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Sriripun Srivilairit	1 Article
Gametocyte Clearance in Uncomplicated and Severe Plasmodium falciparum Malaria after Artesunate-Mefloquine Treatment in Thailand Noppadon Tangpukdee, Srivicha Krudsood, Sriripun Srivilairit, Nanthaporn Phophak, Putza Chonsawat, Wimon Yanpanich, Shigeyuki Kano, Polrat Wilairatana Korean J Parasitol 2008;46(2):65-70. Published online June 20, 2008 DOI: https://doi.org/10.3347/kjp.2008.46.2.65 Abstract PDF Artemisinin-based combination therapy (ACT) is currently promoted as a strategy for treating both uncomplicated and severe falciparum malaria, targeting asexual blood-stage Plasmodium falciparum parasites. However, the effect of ACT on sexual-stage parasites remains controversial. To determine the clearance of sexual-stage P. falciparum parasites from 342 uncomplicated, and 217 severe, adult malaria cases, we reviewed and followed peripheral blood sexual-stage parasites for 4 wk after starting ACT. All patients presented with both asexual and sexual stage parasites on admission, and were treated with artesunate-mefloquine as the standard regimen. The results showed that all patients were asymptomatic and negative for asexual forms before discharge from hospital. The percentages of uncomplicated malaria patients positive for gametocytes on days 3, 7, 14, 21, and 28 were 41.5, 13.1, 3.8, 2.0, and 2.0%, while the percentages of gametocyte positive severe malaria patients on days 3, 7, 14, 21, and 28 were 33.6, 8.2, 2.7, 0.9, and 0.9%, respectively. Although all patients were negative for asexual parasites by day 7 after completion of the artesunate-mefloquine course, gametocytemia persisted in some patients. Thus, a gametocytocidal drug, e.g., primaquine, may be useful in combination with an artesunate-mefloquine regimen to clear gametocytes, so blocking transmission more effectively than artesunate alone, in malaria transmission areas. Citations Citations to this article as recorded by Knowledge about Asymptomatic Malaria and Acceptability of Using Artemisia afra Tea among Health Care Workers (HCWs) in Yaoundé, Cameroon: A Cross-Sectional Survey Abenwie Suh Nchang, Lahngong Shinyuy, Sandra Noukimi, Sylvia Njong, Sylvie Bambara, Edgar Kalimba, Joseph Kamga, Stephen Ghogomu, Michel Frederich, Jean Talom, Jacob Souopgui, Annie Robert International Journal of Environmental Research and Public Health.2023; 20(13): 6309. CrossRef Parasite clearance dynamics in children hospitalised with severe malaria in the Ho Teaching Hospital, Volta Region, Ghana Laura Paris, Richmond G. Tackie, Khalid B. Beshir, John Tampuori, Gordon A. Awandare, Fred N. Binka, Britta C. Urban, Bismarck Dinko, Colin J. Sutherland Parasite Epidemiology and Control.2022; 19: e00276. CrossRef NPC1161B, an 8-Aminoquinoline Analog, Is Metabolized in the Mosquito and Inhibits Plasmodium falciparum Oocyst Maturation Timothy Hamerly, Rebecca E. Tweedell, Bernadette Hritzo, Vincent O. Nyasembe, Babu L. Tekwani, N. P. Dhammika Nanayakkara, Larry A. Walker, Rhoel R. Dinglasan Frontiers in Pharmacology.2019;[Epub] CrossRef Recent Advances in Transmission-Blocking Drugs for Malaria Elimination Ishan Wadi, Mahendra Nath, Anupkumar R Anvikar, Pargat Singh, Abhinav Sinha Future Medicinal Chemistry.2019; 11(23): 3047. CrossRef Comprehensive review on various strategies for antimalarial drug discovery Mitali Mishra, Vikash K. Mishra, Varsha Kashaw, Arun K. Iyer, Sushil Kumar Kashaw European Journal of Medicinal Chemistry.2017; 125: 1300. CrossRef Plasmodium falciparum genotype and gametocyte prevalence in children with uncomplicated malaria in coastal Ghana Ruth Ayanful-Torgby, Akua Oppong, Joana Abankwa, Festus Acquah, Kimberly C. Williamson, Linda Eva Amoah Malaria Journal.2016;[Epub] CrossRef The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission Jared N. Balaich, Derrick K. Mathias, Baldwyn Torto, Bryan T. Jackson, Dingyin Tao, Babak Ebrahimi, Brian B. Tarimo, Xavier Cheseto, Woodbridge A. Foster, Rhoel R. Dinglasan Antimicrobial Agents and Chemotherapy.2016; 60(4): 2108. CrossRef Sexual development in Plasmodium parasites: knowing when it's time to commit Gabrielle A. Josling, Manuel Llinás Nature Reviews Microbiology.2015; 13(9): 573. CrossRef Gametocyte Clearance Kinetics Determined by Quantitative Magnetic Fractionation in Melanesian Children with Uncomplicated Malaria Treated with Artemisinin Combination Therapy Stephan Karl, Moses Laman, Brioni R. Moore, John Benjamin, Tamarah Koleala, Clemencia Ibam, Bernadine Kasian, Peter M. Siba, Andreea Waltmann, Ivo Mueller, Robert C. Woodward, Timothy G. St. Pierre, Timothy M. E. Davis Antimicrobial Agents and Chemotherapy.2015; 59(8): 4489. CrossRef Strategic use of antimalarial drugs that block falciparum malaria parasite transmission to mosquitoes to achieve local malaria elimination Rashad Abdul-Ghani, John C. Beier Parasitology Research.2014; 113(10): 3535. CrossRef A Male and Female Gametocyte Functional Viability Assay To Identify Biologically Relevant Malaria Transmission-Blocking Drugs A. Ruecker, D. K. Mathias, U. Straschil, T. S. Churcher, R. R. Dinglasan, D. Leroy, R. E. Sinden, M. J. Delves Antimicrobial Agents and Chemotherapy.2014; 58(12): 7292. CrossRef Comparison of three methods for detection of gametocytes in Melanesian children treated for uncomplicated malaria Stephan Karl, Moses Laman, Tamarah Koleala, Clemencia Ibam, Bernadine Kasian, Nola N’Drewei, Anna Rosanas-Urgell, Brioni R Moore, Andreea Waltmann, Cristian Koepfli, Peter M Siba, Inoni Betuela, Robert C Woodward, Timothy G St Pierre, Ivo Mueller, Timothy Malaria Journal.2014;[Epub] CrossRef The Effect of Primaquine on Gametocyte Development and Clearance in the Treatment of Uncomplicated Falciparum Malaria With Dihydroartemisinin-Piperaquine in South Sumatra, Western Indonesia: An Open-Label, Randomized, Controlled Trial Inge Sutanto, Sri Suprijanto, Ayleen Kosasih, Muhamad S. Dahlan, Din Syafruddin, Rita Kusriastuti, William A. Hawley, Neil F. Lobo, Feiko O. ter Kuile Clinical Infectious Diseases.2013; 56(5): 685. CrossRef Fitness components and natural selection: why are there different patterns on the emergence of drug resistance in Plasmodium falciparum and Plasmodium vivax? Kristan A Schneider, Ananias A Escalante Malaria Journal.2013;[Epub] CrossRef Effects of Antimalarial Molecules on the Gametocyte Stage of Plasmodium falciparum: The Debate Odile Dechy-Cabaret, Françoise Benoit-Vical Journal of Medicinal Chemistry.2012; 55(23): 10328. CrossRef Efficacy of different primaquine-based antimalarial regimens against Plasmodium falciparum gametocytemia Eliana M. Arango, Yulieth A. Upegui, Jaime Carmona-Fonseca Acta Tropica.2012; 122(2): 177. CrossRef A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines Michael J. Delves, Chandra Ramakrishnan, Andrew M. Blagborough, Didier Leroy, Timothy N.C. Wells, Robert E. Sinden International Journal for Parasitology.2012; 42(11): 999. CrossRef Plasmodium Cell Biology Should Inform Strategies Used In The Development Of Antimalarial Transmission-Blocking Drugs Michael J Delves Future Medicinal Chemistry.2012; 4(18): 2251. CrossRef Laboratory Diagnosis of Tropical Infections Bryan H. Schmitt, Jon E. Rosenblatt, Bobbi S. Pritt Infectious Disease Clinics of North America.2012; 26(2): 513. CrossRef Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study Rashid A Khatib, Jacek Skarbinski, Joseph D Njau, Catherine A Goodman, Berty F Elling, Elizeus Kahigwa, Jacquelin M Roberts, John R MacArthur, Julie R Gutman, Abdunoor M Kabanywanyi, Ernest E Smith, Masha F Somi, Thomas Lyimo, Alex Mwita, Blaise Genton, M Malaria Journal.2012;[Epub] CrossRef Primaquina, gametocitemia de Plasmodium falciparum y bloqueo de transmisión: ineficacia del actual régimen de dosificación Jaime Carmona-Fonseca, Eliana María Arango Flórez MedUNAB.2012; 15(1): 14. CrossRef A Sub-Microscopic Gametocyte Reservoir Can Sustain Malaria Transmission Stephan Karl, David Gurarie, Peter A. Zimmerman, Charles H. King, Tim G. St. Pierre, Timothy M. E. Davis, Steffen Borrmann PLoS ONE.2011; 6(6): e20805. CrossRef Appropriate Time for Primaquine Treatment to Reduce Plasmodium falciparum Transmission in Hypoendemic Areas Polrat Wilairatana, Srivicha Krudsood, Noppadon Tangpukdee The Korean Journal of Parasitology.2010; 48(2): 179. CrossRef Artemisinin-based combination therapies and their introduction in Japan Shigeyuki Kano Journal of Infection and Chemotherapy.2010; 16(6): 375. CrossRef Transmission blocking activity of a standardized neem (Azadirachta indica) seed extract on the rodent malaria parasite Plasmodium berghei in its vector Anopheles stephensi Leonardo Lucantoni, Rakiswendé S Yerbanga, Giulio Lupidi, Luciano Pasqualini, Fulvio Esposito, Annette Habluetzel Malaria Journal.2010;[Epub] CrossRef A Lethal Case of Plasmodium falciparum Infection in a Young Patient with End-stage Renal Failure Who Underwent Regular Hemodialysis Anggoro Budi Hartopo, Doni Priambodo Wijisaksono Internal Medicine.2010; 49(17): 1867. CrossRef The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border Saranath Lawpoolsri, Irwin F Chavez, Surapon Yimsamran, Supalap Puangsa-art, Nipon Thanyavanich, Wanchai Maneeboonyang, Wuthichai Chaimungkun, Pratap Singhasivanon, James H Maguire, Laura L Hungerford Malaria Journal.2010;[Epub] CrossRef Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin Bénédicte Pacorel, Suet C. Leung, Andrew V. Stachulski, Jill Davies, Livia Vivas, Hollie Lander, Stephen A. Ward, Marcel Kaiser, Reto Brun, Paul M. O’Neill Journal of Medicinal Chemistry.2010; 53(2): 633. CrossRef Optimally timing primaquine treatment to reduce Plasmodium falciparum transmission in low endemicity Thai-Myanmar border populations Saranath Lawpoolsri, Eili Y Klein, Pratap Singhasivanon, Surapon Yimsamran, Nipon Thanyavanich, Wanchai Maneeboonyang, Laura L Hungerford, James H Maguire, David L Smith Malaria Journal.2009;[Epub] CrossRef Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children Akintunde Sowunmi, Oluchi O Nkogho, Titilope M Okuboyejo, Grace O Gbotosho, Christian T Happi, Elsie O Adewoye Malaria Journal.2009;[Epub] CrossRef 9,439 View 110 Download Crossref