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Xueliang Zhu	1 Article
Sequence Analysis and Molecular Characterization of Wnt4 Gene in Metacestodes of Taenia solium Junling Hou, Xuenong Luo, Shuai Wang, Cai Yin, Shaohua Zhang, Xueliang Zhu, Yongxi Dou, Xuepeng Cai Korean J Parasitol 2014;52(2):163-168. Published online April 18, 2014 DOI: https://doi.org/10.3347/kjp.2014.52.2.163 Abstract PDF Wnt proteins are a family of secreted glycoproteins that are evolutionarily conserved and considered to be involved in extensive developmental processes in metazoan organisms. The characterization of wnt genes may improve understanding the parasite's development. In the present study, a wnt4 gene encoding 491amino acids was amplified from cDNA of metacestodes of Taenia solium using reverse transcription PCR (RT-PCR). Bioinformatics tools were used for sequence analysis. The conserved domain of the wnt gene family was predicted. The expression profile of Wnt4 was investigated using real-time PCR. Wnt4 expression was found to be dramatically increased in scolex evaginated cysticerci when compared to invaginated cysticerci. In situ hybridization showed that wnt4 gene was distributed in the posterior end of the worm along the primary body axis in evaginated cysticerci. These findings indicated that wnt4 may take part in the process of cysticerci evagination and play a role in scolex/bladder development of cysticerci of T. solium. Citations Citations to this article as recorded by Validation of reference genes for RT-qPCR relative expression analysis during cyst-to-early adult development of Taenia solium Jose Maravi, David Castaneda-Carpio, Renzo Gutierrez-Loli, Segundo W. Del Aguila, Valeria Villar-Davila, Juan Blume-La-Torre, Cristina Guerra-Giraldez, Pablo Smircich PLOS Neglected Tropical Diseases.2026; 20(1): e0013893. CrossRef Transcriptome of Taenia solium during in vitro cyst activation and initial growth into the tapeworm stage David Castaneda-Carpio, Renzo Gutierrez-Loli, Jose Maravi-Jaime, Segundo W. Del Aguila, Valeria Villar-Davila, Luz M. Moyano, Rafael Tapia-Limonchi, Stella M. Chenet, Cristina Guerra-Giraldez Scientific Data.2025;[Epub] CrossRef The significant sex-biased expression pattern of Sp-Wnt4 provides novel insights into the ovarian development of mud crab (Scylla Paramamosain) Ardavan Farhadi, Shaobin Fang, Yin Zhang, Wenxiao Cui, Huan Fang, Mhd Ikhwanuddin, Hongyu Ma International Journal of Biological Macromolecules.2021; 183: 490. CrossRef Transcriptomic profile of two developmental stages of the cestode parasite Mesocestoides corti T. Basika, G.P. Paludo, F.M. Araujo, A.C. Salim, F. Pais, L. Maldonado, N. Macchiaroli, J. Camargo de Lima, M. Rosenzvit, G.C. Oliveira, L. Kamenetzky, H.B. Ferreira Molecular and Biochemical Parasitology.2019; 229: 35. CrossRef Comparative Transcriptomic Analysis of the Larval and Adult Stages of Taenia pisiformis Shaohua Zhang Genes.2019; 10(7): 507. CrossRef Molecular and biochemical characterization of Taenia solium α-enolase Shaohua Zhang, Yanan You, Xuenong Luo, Yadong Zheng, Xuepeng Cai Veterinary Parasitology.2018; 254: 36. CrossRef Transcriptomic analysis of the larva Taenia multiceps W.H. Li, N.Z. Zhang, L. Yue, Y. Yang, L. Li, H.B. Yan, T.T. Li, Z.G. Qu, W.Z. Jia, B.Q. Fu Research in Veterinary Science.2017; 115: 407. CrossRef 11,142 View 82 Download 7 Web of Science Crossref