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Min Kyoung Cho	11 Articles
Comparison of Functional Gene Annotation of Toxascaris leonina and Toxocara canis using CLC Genomics Workbench Ki Uk Kim, Sang Kyun Park, Shin Ae Kang, Mi Kyung Park, Min Kyoung Cho, Ho-jin Jung, Kyung-Yun Kim, Hak Sun Yu Korean J Parasitol 2013;51(5):525-530. Published online October 31, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.5.525 Abstract PDF Supplementary Material The ascarids, Toxocara canis and Toxascaris leonina, are probably the most common gastrointestinal helminths encountered in dogs. In order to understand biological differences of 2 ascarids, we analyzed gene expression profiles of female adults of T. canis and T. leonina using CLC Genomics Workbench, and the results were compared with those of free-living nematode Caenorhabditis elegans. A total of 2,880 and 7,949 ESTs were collected from T. leonina and T. canis, respectively. The length of ESTs ranged from 106 to 4,637 bp with an average insert size of 820 bp. Overall, our results showed that most functional gene annotations of 2 ascarids were quite similar to each other in 3 major categories, i.e., cellular component, biological process, and molecular function. Although some different transcript expression categories were found, the distance was short and it was not enough to explain their different lifestyles. However, we found distinguished transcript differences between ascarid parasites and free-living nematodes. Understanding evolutionary genetic changes might be helpful for studies of the lifestyle and evolution of parasites. Citations Citations to this article as recorded by CRISPR-Cas9 genome editing reveals that the Pgs gene of Fusarium circinatum is involved in pathogenicity, growth and sporulation Alida van Dijk, Andi M. Wilson, Bianke Marx, Bianca Hough, Benedicta Swalarsk-Parry, Lieschen De Vos, Michael J. Wingfield, Brenda D. Wingfield, Emma T. Steenkamp Fungal Genetics and Biology.2025; 177: 103970. CrossRef Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi Jiayu Li, Yingying Fan, Na Li, Yaqiong Guo, Weijian Wang, Kangli Feng, Wei He, Falei Li, Jianbo Huang, Yanhua Xu, Lihua Xiao, Yaoyu Feng International Journal for Parasitology.2024; 54(7): 379. CrossRef Chromosome-level genome assembly of Cryptosporidium parvum by long-read sequencing of ten oocysts Yuancai Chen, Jianying Huang, Huikai Qin, Kaihui Zhang, Yin Fu, Junqiang Li, Rongjun Wang, Kai Chen, Jie Xiong, Wei Miao, Guangying Wang, Longxian Zhang Scientific Data.2024;[Epub] CrossRef High subtelomeric GC content in the genome of a zoonotic Cryptosporidium species Jiayu Li, Na Li, Dawn M. Roellig, Wentao Zhao, Yaqiong Guo, Yaoyu Feng, Lihua Xiao Microbial Genomics .2023;[Epub] CrossRef The Combination of Phages and Faecal Microbiota Transplantation Can Effectively Treat Mouse Colitis Caused by Salmonella enterica Serovar Typhimurium Xinwu Wang, Yating Xing, Yalu Ji, Hengyu Xi, Xiaohe Liu, Li Yang, Liancheng Lei, Wenyu Han, Jingmin Gu Frontiers in Microbiology.2022;[Epub] CrossRef Complete Plastome of Physalis angulata var. villosa, Gene Organization, Comparative Genomics and Phylogenetic Relationships among Solanaceae Xiaori Zhan, Zhenhao Zhang, Yong Zhang, Yadi Gao, Yanyun Jin, Chenjia Shen, Huizhong Wang, Shangguo Feng Genes.2022; 13(12): 2291. CrossRef Mitochondrial genes associated with pyrethroid resistance revealed by mitochondrial genome and transcriptome analyses in the malaria vector Anopheles sinensis (Diptera: Culicidae) Yi‐Ran Ding, Zhen‐Tian Yan, Feng‐Ling Si, Xu‐Dong Li, Qi‐Meng Mao, Sana Asghar, Bin Chen Pest Management Science.2020; 76(2): 769. CrossRef Environmental microbiology: Perspectives for legal and occupational medicine Saverio Giampaoli, Federica Alessandrini, Giovanni Vanni Frajese, Giovanni Guglielmi, Adriano Tagliabracci, Andrea Berti Legal Medicine.2018; 35: 34. CrossRef 9,615 View 96 Download Crossref Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice Shin Ae Kang, Mi-Kyung Park, Min Kyoung Cho, Hak Sun Yu Korean J Parasitol 2013;51(5):583-588. Published online October 31, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.5.583 Abstract PDF To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and measured T-helper (Th) cell-related serial cytokine production after infection. At day 5 post infection (PI), most larvae were detected from the lungs, spleen, intestine, and muscle. Expression of thymic stromal lymphopoietin (TSLP) and CCL11 (eotaxin) showed a significant increase in most infected organs, except the intestine. However, expression of the CXCL1 (Gro-α) gene was most highly enhanced in the intestine at day 14 PI. Th1-related cytokine secretion of splenocytes showed increases at day 28 PI, and the level showed a decrease at day 42 PI. Th2-related cytokine secretion of splenocytes also showed an increase after infection; in particular, IL-5 level showed a significant increase at day 14 PI, and the level showed a decrease at day 28 PI. However, levels of Th17-related cytokines, IL-6 and IL-17A, showed gradual increases until day 42 PI. In conclusion, Th1, Th2, and Th17-related cytokine production might be important in immune responses against T. leonina VLM in experimental mice. Citations Citations to this article as recorded by Histopathological lesions caused by experimental Toxocara canis and Toxascaris leonina infections in farm mink (Neovison vison) Maciej Klockiewicz, Małgorzata Sobczak-Filipiak, Tadeusz Jakubowski, Ewa Długosz Journal of Veterinary Research.2019; 63(2): 205. CrossRef Experimental infection with T. canis and T. leonina in farm mink (Neovison vison) Maciej Klockiewicz, Tadeusz Jakubowski, Małgorzata Sobczak-Filipiak, Justyna Bartosik, Ewa Długosz Journal of Veterinary Research.2019; 63(2): 197. CrossRef 8,969 View 88 Download Crossref Environmental Factors Related to Enterobiasis in a Southeast Region of Korea Dong-Hee Kim, Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Bo Young Kim, Sang Kyun Park, Hak Sun Yu Korean J Parasitol 2013;51(1):139-142. Published online February 18, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.1.139 Abstract PDF Pinworm infection can occur through contact with contaminated surfaces followed by ingestion or even through inhalation of infective eggs. We have limited information regarding environmental contamination by eggs of Enterobius vermicularis. In order to determine environmental risk factors associated with the rate of E. vermicularis infection, we investigated possible environmental risk factors using a questionnaire from 46 kindergartens in 3 different cities of the southeast area of Korea. In total, using the cellotape anal swab technique, 3,422 children were examined for E. vermicularis infection. We evaluated E. vermicularis egg of books, educational materials, toys, room door handles, dusts of window edges, desks, chairs, tables, and dusts of classrooms. The overall egg-positive rate for E. vermicularis was 6.0%, and the prevalence of enterobiasis in each kindergarten ranged between 0% and 16.9%. We found that 78.9% of egg positive kindergartens were managed by private foundations, which was significantly higher, compared with kindergartens managed by public foundations or the nation. Compared with public or national kindergartens, most private kindergartens were located in residential areas and the number of children in these areas was significantly higher. In conclusion, numbers of children in kindergartens was found to be an environmental risk factor associated with transmission of enterobiasis in Korea. Citations Citations to this article as recorded by Comparison of Efficacy of Albendazole, Mebendazole and Pyrantel Pamoate in Achieving Remission and Preventing Recurrence of Enterobius vermicularis Infestation in Children: A Randomised Controlled Trial Annaswamy V. Renuka Devi, Vinoth Selvaraj, B. Sreelatha Venkat, Vanidha Kandasamy Indian Pediatrics.2026;[Epub] CrossRef Pinworm (Enterobius Vermicularis) Infestation: An Updated Review Alexander K.C. Leung, Joseph M. Lam, Benjamin Barankin, Alex H.C. Wong, Kin F. Leong, Kam L. Hon Current Pediatric Reviews.2025; 21(4): 333. CrossRef Enterobius vermicularis infection and its risk factors among rural schoolchildren in Zhejiang Province: a cross-sectional study Jialie Jin, Wei Ruan, Wenjie Xu, Xuan Zhang, Kegen Yu, Hualiang Chen, Jiaqi Zhang, Jimin Sun, Jianmin Jiang, Xiaoxiao Wang Parasitology Research.2025;[Epub] CrossRef A 25-Year-Old Woman With Long-Lasting Abdominal Pain and Spleen Abscess Anthony Amoroso, Priya Nori, David J Riedel, Paolo Agostinis, Dario Cappello, Niccolò Riccardi, Teresa Michelutti, Maria Orsaria, Verena Zerbato, Stefano Di Bella Clinical Infectious Diseases.2023; 77(5): 795. CrossRef Global prevalence of enterobiasis in young children over the past 20 years: a systematic review and meta-analysis Elham Kia Lashaki, Azadeh Mizani, Seyed Abdollah Hosseini, Bentolhoda Habibi, Khadijeh Taherkhani, Amir Javadi, AliReza Taremiha, Samira Dodangeh Osong Public Health and Research Perspectives.2023; 14(6): 441. CrossRef Nutritional status, intestinal parasitic infections, and socio‐environmental conditions in Mbyá‐guaraní children: The current situation in communities incentral Misiones, Argentina María Lorena Zonta, Andrea Servián, Guillermo Panisse, Evelia E. Oyhenart, Graciela T. Navone American Journal of Human Biology.2022;[Epub] CrossRef Enterobiasis among Yemeni children: a cross-sectional study Abdulelah H. Al-Adhroey, Yahya A. Al-Ansi, Mohammed A. Al-Kholani, Abdulrahman H. Amer, Marwan M. Al-Khyat, Fadia H. Al Hubaishi, Radhwan H. Aziz, Ebrahim S. Al-Khateeb, Souad A. Al-Gabri, Tawfik M. Al-Gabri Journal of Parasitic Diseases.2022; 46(3): 722. CrossRef Is pinworm infection still a public health concern among children in resource-rich regions? Trends in pinworm infection prevalence and associated factors among children in Hualien County, Taiwan: a retrospective cross-sectional study Yu-Chao Hsiao, Jen-Hung Wang, Chia-Hsiang Chu, Yu-Hsun Chang, Yung-Chieh Chang, Rong-Hwa Jan, Shao-Yin Chu, Shang-Hsien Yang, Jui-Shia Chen, Ming-Chun Chen BMC Public Health.2022;[Epub] CrossRef High case enterobiasis in school children and potential eggs distribution on the bed Didik Sumanto, Sayono E, Wulandari Meikawati, Tri Dewi Kristini, Wahyu Handoyo, Aris Sugiharto Journal of Microbiology & Experimentation.2022; 10(1): 33. CrossRef Enterobius vermicularis Infection among Preschool Children: A 12-Year (2008-2019) Survey in Large Cities and Provinces of the Republic of Korea Hyejoo Shin, Bong-Kwang Jung, Seungwan Ryoo, Sooji Hong, Taehee Chang, Jiyeon Park, Keon Hoon Lee, Jeonggyu Lee, Jae Young Park, Hoo-Gn Jeoung, Jae Hyun Cho, Jong-Yil Chai The Korean Journal of Parasitology.2021; 59(4): 421. CrossRef Genetic variation of Enterobius vermicularis among schoolchildren in Thailand K. Tomanakan, O. Sanpool, P. Chamavit, V. Lulitanond, P.M. Intapan, W. Maleewong Journal of Helminthology.2020;[Epub] CrossRef Morphological characteristic of Skrjabinema ovis (Nematoda, Oxyuridae) obtained from domestic sheep V. V. Melnychuk, O. I. Reshetylo Regulatory Mechanisms in Biosystems.2020;[Epub] CrossRef Detection of Enterobius vermicularis in greater Berlin, 2007–2017: seasonality and increased frequency of detection Johannes Friesen, Clara Bergmann, Robert Neuber, Jörg Fuhrmann, Thilo Wenzel, Anita Durst, Michael Müller, Ralf Ignatius European Journal of Clinical Microbiology & Infectious Diseases.2019; 38(4): 719. CrossRef Enterobius vermicularis infection: prevalence and risk factors among preschool children in kindergarten in the capital area, Republic of the Marshall Islands Chia-Kwung Fan, Ting-Wu Chuang, Ying-Chieh Huang, Ai-Wen Yin, Chia-Mei Chou, Yu-Ting Hsu, Ramson Kios, Shao-Lun Hsu, Ying-Ting Wang, Mai-Szu Wu, Jia-Wei Lin, Kennar Briand, Chia-Ying Tu BMC Infectious Diseases.2019;[Epub] CrossRef Status of common parasitic diseases in Korea in 2019 Sun Huh Journal of the Korean Medical Association.2019; 62(8): 437. CrossRef Enterobius vermicularis infection and its risk factors among pre-school children in Taipei, Taiwan Kuang-Yao Chen, Chuan-Min Yen, Kao-Pin Hwang, Lian-Chen Wang Journal of Microbiology, Immunology and Infection.2018; 51(4): 559. CrossRef Prevalence ofEnterobius vermicularisamong preschool children in 2003 and 2013 in Xinxiang city, Henan province, Central China Shuai Wang, Zhijun Yao, Yichen Hou, Dong Wang, Haizhu Zhang, Jingbo Ma, Luwen Zhang, Shiguo Liu Parasite.2016; 23: 30. CrossRef Risk factors for Enterobius vermicularis infection in children in Gaozhou, Guangdong, China Hong-Mei Li, Chang-Hai Zhou, Zhi-Shi Li, Zhuo-Hui Deng, Cai-Wen Ruan, Qi-Ming Zhang, Ting-Jun Zhu, Long-Qi Xu, Ying-Dan Chen Infectious Diseases of Poverty.2015;[Epub] CrossRef High Prevalence of <i>Enterobius vermicularis</i> Infection among Schoolchildren in Three Townships around Yangon, Myanmar Jong-Yil Chai, Seung Koo Yang, Jae Won Kim, Soo-Lyoen Choi, Gyu-Young Song, Bong-Kwang Jung, Min-Jae Kim, Jaeeun Cho, Deok-Gyu Kim, Woon-Mok Sohn, Hoo-Gn Jeoung, Seon Cho, Jong-Bok Park, Sooji Hong, Thi Thi Htoon, Htay Htay Tin The Korean Journal of Parasitology.2015; 53(6): 771. CrossRef Clinical Update on Parasitic Diseases Min Seo Korean Journal of Medicine.2013; 85(5): 469. CrossRef 10,915 View 146 Download Crossref Trichinella spiralis Infection Suppressed Gut Inflammation with CD4⁺CD25⁺Foxp3⁺ T Cell Recruitment Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Seon Hee Choi, Soon Cheol Ahn, Hak Sun Yu Korean J Parasitol 2012;50(4):385-390. Published online November 26, 2012 DOI: https://doi.org/10.3347/kjp.2012.50.4.385 Abstract PDF In order to know the effect of pre-existing Trichinella spiralis infection on experimentally induced intestinal inflammation and immune responses, we induced colitis in T. spiralis-infected mice and observed the severity of colitis and the levels of Th1, Th2, and regulatory cytokines and recruitment of CD4⁺CD25⁺Foxp3⁺ T (regulatory T; T_reg) cells. Female C57BL/6 mice were infected with 250 muscle larvae; after 4 weeks, induction of experimental colitis was performed using 3% dextran sulfate sodium (DSS). During the induction period, we observed severity of colitis, including weight loss and status of stool, and evaluated the disease activity index (DAI). A significantly low DAI and degree of weight loss were observed in infected mice, compared with uninfected mice. In addition, colon length in infected mice was not contracted, compared with uninfected mice. We also observed a significant increase in production of pro-inflammatory cytokines, IL-6 and IFN-γ, in spleen lymphocytes treated with DSS; however, such an increase was not observed in infected mice treated with DSS. Of particular interest, production of regulatory cytokines, IL-10 and transforming growth factor (TGF)-β, in spleen lymphocytes showed a significant increase in mice infected with T. spiralis. A similar result was observed in mesenteric lymph nodes (MLN). Subsets of the population of T_reg cells in MLN and spleen showed significant increases in mice infected with T. spiralis. In conclusion, T. spiralis infection can inhibit the DSS-induced colitis in mice by enhancing the regulatory cytokine and T_reg cells recruitment. Citations Citations to this article as recorded by Mechanism of Trichinella spiralis-mediated CD4+ T cell functional imbalance via IDO-dependent tryptophan metabolism Wenhao Yu, Xuhong Yuan, Wenqi Li, Caixia Han International Immunopharmacology.2026; 177: 116517. CrossRef Helminths in alternative therapeutics of inflammatory bowel disease Himani Pandey, Daryl W. T. Tang, Sunny H. Wong, Devi Lal Intestinal Research.2025; 23(1): 8. CrossRef Cathepsin L of Fasciola hepatica meliorates colitis by altering the gut microbiome and inflammatory macrophages Jing-Zhi Gong, Jun-Jie Huang, Ming Pan, Qi-Wang Jin, Yi-Min Fan, Wen-Qian Shi, Si-Yang Huang International Journal of Biological Macromolecules.2025; 286: 138270. CrossRef Improved antiparasitic effects of mebendazole using chitosan and zinc oxide nanocomposites for drug delivery in Trichinella spiralis infected mice during the muscular phase Nabila M. Mira, Aya M. Henaish, Eman A. Moussa, Ibrahim B. Helal, Shaimaa M. Kasem Acta Tropica.2025; 263: 107565. CrossRef Therapeutic potentials of Trichinella spiralis in immune disorders: From allergy to autoimmunity Minkyoung Cho, Hak Sun Yu Parasites, Hosts and Diseases.2025; 63(2): 123. CrossRef Trichinella-derived protein ameliorates colitis by altering the gut microbiome and improving intestinal barrier function Shao Rong Long, Wen Xuan Shang, Hui Ran Zhang, Miao Jiang, Jing Jing Wang, Ruo Dan Liu, Zhong Quan Wang, Jing Cui, Hualei Sun International Immunopharmacology.2024; 127: 111320. CrossRef The gut microbiota is essential for Trichinella spiralis—evoked suppression of colitis Hualei Sun, Shao Rong Long, Miao Jiang, Hui Ran Zhang, Jing Jing Wang, Zi Xuan Liao, Jing Cui, Zhong Quan Wang, Subbaraman Babu PLOS Neglected Tropical Diseases.2024; 18(11): e0012645. CrossRef The Underrated Gut Microbiota Helminths, Bacteriophages, Fungi, and Archaea Maria Jose Garcia-Bonete, Anandi Rajan, Francesco Suriano, Elena Layunta Life.2023; 13(8): 1765. CrossRef Helminth-derived biomacromolecules as therapeutic agents for treating inflammatory and infectious diseases: What lessons do we get from recent findings? Pritha Chakraborty, Vivekanandhan Aravindhan, Suprabhat Mukherjee International Journal of Biological Macromolecules.2023; 241: 124649. CrossRef Potential of human helminth therapy for resolution of inflammatory bowel disease: The future ahead Toshio Arai, Fernando Lopes Experimental Parasitology.2022; 232: 108189. CrossRef Trichinella-induced immunomodulation: Another tale of helminth success F. Bruschi, D.S. Ashour, A.A. Othman Food and Waterborne Parasitology.2022; 27: e00164. CrossRef Trichinella Infection Ameliorated Vincristine-Induced Neuroinflammation in Mice Young Rae Jo, Hwan Tae Park, Hak Sun Yu, Hyun-Hee Kong The Korean Journal of Parasitology.2022; 60(4): 247. CrossRef Immune Protection of a Helminth Protein in the DSS-Induced Colitis Model in Mice Shao Rong Long, Ruo Dan Liu, Deepak Vijaya Kumar, Zhong Quan Wang, Chien-Wen Su Frontiers in Immunology.2021;[Epub] CrossRef Trichinella spiralis:inflammation modulator Jing Ding, Xiaolei Liu, Xue Bai, Yang Wang, Jian Li, Chun Wang, Shicun Li, Mingyuan Liu, Xuelin Wang Journal of Helminthology.2020;[Epub] CrossRef Infection with Toxocara canis Inhibits the Production of IgE Antibodies to α-Gal in Humans: Towards a Conceptual Framework of the Hygiene Hypothesis? Adnan Hodžić, Lourdes Mateos-Hernández, Emilie Fréalle, Patricia Román-Carrasco, Pilar Alberdi, Muriel Pichavant, Veronica Risco-Castillo, Delphine Le Roux, Jérôme Vicogne, Wolfgang Hemmer, Herbert Auer, Ines Swoboda, Georg Duscher, José de la Fuente, Ale Vaccines.2020; 8(2): 167. CrossRef Exposure time determines the protective effect of Trichinella spiralis on experimental colitis Wenxiao Zheng, Zhenrong Ma, Xi Sun, Yehong Huang, Bin Lu, Xiaogang Chen, Xiang Xue, Xuexian Yang, Xiang Wu Microbial Pathogenesis.2020; 147: 104263. CrossRef Effect of Trichinella spp. or derived antigens on chemically induced inflammatory bowel disease (IBD) in mouse models: A systematic review and meta-analysis Jian Li, Xiaolei Liu, Jing Ding, Bin Tang, Xue Bai, Yang Wang, Shicun Li, Mingyuan Liu, Xuelin Wang International Immunopharmacology.2020; 85: 106646. CrossRef Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models Shin Ae Kang, Mi-Kyung Park, Sang Kyun Park, Jun Ho Choi, Da In Lee, So Myong Song, Hak Sun Yu Scientific Reports.2019;[Epub] CrossRef Acute infection with Strongyloides venezuelensis increases intestine production IL-10, reduces Th1/Th2/Th17 induction in colon and attenuates Dextran Sulfate Sodium-induced colitis in BALB/c mice Vanessa Fernandes Rodrigues, Márcia Paulliny Soares Bahia, Núbia Rangel Cândido, João Marcelo Peixoto Moreira, Vinicius Gustavo Oliveira, Emília Souza Araújo, Jailza Lima Rodrigues Oliveira, Michelle de Carvalho Rezende, Ary Correa, Deborah Negrão-Corrêa Cytokine.2018; 111: 72. CrossRef Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis Leonn Mendes Soares Pereira, Samara Tatielle Monteiro Gomes, Ricardo Ishak, Antonio Carlos Rosário Vallinoto Frontiers in Immunology.2017;[Epub] CrossRef Ascaris suum infection modulates inflammation: Implication of CD4+ CD25high Foxp3+ T cells and IL‐10 T. de O. Titz, C. A. A. de Araújo, C. S. Enobe, P. O. Rigato, T. M. Oshiro, M. F. de Macedo‐Soares Parasite Immunology.2017;[Epub] CrossRef Biodegradable Chitosan Decreases the Immune Response to Trichinella spiralis in Mice Klaudia Brodaczewska, Natalia Wolaniuk, Katarzyna Lewandowska, Katarzyna Donskow-Łysoniewska, Maria Doligalska Molecules.2017; 22(11): 2008. CrossRef *Activation and Recruitment of Regulatory T Cells via Chemokine Receptor Activation in Trichinella spiralis-Infected Mice* Jeong-Bin Ahn, Shin Ae Kang, Dong-Hee Kim, Hak Sun Yu The Korean Journal of Parasitology.2016; 54(2): 163. CrossRef Regulatory parameters of the lung immune response during the early phase of experimental trichinellosis Guido H. Falduto, Cecilia C. Vila, María P. Saracino, María V. Gentilini, Stella M. Venturiello Veterinary Parasitology.2016; 231: 47. CrossRef Helminth Regulation of Immunity Fernando Lopes, Chelsea Matisz, José L. Reyes, Humberto Jijon, Ahmed Al-Darmaki, Gilaad G. Kaplan, Derek M. McKay Inflammatory Bowel Diseases.2016; 22(10): 2499. CrossRef Immunomodulatory potential of particular Trichinella spiralis muscle larvae excretory–secretory components J. Cvetkovic, Lj. Sofronic-Milosavljevic, N. Ilic, M. Gnjatovic, I. Nagano, A. Gruden-Movsesijan International Journal for Parasitology.2016; 46(13-14): 833. CrossRef Allergenicity of two Anisakis simplex allergens evaluated in vivo using an experimental mouse model Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Maria Luisa Caballero, Teresa Perez-Pinar, Rosa Rodriguez-Perez, Mee Sun Ock, Hee Jae Cha, Yeon Chul Hong, Hak Sun Yu Experimental Parasitology.2014; 146: 71. CrossRef Excretory/Secretory Products from Trichinella spiralis Adult Worms Ameliorate DSS-Induced Colitis in Mice Xiaodi Yang, Yaping Yang, Yunyun Wang, Bin Zhan, Yuan Gu, Yuli Cheng, Xinping Zhu, Udai P. Singh PLoS ONE.2014; 9(5): e96454. CrossRef Trichinella spiralisimmunomodulation: an interactive multifactorial process Dalia S Ashour Expert Review of Clinical Immunology.2013; 9(7): 669. CrossRef 10,501 View 94 Download Crossref A 24 kDa Excretory-Secretory Protein of Anisakis simplex Larvae Could Elicit Allergic Airway Inflammation in Mice Hye-Kyung Park, Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Yun Seong Kim, Ki Uk Kim, Min Ki Lee, Mee Sun Ock, Hee Jae Cha, Hak Sun Yu Korean J Parasitol 2011;49(4):373-380. Published online December 16, 2011 DOI: https://doi.org/10.3347/kjp.2011.49.4.373 Abstract PDF We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means that As22U may play a role as an allergen. In order to determine the contribution of As22U to allergic reactions, we treated mice with 6 times intra-nasal application of recombinant As22U (rAs22U). In the group challenged with rAs22U and ovalbumin (OVA), the number of eosinophils in the bronchial alveolar lavage fluid (BALF) was significantly increased, as compared to the group receiving only OVA. In addition, mice treated with rAs22U and OVA showed significantly increased airway hyperresponsiveness. Thus, severe inflammation around the airway and immune cell recruitment was observed in mice treated with rAs22U plus OVA. The levels of IL-4, IL-5, and IL-13 cytokines in the BALF increased significantly after treatment with rAs22U and OVA. Similarly, the levels of anti-OVA specific IgE and IgG1 increased in mice treated with rAs22U and OVA, compared to those treated only with OVA. The Gro-α (CXCL1) gene expression in mouse lung epithelial cells increased instantly after treatment with rAs22U, and allergy-specific chemokines eotaxin (CCL11) and thymus-and-activation-regulated-chemokine (CCL17) gene expressions significantly increased at 6 hr after treatment. In conclusion, rAs22U may induce airway allergic inflammation, as the result of enhanced Th2 and Th17 responses. Citations Citations to this article as recorded by Anisakis pegreffii Extract Induces Airway Inflammation with Airway Remodeling in a Murine Model System Jun Ho Choi, Ju Yeong Kim, Myung-hee Yi, Myungjun Kim, Tai-Soon Yong, Kalman Imre BioMed Research International.2021;[Epub] CrossRef Allergen-like Molecules from Parasites Ju Yeong Kim, Myung-Hee Yi, Tai-Soon Yong Current Protein & Peptide Science.2020; 21(2): 186. CrossRef Research Note. Prevalence, protein analysis and possible preventive measures against zoonotic anisakid larvae isolated from marine Atherina fish M. Samir, M. A. Amin, A. O. Hassan, A. M. Merwad, M. A. I. Awadallah Helminthologia.2015; 52(4): 375. CrossRef Allergenicity of two Anisakis simplex allergens evaluated in vivo using an experimental mouse model Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Maria Luisa Caballero, Teresa Perez-Pinar, Rosa Rodriguez-Perez, Mee Sun Ock, Hee Jae Cha, Yeon Chul Hong, Hak Sun Yu Experimental Parasitology.2014; 146: 71. CrossRef Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice Shin Ae Kang, Mi-Kyung Park, Min Kyoung Cho, Hak Sun Yu The Korean Journal of Parasitology.2013; 51(5): 583. CrossRef 9,793 View 76 Download Crossref Parasitic Helminth Cystatin Inhibits DSS-Induced Intestinal Inflammation Via IL-10⁺F4/80⁺ Macrophage Recruitment Sung Won Jang, Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Byoung-Kuk Na, Soon Cheol Ahn, Dong-Hee Kim, Hak Sun Yu Korean J Parasitol 2011;49(3):245-254. Published online September 30, 2011 DOI: https://doi.org/10.3347/kjp.2011.49.3.245 Abstract PDF Many immune down-regulatory molecules have been isolated from parasites, including cystatin (cystain protease inhibitor). In a previous study, we isolated and characterized Type I cystatin (CsStefin-1) of the liver fluke, Clonorchis sinensis. To investigate whether the CsStefin-1 might be a new host immune modulator, we induced intestinal inflammation in mice by dextran sodium sulfate (DSS) and treated them with recombinant CsStefin-1 (rCsStefin-1). The disease activity index (DAI) increased in DSS only-treated mice. In contrast, the DAI value was significantly reduced in rCsStefin-1-treated mice than DSS only-treated mice. In addition, the colon length of DSS only-treated mice was shorter than that of rCsStefin-1 treated mice. The secretion levels of IFN-γ and TNF-α in the spleen and mesenteric lymph nodes (MLNs) were significantly increased by DSS treatment, but the level of TNF-α in MLNs was significantly decreased by rCsStefin-1 treatment. IL-10 production in both spleen and MLNs was significantly increased, and IL-10⁺F4/80⁺ macrophage cells were significantly increased in the spleen and MLNs of rCsStefin-1 treated mice after DSS treatment. In conclusion, rCsStefin-1 could reduce the intestinal inflammation occurring after DSS treatment, these effects might be related with recruitment of IL-10 secreting macrophages. Citations Citations to this article as recorded by Crystal structure of Echinococcus multilocularis cystatin B reveals a novel feature in classical stefins Wenbin Hong, Zhe Cheng, Zhijian Xu, Shukun Zhong, Xianshu Liu, Nouhoum Dibo, Ziyi Dai, Yuzhou Lin, Wenchang Lai, HuaRui Jia, Xiaomin Shang, Shuaiqin Huang Scientific Reports.2026;[Epub] CrossRef Schistosoma japonicum cystatin attenuated CLP-induced sepsis in mice though inducing tolerogenic dendritic cells and regulatory T cells Yi-Xiang Wang, Yi-Dan Ma, Hui-Hui Li, Wen-Juan Duo, Qi-Wang Jin, Kai-Jun Zhou, Yan-Ran Gao, Jun-Nan He, Yu-Jie Xie, Liang Chu, Xiao-Di Yang Comparative Immunology, Microbiology and Infectious Diseases.2025; 120: 102345. CrossRef PD-1-dependent therapeutic effect of Trichinella spiralis cystatin on myocardial infarction in a mice model Weixiao Zhang, Wenhui Yin, Hongtao Wang, Lingqin Wu, Chang Li, Xinyu Peng, Xiang Li, Kaibo Jiang, Huiqi Yang, Chenyue Dang, Erhe Gao, Qiwang Jin, Xiaodi Yang Parasites & Vectors.2025;[Epub] CrossRef Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick Amblyomma sculptum, vector of Brazilian spotted fever Wilson Santos Molari, Mohamed Amine Jmel, Josiane Betim Assis, Alan Frazão-Silva, Júlia Moura Bernardi, Gretta Huamanrayme, José María Medina, Eliane Esteves, Solange Cristina Antão, Gabriel Cerqueira Alves Costa, Aparecida Sadae Tanaka, Andréa Cristina F Frontiers in Immunology.2025;[Epub] CrossRef A potential role of protein extractions from Metagonimus yokogawai in amelionating inflammation in patients with ankylosing spondylitis Eun Jeong Won, Yu Jeong Lee, Moon-Ju Kim, Hae-In Lee, Hyun Hee Jang, Seong Hoon Kim, Hee Min Yoo, Namki Cho, Seung Cheol Shim, Tae-Jong Kim Experimental Parasitology.2024; 259: 108718. 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Published online September 30, 2011 DOI: https://doi.org/10.3347/kjp.2011.49.3.235 Abstract PDF In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2 responses in T. spiralis-infected PAR2 knockout (KO) mice. The levels of the Th2 cell-secreted cytokines, IL-4, IL-5, and IL-13 were markedly reduced in the PAR2 KO mice as compared to the wild type mice following infection with T. spiralis. The serum levels of parasite-specific IgE increased significantly in the wild type mice as the result of T. spiralis infection, but this level was not significantly increased in PAR2 KO mice. The expression level of thymic stromal lymphopoietin, IL-25, and eotaxin gene (the genes were recently known as Th2 response initiators) of mouse intestinal epithelial cells were increased as the result of treatment with T. spiralis excretory-secretory proteins. 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Published online June 14, 2011 DOI: https://doi.org/10.3347/kjp.2011.49.2.139 Abstract PDF The present study was performed to estimate the seroprevalence of larval Anisakis simplex infection among the residents health-examined in 3 hospitals in southern parts of Korea. A total of 498 serum samples (1 serum per person) were collected in 3 hospitals in Busan Metropolitan city, Masan city, and Geoje city in Gyeongsangnam-do (Province) and were examined by IgE-ELISA and IgE-western blotting with larval A. simplex crude extract and excretory-secretory products (ESP). The prevalence of antibody positivity was 5.0% and 6.6% with ELISA against crude extracts and ESP, respectively. It was also revealed that infection occurred throughout all age groups and higher in females than in males. A specific protein band of 130 kDa was detected from 10 patients with western blot analysis against crude extract and ESP among those who showed positive results by ELISA. Our study showed for the first time the seroprevalence of anisakiasis in Korea. The allergen of 130 kDa can be a candidate for serologic diagnosis of anisakiasis. Citations Citations to this article as recorded by Seroprevalence of IgG and IgE Antibodies Against Anisakis in the Presumably Healthy Population of the Canary Islands Eligia González-Rodríguez, Marta Rodero, J. Alberto Montoya-Alonso, Kevin M. Santana-Hernández, Myriam R. Ventura, Carmen Cuéllar, Eligia Rodríguez-Ponce Antibodies.2025; 14(3): 60. CrossRef Proteome identification of common immunological proteins of two nematode parasites Shin Ae Kang, Hak Sun Yu Parasites, Hosts and Diseases.2024; 62(3): 342. CrossRef Progress in Anisakis Allergy Research: Milestones and Reversals Alvaro Daschner, Carmen Cuéllar Current Treatment Options in Allergy.2020; 7(4): 457. CrossRef IgE sensitization to Anisakis pegreffii in Italy: Comparison of two methods for the diagnosis of allergic anisakiasis S. Mattiucci, A. Colantoni, B. 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CrossRef Clinical Characteristics of Gastroallergic Anisakiasis and Diagnostic Implications of Immunologic Tests Young-Bae Chung, Jaechun Lee Allergy, Asthma & Immunology Research.2014; 6(3): 228. CrossRef Preventive and Therapeutic Effects of <italic>Anisakis simplex</italic> Larval Protein in a Mouse Model of Crohn’S Disease Hee-Jae Cha, Mee Sun Ock Kosin Medical Journal.2013; 28(2): 107. CrossRef Cross-sectional study of serum reactivity to Anisakis simplex in healthy adults in Niter?i, Brazil Israel Junior, Mauricio Vericimo, Luciana Cardoso, Sergio Clemente, Elmiro Nascimento, Gerlinde Teixeira Acta Parasitologica.2013;[Epub] CrossRef Detection of Microorganisms in Granulomas That Have Been Formalin-Fixed: Review of the Literature Regarding Use of Molecular Methods Jeannette Guarner Scientifica.2012; 2012: 1. CrossRef Anisakidosis in Korea; Changes Over the Last Decade Hee Jae Cha, Mee Sun Ock Kosin Medical Journal.2012; 27(2): 73. CrossRef Prevalence of Zoonotic Anisakid Nematodes in Inuit-Harvested Fish and Mammals from the Eastern Canadian Arctic Erica L. Pufall, Andria Jones-Bitton, Scott A. McEwen, Tanya M. Brown, Victoria L. Edge, Jerzy Rokicki, Katarzyna Karpiej, Andrew S. Peregrine, Manon Simard Foodborne Pathogens and Disease.2012; 9(11): 1002. CrossRef A technique for the intra-gastric administration of live larvae of Anisakis simplex in mice Israel Figueiredo, Luciana Cardoso, Gerlinde Teixeira, Leila Lopes, Sergio Carmona São Clemente, Mauricio Afonso Vericimo Experimental Parasitology.2012; 130(3): 285. CrossRef 10,343 View 92 Download Crossref Parents' Knowledge about Enterobiasis Might Be One of the Most Important Risk Factors for Enterobiasis in Children Dong-Hee Kim, Hyun-Mi Son, Joo Young Kim, Min Kyoung Cho, Mee Kyung Park, Sin Ye Kang, Bo Young Kim, Hak Sun Yu Korean J Parasitol 2010;48(2):121-126. Published online June 17, 2010 DOI: https://doi.org/10.3347/kjp.2010.48.2.121 Abstract PDF To know the prevalence of Enterobius vermicularis infection and what are the most important risk factors, we evaluated the incidence and risk factors of enterobiasis among children attended in kindergartens in Busan metropolitan city, Republic of Korea. A total of 1,674 children from 21 kindergartens in 11 of 16 autonomous districts of Busan were evaluated for E. vermicularis infection by the cellotape anal swab technique. The overall egg-positive rate for E. vermicularis was 10.7% (179/1,674), and the prevalence of enterobiasis in each kindergarten ranged between 0% and 32.4%. There was an increasing tendency of the egg positive rate according to the population density; the higher the population density communities had, the higher egg-positive rate for E. vermicularis was detected (P = 0.001). Among personal hygiene factors involving children, thumb-sucking (P = 0.036) and fingernail-trimming (P = 0.024) were highly associated with enterobiasis. In addition, taking anthelmintic medications against E. vermicularis infection was strongly associated with enterobiasis (P = 0.014). Moreover, parents' knowledge of enterobiasis was correlated significantly with the incidence of enterobiasis of their children (P = 0.006). In conclusion, we need to consider not only personal hygiene but also parents' knowledge about enterobiasis as a factor in order to develop new strategies for elimination or to complete reduction of enterobiasis in Korea. 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