Parasites, Hosts and Diseases

Skip to main navigation Skip to main content

OPEN ACCESS

Page Path

HOME
BROWSE ARTICLES

Author index detail contents
Kyoung-Ho Pyo	10 Articles
Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment Kyoung-Ho Pyo, Bong-Kwang Jung, Chun-Feng Xin, You-Won Lee, Jong-Yil Chai, Eun-Hee Shin Korean J Parasitol 2014;52(6):605-612. Published online December 23, 2014 DOI: https://doi.org/10.3347/kjp.2014.52.6.605 Abstract PDF Toxoplasma gondii is an intracellular protozoan parasite that causes a Th1 cellular immunity. Our previous study showed that T. gondii lysate antigen (TLA) treatment in S180 tumor-bearing mice resulted in tumor reduction by suppressing CD31 expression, a marker of angiogenesis. In the present study, to investigate tumor suppressive effect of TLA under the absence of T lymphocytes, athymic nude mice were compared with euthymic mice in the anti-tumorigenic effect triggered by TLA in CT26 tumors. According to the results, intratumorally injected TLA reduced tumor growth and TIMP-1 level, a metastatic marker, in both euthymic and athymic mice. TLA treatment led to a sharp increase in IL-12 expression in serum cytokine profiling of athymic mice, and increased MyD88 signals in macrophages derived from the bone marrow, implying the activation of innate immunity. The selective induction of IL-12 by TLA treatment had an anti-tumorigenic effect. Citations Citations to this article as recorded by Toxoplasma gondii as a drug for anti-tumor immunotherapy: mechanisms, challenges, and perspectives Jing Li, Eman E. El Shanawany, Soad E. Hassan, Peng-Yao Li, Jia-Hui Sun, Hong-Mei Li, Shao-Hong Lu, Xiao-Nong Zhou, Bin Zheng Parasite.2026; 33: 4. CrossRef Glancing at the role of Toxoplasma gondii in neuro-oncology: from risk factor to therapeutic target Maha M. Eissa, Noor Al-Huda F. Ali, Nahla El Skhawy Infectious Agents and Cancer.2026;[Epub] CrossRef Toxoplasma gondii and a Cancer Biology Dichotomy: A Systematic Review of Experimental Studies of Its Antitumor and Pro-Tumor Effects Saachi Jhandi, Brenda Anissa Vera, Julian Galindo, Jose G. Montoya, Despina G. Contopoulos-Ioannidis Pathogens.2026; 15(4): 351. CrossRef An Overview of the Dichotomous Role of Microbiota in Cancer Progression and Management Pooja Jain, Sradhanjali Mohapatra, Uzma Farooq, Nazia Hassan, Mohd. Aamir Mirza, Zeenat Iqbal Current Cancer Drug Targets.2025; 25(1): 38. CrossRef Bug as a drug: Unveiling anti-cancer properties of Toxoplasma gondii and its therapeutic prospects in cancer immunotherapy Yie Wei Chua, Sek Chuen Chow Acta Tropica.2025; 267: 107684. CrossRef From pathogen to cure: exploring the antitumor potential of Toxoplasma gondii Parisa Alipanahi, Arezou Khosrojerdi, Abdol Satar Pagheh, Kareem Hatam-Nahavandi, Ehsan Ahmadpour Infectious Agents and Cancer.2025;[Epub] CrossRef Bridging the gap for diverse applications of parasites as advanced cancer therapeutics: current progress and future directions Maha M. Eissa, Marwa H. El-Faham, Nahla El Skhawy Infectious Agents and Cancer.2025;[Epub] CrossRef Evaluation of Antitumor Effects of Toxoplasma gondii Different Antigens on Ehrlich Solid Carcinoma in Mice Salwa S. Younis, Basma M. Elmansory, Hend A. Elrefaey, Nahla A. Nasef, Sara H. Elakshar, Radwa A. Awad, Ghada A. Gamea Parasite Immunology.2025;[Epub] CrossRef Parasites’ immunomodulators: a breakthrough in immunotherapeutics displaying antineoplastic activity against human colorectal and hepatocellular carcinoma cells Nahla El Skhawy, Ahmed Shehata, Maha M. Eissa Infectious Agents and Cancer.2025;[Epub] CrossRef A novel enemy of cancer: recent investigations into protozoan anti-tumor properties Zhi Zheng, Xiao Lu, Dong Zhou, Xu-feng Deng, Quan-xing Liu, Xiao-bing Liu, Jiao Zhang, Yan-qi Li, Hong Zheng, Ji-gang Dai Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef Parasite-enhanced immunotherapy: transforming the “cold” tumors to “hot” battlefields Yujun Xie, Jinyan Wang, Yafei Wang, Yalin Wen, Yanping Pu, Benfan Wang Cell Communication and Signaling.2024;[Epub] CrossRef Parasites revive hope for cancer therapy Maha M. Eissa, Ahmed Ebada Salem, Nahla El Skhawy European Journal of Medical Research.2024;[Epub] CrossRef Toxoplasma gondii-Derived Exosomes: A Potential Immunostimulant and Delivery System for Tumor Immunotherapy Superior to Toxoplasma gondii Lai-Xi Zhao, Qiong Sun, Chong Wang, Jia-Jia Liu, Xiao-Rong Yan, Meng-Ci Shao, Li Yu, Wen-Hua Xu, Rui Xu International Journal of Nanomedicine.2024; Volume 19: 12421. CrossRef Association of Neuroblastoma (NB) SH-SY5Y Cells with Antibodies of Parasitic Origin (Anti-Acanthamoeba and Anti-Toxocara canis) Víctor Alberto Maravelez Acosta, Maria de Lourdes Caballero Garcia, Genaro Patiño López, María del Pilar Crisóstomo Vázquez, Luz Ofelia Franco Sandoval, Leticia Eligio García International Journal of Molecular Sciences.2024; 25(24): 13577. CrossRef Promising effects of parasite-derived compounds on tumor regression: a systematic review of in vitro and in vivo studies Ali Asghari, Hassan Nourmohammadi, Hamidreza Majidiani, Seyyed Ali Shariatzadeh, Davood Anvari, Sadegh Shamsinia, Ezatollah Ghasemi, Morteza Shams, Gholam Basati Environmental Science and Pollution Research.2022; 29(22): 32383. CrossRef Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth Jiating Chen, Wenzhong Liao, HongJuan Peng Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef Neospora caninum inhibits tumor development by activating the immune response and destroying tumor cells in a B16F10 melanoma model Xiaojin Li, Meng Qi, Kai He, Haiyan Liu, Wenlan Yan, Lizhuo Zhao, Yanyan Jia, Lei He, Chaochao Lv, Min Zhang, Zhiguo Wei, Wenchao Yan, Tianqi Wang, Fuchang Yu, Weifeng Qian Parasites & Vectors.2022;[Epub] CrossRef Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections Ragab M. Fereig, Mosaab A. Omar, Abdullah F. Alsayeqh Vaccines.2022; 10(12): 2082. CrossRef Toxoplasma GRA16 Inhibits NF-κB Activation through PP2A-B55 Upregulation in Non-Small-Cell Lung Carcinoma Cells Seung-Hwan Seo, Sang-Gyun Kim, Ji-Hun Shin, Do-Won Ham, Eun-Hee Shin International Journal of Molecular Sciences.2020; 21(18): 6642. CrossRef Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53‐dependent apoptosis and anticancer effect Sang‐Gyun Kim, Seung‐Hwan Seo, Ji‐Hun Shin, Jung‐Pyo Yang, Sang Hyung Lee, Eun‐Hee Shin Journal of Cellular and Molecular Medicine.2019; 23(5): 3234. CrossRef Characteristics of Infection Immunity Regulated by Toxoplasma gondii to Maintain Chronic Infection in the Brain Young Sang Hwang, Ji-Hun Shin, Jung-Pyo Yang, Bong-Kwang Jung, Sang Hyung Lee, Eun-Hee Shin Frontiers in Immunology.2018;[Epub] CrossRef Microorganisms in the Treatment of Cancer: Advantages and Limitations Klaudia Łukasiewicz, Marek Fol Journal of Immunology Research.2018; 2018: 1. CrossRef The Neurotropic Parasite Toxoplasma gondii Induces Sustained Neuroinflammation with Microvascular Dysfunction in Infected Mice Vanessa Estato, Joice Stipursky, Fabiana Gomes, Tally C. Mergener, Edwards Frazão-Teixeira, Silvana Allodi, Eduardo Tibiriçá, Helene S. Barbosa, Daniel Adesse The American Journal of Pathology.2018; 188(11): 2674. CrossRef Puzzling and ambivalent roles of malarial infections in cancer development and progression ERIC FAURE Parasitology.2016; 143(14): 1811. CrossRef NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells Ya Hong Yuan, Chun Fang Zhou, Jiang Yuan, Li Liu, Xing Rong Guo, Xiao Li Wang, Yan Ding, Xiao Nan Wang, Dong Sheng Li, Han Jun Tu Oncology Letters.2016; 12(5): 3167. CrossRef Immune adjuvant effect of aToxoplasma gondiiprofilin-like protein in autologous whole-tumor-cell vaccination in mice Kyoung-Ho Pyo, You-Won Lee, Sun Min Lim, Eun-Hee Shin Oncotarget.2016; 7(45): 74107. CrossRef 14,792 View 88 Download 25 Web of Science Crossref Phylogenetic Relationships of 3 Korean Neodiplostomum Species (Digenea: Neodiplostomidae) Based on Partial CO1 Gene Kyoung-Ho Pyo, Jo Woon Yi Lee, Jin-Ju Lee, Yun-Kyu Park, Eun-Hee Shin, Jong-Yil Chai Korean J Parasitol 2014;52(3):325-329. Published online June 26, 2014 DOI: https://doi.org/10.3347/kjp.2014.52.3.325 Abstract PDF The phylogenetic relationships of the 3 Neodiplostomum spp. (Digenea: Neodiplostomidae) occurring in Korea (N. seoulense, N. leei, and N. boryongense) were analyzed using the partial mitochondrial cytochrome c oxidase subunit 1 (CO1) gene. The adult flukes were recovered from Sprague-Dawley rats (N. seoulense) and newborn chicks (N. leei and N. boryongense) experimentally infected with the neodiplostomula from the grass snake, Rhabdophis tigrinus tigrinus. The genomic DNA was amplified using specific primers, and the sequence of CO1 was obtained. According to the results, the pairwise similarity was 96.1% between N. boryongense and N. seoulense, but was 95.0% between N. boryongense and N. leei and 94.2% between N. leei and N. seoulense. The results demonstrated a closer phylogenetic relationship between N. seoulense and N. boryongense. This high relationship of N. seoulense and N. boryongense may be related to their similar morphologic features including the limited distribution of vitellaria and the presence of a genital cone. N. leei is distinct on the other hand with an extensive distribution of vitellaria and the absence of a genital cone. Citations Citations to this article as recorded by Neodiplostomum cf. seoulense (Seo, Rim, Lee, 1964) sensu Pyo et al., 2014 (Trematoda: Diplostomidae Poirier, 1886): morphology, life cycle, and phylogenetic relationships A. V. Izrailskaia, V. V. Besprozvannykh Journal of Helminthology.2023;[Epub] CrossRef Paraphyly of Conodiplostomum Dubois, 1937 Petr Heneberg, Jiljí Sitko, Miroslav Těšínský Parasitology International.2020; 76: 102033. CrossRef New data on Neodiplostomum americanum Chandler and Rausch, 1947 (Digenea: Diplostomidae), in the Great Horned Owl Bubo virginianus Gmelin, 1788 and the Eastern Screech Owl Megascops asio Linnaeus, 1758 in Mississippi, USA Ethan T. Woodyard, Thomas G. Rosser, Matt J. Griffin Parasitology Research.2017; 116(8): 2075. CrossRef 9,281 View 82 Download 4 Web of Science Crossref STAT6 Expression and IL-13 Production in Association with Goblet Cell Hyperplasia and Worm Expulsion of Gymnophalloides seoi from C57BL/6 Mice Jin-Joo Lee, Donghee Kim, Kyoung-Ho Pyo, Min-Ki Kim, Hyo-Jin Kim, Jong-Yil Chai, Eun-Hee Shin Korean J Parasitol 2013;51(5):589-594. Published online October 31, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.5.589 Abstract PDF In intestinal helminth infections, Th2 immune respones are generally associated with mucin secretion for worm expulsion from the host intestine. In particular, IL-4 and IL-13 are the important cytokines related with intestinal mucus production via STAT6 signalling in nematode infections. However, this perspective has never been studied in Gymnophalloides seoi infection. The present study aimed to observe the STAT6 signalling and cytokine responses in C57BL/6 mice, a mouse strain resistant to infection with this trematode. The results showed that worm expulsion occurred actively during days 1-2 post-infection (PI), when goblet cells began to proliferate in the small intestine. The STAT6 gene expression in the mouse spleen became remarkable from day 2 PI. Moreover, G. seoi infection induced a significant increase of IL-13 from day 4 PI in the spleen of infected mice. Our results suggested that goblet cell hyperplasia and worm expulsion in G. seoi-infected mice should be induced by STAT6 signalling, in which IL-13 may be involved as a dominant triggering cytokine. Citations Citations to this article as recorded by Immune Regulation of Goblet Cell and Mucus Functions in Health and Disease Jenny K. Gustafsson, Gunnar C. Hansson Annual Review of Immunology .2025; 43(1): 169. CrossRef The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis Franziska Bayer, Olga Dremova, My Phung Khuu, Könül Mammadova, Giulia Pontarollo, Klytaimnistra Kiouptsi, Natalia Soshnikova, Helen Louise May-Simera, Kristina Endres, Christoph Reinhardt Nutrients.2021; 13(7): 2198. CrossRef Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity Songwei Yang, Min Yu Journal of Inflammation Research.2021; Volume 14: 3171. CrossRef The relationship between intestinal goblet cells and the immune response Mingming Zhang, Chenchen Wu Bioscience Reports.2020;[Epub] CrossRef Developmental expression of STATs, nuclear factor-κB and inflammatory genes in the jejunum of piglets during weaning Hongbo Yi, Denghu Jiang, Lin Zhang, Haitao Xiong, Feifei Han, Yizhen Wang International Immunopharmacology.2016; 36: 199. CrossRef Increased Intestinal Epithelial Cell Turnover and Intestinal Motility in Gymnophalloides seoi-Infected C57BL/6 Mice Sang Hyub Lee, Bong-Kwang Jung, Jae-Hwan Park, Eun-Hee Shin, Jong-Yil Chai The Korean Journal of Parasitology.2014; 52(3): 273. CrossRef 9,335 View 89 Download Crossref Effect of Temperature on Embryonation of Ascaris suum Eggs in an Environmental Chamber Min-Ki Kim, Kyoung-Ho Pyo, Young-Sang Hwang, Ki Hwan Park, In Gyun Hwang, Jong-Yil Chai, Eun-Hee Shin Korean J Parasitol 2012;50(3):239-242. Published online August 13, 2012 DOI: https://doi.org/10.3347/kjp.2012.50.3.239 Abstract PDF The influence of temperature on the development and embryonation of Ascaris suum eggs was studied using coarse sand medium in an environmental chamber with 50% humidity. The time required for development and embryonation of eggs was examined under 3 different temperature conditions, 5℃, 25℃, and 35℃. A. suum eggs did not develop over 1 month at the temperature of 5℃. However, other temperature conditions, 25℃ and 35℃, induced egg development to the 8-cell-stage at days 5-6 after incubation. All eggs examined developed to the 8-cell stage at day 6 after incubation in the sand medium at 25℃. The higher temperature, 35℃, slightly accelerated the A. suum egg development compared to 25℃, and the development to the 8-cell stage occurred within day 5 after incubation. The formation of larvae in A. suum eggs at temperatures of 35℃ and 25℃ appeared at days 17 and 19 after incubation, respectively. These findings show that 35℃ condition shortens the time for the development of A. suum eggs to the 8-cell-stage in comparison to 25℃, and suggest the possibility of accelerated transmission of this parasite, resulting from global warming and ecosystem changes. Citations Citations to this article as recorded by Survival and temporal change in the viability of Ascaridia galli eggs exposed to refrigeration or freezing temperatures in the presence of a cryoprotectant T. Feyera, B. Sharpe, I. Ruhnke, T. Elliott, S. Walkden-Brown Journal of Helminthology.2026;[Epub] CrossRef Possibilities of decontaminating organic waste from swine-farming complexes using anaerobic digestion Olexandra Boyko, Viktor Brygadyrenko, Yelizaveta Chernysh, Viktoriia Chubur, Hynek Roubík Biomass Conversion and Biorefinery.2025; 15(7): 11175. CrossRef Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the effects of climate change on the risk of transmission of foodborne pathogens Antonio Valero Díaz, Rosa María Capita González, Baltasar Mayo Pérez, Azucena del Carmen Mora Gutiérrez, María Dolores Rodrigo Aliaga, Gloria Sánchez Moragas, Paula Arrabal Durán Food Risk Assess Europe.2025;[Epub] CrossRef Spatial modeling of soil-transmitted helminthiases in Colombia under climate change scenarios Mario J. Olivera, Julián Felipe Porras-Villamil, Màrius Vicent Fuentes Biomédica.2025; 45(Sp. 2): 68. CrossRef Exposure of American Black Bears (Ursus americanus) to Ticks, Tick-Borne Diseases, and Intestinal Parasites in Wisconsin Nika S. Reichert, Daniela Mathieu, Christopher J. Katz, Kent A. Hatch Diversity.2024; 16(9): 537. CrossRef Environmental modulators on the development of the raccoon roundworm (Baylisascaris procyonis): Effects of temperature on the embryogenesis Robin Stutz, Dorian D. Dörge, Anna V. Schantz, Norbert Peter, Sven Klimpel International Journal for Parasitology: Parasites and Wildlife.2024; 25: 100997. CrossRef Influence of Tempetature on Viability and Deveplopment of Heterakis gallinarum (Nematoda, Heterakidae) Eggs V. Yevstafieva, O. Omelchenko , V. Melnychuk , L. Nagorna , M. Petrenko , B. Shaferivskyi , S. Kravchenko , K. Suprunenko , L. Karysheva , S. Sheiko , T. Burda , N. Syzonenko , O. Savenkova , V. Liulka zoodiversity.2024; 58(5): 435. CrossRef Analysis of application status and development prospect of environmental chambers: A review Dong Xie, Haixia Zhou, Lifeng Zhou, Chuck Wah Yu Indoor and Built Environment.2023; 32(2): 305. CrossRef Why Are We Still a Worm World in the 2020s? An Overview of Risk Factors and Endemicity for Soil-Transmitted Helminthiasis Adelson Ferreira Ramos Neto, Yvanna Louise Di Christine Oliveira, Luciana Maria de Oliveira, Roseli La Corte, Sona Jain, Divaldo Pereira de Lyra Junior, Ricardo Toshio Fujiwara, Silvio Santana Dolabella Acta Parasitologica.2023; 68(3): 481. CrossRef *Epidemiology of gastrointestinal helminths among chickens (Gallus domesticus) from Borno State, Northeastern Nigeria: prevalence, helminth burden and associated risk factors* Jallailudeen Rabana Lawal, Saleh Mohammed Jajere, Umar Isa Ibrahim, Abdullahi Abubakar Biu, Dauda Jonathan Revue d’élevage et de médecine vétérinaire des pays tropicaux.2023; 76: 1. CrossRef The Prospective Effects of Climate Change on Neglected Tropical Diseases in the Eastern Mediterranean Region: a Review Ahmed K. Al-Delaimy Current Environmental Health Reports.2022; 9(2): 315. CrossRef Method optimisation for prolonged laboratory storage of Ascaridia galli eggs Anwar Shifaw, Teka Feyera, Timothy Elliott, Brendan Sharpe, Isabelle Ruhnke, Stephen W. Walkden-Brown Veterinary Parasitology.2022; 309: 109758. CrossRef Schistosoma mansoni and soil-transmitted helminths among schoolchildren in An-Nadirah District, Ibb Governorate, Yemen after a decade of preventive chemotherapy Walid M. S. Al-Murisi, Abdulsalam M. Al-Mekhlafi, Mohammed A. K. Mahdy, Sami Ahmed Al-Haidari, Dhekra A. Annuzaili, Ahmed Ali Qaid Thabit, Marcello Otake Sato PLOS ONE.2022; 17(8): e0273503. CrossRef Ascaridia galli eggs obtained from fresh excreta, worm uteri or worms cultured in artificial media differ in embryonation capacity and infectivity Anwar Shifaw, Isabelle Ruhnke, Timothy Elliott, Brendan Sharpe, Teka Feyera, Stephen W. Walkden-Brown Veterinary Parasitology.2022; 310: 109792. CrossRef The Effects of Allium sativum L., Artemisia absinthium L., Cucurbita pepo L., Coriandrum sativum L., Satureja hortensis L. and Calendula officinalis L. on the Embryogenesis of Ascaris suum Eggs during an In Vitro Experimental Study Mihai-Horia Băieş, Călin Gherman, Zsolt Boros, Diana Olah, Ana-Maria Vlase, Anamaria Cozma-Petruț, Adriana Györke, Doina Miere, Laurian Vlase, Gianina Crișan, Marina Spînu, Vasile Cozma Pathogens.2022; 11(9): 1065. CrossRef Persistent Ascaris Transmission Is Possible in Urban Areas Even Where Sanitation Coverage Is High Drew Capone, Troy Barker, Oliver Cumming, Abeoseh Flemister, Riley Geason, Elizabeth Kim, Jackie Knee, Yarrow Linden, Musa Manga, Mackenzie Meldrum, Rassul Nala, Simrill Smith, Joe Brown Environmental Science & Technology.2022; 56(22): 15969. CrossRef The impact of climate change on neglected tropical diseases: a systematic review Rachel Tidman, Bernadette Abela-Ridder, Rafael Ruiz de Castañeda Transactions of The Royal Society of Tropical Medicine and Hygiene.2021; 115(2): 147. CrossRef Effective low-cost preservation of human stools in field-based studies for helminth and microbiota analysis Katharina Stracke, Poom Adisakwattana, Suparat Phuanukoonnon, Tippayarat Yoonuan, Akkarin Poodeepiyasawat, Paron Dekumyoy, Kittipong Chaisiri, Alexandra Roth Schulze, Stephen Wilcox, Harin Karunajeewa, Rebecca J. Traub, Aaron R. Jex International Journal for Parasitology.2021; 51(9): 741. CrossRef Ascaris lumbricoideseggs or artefacts? A diagnostic conundrum M. P. Maurelli, L. C. Alves, C. S. Aggarwal, P. Cociancic, B. Levecke, P. Cools, A. Montresor, D. Ianniello, L. Gualdieri, G. Cringoli, L. Rinaldi Parasitology.2021; 148(13): 1554. CrossRef Inactivating Effects of Common Laboratory Disinfectants, Fixatives, and Temperatures on the Eggs of Soil Transmitted Helminths Kristine J. Kines, Mark Fox, MacKevin Ndubuisi, Guilherme G. Verocai, Vitaliano Cama, Richard S. Bradbury, Anat Florentin Microbiology Spectrum.2021;[Epub] CrossRef Comparison of multi-parallel qPCR and double-slide Kato-Katz for detection of soil-transmitted helminth infection among children in rural Bangladesh Jade Benjamin-Chung, Nils Pilotte, Ayse Ercumen, Jessica R. Grant, Jacqueline R. M. A. Maasch, Andrew M. Gonzalez, Ashanta C. Ester, Benjamin F. Arnold, Mahbubur Rahman, Rashidul Haque, Alan E. Hubbard, Stephen P. Luby, Steven A. Williams, John M. Colford PLOS Neglected Tropical Diseases.2020; 14(4): e0008087. CrossRef Viability and development of Ascaridia galli eggs recovered in artificial media followed by storage under different conditions T. Feyera, I. Ruhnke, B. Sharpe, T. Elliott, D.L.M. Campbell, S.W. Walkden-Brown Journal of Helminthology.2020;[Epub] CrossRef Molecular identification of potential intermediate hosts of Aulonocephalus pennula from the order Orthoptera C. Henry, M.Z. Brym, A. Kalyanasundaram, R.J. Kendall Journal of Helminthology.2019; 93(2): 166. CrossRef Quick incubation process to determine inactivation of Ascaris and Toxocara eggs C. Maya, M. Pérez, G. Velásquez, J. A. Barrios, A. Román, B. Jiménez Water Science and Technology.2019; 80(12): 2328. CrossRef Manure management and public health: Sanitary and socio-economic aspects among urban livestock-keepers in Cambodia Gunilla Ström, Ann Albihn, Tomas Jinnerot, Sofia Boqvist, Agnes Andersson-Djurfeldt, Seng Sokerya, Kristina Osbjer, Sorn San, Holl Davun, Ulf Magnusson Science of The Total Environment.2018; 621: 193. CrossRef Seasonally timed treatment programs for Ascaris lumbricoides to increase impact—An investigation using mathematical models Emma L. Davis, Leon Danon, Joaquín M. Prada, Sharmini A. Gunawardena, James E. Truscott, Johnny Vlaminck, Roy M. Anderson, Bruno Levecke, Eric R Morgan, T. Deirdre Hollingsworth, Guillermina Avila PLOS Neglected Tropical Diseases.2018; 12(1): e0006195. CrossRef The impact of seasonality on the dynamics and control of Ascaris lumbricoides infections A.J. Cooper, T. Déirdre Hollingsworth Journal of Theoretical Biology.2018; 453: 96. CrossRef The time–temperature relationship for the inactivation of Ascaris eggs D. Naidoo, G. L. Foutch Journal of Water, Sanitation and Hygiene for Development.2018; 8(1): 123. CrossRef Prevalence of Toxoplasma gondii and Potentially Zoonotic Helminths in Wild Boars (Sus scrofa) Hunted in Central Italy Roberto Amerigo Papini, Sara Vannucci, Guido Rocchigiani, Simona Nardoni, Francesca Mancianti Macedonian Veterinary Review.2018; 41(1): 83. CrossRef Seroprevalence of five parasitic pathogens in pregnant women in ten Caribbean countries Fengguang Guo, Martin S. Forde, Stephen R. Werre, Rosina C. Krecek, Guan Zhu Parasitology Research.2017; 116(1): 347. CrossRef Effects of climate change on the occurrence and distribution of livestock diseases B. Bett, P. Kiunga, J. Gachohi, C. Sindato, D. Mbotha, T. Robinson, J. Lindahl, D. Grace Preventive Veterinary Medicine.2017; 137: 119. CrossRef A multilevel study of the environmental determinants of swine ascariasis in England Ângelo Joel Mendes, Ana Isabel Ribeiro, Milton Severo, João Niza-Ribeiro Preventive Veterinary Medicine.2017; 148: 10. CrossRef Climate Change Contribution to the Emergence or Re-Emergence of Parasitic Diseases Erica E Short, Cyril Caminade, Bolaji N Thomas Infectious Diseases: Research and Treatment.2017;[Epub] CrossRef Embryonation ability of Ascaridia galli eggs isolated from worm uteri or host faeces Shayan Rahimian, Matthias Gauly, Gürbüz Daş Veterinary Parasitology.2016; 215: 29. CrossRef Temperature dependent embryonic development of Trichuris suis eggs in a medicinal raw material Nermina Vejzagić, Helene Kringel, Johan Musaeus Bruun, Allan Roepstorff, Stig Milan Thamsborg, Anette Blak Grossi, Christian M.O. Kapel Veterinary Parasitology.2016; 215: 48. CrossRef Climate change and foodborne transmission of parasites: A consideration of possible interactions and impacts for selected parasites Kjersti Selstad Utaaker, Lucy J. Robertson Food Research International.2015; 68: 16. CrossRef Effect of temperature and shear stress on the viability of Ascaris suum J. E. Thomas, J. T. Podichetty, Y. Shi, D. Belcher, R. Dunlap, K. McNamara, M. V. Reichard, J. Smay, A. J. Johannes, G. L. Foutch Journal of Water, Sanitation and Hygiene for Development.2015; 5(3): 402. CrossRef Effect of fenbendazole on shedding and embryonation of Ascaris suum eggs from naturally infected sows Jeremy Pittman, Gil Myers, Kenneth Stalder, Locke Karriker Journal of Swine Health and Production.2015; 23(5): 252. CrossRef Effects of Some Pesticides on Development of Ascaris suum Eggs Yong-Man Yu, Jin-Won Kim, Won-Seok Na, Young-Nam Youn, In-Wook Choi, Young-Ha Lee The Korean Journal of Parasitology.2014; 52(1): 111. CrossRef Assessment of parasitic contamination of raw vegetables in Mannuthy, Kerala state, India B. Sunil, Divya Rani Thomas, C. Latha, H. Shameem Veterinary World.2014; 7(4): 253. CrossRef 16,286 View 197 Download Crossref Depressed Neuronal Growth Associated Protein (GAP)-43 Expression in the Small Intestines of Mice Experimentally Infected with Neodiplostomum seoulense Kyoung-Ho Pyo, Eun-Young Kang, Bong-Kwang Jung, Jung-Ho Moon, Jong-Yil Chai, Eun-Hee Shin Korean J Parasitol 2012;50(1):89-93. Published online March 6, 2012 DOI: https://doi.org/10.3347/kjp.2012.50.1.89 Abstract PDF Neodiplostomum seoulense (Digenea: Neodiplostomidae) is an intestinal trematode that can cause severe mucosal pathology in the small intestines of mice and even mortality of the infected mice within 28 days after infection. We observed neuronal growth associated protein-43 (GAP-43) expression in the myenteric plexus of the small intestinal wall of N. seoulense-infected mice until day 35 post-infection (PI). BALB/c mice were infected with 200 or 500 N. seoulense metacercariae isolated from naturally infected snakes and were killed every 7 days for immunohistochemical demonstration of GAP-43 in the small intestines. N. seoulense-infected mice showed remarkable dilatation of intestinal loops compared with control mice through days 7-28 PI. Conversely, GAP-43 expression in the mucosal myenteric plexus was markedly (P<0.05) reduced in the small intestines of N. seoulense-infected mice during days 7-28 PI and was slightly normalized at day 35 PI. From this study, it is evident that neuronal damage occurs in the intestinal mucosa of N. seoulense-infected mice. However, the correlation between intestinal pathology, including the loop dilatation, and depressed GAP-43 expression remains to be elucidated. Citations Citations to this article as recorded by Enhanced serotonin signaling increases intestinal neuroplasticity Chasen J. Greig, Neeru Gandotra, John J. Tackett, Michaela C. Bamdad, Robert A. Cowles Journal of Surgical Research.2016; 206(1): 151. CrossRef 9,250 View 68 Download Crossref Resistance to Toxoplasma gondii Infection in Mice Treated with Silk Protein by Enhanced Immune Responses Joung-Ho Moon, Kyoung-Ho Pyo, Bong-Kwang Jung, Hyang Sook Chun, Jong-Yil Chai, Eun-Hee Shin Korean J Parasitol 2011;49(3):303-308. Published online September 30, 2011 DOI: https://doi.org/10.3347/kjp.2011.49.3.303 Abstract PDF This study investigated whether elevated host immune capacity can inhibit T. gondii infection. For this purpose, we used silk protein extracted from Bombyx mori cocoons as a natural supplement to augment immune capacity. After silk protein administration to BALB/c mice for 6 weeks, ratios of T lymphocytes (CD4⁺ and CD8⁺ T-cells) and splenocyte proliferative capacities in response to Con A or T. gondii lysate antigen (TLA) were increased. Of various cytokines, which regulate immune systems, Th1 cytokines, such as IFN-γ, IL-2, and IL-12, were obviously increased in splenocyte primary cell cultures. Furthermore, the survival of T. gondii (RH strain)-infected mice increased from 2 days to 5 or more days. In a state of immunosuppression induced by methylprednisolone acetate, silk protein-administered mice were resistant to reduction in T-lymphocyte (CD4⁺ and CD8⁺ T-cells) numbers and the splenocyte proliferative capacity induced by Con A or TLA with a statistical significance. Taken together, our results suggest that silk protein augments immune capacity in mice and the increased cellular immunity by silk protein administration increases host protection against acute T. gondii infection. Citations Citations to this article as recorded by Oral Toxicity and Hypotensive Influence of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons of Bombyx mori in Rodent Studies Chainarong Tocharus, Virakboth Prum, Manote Sutheerawattananonda Foods.2024; 13(21): 3505. CrossRef Low dose administration of mature silkworm powder induces gastric mucosal defense factors in ethanol-induced gastric injury rat model Da-Young Lee, Moon-Young Song, Kyung-Sook Hong, Sun-Mi Yun, Young-Min Han, Eun-Hee Kim Food Science and Biotechnology.2023; 32(11): 1551. CrossRef Dietary administration of silk microparticles improves the epidermal and dermal regeneration after a skin wounding in gilthead seabream (Sparus aurata L.) Nora Albaladejo-Riad, Cristóbal Espinosa Ruiz, M. Ángeles Esteban Fish & Shellfish Immunology.2022; 124: 92. CrossRef The effect of silk peptide on immune system, A randomized, double-blind, placebo-controlled clinical trial Jin-Taek Hwang, Jung Min Cho, In Hye Jeong, Jeong-yong Lee, Ki-Chan Ha, Hyang-Im Baek, Hye Jeong Yang, Min Jung Kim, Jong Ho Lee Journal of Functional Foods.2019; 55: 275. CrossRef Silk peptide treatment potentiates natural killer cell activity in vitro and induces natural killer cell maturation and activation in mouse splenocytes Sun-Hee Jang, Mi-Sun Oh, Hyang-Im Baek, Ki-Chan Ha, Jeong-Yong Lee, Yong-Suk Jang Pharmaceutical Biology.2019; 57(1): 369. CrossRef Oral Administration of Silk Peptide Enhances the Maturation and Cytolytic Activity of Natural Killer Cells Sun-Hee Jang, Mi-Sun Oh, Hyang-Im Baek, Ki-Chan Ha, Jeong-Yong Lee, Yong-Suk Jang Immune Network.2018;[Epub] CrossRef Biomaterials-Based Vaccination Strategies for the Induction of CD8+T Cell Responses Charles B. Chesson, Shaunte Ekpo-Otu, Janice J. Endsley, Jai S. Rudra ACS Biomaterials Science & Engineering.2017; 3(2): 126. CrossRef STAT6 Expression and IL-13 Production in Association with Goblet Cell Hyperplasia and Worm Expulsion of Gymnophalloides seoi from C57BL/6 Mice Jin-Joo Lee, Donghee Kim, Kyoung-Ho Pyo, Min-Ki Kim, Hyo-Jin Kim, Jong-Yil Chai, Eun-Hee Shin The Korean Journal of Parasitology.2013; 51(5): 589. CrossRef 10,093 View 88 Download Crossref Immune Responses of Mice Intraduodenally Infected with Toxoplasma gondii KI-1 Tachyzoites Eun-Hee Shin, Yeoun Sook Chun, Won-Hee Kim, Jae-Lip Kim, Kyoung-Ho Pyo, Jong-Yil Chai Korean J Parasitol 2011;49(2):115-123. Published online June 14, 2011 DOI: https://doi.org/10.3347/kjp.2011.49.2.115 Abstract PDF Toxoplasma gondii Korean isolate (KI-1) tachyzoites were inoculated intraduodenally to BALB/c mice using a silicon tube, and the course of infection and immune responses of mice were studied. Whereas control mice, that were infected intraperitoneally, died within day 7 post-infection (PI), the intraduodenally infected mice survived until day 9 PI (infection with 1×10⁵ tachyzoites) or day 11 PI (with 1×10⁶ tachyzoites). Based on histopathologic (Giemsa stain) and PCR (B1 gene) studies, it was suggested that tachyzoites, after entering the small intestine, invaded into endothelial cells, divided there, and propagated to other organs. PCR appeared to be more sensitive than histopathology to detect infected organs and tissues. The organisms spread over multiple organs by day 6 PI. However, proliferative responses of splenocytes and mesenteric lymph node (MLN) cells in response to con A or Toxoplasma lysate antigen decreased significantly, suggesting immunosuppression. Splenic CD4⁺ and CD8⁺ T-lymphocytes showed decreases in number until day 9 PI, whereas IFN-γ and IL-10 decreased slightly at day 6 PI and returned to normal levels by day 9 PI. No TNF-α was detected throughout the experimental period. The results showed that intraduodenal infection with KI-1 tachyzoites was successful but did not elicit significant mucosal immunity in mice and allowed dissemination of T. gondii organisms to systemic organs. The immunosuppression of mice included reduced lymphoproliferative responses to splenocytes and MLN cells to mitogen and low production of cytokines, such as IFN-γ, TNF-α, and IL-10, in response to T. gondii infection. Citations Citations to this article as recorded by Harnessing antigenic proteins of Toxoplasma gondii for efficient diagnosis: a study of promising candidates Saumya Srivastava, Anil Kumar Gupta, Amit Singh, Sudip Kumar Datta, Sarman Singh Journal of Parasitic Diseases.2025; 49(4): 897. CrossRef Toxoplasma gondii macrophage migration inhibitory factor shows anti– Mycobacterium tuberculosis potential via AZIN1/STAT1 interaction Chanjin Yoon, Hyo Keun Kim, Yu Seong Ham, Woo Jin Gil, Seok-Jun Mun, Euni Cho, Jae-Min Yuk, Chul-Su Yang Science Advances.2024;[Epub] CrossRef The effects of toxoplasmosis on sex ratio at birth Jaroslav Flegr, Šárka Kaňková Early Human Development.2020; 141: 104874. CrossRef Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53‐dependent apoptosis and anticancer effect Sang‐Gyun Kim, Seung‐Hwan Seo, Ji‐Hun Shin, Jung‐Pyo Yang, Sang Hyung Lee, Eun‐Hee Shin Journal of Cellular and Molecular Medicine.2019; 23(5): 3234. CrossRef Kinetics of acute infection with Toxoplasma gondii and histopathological changes in the duodenum of rats Aline Rosa Trevizan, Suellen Laís Vicentino-Vieira, Paulo da Silva Watanabe, Marcelo Biondaro Góis, Gessilda de Alcântara Nogueira de Melo, João Luiz Garcia, Eduardo José de Almeida Araújo, Débora de Mello Gonçales Sant'Ana Experimental Parasitology.2016; 165: 22. CrossRef In vitro inhibition of Toxoplasma gondii by the anti-malarial candidate, 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol Chun-Feng Xin, Hye-Sook Kim, Akira Sato, Hak-Jae Lee, You-Won Lee, Kyoung-Ho Pyo, Eun-Hee Shin Parasitology International.2016; 65(5): 494. CrossRef Immune adjuvant effect of aToxoplasma gondiiprofilin-like protein in autologous whole-tumor-cell vaccination in mice Kyoung-Ho Pyo, You-Won Lee, Sun Min Lim, Eun-Hee Shin Oncotarget.2016; 7(45): 74107. CrossRef Resistance toToxoplasma gondiiInfection in Mice Treated with Silk Protein by Enhanced Immune Responses Joung-Ho Moon, Kyoung-Ho Pyo, Bong-Kwang Jung, Hyang Sook Chun, Jong-Yil Chai, Eun-Hee Shin The Korean Journal of Parasitology.2011; 49(3): 303. CrossRef 10,426 View 90 Download Crossref CD8⁺ T-cell Activation in Mice Injected with a Plasmid DNA Vaccine Encoding AMA-1 of the Reemerging Korean Plasmodium vivax Hyo-Jin Kim, Bong-Kwang Jung, Jin-Joo Lee, Kyoung-Ho Pyo, Tae Yun Kim, Byung-il Choi, Tae Woo Kim, Hajime Hisaeda, Kunisuke Himeno, Eun-Hee Shin, Jong-Yil Chai Korean J Parasitol 2011;49(1):85-90. Published online March 18, 2011 DOI: https://doi.org/10.3347/kjp.2011.49.1.85 Abstract PDF Relatively little has been studied on the AMA-1 vaccine against Plasmodium vivax and on the plasmid DNA vaccine encoding P. vivax AMA-1 (PvAMA-1). In the present study, a plasmid DNA vaccine encoding AMA-1 of the reemerging Korean P. vivax has been constructed and a preliminary study was done on its cellular immunogenicity to recipient BALB/c mice. The PvAMA-1 gene was cloned and expressed in the plasmid vector UBpcAMA-1, and a protein band of approximately 56.8 kDa was obtained from the transfected COS7 cells. BALB/c mice were immunized intramuscularly or using a gene gun 4 times with the vaccine, and the proportions of splenic T-cell subsets were examined by fluorocytometry at week 2 after the last injection. The spleen cells from intramuscularly injected mice revealed no significant changes in the proportions of CD8⁺ T-cells and CD4⁺ T-cells. However, in mice immunized using a gene gun, significantly higher (P<0.05) proportions of CD8⁺ cells were observed compared to UB vector-injected control mice. The results indicated that cellular immunogenicity of the plasmid DNA vaccine encoding AMA-1 of the reemerging Korean P. vivax was weak when it was injected intramuscularly; however, a promising effect was observed using the gene gun injection technique. Citations Citations to this article as recorded by Live Vaccination with Blood-Stage Plasmodium yoelii 17XNL Prevents the Development of Experimental Cerebral Malaria Takashi Imai, Ha Ngo-Thanh, Kazutomo Suzue, Aoi Shimo, Akihiro Nakamura, Yutaka Horiuchi, Hajime Hisaeda, Takashi Murakami Vaccines.2022; 10(5): 762. CrossRef Immunotherapeutic Effects of Different Doses of Mycobacterium tuberculosis ag85a/b DNA Vaccine Delivered by Electroporation Yan Liang, Lei Cui, Li Xiao, Xiao Liu, Yourong Yang, Yanbo Ling, Tong Wang, Lan Wang, Jie Wang, Xueqiong Wu Frontiers in Immunology.2022;[Epub] CrossRef Long-Term Humoral and Cellular Immune Responses Elicited by a Heterologous Plasmodium vivax Apical Membrane Antigen 1 Protein Prime/Adenovirus Boost Immunization Protocol Leoneide Érica Maduro Bouillet, Mariana Oliveira Dias, Natália Alves Dorigo, Andrew Douglas Moura, Bruce Russell, Francois Nosten, Laurent Renia, Érika Martins Braga, Ricardo Tostes Gazzinelli, Maurício M. Rodrigues, Irene S. Soares, Oscar Bruna-Romero, J Infection and Immunity.2011; 79(9): 3642. CrossRef 10,187 View 74 Download Crossref Suppressed CD31 Expression in Sarcoma-180 Tumors after Injection with Toxoplasma gondii Lysate Antigen in BALB/c Mice Kyoung-Ho Pyo, Bong-Kwang Jung, Jong-Yil Chai, Eun-Hee Shin Korean J Parasitol 2010;48(2):171-174. Published online June 17, 2010 DOI: https://doi.org/10.3347/kjp.2010.48.2.171 Abstract PDF The anti-tumorigenic effects of Toxoplasma gondii (RH) antigens were studied in a murine sarcoma-180 tumor model. To determine the anti-tumor effects, the reduction in tumor size and expression of CD31 (an angiogenesis marker in the tumor tissue) were examined after injection of BALB/c mice with T. gondii lysate antigen (TLA) or formalin-fixed, proliferation-inhibited, T. gondii tachyzoites. Tumors were successfully produced by an intradermal injection of sarcoma-180 cells with plain Matrigel in the mid-backs of mice. After injection with TLA or formalin-fixed T. gondii tachyzoites, the increase in tumor size and weight nearly stopped while tumor growth continued in control mice that were injected with PBS. CD31 expression in TLA-treated or formalin-fixed T. gondii-injected mice was lower than the control mice. Accordingly, the present study shows that the treatment of mice with formalin-fixed T. gondii or TLA in the murine sarcoma-180 tumor model results in a decrease of both tumor size and CD31 expression. Citations Citations to this article as recorded by Unveiling the anti-neoplastic potential of Schistosoma mansoni-derived antigen against breast cancer: a pre-clinical study Maha Mohamed Eissa, Sonia Rifaat Ahmed Allam, Cherine Adel Ismail, Rasha Abdelmawla Ghazala, Nahla El Skhawy, Inass Ibrahim Ahmed Zaki, Eman Ibrahim El-said Ibrahim European Journal of Medical Research.2025;[Epub] CrossRef Bug as a drug: Unveiling anti-cancer properties of Toxoplasma gondii and its therapeutic prospects in cancer immunotherapy Yie Wei Chua, Sek Chuen Chow Acta Tropica.2025; 267: 107684. CrossRef From pathogen to cure: exploring the antitumor potential of Toxoplasma gondii Parisa Alipanahi, Arezou Khosrojerdi, Abdol Satar Pagheh, Kareem Hatam-Nahavandi, Ehsan Ahmadpour Infectious Agents and Cancer.2025;[Epub] CrossRef Evaluation of Antitumor Effects of Toxoplasma gondii Different Antigens on Ehrlich Solid Carcinoma in Mice Salwa S. Younis, Basma M. Elmansory, Hend A. Elrefaey, Nahla A. Nasef, Sara H. Elakshar, Radwa A. Awad, Ghada A. Gamea Parasite Immunology.2025;[Epub] CrossRef Parasites’ immunomodulators: a breakthrough in immunotherapeutics displaying antineoplastic activity against human colorectal and hepatocellular carcinoma cells Nahla El Skhawy, Ahmed Shehata, Maha M. Eissa Infectious Agents and Cancer.2025;[Epub] CrossRef Trichinella spiralis Larval Extract as a Biological Anti‐Tumor Therapy in a Murine Model of Ehrlich Solid Carcinoma Salwa S. Younis, Amina M. Salama, Dalia A. Elmehy, Nehal A. Heabah, Hanem M. Rabah, Sara H. Elakshar, Radwa A. Awad, Ghada A. Gamea Parasite Immunology.2024;[Epub] CrossRef Mining parasites for their potential as novel therapeutic agents against cancer Neha Sylvia Walter, Shalmoli Bhattacharyya Medical Oncology.2024;[Epub] CrossRef Parasite-enhanced immunotherapy: transforming the “cold” tumors to “hot” battlefields Yujun Xie, Jinyan Wang, Yafei Wang, Yalin Wen, Yanping Pu, Benfan Wang Cell Communication and Signaling.2024;[Epub] CrossRef Parasites revive hope for cancer therapy Maha M. Eissa, Ahmed Ebada Salem, Nahla El Skhawy European Journal of Medical Research.2024;[Epub] CrossRef Association of Neuroblastoma (NB) SH-SY5Y Cells with Antibodies of Parasitic Origin (Anti-Acanthamoeba and Anti-Toxocara canis) Víctor Alberto Maravelez Acosta, Maria de Lourdes Caballero Garcia, Genaro Patiño López, María del Pilar Crisóstomo Vázquez, Luz Ofelia Franco Sandoval, Leticia Eligio García International Journal of Molecular Sciences.2024; 25(24): 13577. CrossRef Prophylactic antineoplastic activity of Toxoplasma gondii RH derived antigen against ehrlich solid carcinoma with evidence of shared antigens by comparative immunoblotting Maha M. Eissa, Maha R. Gaafar, Layla K. Younis, Cherine A. Ismail, Nahla El Skhawy Infectious Agents and Cancer.2023;[Epub] CrossRef Toxoplasma gondii-derived antigen modifies tumor microenvironment of Ehrlich solid carcinoma murine model and enhances immunotherapeutic activity of cyclophosphamide Cherine A. Ismail, Maha M. Eissa, Maha R. Gaafar, Layla K. Younis, Nahla El Skhawy Medical Oncology.2023;[Epub] CrossRef Shedding light on a mysterious link between Toxoplasma gondii and cancer: A review Nahla El Skhawy, Maha M. Eissa Experimental Parasitology.2023; 250: 108544. CrossRef Human Anti-Toxoplasma Antibodies Attach Strongly to Breast Cancer Cells Fatemeh Hosseini, Zohreh Farahbakhsh, Azar Balouti, Reza Kalantari, Gholamreza Pourshahbazi, Somayeh Mousavi Mobarakeh, Morteza Yousefi, Hossein Yousofi Darani International Journal of Cancer Management.2023;[Epub] CrossRef Promising effects of parasite-derived compounds on tumor regression: a systematic review of in vitro and in vivo studies Ali Asghari, Hassan Nourmohammadi, Hamidreza Majidiani, Seyyed Ali Shariatzadeh, Davood Anvari, Sadegh Shamsinia, Ezatollah Ghasemi, Morteza Shams, Gholam Basati Environmental Science and Pollution Research.2022; 29(22): 32383. CrossRef Evaluation of cytotoxic activity of live toxoplasma gondii tachyzoites and toxoplasma antigen on MCF-7 human breast cancer cell line Maha M. Eissa, Maha R. Gaafar, Layla K. Younis, Cherine A. Ismail, Nahla El Skhawy EUREKA: Life Sciences.2022; (2): 45. CrossRef Anti-Tumor Effect of Parasitic Protozoans Haojie Ding, Songrui Wu, Zi Jin, Bin Zheng, Yuan Hu, Ke He, Shaohong Lu, Xunhui Zhuo Bioengineering.2022; 9(8): 395. CrossRef Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth Jiating Chen, Wenzhong Liao, HongJuan Peng Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef Anti-cancer immunoprotective effects of immunization with hydatid cyst wall antigens in a non-immunogenic and metastatic triple-negative murine mammary carcinoma model Mahshid Shakibapour, Amirhosein Kefayat, Mohammad Reza Mofid, Behrokh Shojaie, Fereshteh Mohamadi, Seydeh Maryam Sharafi, Mahdi Mahmoudzadeh, Hossein Yousofi Darani International Immunopharmacology.2021; 99: 107955. CrossRef Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis Tao-Tao Yue, Nan Zhang, Jian-Hua Li, Xiang-Yun Lu, Xiao-Cen Wang, Xin Li, Hong-Bo Zhang, Shu-Qin Cheng, Bo-Bo Wang, Peng-Tao Gong, Xi-Chen Zhang Parasites & Vectors.2021;[Epub] CrossRef Toxoplasma GRA16 Inhibits NF-κB Activation through PP2A-B55 Upregulation in Non-Small-Cell Lung Carcinoma Cells Seung-Hwan Seo, Sang-Gyun Kim, Ji-Hun Shin, Do-Won Ham, Eun-Hee Shin International Journal of Molecular Sciences.2020; 21(18): 6642. CrossRef Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53‐dependent apoptosis and anticancer effect Sang‐Gyun Kim, Seung‐Hwan Seo, Ji‐Hun Shin, Jung‐Pyo Yang, Sang Hyung Lee, Eun‐Hee Shin Journal of Cellular and Molecular Medicine.2019; 23(5): 3234. CrossRef Anti-Toxoplasma gondii antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes Fereshteh Mohamadi, Mahshid Shakibapour, Seyedeh Sharafi, Ali Andalib, Sepideh Tolouei, Hossein Yousofi Darani Biomedical Reports.2019;[Epub] CrossRef Plasmodium yoelii infection inhibits murine leukaemia WEHI-3 cell proliferation in vivo by promoting immune responses Zhen-Zhen Tong, Zheng-Ming Fang, Qi Zhang, Yun Zhan, Yue Zhang, Wan-Fang Jiang, Xiao Hou, Yong-Long Li, Ting Wang Infectious Diseases of Poverty.2018;[Epub] CrossRef Immune adjuvant effect of aToxoplasma gondiiprofilin-like protein in autologous whole-tumor-cell vaccination in mice Kyoung-Ho Pyo, You-Won Lee, Sun Min Lim, Eun-Hee Shin Oncotarget.2016; 7(45): 74107. CrossRef Common antigens between hydatid cyst and cancers Shima Daneshpour, Mehran Bahadoran, Seyed Hossein Hejazi, Abas Ali Eskandarian, Mehdi Mahmoudzadeh, Hossein Yousofi Darani Advanced Biomedical Research.2016;[Epub] CrossRef Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment Kyoung-Ho Pyo, Bong-Kwang Jung, Chun-Feng Xin, You-Won Lee, Jong-Yil Chai, Eun-Hee Shin The Korean Journal of Parasitology.2014; 52(6): 605. CrossRef Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines Barbara A. Fox, Kiah L. Sanders, Shan Chen, David J. Bzik Trends in Parasitology.2013; 29(9): 431. CrossRef Parasites and Cancers: Parasite Antigens as Possible Targets for Cancer Immunotherapy Hossein Yousofi Darani, Morteza Yousefi Future Oncology.2012; 8(12): 1529. CrossRef Toxoplasma gondii Infection in the Brain Inhibits Neuronal Degeneration and Learning and Memory Impairments in a Murine Model of Alzheimer's Disease Bong-Kwang Jung, Kyoung-Ho Pyo, Ki Young Shin, Young Sang Hwang, Hyoungsub Lim, Sung Joong Lee, Jung-Ho Moon, Sang Hyung Lee, Yoo-Hun Suh, Jong-Yil Chai, Eun-Hee Shin, Markus M. Heimesaat PLoS ONE.2012; 7(3): e33312. CrossRef Resistance toToxoplasma gondiiInfection in Mice Treated with Silk Protein by Enhanced Immune Responses Joung-Ho Moon, Kyoung-Ho Pyo, Bong-Kwang Jung, Hyang Sook Chun, Jong-Yil Chai, Eun-Hee Shin The Korean Journal of Parasitology.2011; 49(3): 303. CrossRef 10,116 View 115 Download Crossref Detection of Gnathostoma spinigerum Third-Stage Larvae in Snakeheads Purchased from a Central Part of Myanmar Bong-Kwang Jung, Jin-Ju Lee, Kyoung-Ho Pyo, Hyeong-Jin Kim, Hoo-Gn Jeong, Cheong-Ha Yoon, Soon-Hyung Lee, Eun-Hee Shin, Jong-Yil Chai Korean J Parasitol 2008;46(4):285-288. Published online December 20, 2008 DOI: https://doi.org/10.3347/kjp.2008.46.4.285 Abstract PDF To examine the infection status of freshwater fish with Gnathostoma spp. larvae in Myanmar, we purchased 15 snakeheads, Channa striatus, from a local market in a suburban area of Naypyidaw, the new capital city. Two larval gnathostomes were collected using an artificial digestion technique, and observed by a light microscope and a scanning electron microscope. The size of an intact larva was 2.65 mm long and 0.32 mm wide. The characteristic morphology of the larvae included the presence of a long esophagus (0.80 mm long), 2 pairs of cervical sacs (0.43 mm long), and a characteristic head bulb with 4 rows of hooklets. The number of hooklets in the 1st, 2nd, 3rd, and 4th row was 45, 48, 50, and 52, respectively. Based on these morphological characters, the larvae were identified as the advanced 3rd-stage larvae of Gnathostoma spinigerum. This is the first report of detection of G. spinigerum 3rd-stage larvae in the central part of Myanmar. Our study suggests that intake of raw meat of snakehead fish in Myanmar may result in human gnathostomiasis. Citations Citations to this article as recorded by The occurrence and clinical importance of infectious stage of Echinocephalus (Nematoda: Gnathostomidae) larvae in selected Australian edible fish Shokoofeh Shamsi, Eleanor Steller, Xiaocheng Zhu Parasitology International.2021; 83: 102333. CrossRef Detection of Gnathostoma spinigerum Advanced 3rd-Stage Larvae in the Chinese Edible Frog, Hoplobatrachus rugulosus, from Local Markets in Phnom Penh, Cambodia Woon-Mok Sohn, Bong-Kwang Jung, Sooji Hong, Seungwan Ryoo, Keon Hoon Lee, Virak Khieu, Jong-Yil Chai The Korean Journal of Parasitology.2021; 59(5): 519. CrossRef Larval Gnathostomes and Spargana in Chinese Edible Frogs, Hoplobatrachus rugulosus, from Myanmar: Potential Risk of Human Infection Jong-Yil Chai, Bong-Kwang Jung, Jin-Youp Ryu, Hyun-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn The Korean Journal of Parasitology.2020; 58(4): 467. CrossRef Larval Gnathostomes and Zoonotic Trematode Metacercariae in Fish from a Local Market in Yangon City, Myanmar Jong-Yil Chai, Bong-Kwang Jung, Keon Hoon Lee, Jin-Youp Ryu, Hyeon-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn The Korean Journal of Parasitology.2020; 58(6): 701. CrossRef Molecular identification and genetic diversity of Gnathostoma spinigerum larvae in freshwater fishes in southern Lao PDR, Cambodia, and Myanmar Patcharaporn Boonroumkaew, Oranuch Sanpool, Rutchanee Rodpai, Lakkhana Sadaow, Chalermchai Somboonpatarakun, Sakhone Laymanivong, Win Pa Pa Aung, Mesa Un, Porntip Laummaunwai, Pewpan M. Intapan, Wanchai Maleewong Parasitology Research.2019; 118(5): 1465. CrossRef Gnathostomatidae nematode parasite of Colomesus psittacus (Osteichthyes, Tetraodontiformes) in the Ilha de Marajó, Brazilian Amazon Raul Henrique da Silva Pinheiro, Ricardo Luís Sousa Santana, Francisco Tiago Vasconcelos Melo, Jeannie Nascimento dos Santos, Elane Guerreiro Giese Revista Brasileira de Parasitologia Veterinária.2017; 26(3): 340. CrossRef *Larval Gnathostoma spinigerum* Detected in Asian Swamp Eels, Monopterus albus, Purchased from a Local Market in Yangon, Myanmar** Jong-Yil Chai, Woon-Mok Sohn, Byoung-Kuk Na, Jong-Bok Park, Hoo-Gn Jeoung, Eui-Hyug Hoang, Thi Thi Htoon, Htay Htay Tin The Korean Journal of Parasitology.2015; 53(5): 619. CrossRef Zoonoses in South-East Asia: a regional burden, a global threat Marion Bordier, François Roger Animal Health Research Reviews.2013; 14(1): 40. CrossRef Gnathostoma spinigerum: Immunodepression in experimental infected mice Wilai Saksirisampant, Sunida Thaisom, Mai Ratanavararak, Benjamas Wongsatayanon Thanomsub Experimental Parasitology.2012; 132(3): 320. CrossRef 10,618 View 102 Download Crossref