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Young S. Hong	1 Article
RNA Interference in Infectious Tropical Diseases Seokyoung Kang, Young S. Hong Korean J Parasitol 2008;46(1):1-15. Published online March 20, 2008 DOI: https://doi.org/10.3347/kjp.2008.46.1.1 Abstract PDF Introduction of double-stranded RNA (dsRNA) into some cells or organisms results in degradation of its homologous mRNA, a process called RNA interference (RNAi). The dsRNAs are processed into short interfering RNAs (siRNAs) that subsequently bind to the RNA-induced silencing complex (RISC), causing degradation of target mRNAs. Because of this sequence-specific ability to silence target genes, RNAi has been extensively used to study gene functions and has the potential to control disease pathogens or vectors. With this promise of RNAi to control pathogens and vectors, this paper reviews the current status of RNAi in protozoans, animal parasitic helminths and disease-transmitting vectors, such as insects. Many pathogens and vectors cause severe parasitic diseases in tropical regions and it is difficult to control once the host has been invaded. Intracellularly, RNAi can be highly effective in impeding parasitic development and proliferation within the host. To fully realize its potential as a means to control tropical diseases, appropriate delivery methods for RNAi should be developed, and possible off-target effects should be minimized for specific gene suppression. RNAi can also be utilized to reduce vector competence to interfere with disease transmission, as genes critical for pathogenesis of tropical diseases are knockdowned via RNAi. Citations Citations to this article as recorded by Molecular and structural analysis of a novel vitellogenin protein (SpVTG3) and its roles in the embryonic development of mud crab Scylla paramamosain Zhaowei Zhong, Yan Xu, Yonghua Jiang, Ziping Zhang, Xianyuan Zeng, Zhihua Zou, Yilei Wang International Journal of Biological Macromolecules.2025; 319: 145394. CrossRef In vivo inhibition of the Ostreid Herpesvirus-1 (OsHV-1) replication in juveniles of the Pacific oyster Crassostrea gigas by a specific RNAi targeting the viral DNA polymerase gene Carolina Gallardo-Ybarra, Arturo Sánchez-Paz, Trinidad Encinas-García, Christian Minjarez-Osorio, Adriana Muhlia-Almazán, Ariel Cruz-Villacorta, José Manuel Grijalva-Chon, Enrique De La Re Vega Aquaculture International.2024; 32(3): 3061. 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CrossRef Application of RNA interference in triatomine (Hemiptera: Reduviidae) studies Rafaela M. M. Paim, Ricardo N. Araujo, Michael J. Lehane, Nelder F. Gontijo, Marcos H. Pereira Insect Science.2013; 20(1): 40. CrossRef Exploring RNAi as a therapeutic strategy for controlling disease in aquaculture Paula C. Lima, James O. Harris, Mathew Cook Fish & Shellfish Immunology.2013; 34(3): 729. CrossRef First Comparative Transcriptomic Analysis of Wild Adult Male and Female Lutzomyia longipalpis, Vector of Visceral Leishmaniasis Christina B. McCarthy, María Soledad Santini, Paulo F. P. Pimenta, Luis A. Diambra, Kelly A. Brayton PLoS ONE.2013; 8(3): e58645. CrossRef Thermodynamic basis of selectivity in guide‐target‐mismatched rna interference Thomas T. Joseph, Roman Osman Proteins: Structure, Function, and Bioinformatics.2012; 80(5): 1283. 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