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Yeon-Joo Kim	3 Articles
Molecular Cloning of Plasmodium vivax Calcium-Dependent Protein Kinase 4 Kyung-Mi Choi, Jung-Yeon Kim, Sung-Ung Moon, Hyeong-Woo Lee, Jetsumon Sattabongkot, Byoung-Kuk Na, Dae-Won Kim, Eun-Jung Suh, Yeon-Joo Kim, Shin-Hyeong Cho, Ho-Sa Lee, Ho-Gun Rhie, Tong-Soo Kim Korean J Parasitol 2010;48(4):319-324. Published online December 16, 2010 DOI: https://doi.org/10.3347/kjp.2010.48.4.319 Abstract PDF A family of calcium-dependent protein kinases (CDPKs) is a unique enzyme which plays crucial roles in intracellular calcium signaling in plants, algae, and protozoa. CDPKs of malaria parasites are known to be key regulators for stage-specific cellular responses to calcium, a widespread secondary messenger that controls the progression of the parasite. In our study, we identified a gene encoding Plasmodium vivax CDPK4 (PvCDPK4) and characterized its molecular property and cellular localization. PvCDPK4 was a typical CDPK which had well-conserved N-terminal kinase domain and C-terminal calmodulin-like structure with 4 EF hand motifs for calcium-binding. The recombinant protein of EF hand domain of PvCDPK4 was expressed in E. coli and a 34 kDa product was obtained. Immunofluorescence assay by confocal laser microscopy revealed that the protein was expressed at the mature schizont of P. vivax. The expression of PvCDPK4-EF in schizont suggests that it may participate in the proliferation or egress process in the life cycle of this parasite. Citations Citations to this article as recorded by Two Calcium-Dependent Protein Kinases fromChlamydomonas reinhardtiiare transcriptionally regulated by nutrient starvation Mustafa J Motiwalla, Marilyn P Sequeira, Jacinta S D'Souza Plant Signaling & Behavior.2014; 9(1): e27969. CrossRef Molecular characterization and analysis of a novel calcium-dependent protein kinase from Eimeria tenella H.Y. HAN, S.H. ZHU, L.L. JIANG, Y. LI, H. DONG, Q.P. ZHAO, C.L. KONG, B. HUANG Parasitology.2013; 140(6): 746. CrossRef Calcium signaling in closely related protozoan groups (Alveolata): Non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic Apicomplexa (Plasmodium, Toxoplasma) H. Plattner, I.M. Sehring, I.K. Mohamed, K. Miranda, W. De Souza, R. Billington, A. Genazzani, E.-M. Ladenburger Cell Calcium.2012; 51(5): 351. CrossRef 8,897 View 67 Download Crossref High Levels of Antibodies to Plasmodium falciparum Liver Stage Antigen-1 in Naturally Infected Individuals in Myanmar Hyeong-Woo Lee, Sung-Ung Moon, Yeon-Joo Kim, Shin-Hyeong Cho, Khin Lin, Byoung-Kuk Na, Tong-Soo Kim Korean J Parasitol 2008;46(3):195-198. Published online September 20, 2008 DOI: https://doi.org/10.3347/kjp.2008.46.3.195 Abstract PDF Plasmodium falciparum liver stage antigen-1 (PfLSA-1) is one of the few antigens expressed exclusively in liver stage parasites. In this study, we evaluated the antibody responses against recombinant PfLSA-1 in naturally infected individuals in Myanmar. High levels of antibody responses (70.7%) were detected in 82 serum samples from 116 infected individuals, and IgG responses to PfLSA-1 principally composed of responses of IgG1 and IgG3 subclasses. These results show that PfLSA-1 elicits effective antibody responses in individuals infected with P. falciparum, and thus it could be not only an attractive candidate protein for vaccine development, but also a useful antigen for serodiagnosis of the infection. Citations Citations to this article as recorded by High-density Peptide Arrays Help to Identify Linear Immunogenic B-cell Epitopes in Individuals Naturally Exposed to Malaria Infection Thomas Jaenisch, Kirsten Heiss, Nico Fischer, Carolin Geiger, F. Ralf Bischoff, Gerhard Moldenhauer, Leszek Rychlewski, Ali Sié, Boubacar Coulibaly, Peter H. Seeberger, Lucjan S. Wyrwicz, Frank Breitling, Felix F. Loeffler Molecular & Cellular Proteomics.2019; 18(4): 642. CrossRef Comparison of the antibody responses to Plasmodium vivax and Plasmodium falciparum antigens in residents of Mandalay, Myanmar Tong-Soo Kim, Hyung-Hwan Kim, Jung-Yeon Kim, Yoon Kong, Byoung-Kuk Na, Khin Lin, Sung-Ung Moon, Yeon-Joo Kim, Myoung-Hee Kwon, Youngjoo Sohn, Hyuck Kim, Hyeong-Woo Lee Malaria Journal.2011;[Epub] CrossRef 8,612 View 100 Download Crossref Usefulness of the recombinant liver stage antigen-3 for an early serodiagnosis of Plasmodium falciparum infection Hyeong-Woo Lee, Sung-Ung Moon, Hye-Sun Ryu, Yeon-Joo Kim, Shin-Hyeong Cho, Gyung-Tae Chung, Khin Lin, Byoung-Kuk Na, Yoon Kong, Kyung-Suk Chung, Tong-Soo Kim Korean J Parasitol 2006;44(1):49-54. Published online March 20, 2006 DOI: https://doi.org/10.3347/kjp.2006.44.1.49 Abstract PDF In order to develop tools for an early serodiagnosis of Plasmodium falciparum infection, we evaluated the usefulness of P. falciparum liver stage antigen-3 (LSA-3) as a serodiagnostic antigen. A portion of LSA-3 gene was cloned, and its recombinant protein (rLSA-3) was expressed in Escherichia coli and purified by column chromatography. The purified rLSA-3 and 120 test blood/serum samples collected from inhabitants in malaria-endemic areas of Mandalay, Myanmar were used for this study. In microscopic examinations of blood samples, P. falciparum positive rate was 39.1% (47/120) in thin smear trials, and 33.3% (40/120) in thick smear trials. Although the positive rate associated with the rLSA-3 (30.8%) was lower than that of the blood stage antigens (70.8%), rLSA-3 based enzyme-linked immunosorbent assay could detect 12 seropositive cases (10.0%), in which blood stage antigens were not detected. These results indicate that the LSA-3 is a useful antigen for an early serodiagnosis of P. falciparum infection. Citations Citations to this article as recorded by Development of new real-time PCR assays for detection and species differentiation of Plasmodium ovale Wenqiao He, Rachel Sendor, Varun R. Potlapalli, Melchior M. Kashamuka, Antoinette K. Tshefu, Fernandine Phanzu, Albert Kalonji, Billy Ngasala, Kyaw Lay Thwai, Jonathan J. Juliano, Jessica T. Lin, Jonathan B. Parr, Georges Snounou PLOS Neglected Tropical Diseases.2024; 18(9): e0011759. CrossRef First characterization of Plasmodium vivax liver stage antigen (PvLSA) using synthetic peptides Youn-Kyoung Goo, Eun-Jeong Seo, Yeon-kyung Choi, Hyun-Il Shin, Jetsumon Sattabongkot, So-Young Ji, Chom-Kyu Chong, Shin-Hyung Cho, Won-Ja Lee, Jung-Yeon Kim Parasites & Vectors.2014;[Epub] CrossRef Comparison of the antibody responses to Plasmodium vivax and Plasmodium falciparum antigens in residents of Mandalay, Myanmar Tong-Soo Kim, Hyung-Hwan Kim, Jung-Yeon Kim, Yoon Kong, Byoung-Kuk Na, Khin Lin, Sung-Ung Moon, Yeon-Joo Kim, Myoung-Hee Kwon, Youngjoo Sohn, Hyuck Kim, Hyeong-Woo Lee Malaria Journal.2011;[Epub] CrossRef Assessment of exposure to Plasmodium falciparum transmission in a low endemicity area by using multiplex fluorescent microsphere-based serological assays Jean Biram Sarr, Eve Orlandi-Pradines, Sonia Fortin, Cheikh Sow, Sylvie Cornelie, François Rogerie, Soihibou Guindo, Lassana Konate, Thierry Fusaï, Gilles Riveau, Christophe Rogier, Franck Remoue Parasites & Vectors.2011;[Epub] CrossRef The malaria candidate vaccine liver stage antigen-3 is highly conserved in Plasmodium falciparum isolates from diverse geographical areas Eric Prieur, Pierre Druilhe Malaria Journal.2009;[Epub] CrossRef High Levels of Antibodies to Plasmodium falciparum Liver Stage Antigen-1 in Naturally Infected Individuals in Myanmar Hyeong-Woo Lee, Sung-Ung Moon, Yeon-Joo Kim, Shin-Hyeong Cho, Khin Lin, Byoung-Kuk Na, Tong-Soo Kim The Korean Journal of Parasitology.2008; 46(3): 195. CrossRef Liver stage antigen 3 isolated from a cDNA library of Plasmodium falciparum erythrocytic stages Eva M. Moyano, Luis Miguel González, Susana Arahuetes, Agustín Benito Parasitology Research.2007; 102(1): 111. CrossRef 8,966 View 69 Download Crossref