Angiostrongyliasis, caused by Angiostrongylus cantonensis infection, is a food-borne parasitic disease. Its larvae evoke eosinophilic inflammation in the central nervous system, but can also cause pathological changes in the eyes. Among ocular angiostrongyliasis cases, the incidence of optic neuritis is low and only few sporadic reports exist. Some patients with optic neuritis developed obvious hypopsia or even vision loss, which would seriously influence the quality of life of patients. Prompt treatment of optic neuritis caused by A. cantonensis is the key factor for minimizing the incidence of serious complications of this disease. In this review, we first provide a comprehensive overview of ocular angiostrongyliasis, and then focus on the clinical features of optic neuritis caused by A. cantonensis.
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Seroprevalence of Angiostrongylus cantonensis in suspected human angiostrongyliasis cases and clinical manifestations in a tertiary care hospital in Thailand: a retrospective 18-year longitudinal study Lakkhana Sadaow, Thidarat K. Prasongdee, Phuangphaka Sadee, Sureeporn Naonongwai, Patcharaporn Boonroumkaew, Rutchanee Rodpai, Oranuch Sanpool, Amnat Kitkhuandee, Verajit Chotmongkol, Kittisak Sawanyawisuth, Pewpan M. Intapan, Wanchai Maleewong Food and Waterborne Parasitology.2025; 41: e00290. CrossRef
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