Parasites, Hosts and Diseases

Skip to main navigation Skip to main content

OPEN ACCESS

Page Path

HOME
BROWSE ARTICLES

Author index detail contents
Ok-Sun Hwang	2 Articles
Effects of specific monoclonal antibodies to dense granular proteins on the invasion of Toxoplasma gondii in vitro and in vivo Dong Yeob Cha, In Kwan Song, Gye Sung Lee, Ok-Sun Hwang, Hyung-Jun Noh, Seung-Dong Yeo, Dae-Whan Shin, Young-Ha Lee Korean J Parasitol 2001;39(3):233-240. Published online September 30, 2001 DOI: https://doi.org/10.3347/kjp.2001.39.3.233 Abstract PDF Although some reports have been published on the protective effect of antibodies to Toxoplasma gondii surface membrane proteins, few address the inhibitory activity of antibodies to dense granular proteins (GRA proteins). Therefore, we performed a series of experiments to evaluate the inhibitory effects of monoclonal antibodies (mAbs) to GRA proteins (GRA2, 28 kDa; GRA6, 32 kDa) and surface membrane protein (SAG1, 30 kDa) on the invasion of T. gondii tachyzoites. Passive immunization of mice with one of three mAbs following challenge with a lethal dose of tachyzoites significantly increased survival compared with results for mice treated with control ascites. The survival times of mice challenged with tachyzoites pretreated with anti-GRA6 or anti-SAG1 mAb were significantly increased. Mice that received tachyzoites pretreated with both mAb and complement had longer survival times than those that received tachyzoites pretreated with mAb alone. Invasion of tachyzoites into fibroblasts and macrophages was significantly inhibited in the anti-GRA2, anti-GRA6 or anti-SAG1 mAb pretreated group. Pretreatment with mAb and complement inhibited invasion of tachyzoites in both fibroblasts and macrophages. These results suggest that specific antibodies to dense-granule molecules may be useful for controlling infection with T. gondii. Citations Citations to this article as recorded by Different kinetics of humoral response against individual antigens in the ovine model of Toxoplasma gondii infection and its pathological association Paula Formigo, Ignacio Gual, Germán J. Cantón, Luisa F. Mendoza Morales, Emiliano Sosa, Agustina Soto Cabrera, Valeria Scioli, Claudia Morsella, Valeria A. Sander, Dadin P. Moore, Sergio O. Angel, Lucía M. Campero, Marina Clemente Frontiers in Immunology.2025;[Epub] CrossRef Immune system roles in pathogenesis, prognosis, control, and treatment of Toxoplasma gondii infection Mohammad Mahdi Jafari, Zahra Azimzadeh Tabrizi, Mohammad Saaid Dayer, Nazanin Atieh Kazemi-Sefat, Mahshid Mohtashamifard, Rahimeh Mohseni, Atefeh Bagheri, Saeed Bahadory, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar International Immunopharmacology.2023; 124: 110872. CrossRef A Novel Vaccine Candidate: Recombinant Toxoplasma gondii Perforin-Like Protein 2 Stimulates Partial Protective Immunity Against Toxoplasmosis Xiaowei Tian, Hanqi Sun, Meng Wang, Guangmin Wan, Tong Xie, Xuefang Mei, Zhenchao Zhang, Xiangrui Li, Shuai Wang Frontiers in Veterinary Science.2022;[Epub] CrossRef Control of human toxoplasmosis Nicholas C. Smith, Cibelly Goulart, Jenni A. Hayward, Andreas Kupz, Catherine M. Miller, Giel G. van Dooren International Journal for Parasitology.2021; 51(2-3): 95. CrossRef Engineering and Functional Evaluation of Neutralizing Antibody Fragments Against Congenital Toxoplasmosis Anne di Tommaso, Matthieu O Juste, Zineb Lakhrif, Marie-Noëlle Mévélec, Coraline Borowczyk, Pierre Hammeni, Guillaume Désoubeaux, Nathalie Van Langendonck, Françoise Debierre-Grockiego, Nicolas Aubrey, Isabelle Dimier-Poisson The Journal of Infectious Diseases.2021; 224(4): 705. CrossRef Treatment of toxoplasmosis: Current options and future perspectives Neda Konstantinovic, Hélène Guegan, Tijana Stäjner, Sorya Belaz, Florence Robert-Gangneux Food and Waterborne Parasitology.2019; 15: e00036. CrossRef Toxoplasma gondii-positive human sera recognise intracellular tachyzoites and bradyzoites with diverse patterns of immunoreactivity Marijo S. Roiko, Kaice LaFavers, Diane Leland, Gustavo Arrizabalaga International Journal for Parasitology.2018; 48(3-4): 225. CrossRef Interferon-γ-dependent protection against Neospora caninum infection conferred by mucosal immunization in IL-12/IL-23 p40-deficient mice Pedro Ferreirinha, Ricardo Fróis-Martins, Luzia Teixeira, António Rocha, Manuel Vilanova, Alexandra Correia Vaccine.2018; 36(32): 4890. CrossRef Plant-derived chimeric antibodies inhibit the invasion of human fibroblasts byToxoplasma gondii Sherene Swee Yin Lim, Kek Heng Chua, Greta Nölke, Holger Spiegel, Wai Leong Goh, Sek Chuen Chow, Boon Pin Kee, Rainer Fischer, Stefan Schillberg, Rofina Yasmin Othman PeerJ.2018; 6: e5780. CrossRef Toxoplasma gondii Elongation Factor 1-Alpha (TgEF-1α) Is a Novel Vaccine Candidate Antigen against Toxoplasmosis Shuai Wang, Zhenchao Zhang, Yujian Wang, Javaid A. Gadahi, Lixin Xu, Ruofeng Yan, Xiaokai Song, Xiangrui Li Frontiers in Microbiology.2017;[Epub] CrossRef Evaluation of Immunoprotection Conferred by the Subunit Vaccines of GRA2 and GRA5 against Acute Toxoplasmosis in BALB/c Mice Xiao T. Ching, Mun Y. Fong, Yee L. Lau Frontiers in Microbiology.2016;[Epub] CrossRef Recent Advances in Toxoplasma gondii Immunotherapeutics Sherene Swee-Yin Lim, Rofina Yasmin Othman The Korean Journal of Parasitology.2014; 52(6): 581. CrossRef Generation of a Neutralizing Human Monoclonal Antibody Fab Fragment to Surface Antigen 1 ofToxoplasma gondiiTachyzoites Yong-Feng Fu, Meng Feng, Kenji Ohnishi, Tamon Kimura, Johbu Itoh, Xun-Jia Cheng, Hiroshi Tachibana, J. H. Adams Infection and Immunity.2011; 79(1): 512. CrossRef GRA Proteins of Toxoplasma gondii: Maintenance of Host-Parasite Interactions across the Parasitophorous Vacuolar Membrane Ho-Woo Nam The Korean Journal of Parasitology.2009; 47(Suppl): S29. CrossRef Protective Th1 immune responses against chronic toxoplasmosis induced by a protein–protein vaccine combination but not by its DNA–protein counterpart E. Jongert, D. Verhelst, M. Abady, E. Petersen, N. Gargano Vaccine.2008; 26(41): 5289. CrossRef Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid A (MPL) adjuvant against Toxoplasma chronic infection in mice Majid Golkar, Mohammad-Ali Shokrgozar, Sima Rafati, Karine Musset, Mehdi Assmar, Reza Sadaie, Marie-France Cesbron-Delauw, Corinne Mercier Vaccine.2007; 25(21): 4301. CrossRef 9,551 View 84 Download Crossref Seroepidemiological study of Toxoplasma gondii infection in the rural area Okcheon-gun, Korea Young-Ha Lee, Hyung-Jun Noh, Ok-Sun Hwang, Sang-Keol Lee, Dae-Whan Shin Korean J Parasitol 2000;38(4):251-256. Published online December 31, 2000 DOI: https://doi.org/10.3347/kjp.2000.38.4.251 Abstract PDF There have been some reports about the prevalence of anti-Toxoplasma gondii antibody among Koreans, and most of all data were taken from patients visiting hospitals. However, the epidemiological data of the community-based study in Korea are rare. This study was performed to evaluate the seroprevalence of toxoplasmosis among the inhabitants of the rural area Okcheon-gun, Korea. A total of 1,109 serum samples (499 males, 610 females) were examined for the IgG antibodies by ELISA. To set up the cut-off point for ELISA, we used a commercial latex agglutination (LA) kit. The sensitivity and specificity of ELISA against LA test were 89.5%, and 98.6% respectively. Among 1,109 sera, 6.9% showed seropositivity by ELISA. The positive rates of males and females were 6.0% and 7.2%, respectively. However, there were no significant differences between sexes. Comparing the age groups, the highest seropositive rate showed in the seventies or higher, and their rates had a tendency to increase with age (0.05 < p < 0.3). These results revealed that the seroprevalence of toxoplasmosis in rural inhabitants is similar to previous reports in Korea; however we need further investigation to clarify the prevalence of toxoplasmosis in the general population. Citations Citations to this article as recorded by Molecular Detection of Toxoplasma gondii and Neospora caninum in Naturally Infected sheep, cow, and buffalo Milk Tuğçe Tuygun, Serbülent Yiğit, Elif Burcu Gençay Topçu, Şinasi Umur Acta Parasitologica.2025;[Epub] CrossRef Clinical characteristics of toxoplasmosis patients in Korea: A retrospective study using health insurance review and assessment service data and electronic medical records Do-Won Ham, Bong-Kwang Jung, Ji-Hun Shin, Yong Joon Kim, Kyoung Yul Seo, Seung Mi Lee, Jae Hyoung Im, Jeong-Ran Kwon, Ho-Sung Lee, Kyung-Won Hwang, Eun-Hee Shin Parasites, Hosts and Diseases.2024; 62(4): 424. CrossRef Seroprevalence of Toxoplasma gondii among general population in Bosnia and Herzegovina: 10-Years single center experience Božo Šušak, Katarina Martinović, Sanja Jakovac, Jurica Arapović Clinical Epidemiology and Global Health.2023; 22: 101336. CrossRef Epidemiology of Toxoplasmosis among the Pakistani Population: A Systematic Review and Meta-Analysis Tehniat Shoukat, Usman Ayub Awan, Tahir Mahmood, Muhammad Sohail Afzal, Samia Wasif, Haroon Ahmed, Jianping Cao Pathogens.2022; 11(6): 675. CrossRef toxoplasmosis CABI Compendium.2022;[Epub] CrossRef Evaluation of Toxoplasma gondii infection in western Iran: seroepidemiology and risk factors analysis Morteza Mousavi-Hasanzadeh, Hossein Sarmadian, Reza Ghasemikhah, Mojtaba Didehdar, Maryam Shahdoust, Mahshid Maleki, Mahdieh Taheri Tropical Medicine and Health.2020;[Epub] CrossRef Seroprevalence of anti-Toxoplasma IgG and IgM among individuals who were referred to medical laboratories in Mazandaran province, northern Iran Mehdi Sharif, Ahmad Daryani, Zahra Ebrahimnejad, Shirzad Gholami, Ehsan Ahmadpour, Samaneh Borhani, Narges Lamsechi Journal of Infection and Public Health.2016; 9(1): 75. CrossRef Seroprevalence of toxoplasmosis in mentally retarded patients in Iranian rehabilitation centers Behrouz Ezatpour, Mohammad Zibaie, Hessam Rahmati, Yadollah Pournia, Mehdi Azami, Farzad Ebrahimzadeh, Mozhgan Azadpour, Maryam Jamshidian Ghalesefidi Journal of Parasitic Diseases.2015; 39(1): 13. CrossRef Seroprevalence of Toxoplasma gondii in the Iranian general population: A systematic review and meta-analysis Ahmad Daryani, Shahabeddin Sarvi, Mohsen Aarabi, Azadeh Mizani, Ehsan Ahmadpour, Azar Shokri, Mohammad-Taghi Rahimi, Mehdi Sharif Acta Tropica.2014; 137: 185. CrossRef Prevalence of toxoplasmosis in France in 1998: Is there a difference between men and women? At what age do children become infected? H. Bellali, H. Pelloux, I. Villena, H. Fricker-Hidalgo, Y. Le Strat, V. Goulet Revue d'Épidémiologie et de Santé Publique.2013; 61(4): 311. CrossRef Serologic Survey of Toxoplasmosis in Seoul and Jeju-do, and a Brief Review of Its Seroprevalence in Korea Hyemi Lim, Sang-Eun Lee, Bong-Kwang Jung, Min-Ki Kim, Mi Youn Lee, Ho-Woo Nam, Jong-Gyun Shin, Cheong-Ha Yun, Han-Ik Cho, Eun-Hee Shin, Jong-Yil Chai The Korean Journal of Parasitology.2012; 50(4): 287. CrossRef Fine Needle Aspiration Cytology(FNAC) and Excisional Biopsy Results in Seropositive Toxoplasmic Lymphadenitis Jun Ho Park, Kyoung Kyu Lee, Young Min Lee, Hun Po Cho Journal of Clinical Otolaryngology Head and Neck Surgery.2012; 23(2): 237. CrossRef Frequency of Detection of Immunoglobulins ofToxoplasma gondii, Leptospiraspp., andBrucella abortusin Livestock/Farm and Abattoir Workers in Trinidad Abiodun Adesiyun, Mervyn Campbell, Saed Rahaman, Sham Bissessar, Alva Stewart-Johnson, Shakti Dookeran, Marquita Gittens-St. Hilaire Journal of Agromedicine.2011; 16(3): 200. CrossRef Proteomic Analysis ofToxoplasma gondiiKI-1 Tachyzoites Si-Hwan Choi, Tae Yun Kim, Sung Goo Park, Guang-Ho Cha, Dae-Whan Shin, Jong-Yil Chai, Young-Ha Lee The Korean Journal of Parasitology.2010; 48(3): 195. CrossRef A Case of Cerebral Toxoplasmosis Following Tandem Autologous Stem Cell Transplantation in a Multiple Myeloma Patient Kye-Hyung Kim, Kyoung-Ho Song, Jae Hyun Jeon, Wan Beom Park, Sang-Won Park, Hong Bin Kim, Nam Joong Kim, Inho Kim, Myoung-don Oh Infection and Chemotherapy.2010; 42(3): 181. CrossRef Review of Zoonotic Parasites in Medical and Veterinary Fields in the Republic of Korea Heejeong Youn The Korean Journal of Parasitology.2009; 47(Suppl): S133. CrossRef Seroprevalence of Toxoplasma gondii Infection and Characteristics of Seropositive Patients in General Hospitals in Daejeon, Korea Dae-Whan Shin, Dong-Yeub Cha, Quan Juan Hua, Guang-Ho Cha, Young-Ha Lee The Korean Journal of Parasitology.2009; 47(2): 125. CrossRef Genotyping of a Korean isolate of Toxoplasma gondii by multilocus PCR-RFLP and microsatellite analysis Juan-Hua Quan, Tae Yun Kim, In-Uk Choi, Young-Ha Lee The Korean Journal of Parasitology.2008; 46(2): 105. CrossRef Seroepidemiological study of toxoplasmosis in intellectual disability children in rehabilitation centers of northern Iran M. Sharif, H. Ziaei, A. Daryani, A. Ajami Research in Developmental Disabilities.2007; 28(3): 219. CrossRef Serological evidence for remarkably variable prevalence rates of Toxoplasma gondii in children of major residential areas in United Arab Emirates Y.A Abu-Zeid Acta Tropica.2002; 83(1): 63. CrossRef 9,769 View 93 Download Crossref