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Yan Fu	3 Articles
Expression of Translationally Controlled Tumor Protein (TCTP) Gene of Dirofilaria immitis Guided by Transcriptomic Screening Yan Fu, Jingchao Lan, Xuhang Wu, Deying Yang, Zhihe Zhang, Huaming Nie, Rong Hou, Runhui Zhang, Wanpeng Zheng, Yue Xie, Ning Yan, Zhi Yang, Chengdong Wang, Li Luo, Li Liu, Xiaobin Gu, Shuxian Wang, Xuerong Peng, Guangyou Yang Korean J Parasitol 2014;52(1):21-26. Published online February 19, 2014 DOI: https://doi.org/10.3347/kjp.2014.52.1.21 Abstract PDF Dirofilaria immitis (heartworm) infections affect domestic dogs, cats, and various wild mammals with increasing incidence in temperate and tropical areas. More sensitive antibody detection methodologies are required to diagnose asymptomatic dirofilariasis with low worm burdens. Applying current transcriptomic technologies would be useful to discover potential diagnostic markers for D. immitis infection. A filarial homologue of the mammalian translationally controlled tumor protein (TCTP) was initially identified by screening the assembled transcriptome of D. immitis (DiTCTP). A BLAST analysis suggested that the DiTCTP gene shared the highest similarity with TCTP from Loa loa at protein level (97%). A histidine-tagged recombinant DiTCTP protein (rDiTCTP) of 40 kDa expressed in Escherichia coli BL21 (DE3) showed immunoreactivity with serum from a dog experimentally infected with heartworms. Localization studies illustrated the ubiquitous presence of rDiTCTP protein in the lateral hypodermal chords, dorsal hypodermal chord, muscle, intestine, and uterus in female adult worms. Further studies on D. immitis-derived TCTP are warranted to assess whether this filarial protein could be used for a diagnostic purpose. Citations Citations to this article as recorded by Molecular Discovery of Filarial Nematode DNA in an Endangered Wild Pinniped (Galapagos Sea Lion, Zalophus wollebaeki) Isabella G. Livingston, Taylor M. Gregory, Eleanor C. Hawkins, Ashley Cave, Andrea Loyola, Shelly L. Vaden, Diane Deresienski, Marjorie Riofrío‐Lazo, Gregory A. Lewbart, Diego Páez‐Rosas, Matthew Breen Ecology and Evolution.2024;[Epub] CrossRef Development of TaqMan Quantitative PCR Assays for Duplex Detection of Dirofilaria immitis COI and Dog GAPDH from Infected Dog Blood In Young Oh, Kyung Tae Kim, Sun-Yeong Gwon, Ho Joong Sung The Korean Journal of Clinical Laboratory Science.2019; 51(1): 64. CrossRef Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics Daniele Chaves-Moreira, Fernando Hitomi Matsubara, Zelinda Schemczssen-Graeff, Elidiana De Bona, Vanessa Ribeiro Heidemann, Clara Guerra-Duarte, Luiza Helena Gremski, Carlos Chávez-Olórtegui, Andrea Senff-Ribeiro, Olga Meiri Chaim, Raghuvir Krishnaswamy A Toxins.2019; 11(6): 355. CrossRef Development of Real-time PCR Assays for Detection ofDirofilaria immitisfrom Infected Dog Blood In Young Oh, Kyung Tae Kim, Jin Hyun Jun, Jae-Ho Shin, Ho Joong Sung Korean Journal of Clinical Laboratory Science.2016; 48(2): 88. CrossRef 9,551 View 84 Download 3 Web of Science Crossref Genetic Variation of Taenia Pisiformis Collected from Sichuan, China, Based on the Mitochondrial Cytochrome b gene Deying Yang, Yongjun Ren, Yan Fu, Yue Xie, Huaming Nie, Xiang Nong, Xiaobin Gu, Shuxian Wang, Xuerong Peng, Guangyou Yang Korean J Parasitol 2013;51(4):449-452. Published online August 30, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.4.449 Abstract PDF Taenia pisiformis is one of the most important parasites of canines and rabbits. T. pisiformis cysticercus (the larval stage) causes severe damage to rabbit breeding, which results in huge economic losses. In this study, the genetic variation of T. pisiformis was determined in Sichuan Province, China. Fragments of the mitochondrial cytochrome b (cytb) (922 bp) gene were amplified in 53 isolates from 8 regions of T. pisiformis. Overall, 12 haplotypes were found in these 53 cytb sequences. Molecular genetic variations showed 98.4% genetic variation derived from intra-region. F_ST and Nm values suggested that 53 isolates were not genetically differentiated and had low levels of genetic diversity. Neutrality indices of the cytb sequences showed the evolution of T. pisiformis followed a neutral mode. Phylogenetic analysis revealed no correlation between phylogeny and geographic distribution. These findings indicate that 53 isolates of T. pisiformis keep a low genetic variation, which provide useful knowledge for monitoring changes in parasite populations for future control strategies. Citations Citations to this article as recorded by Sequence analysis of the cytb gene of Mesocestoides Vaillant, 1863 tetrathyridia from small mammals of the Russian Far East N.A. Pospekhova, V.V. Pereverzeva, N.E. Dokuchaev, A.A. Primak Proceedings of the Zoological Institute RAS.2025; 329(1): 64. CrossRef A survey of morphological, molecular, and histopathological characteristics of Taenia pisiformis metacestode in Egyptian rabbits (Oryctolagus cuniculus) Refaat Ras, Amanallah El-Bahrawy, Adel Abdelkhalek, Florica Morariu, Ayman N. Elsayed, Doaa S. Nouh, Anamaria Plesko, Marius Stelian Ilie, Manar AbdelMageed Frontiers in Veterinary Science.2025;[Epub] CrossRef Infection of Egyptian domestic rabbits, Oryctolagus cuniculus, with Cysticercus pisiformis (Cestoda: Taeniidae): morphological, molecular, and histopathological diagnostic tools Soheir A. H. Rabie, Wafaa A. Abuelwafa, Mouchira M. Mohi Eldin, Nermean M. Hussein Journal of Parasitic Diseases.2024; 48(4): 810. CrossRef Morphometry, molecular identification and histopathology of Passalurus ambiguus Rudolphi, 1819 in domestic rabbits (Oryctolagus cuniculus) in Qena, Upper Egypt Nermean M. Hussein, Soheir A. H. Rabie, Wafaa A. Abuelwafa, Mouchira M. Mohi ElDin Journal of Parasitic Diseases.2022; 46(2): 511. CrossRef Theileria, Hepatozoon and Taenia infection in great gerbils (Rhombomys opimus) in northwestern China Na Ji, Xueling Chen, Gang Liu, Shanshan Zhao, Wenbo Tan, Guangyuan Liu, Jiangguo Zhang, Yuanzhi Wang International Journal for Parasitology: Parasites and Wildlife.2021; 15: 79. CrossRef Molecular Confirmation of Massive Taenia pisiformis Cysticercosis in One Rabbit in Poland Małgorzata Samorek-Pieróg, Jacek Karamon, Adam Brzana, Ewa Bilska-Zając, Jolanta Zdybel, Tomasz Cencek Pathogens.2021; 10(8): 1029. CrossRef Spatiotemporal monitoring of Cysticercus pisiformis in European wild rabbit (Oryctolagus cuniculus) in Mediterranean ecosystems in southern Spain Susana Remesar, Sabrina Castro-Scholten, Débora Jiménez-Martín, Leonor Camacho-Sillero, Patrocinio Morrondo, Carlos Rouco, Félix Gómez-Guillamón, David Cano-Terriza, Ignacio García-Bocanegra Preventive Veterinary Medicine.2021; 197: 105508. CrossRef *Molecular Characterization of Enterocytozoon bieneusi* in Domestic Rabbits (Oryctolagus cuniculus) in Northeastern China** Xiao-Xuan Zhang, Jing Jiang, Ya-Nan Cai, Chun-Feng Wang, Peng Xu, Gui-Lian Yang, Quan Zhao The Korean Journal of Parasitology.2016; 54(1): 81. CrossRef Genetic Structure Analysis of Spirometra erinaceieuropaei Isolates from Central and Southern China Xi Zhang, Jing Cui, Li Na Liu, Peng Jiang, Han Wang, Xin Qi, Xing Qi Wu, Zhong Quan Wang, Wolfgang Arthofer PLOS ONE.2015; 10(3): e0119295. CrossRef 9,870 View 93 Download Crossref Comparative Efficacy of Ivermectin and Levamisole for Reduction of Migrating and Encapsulated Larvae of Baylisascaris transfuga in Mice Yan Fu, Hua-Ming Nie, Li-Li Niu, Yue Xie, Jia-Bo Deng, Qiang Wang, Guang-You Yang, Xiao-Bin Gu, Shu-Xian Wang Korean J Parasitol 2011;49(2):145-151. Published online June 14, 2011 DOI: https://doi.org/10.3347/kjp.2011.49.2.145 Abstract PDF The comparative efficacy of 2 anthelmintics (ivermectin and levamisole) against Baylisascaris transfuga migrating and encapsulated larvae was studied in mice. A total of 60 BALB/c mice inoculated each with about 1,000 embryonated B. transfuga eggs were equally divided into 6 groups (A-F) randomly. Mice of groups A and B were treated with ivermectin and levamisole, respectively, on day 3 post-infection (PI). Mice of groups A-C were killed on day 13 PI. Similarly, groups D and E were treated with ivermectin and levamisole, respectively, on day 14 PI, and all mice of groups D-F were treated on day 24 PI. The groups C and F were controls. Microexamination was conducted to count the larvae recovering from each mouse. The percentages of reduction in the number of migrating larvae recovered from group A (ivermectin) and B (levamisole) were 88.3% and 81.1%, respectively. In addition, the reduction in encapsulated larvae counts achieved by ivermectin (group D) and levamisole (group E) was 75.0% and 49.2%, respectively. The results suggested that, to a certain extent, both anthelmintics appeared to be more effective against migrating larvae than encapsulated larvae. However, in the incipient stage of infection, ivermectin may be more competent than levamisole as a larvicidal drug for B. transfuga. Citations Citations to this article as recorded by Rosmarinic acid improves cyclophosphamide-induced immunosuppression in mice by immunomodulatory and antioxidant effects Yi-Lun Wang, Wan Ni Food Bioscience.2023; 56: 103152. CrossRef Survey on gastro-intestinal parasites of captive sun bears in Malaysia S.S. Abdul-Mawah, Y. Norma-Rashid, R. Ramli Ursus.2023;[Epub] CrossRef Chromosome‐scale assembly and whole‐genome sequencing of 266 giant panda roundworms provide insights into their evolution, adaptation and potential drug targets Lei Han, Tianming Lan, Desheng Li, Haimeng Li, Linhua Deng, Zhiwei Peng, Shaowen He, Yanqiang Zhou, Ruobing Han, Lingling Li, Yaxian Lu, Haorong Lu, Qing Wang, Shangchen Yang, Yixin Zhu, Yunting Huang, Xiaofang Cheng, Jieyao Yu, Yulong Wang, Heting Sun, H Molecular Ecology Resources.2022; 22(2): 768. CrossRef Beyond the raccoon roundworm: The natural history of non-raccoon Baylisascaris species in the New World Sarah G.H. Sapp, Pooja Gupta, Melissa K. Martin, Maureen H. Murray, Kevin D. Niedringhaus, Madeleine A. Pfaff, Michael J. Yabsley International Journal for Parasitology: Parasites and Wildlife.2017; 6(2): 85. CrossRef Update on Baylisascariasis, a Highly Pathogenic Zoonotic Infection Carlos Graeff-Teixeira, Alessandra Loureiro Morassutti, Kevin R. Kazacos Clinical Microbiology Reviews.2016; 29(2): 375. CrossRef Cloning and characterization of a novel sigma-like glutathione S-transferase from the giant panda parasitic nematode, Baylisascaris schroederi Yue Xie, Xuan Zhou, Lin Chen, Zhihe Zhang, Chengdong Wang, Xiaobin Gu, Tao Wang, Xuerong Peng, Guangyou Yang Parasites & Vectors.2015;[Epub] CrossRef 8,585 View 58 Download Crossref