo Kim Korean J Parasitol 2010;48(4):319-324. Published online December 16, 2010 DOI: https://doi.org/10.3347/kjp.2010.48.4.319 Abstract PDF A family of calcium-dependent protein kinases (CDPKs) is a unique enzyme which plays crucial roles in intracellular calcium signaling in plants, algae, and protozoa. CDPKs of malaria parasites are known to be key regulators for stage-specific cellular responses to calcium, a widespread secondary messenger that controls the progression of the parasite. In our study, we identified a gene encoding Plasmodium vivax CDPK4 (PvCDPK4) and characterized its molecular property and cellular localization. PvCDPK4 was a typical CDPK which had well-conserved N-terminal kinase domain and C-terminal calmodulin-like structure with 4 EF hand motifs for calcium-binding. The recombinant protein of EF hand domain of PvCDPK4 was expressed in E. coli and a 34 kDa product was obtained. Immunofluorescence assay by confocal laser microscopy revealed that the protein was expressed at the mature schizont of P. vivax. The expression of PvCDPK4-EF in schizont suggests that it may participate in the proliferation or egress process in the life cycle of this parasite. Citations Citations to this article as recorded by Two Calcium-Dependent Protein Kinases fromChlamydomonas reinhardtiiare transcriptionally regulated by nutrient starvation Mustafa J Motiwalla, Marilyn P Sequeira, Jacinta S D'Souza Plant Signaling & Behavior.2014; 9(1): e27969. CrossRef Molecular characterization and analysis of a novel calcium-dependent protein kinase from Eimeria tenella H.Y. HAN, S.H. ZHU, L.L. JIANG, Y. LI, H. DONG, Q.P. ZHAO, C.L. KONG, B. HUANG Parasitology.2013; 140(6): 746. CrossRef Calcium signaling in closely related protozoan groups (Alveolata): Non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic Apicomplexa (Plasmodium, Toxoplasma) H. Plattner, I.M. Sehring, I.K. Mohamed, K. Miranda, W. De Souza, R. Billington, A. Genazzani, E.-M. Ladenburger Cell Calcium.2012; 51(5): 351. CrossRef 8,541 View 67 Download Crossref