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Ki-Man Kang	2 Articles
Cytokine and antibody responses of reactivated murine toxoplasmosis upon administration of dexamethasone Ki-Man Kang, In-Uk Choi, Dae-Whan Shin, Young-Ha Lee Korean J Parasitol 2006;44(3):209-219. Published online September 20, 2006 DOI: https://doi.org/10.3347/kjp.2006.44.3.209 Abstract PDF Toxoplasma gondii has been shown to result in life-threatening encephalitis in immunocompromised patients after reactivation of dormant parasites. In order to obtain information on immune responses related to this phenomenon, BALB/c mice were infected with 25 cysts of the 76K strain of T. gondii, then, treated orally with dexamethasone (Toxo/Dexa-treated group) in order to reactivate the chronic toxoplasmosis. None of the T. gondii-infected mice died during the experimental periods, whereas the Toxo/Dexa-treated mice evidenced a significant attenuation of survival periods. Toxoplasma-specific IgG2a, IgA and IgM titers in sera were significantly depressed in the Toxo/Dexa-treated mice; however, the IgG1 sera titers were similar to those seen in the Toxoplasma-infected mice. The percentages of CD4+ and CD8α+ T cells in the Toxo/Dexa-treated mice were significantly reduced 2 weeks after dexamethasone treatment. IFN-γ and IL-10 production levels in the Toxo/Dexa-treated mice were depressed significantly, whereas IL-4 production was increased temporarily. The expression levels of the Toxoplasma-specific P30 and B1 genes were found to have been increased in the Toxo/Dexa-treated mice in comparison with the Toxoplasma-infected mice. Collectively, the findings of this study demonstrate that reactivation of murine toxoplasmosis as the result of dexamethasone treatment induced a depression in Th1 immune responses, whereas Th2 immune responses were not significantly influenced. Citations Citations to this article as recorded by Potential Therapeutic Effects of Isopropyltoluene (P-Cymene) Against Toxoplasma gondii Infection in Dexamethasone-Immunosuppressed Mice Zafer Saad Alshehri Acta Parasitologica.2025;[Epub] CrossRef Identification of novel biomarkers for anti-Toxoplasma gondii IgM detection and the potential application in rapid diagnostic fluorescent tests Minh-Ngoc Nguyen, Seon-Ju Yeo, Hyun Park Frontiers in Microbiology.2024;[Epub] CrossRef Development of experimental models of reactivated toxoplasmosis Neda Bauman, Jelena Srbljanović, Ivana Čolović-Čalovski Medicinski podmladak.2024; 75(6): 30. CrossRef Toxoplasma gondii clonal type III is the dominant genotype identified in Grenadian pigs Alfred Chikweto, Andy Alhassan, Chunlei Su, Calum Macpherson, Muhammad Iqbal Bhaiyat, Jitender P. Dubey Veterinary Medicine and Science.2022; 8(5): 2005. CrossRef Anti-Toxoplasma gondii IgM Long Persistence: What Are the Underlying Mechanisms? José Antonio Vargas-Villavicencio, Irma Cañedo-Solares, Dolores Correa Microorganisms.2022; 10(8): 1659. CrossRef Immunological, histopathological, and ultrastructural evidence of steroid-induced reactivation of chronic murine toxoplasmosis Aida A. Abdel-Magied, Doaa S. Ghorab, Abeer A. Elhenawy, Nora I. Aboulfotouh Ultrastructural Pathology.2021; 45(1): 28. CrossRef Development of Neurological Mouse Model for Toxoplasmosis Using Toxoplasma gondii Isolated from Chicken in Kenya John Mokua Mose, David Muchina Kamau, John Maina Kagira, Naomi Maina, Maina Ngotho, Adele Njuguna, Simon Muturi Karanja Pathology Research International.2017; 2017: 1. CrossRef Strength and Aerobic Physical Exercises Are Able to Increase Survival of Toxoplasma gondii-Infected C57BL/6 Mice by Interfering in the IFN-γ Expression Miguel J. S. Bortolini, Murilo V. Silva, Fábio M. Alonso, Luciana A. Medeiros, Fernando R. Carvalho, Lourenço F. Costa, Neide M. Silva, Nilson Penha-Silva, Tiago W. P. Mineo, José R. Mineo Frontiers in Physiology.2016;[Epub] CrossRef Toxoplasma gondii meningoencephalitis without cerebral MRI findings in a patient with ulcerative colitis under immunosuppressive treatment S. F. Assimakopoulos, V. Stamouli, D. Dimitropoulou, A. Spiliopoulou, G. Panos, E. D. Anastassiou, M. Marangos, I. Spiliopoulou Infection.2015; 43(5): 589. CrossRef Toxoplasma gondii 70 kDa Heat Shock Protein: Systemic Detection Is Associated with the Death of the Parasites by the Immune Response and Its Increased Expression in the Brain Is Associated with Parasite Replication Paulo Victor Czarnewski Barenco, Elaine Vicente Lourenço, Jair Pereira Cunha-Júnior, Karine Cristine Almeida, Maria Cristina Roque-Barreira, Deise Aparecida Oliveira Silva, Ester Cristina Borges Araújo, Loyane Bertagnolli Coutinho, Mário Cézar Oliveira, T PLoS ONE.2014; 9(5): e96527. CrossRef Evaluation of the immunosuppressive effect of cyclophosphamide and dexamethasone in mice with visceral toxocariasis Luciana Farias da Costa de Avila, Juliana Santos Vieira da Fonseca, Gisele Ferreira Dutra, Paula de Lima Telmo, Ana Maria Wolkmer Azambuja Silva, Maria Elisabeth Aires Berne, Pedro Eduardo Almeida da Silva, Fabricio Rochedo Conceição, Carlos James Scaini Parasitology Research.2012; 110(1): 443. CrossRef Real-Time RT-PCR on SAG1 and BAG1 Gene Expression during Stage Conversion in Immunosuppressed Mice Infected with Toxoplasma gondii Tehran Strain Monavar Selseleh, Mohammad Hossein Modarressi, Mehdi Mohebali, Saeedeh Shojaee, Mohammad Reza Eshragian, Mina Selseleh, Ebrahim Azizi, Hossein Keshavarz The Korean Journal of Parasitology.2012; 50(3): 199. CrossRef Toxoplasma gondii: Simple duplex RT-PCR assay for detecting SAG1 and BAG1 genes during stage conversion in immunosuppressed mice Aongart Mahittikorn, Hannes Wickert, Yaowalark Sukthana Experimental Parasitology.2010; 124(2): 225. CrossRef Autism spectrum disorders may be due to cerebral toxoplasmosis associated with chronic neuroinflammation causing persistent hypercytokinemia that resulted in an increased lipid peroxidation, oxidative stress, and depressed metabolism of endogenous and exo Joseph Prandota Research in Autism Spectrum Disorders.2010; 4(2): 119. CrossRef Migraine Associated with Patent Foramen Ovale May Be Caused by Reactivation of Cerebral Toxoplasmosis Triggered by Arterial Blood Oxygen Desaturation Joseph Prandota International Journal of Neuroscience.2010; 120(2): 81. CrossRef DoesToxoplasma gondiiInfection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)? Joanna Matowicka-Karna, Violetta Dymicka-Piekarska, Halina Kemona Clinical and Developmental Immunology.2009; 2009: 1. CrossRef Idiopatyczne nadciśnienie śródczaszkowe, guz rzekomy czaszki oraz aseptyczne zapalenie opon mogą być spowodowane reaktywacją latentnej toksoplazmozy mózgowej Józef Prandota Pediatria Polska.2009; 84(5): 453. CrossRef THE IMPORTANCE OF TOXOPLASMA GONDII INFECTION IN DISEASES PRESENTING WITH HEADACHES. HEADACHES AND ASEPTIC MENINGITIS MAY BE MANIFESTATIONS OF THE JARISCH-HERXHEIMER REACTION JOSEPH PRANDOTA International Journal of Neuroscience.2009; 119(12): 2144. CrossRef Antiallergic Effects of Lactobacillus pentosus Strain S-PT84 Mediated by Modulation of Th1/Th2 Immunobalance and Induction of IL-10 Production Yuji Nonaka, Takayuki Izumo, Fumi Izumi, Toshihiro Maekawa, Hiroshi Shibata, Aoi Nakano, Atsuko Kishi, Kaoru Akatani, Yoshinobu Kiso International Archives of Allergy and Immunology.2008; 145(3): 249. CrossRef Recurrent Headache as the Main Symptom of Acquired Cerebral Toxoplasmosis in Nonhuman Immunodeficiency Virus-infected Subjects With no Lymphadenopathy Joseph Prandota American Journal of Therapeutics.2007; 14(1): 63. CrossRef 9,945 View 79 Download Crossref Effects of iNOS inhibitor on IFN-γ production and apoptosis of splenocytes in genetically different strains of mice infected with Toxoplasma gondii Ki-Man Kang, Gye-Sung Lee, Jae-Ho Lee, In-Wook Choi, Dae-Whan Shin, Young-Ha Lee Korean J Parasitol 2004;42(4):175-183. Published online December 20, 2004 DOI: https://doi.org/10.3347/kjp.2004.42.4.175 Abstract PDF To evaluate the role of nitric oxide (NO) in IFN-γ production and apoptosis of splenocytes in genetically different strains of mice with toxoplasmosis, BALB/c (a toxoplasmosis resistant strain) and C57BL/6 (a toxoplasmosis susceptible strain) mice were infected with Toxoplasma gondii cysts orally and subsequently injected intraperitoneally with aminoguanidine, an iNOS inhibitor (AG; 35 mg/kg per mouse daily for 14 days). When BALB/c or C57BL/6 mice were infected with T. gondii without AG treatment, number of brain cysts, NO and IFN-γ production by splenocytes, and percentages of apoptotic splenocytes were increased compared to uninfected control mice without AG treatment. AG treatment increased the number of brain cysts, and reduced NO and IFN-γ production in T. gondii-infected C57BL/6 mice. In contrast, in T. gondii-infected BABL/c mice, the number of brain cysts, and NO and IFN-γ production of splenocytes was not altered by treatment with AG. However, the percentages of apoptotic splenocytes in T. gondii-infected BALB/c or C57BL/6 mice were not affected by AG treatment. These results suggest that NO modulates IFN-γ production in T. gondii-infected C57BL/6 mice, and that NO is involved in mediating a protective response in toxoplasmosis susceptible, but not resistant, mice strain during acute infection. Citations Citations to this article as recorded by Effect of spiramycin versus aminoguanidine and their combined use in experimental toxoplasmosis Marwa Omar, Beessa E. Abaza, Esraa Mousa, Shereen M. Ibrahim, Hayam E. Rashed, Tahani I. Farag Journal of Parasitic Diseases.2021; 45(4): 1014. CrossRef Recombinant TgHSP70 Immunization Protects against Toxoplasma gondii Brain Cyst Formation by Enhancing Inducible Nitric Oxide Expression Paulo Czarnewski, Ester C. B. Araújo, Mário C. Oliveira, Tiago W. P. Mineo, Neide M. Silva Frontiers in Cellular and Infection Microbiology.2017;[Epub] CrossRef Pathophysiological mechanisms of diarrhea caused by theVibrio choleraeO1 El Tor variant: anin vivostudy in mice Saravut Satitsri, Pawin Pongkorpsakol, Potjanee Srimanote, Varanuj Chatsudthipong, Chatchai Muanprasat Virulence.2016; 7(7): 789. CrossRef Oxidative stress and tryptophan degradation pattern of acute Toxoplasma gondii infection in mice Ayse Basak Engin, Funda Dogruman-Al, Ugur Ercin, Bekir Celebi, Cahit Babur, Neslihan Bukan Parasitology Research.2012; 111(4): 1725. CrossRef Distinct roles for nitric oxide in resistant C57BL/6 and susceptible BALB/c mice to control Burkholderia pseudomallei infection Katrin Breitbach, Patimaporn Wongprompitak, Ivo Steinmetz BMC Immunology.2011;[Epub] CrossRef MMHD [(S,E)-2-Methyl-1-(2-methylthiazol-4-yl) hexa-1,5-dien-ol], a Novel Synthetic Compound Derived From Epothilone, Suppresses Nuclear Factor-κB–Mediated Cytokine Expression in Lipopolysaccharide-Stimulated BV-2 Microglia Na-Ra Jeon, Sushruta Koppula, Byung-Wook Kim, Su-Ho Park, Hyo-Won Lee, Dong-Kug Choi Journal of Pharmacological Sciences.2010; 112(2): 158. CrossRef The immunobiology of the innate response to Toxoplasma gondii Catherine M. Miller, Nicola R. Boulter, Rowan J. Ikin, Nicholas C. Smith International Journal for Parasitology.2009; 39(1): 23. CrossRef Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients Ulku Karaman, Tuncay Celik, Tugba Raika Kiran, Cemil Colak, Nilgun Ulfet Daldal The Korean Journal of Parasitology.2008; 46(4): 293. CrossRef Toxoplasma gondii infection induces apoptosis in noninfected macrophages: role of nitric oxide and other soluble factors Y. NISHIKAWA, O. KAWASE, O. VIELEMEYER, H. SUZUKI, K. A. JOINER, X. XUAN, H. NAGASAWA Parasite Immunology.2007; 29(7): 375. CrossRef 9,343 View 114 Download Crossref