The effect of transferred immune serum and IgG on the response of recipient mice to concurrent infections with larvae has been investigated. Following one infection, recipient mice harboured fewer worms than control mice, the worms were stunted and thier fecundities were greatly reduced. Four concurrent infections was found to reduce worm burden and worm fecundity, and induce an increase of serum antibody titers in no-treatment and normal serum given mice.
On the other hand the transferred immune serum and IgG appeared to adversely affect the protective immune response in recipient mice. In recipient mice, worm fecundity was consistently increased throughout experiment and harboured more worms after four infections than control mice. Serum anti-N. dubius antibody titers of mice made passively immune by transfer of immune serum and IgG were not significant difference between one infection and four infections. Thus, transferred immune serum and IgG may debilitate host antibody production.
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Immunity to Babesia microti in male mice selected as resistant or susceptible to Nematospiroidesdubius F. Parrodi, I.G. Wright, C. Dobson International Journal for Parasitology.1988; 18(4): 539. CrossRef
A survey on soil samples collected from the vegetable gardens and vinyl houses in the vicinity of Taegu was conducted for the discovery of helminth eggs and larvae from October 1981 to September 1982. The samples collected were examined utilizing the "Commonly Employed" and Kamiya's techniques. The details of comparative features of larval nematodes are taken from the handbook of parasitology by Matsubasyhi et al. (1965). The results were compared with the data obtained from soil samples collected at the same area by Lee(1976). Five kinds of helminth eggs, ascarid, hookworm, liver fluke, Trichostrongylidae, and whipworm and undetermined eggs were found. Of these, the incidence of ascarid eggs was found to be the highest, 70.5 per cent, followed by whipworm and hookworm eggs, 9.9 and 9.2 per cent, respectively. The average number of ascarid eggs per 100 grams of soil was higher in the vinyl houses, compared with the number in the vegetable gardens than in the vinyl houses. By contrast, the number of hookworm eggs was relatively high in the vegetable gardens. In the monthly incidences of helminth eggs, ascarid eggs were found every month, continuing fairly high incidences all the year round.
However, hookworm eggs was found for 8 months from February and September, with low monthly incidences between 4.0 and 22.2 per cent, and Trichostrongylidae eggs were found for 6 months from April to September, with lower incidences than those of hookworm. Three kinds of larval nematodes, the filariform and rhabditoid larvae of hookworm, Trichostrongylidae, and undetermined larvae were found in the soil of farms, but the incidences of larvae were quite low. The average number of larvae per 100 grams of soil was 0.05. When the number of eggs per 100 grams of the soil in 1976 were compared with 1982, pronounced reduction of the number was encountered in all helminth eggs. However, the incidences and the average number of larvae per 100 grams of the soil were so low that it was impossible to compare the data between 1976 and 1982.
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IgA response in mice infected with Neodiplostomum seoulensis S Huh, S U Lee, M H Won, Y G Jeong, Y H Kwon, C S Choi The Korean Journal of Parasitology.1995; 33(1): 55. CrossRef
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A 25-year old Korean male was admitted to Seoul National University Hospital on July 5, 1982 because of fever, epigastric discomfort and diarrhea. Laboratory examination revealed moderate eosinophilia, and large operculated helminth eggs in stool repeatedly. Other laboratory test resulted in normal range and bacteriological cultures were nefative. Under the impression of intestinal fluke infection, bithionol treatment with magnesium purgation was tried. From the diarrheal stool after treatment, a total of 79 small adult trematodes was collected, and identified as Fibricola seoulensis. The patient had eaten raw viscera of 2 snakes 9 days before admission in a rural village in Korea.
It was assumed that this is the first record that described human infection by an adult diplostomatid fluke.
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The effect of reinfection with Neodiplostomum seoulensis on the histopathology and activities of brush border membrane bound enzymes in the rat small intestine J R Yu, S T Hong, J Y Chai, S H Lee The Korean Journal of Parasitology.1995; 33(1): 37. CrossRef
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The nervous system of Fibricola seoulensis by acetylcholinesterase histochemistry E W Cheon, C H Kim The Korean Journal of Parasitology.1993; 31(4): 321. CrossRef
Transmission electron microscopic ultrastructure of the tegument of Fibricola seoulensis W M Sohn, S H Lee The Korean Journal of Parasitology.1993; 31(4): 301. CrossRef
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The life cycle and larval development of Fibricola seoulensis (Trematoda: Diplostomatidae) Byong Seol Seo, Soon Hyung Lee, Jong Yil Chai, Sung Jong Hong, Sung Tae Hong The Korean Journal of Parasitology.1988; 26(3): 179. CrossRef
Egg laying capacity of Fibricola seoulensis in mice and rats Sung Tae Hong, Chang Hyun Kim, Sun Huh, Soon Hyung Lee The Korean Journal of Parasitology.1988; 26(2): 117. CrossRef
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Growth and development of Fibricola seoulensis metacercariae in tadpoles Soon Hyung Lee, Shon Moon Shin, Sung Tae Hong, Woon Mok Sohn, Jong Yil Chai, Byong Seol Seo The Korean Journal of Parasitology.1986; 24(2): 109. CrossRef
A study on the infection status of tadpoles and frogs by the metacercariae of Fibricola seoulensis in Korea Sung Tae Hong, Soon Hyung Lee, Jong Yil Chai, Byong Seol Seo The Korean Journal of Parasitology.1985; 23(1): 73. CrossRef
A histopathological study on the intestine of mice and rats experimentally infected by Fibricola Seoulensis Soon Hyung Lee, Byong Hoon Yoo, Sung Tae Hong, Jong Yil Chai, Byong Seol Seo, Je Geun Chi The Korean Journal of Parasitology.1985; 23(1): 58. CrossRef
Studies on intestinal trematodes in Korea XIX. Light and scanning electron microscopy of Fibricola seoulensis collected from albino rats treated with praziquantel Byong Seol Seo, In June Cha, Jong Yil Chai, Sung Jong Hong, Soon Hyung Lee The Korean Journal of Parasitology.1985; 23(1): 47. CrossRef
Studies on intestinal trematodes in Korea XVIII. Effects of praziquantel in the treatment of Fibricola seoulensis infection in albino rats Soon Hyung Lee, Jong Yil Chai, Byoug Seol Seo The Korean Journal of Parasitology.1985; 23(1): 41. CrossRef
Studies on intestinal trematodes in Korea X. Scanning electron microscopic observation on the tegument of Fibricola seoulensis Byong Seol Seo, Soon Hyung Lee, Jong Yil Chai, Sung Tae Hong, Sung Jong Hong The Korean Journal of Parasitology.1984; 22(1): 21. CrossRef
Fifteen human cases of Fibricola seoulensis infection in Korea Sung Tae Hong, Tai Kwon Cho, Sung Jong Hong, Jong Yil Chai, Soon Hyung Lee, Byong Seol Seo The Korean Journal of Parasitology.1984; 22(1): 61. CrossRef
Studies on intestinal trematodes in Korea IX. Recovery rate and development of Fibricola seoulensis in experimental animals Sung Jong Hong, Soon Hyung Lee, Byong Seol Seo, Sung Tae Hong, Jong Yil Chai The Korean Journal of Parasitology.1983; 21(2): 224. CrossRef
Studies on intestinal trematodes in Korea VI. On the metacercaria and the second intermediate host of Fibricola seoulensis Sung Tae Hong, Sung Jong Hong, Soon Hyung Lee, Byong Seol Seo, Je Geun Chi The Korean Journal of Parasitology.1982; 20(2): 101. CrossRef
Studies on intestinal trematodes in Korea VII. Growth, development and recovery of Fibricola seoulensis from experimentally infected rats and mice Sung Tae Hong The Korean Journal of Parasitology.1982; 20(2): 112. CrossRef
This study was carried out to confirm the infection source of the human case of Fibricola seoulensis, and to reveal out a part of its life cycle in Korea. Also the morphological characteristics of the metacercaria were described. The results were summarized as follows: Rana nigromaculata and Natrix tigrina lateralis were found to be infected naturally by the metacercariae(diplostomula) of F. seoulensis. The metacercarial capsule was round to elliptical in tissue of the intermediate hosts with a long diameter 0.232 - 0.385 mm. Liberated metacercariae were ovoid with small conical posterior body. Body length measured 0.199 - 0.312 mm and width 0.153 - 0.252 mm. The infection rate of R.
nigromaculata by the metacercariae ranged from 87% to 100% by area, and the number of the larvae ranged from 3 to 390 by frog. The metacercariae were found in skeletal muscle of frogs, from head to hindlegs. All examined N. t. lateralis were found to be infected by the metacercariae with the range of numbers frome 3 to 35,918. The larvae were collected from all viscera and body segments except for the head of the snakes. However, a great majority of the metacercariae were collected from the stomach.
Hematoxylin-eosin stained preparations of frog skeletal muscle and snakes stomach revealed that the metacercariae had no cyst wall of worm origin, but encapsulated by the host tissue. Some of them were found in dilated lymphatic vessels. The larval infection was associated with slight or severe inflammatory reaction even with granuloma formation.
By above results, it was concluded that the frog, Rana nigromaculata, was the second intermediate host, and the snake Natrix tigrina lateralis was a paratenic host of F.
seoulensis in nature in Korea.
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Neodiplostomum cf. seoulense (Seo, Rim, Lee, 1964) sensu Pyo et al., 2014 (Trematoda: Diplostomidae Poirier, 1886): morphology, life cycle, and phylogenetic relationships A. V. Izrailskaia, V. V. Besprozvannykh Journal of Helminthology.2023;[Epub] CrossRef
Three Nematode Species Recovered from Terrestrial Snakes in Republic of Korea Seongjun Choe, Junsik Lim, Hyun Kim, Youngjun Kim, Heejong Kim, Dongmin Lee, Hansol Park, Hyeong-Kyu Jeon, Keeseon S. Eom The Korean Journal of Parasitology.2016; 54(2): 205. CrossRef
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NEODIPLOSTOMUM LEEI N. SP. (DIGENEA: NEODIPLOSTOMIDAE) FROM CHICKS INFECTED WITH METACERCARIAE FROM THE GRASS SNAKE RHABDOPHIS TIGRINA Jong-Yil Chai, Eun-Hee Shin Journal of Parasitology.2002; 88(6): 1181. CrossRef
Host Specificity of Austropeplea ollula (Gastropoda: Lymnaeidae) to Miracidial Infection with a Human Intestinal Fluke Neodiplostomum seoulense (Trematoda: Diplostomatidae) in Korea P. R. Chung*, Y. Jung, Y. K. Park, M. G. Hwang Journal of Parasitology.2002; 88(3): 630. CrossRef
Metacercariae of Pharyngostomum cordatum found from the European grass snake, Rhabdophis tigrina, and its experimental infection to cats J Y Chai, W M Sohn, H L Chung, S T Hong, S H Lee The Korean Journal of Parasitology.1990; 28(3): 175. CrossRef
The life cycle and larval development of Fibricola seoulensis (Trematoda: Diplostomatidae) Byong Seol Seo, Soon Hyung Lee, Jong Yil Chai, Sung Jong Hong, Sung Tae Hong The Korean Journal of Parasitology.1988; 26(3): 179. CrossRef
Growth and development of Fibricola seoulensis metacercariae in tadpoles Soon Hyung Lee, Shon Moon Shin, Sung Tae Hong, Woon Mok Sohn, Jong Yil Chai, Byong Seol Seo The Korean Journal of Parasitology.1986; 24(2): 109. CrossRef
A histopathological study on the intestine of mice and rats experimentally infected by Fibricola Seoulensis Soon Hyung Lee, Byong Hoon Yoo, Sung Tae Hong, Jong Yil Chai, Byong Seol Seo, Je Geun Chi The Korean Journal of Parasitology.1985; 23(1): 58. CrossRef
A study on the infection status of tadpoles and frogs by the metacercariae of Fibricola seoulensis in Korea Sung Tae Hong, Soon Hyung Lee, Jong Yil Chai, Byong Seol Seo The Korean Journal of Parasitology.1985; 23(1): 73. CrossRef
Studies on intestinal trematodes in Korea XVIII. Effects of praziquantel in the treatment of Fibricola seoulensis infection in albino rats Soon Hyung Lee, Jong Yil Chai, Byoug Seol Seo The Korean Journal of Parasitology.1985; 23(1): 41. CrossRef
Studies on intestinal trematodes in Korea X. Scanning electron microscopic observation on the tegument of Fibricola seoulensis Byong Seol Seo, Soon Hyung Lee, Jong Yil Chai, Sung Tae Hong, Sung Jong Hong The Korean Journal of Parasitology.1984; 22(1): 21. CrossRef
Fifteen human cases of Fibricola seoulensis infection in Korea Sung Tae Hong, Tai Kwon Cho, Sung Jong Hong, Jong Yil Chai, Soon Hyung Lee, Byong Seol Seo The Korean Journal of Parasitology.1984; 22(1): 61. CrossRef
Studies on intestinal trematodes in Korea IX. Recovery rate and development of Fibricola seoulensis in experimental animals Sung Jong Hong, Soon Hyung Lee, Byong Seol Seo, Sung Tae Hong, Jong Yil Chai The Korean Journal of Parasitology.1983; 21(2): 224. CrossRef
Studies on intestinal trematodes in Korea V. A human case infected by Fibricola seoulensis (Trematoda: Diplostomatidae) Byong Seol Seo, Soon Hyung Lee, Sung Tae Hong, Sung Jong Hong, Chung Yong Kim, Hun Yong Lee The Korean Journal of Parasitology.1982; 20(2): 93. CrossRef
Studies on intestinal trematodes in Korea VII. Growth, development and recovery of Fibricola seoulensis from experimentally infected rats and mice Sung Tae Hong The Korean Journal of Parasitology.1982; 20(2): 112. CrossRef
This study was carried out to observe the growth and development of Fibricola seoulensis in experimentally infected rats and mice. The metacercariae were obtained from naturally infected Natrix tigrina lateralis which were collected in Hoengseong Gun, Gangweon Do, in August 1982.
The results were summarized as follows. Growth and development of worm were not different between the rat and mouse. Body growth was attained within a week in both hosts.
The testes differentiated first on the 2nd day after infection, and then ovary on the 3rd day, vitelline follicles on the 4th day, vitelline reservoir on the 5th day. A few eggs appeared in uterus on the 5th day and in feces on the 6th day. The body length grew almost linearly for the first 7 days after infection. The growth of posterior body was more remarkable, and the ratio of posterior body length to that of anterior body increased to 1.099 until 4 weeks after infection. The worms of 4weeks age in rats measured 1.10-1.92 mm long and 0.511 - 0.696 mm wide. The morphological characteristics of adult worms were identical to the original description of F. seoulensis, though dimensions varied in wider range. The worms were recovered from the rats 12.5% on the day after infecion, and the rate ranged 21.0-59.0% up to 6th day. One week after infection, the rates were 42.6%, 60.9% and 43.9% respectively by the metacercarial group of 200, 1,000 and 2,000 and the rates decreased to 16.2%, 29.1% and 3.1% respectively by the group on the 4th week after infection.
Most of the worms were recovered from duodenum, and a part of worms were found in jejunum or ileum in heavily infected rats. The worms of 23.5-63.5% were recovered from mice from 3 to 10 days after infection. A great majority of them was found in duodenum, too.
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Clinical and histopathological findings in mice heavily infected with Fibricola seoulensis Sun Huh, Jong Yil Chai, Sung Tae Hong, Soon Hyung Lee The Korean Journal of Parasitology.1988; 26(1): 45. CrossRef
A histopathological study on the intestine of mice and rats experimentally infected by Fibricola Seoulensis Soon Hyung Lee, Byong Hoon Yoo, Sung Tae Hong, Jong Yil Chai, Byong Seol Seo, Je Geun Chi The Korean Journal of Parasitology.1985; 23(1): 58. CrossRef
Studies on intestinal trematodes in Korea XVIII. Effects of praziquantel in the treatment of Fibricola seoulensis infection in albino rats Soon Hyung Lee, Jong Yil Chai, Byoug Seol Seo The Korean Journal of Parasitology.1985; 23(1): 41. CrossRef
Studies on intestinal trematodes in Korea X. Scanning electron microscopic observation on the tegument of Fibricola seoulensis Byong Seol Seo, Soon Hyung Lee, Jong Yil Chai, Sung Tae Hong, Sung Jong Hong The Korean Journal of Parasitology.1984; 22(1): 21. CrossRef
Studies on intestinal trematodes in Korea IX. Recovery rate and development of Fibricola seoulensis in experimental animals Sung Jong Hong, Soon Hyung Lee, Byong Seol Seo, Sung Tae Hong, Jong Yil Chai The Korean Journal of Parasitology.1983; 21(2): 224. CrossRef
Studies on intestinal trematodes in Korea V. A human case infected by Fibricola seoulensis (Trematoda: Diplostomatidae) Byong Seol Seo, Soon Hyung Lee, Sung Tae Hong, Sung Jong Hong, Chung Yong Kim, Hun Yong Lee The Korean Journal of Parasitology.1982; 20(2): 93. CrossRef
Studies on intestinal trematodes in Korea VI. On the metacercaria and the second intermediate host of Fibricola seoulensis Sung Tae Hong, Sung Jong Hong, Soon Hyung Lee, Byong Seol Seo, Je Geun Chi The Korean Journal of Parasitology.1982; 20(2): 101. CrossRef
This study was carried out to observe the chronological tegumental changes of juvenile C. sinensis using scanning and transmission electron microscopes (SEM and TEM). The subjected worms were the excysted metacercaria, and l day, 1 week, 2 week and 4 week old worms. By observation with SEM, the tegument of excysted metacercaria showed many transverse wrinkling or shallow rugae, especially remarkable in anterior half of body, i.e., anterior to ventral sucker.
Many spines were arrayed on the whole body surface, and double or triple pointed on anterior half and single pointed on posterior half. The observed sensory papillae were composed of 3 types. The ciliated knob-like papillae (type A in Fujino's classification) were abundant on anterior half, especially around oral sucker. A few plate like elevated papillae (type B) were found on middle part and non-ciliated round swellings (type C papillae) were observed around ventral sucker. The tegumental surface of 1 day old worms showed deeper rugae, and the posterior body end was covered with cobble stone-like processes of distal cytoplasm. The spines protruded further and the spines on posterior half of body changed to scale-like ones. The tegument of 1 week old worms became velvety and the spines grew further in length, but the density decreased. The tegumental processes differentiated much finely in the 2 week and 4 week old specimens and the spines or sensory papillae decreased of their relative density. The basic tegumental structures, such as distal cytoplasm containing various granules, vesicles and spines, basement membrane complex, muscular layers and tegumental cells were also monitored in 1 week old worms by TEM.
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Surface ultrastructure of Metagonimus miyatai metacercariae and adults J Y Chai, Y J Kang, S Y Choi, S M Guk, J R Yu, S H Lee The Korean Journal of Parasitology.1998; 36(4): 217. CrossRef
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Surface ultrastructure of Heterophyes nocens (Trematoda: Heterophyidae) J Y Chai, H L Chung, M H Choi, W M Sohn, S J Hong, S H Lee The Korean Journal of Parasitology.1992; 30(2): 75. CrossRef
Tegumental ultrastructures of Paragonimus iloktsuenensis according to the developmental stages S H Lee, S J Kim, J Y Chai, W M Sohn The Korean Journal of Parasitology.1989; 27(1): 57. CrossRef
Early morphogenesis in the platyhelminthes with special reference to egg development and development of cestode larvae M.D.B. Burt International Journal for Parasitology.1987; 17(1): 241. CrossRef
Scanning electron microscopical findings of Echinochasmus japonicus tegument Soon Hyung Lee, Woon Mok Sohn, Sung Tae Hong The Korean Journal of Parasitology.1987; 25(1): 51. CrossRef
Ultrastructural studies on the surface of Paragonimus westermani metacercaria Kyong Min Kim, Myoung Hee Ahn, Duk Young Min The Korean Journal of Parasitology.1987; 25(2): 129. CrossRef
Tegumental ultrastructures of Echinostoma hortense observed by scanning electron microscopy Soon Hyung Lee, Sung Jong Hong, Jong Yil Chai, Sung Tae Hong, Byong Seol Seo The Korean Journal of Parasitology.1986; 24(1): 63. CrossRef
Studies on intestinal trematodes in Korea X. Scanning electron microscopic observation on the tegument of Fibricola seoulensis Byong Seol Seo, Soon Hyung Lee, Jong Yil Chai, Sung Tae Hong, Sung Jong Hong The Korean Journal of Parasitology.1984; 22(1): 21. CrossRef
Study on Metagonimus yokogawai(Katsurada, 1912) in Korea VII. Electron microscopic observation on the tegumental structure Soon Hyung Lee, Byong Seol Seo, Jong Yil Chai, Sung Jong Hong The Korean Journal of Parasitology.1984; 22(1): 1. CrossRef
The infection rates with cercaria and metacercaria of the Clonorchis sinensis in snail and fish hosts, and the prevalence among the inhabitants in the lower Nag Dong river in Busan were investigated in the period from June 1981 to March 1982. The stool examination and E.P.G. count for prevalence and intensity of clonorchiasis were done by cellophane thick smear and Stoll's egg count methods. The prevalence rate of clonorchiasis among inhabitants of 3 towns in Bug Gu, was 38.4% among a total of 1,384 persons examined. By town, the prevalence in Gu Po was 25.4% out of 330 persons examined, 39.3% in 438 examined in Gang Dong and 44.8% out of 616 in examined in Myeng Ji respectively.
According to sex, the male(41.9%) showed relatively higher rate than female(35.3%). By age, increase of rate was observed as increase in age. The highest rate was 80.7% in 50-59 years group. The intensity of infection was light: 89.1% of examined cases were below 10,000 E.P.G. ; by area 80.9%(Gu Po), 80.2%(Gang Dong), 97.3%(Myeng JI). Out of fresh water fish species collected, 2 species were not infected with metacercaria. The metacercarial detection rate from fish in low Nag Dong river showed 100% in Pseudorasbora parva, Pseudogobio esocinus(41.4%), Hemibarbus labeo(37.1%), Acheilognathus limbata(33.3%) and Erythroculter erthropterus(4.5%) respectively. The mean number of metacercaria per gram of muscle was 21.2 in P. parva, P.
esocinus(15.0), H. labeo(11.9), A. limbata(6.3), and E.
erythropterus(1.6) respectively. Though 7 area along Nag Dong river were surveyed for Parafossarulus manchouricus, the snails were not found at all areas except for one area, Seo Nam stream; and the cercaria was infected 0.9% out of 708 examined.
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Epidemiological studies of digenetic trematodes in Yongyang County, Kyungpook Province D I Chung, Y I Kim, K R Lee, D W Choi The Korean Journal of Parasitology.1991; 29(4): 325. CrossRef
Larvicidal action of liquid nitrogen against metacercariae of Clonorchis sinensis Soo Bok Song The Korean Journal of Parasitology.1987; 25(2): 123. CrossRef
Survey on encysted cercaria of trematodes from fresh-water fishes in Tongjin riverside areas in Korea Jae Ku Rhee, Moon Ho Rim, Byeong Kirl Baek, Ho Il Lee The Korean Journal of Parasitology.1984; 22(2): 190. CrossRef
The present work was done to isolate the anthelmintic substance from the tuber of Bletilla striata which grows Gangweon-do of the Korea peninsula. The dried B. striata tuber was extracted with ethyl ether by a Soxhlet extractor at 40C for 24 hours, and then the extract was separated into insoluble material (negative wormicidal) and soluble material (positive wormicidal) by petroleum ether solvent.
The wormicidal substance was separated in the silica gel column chromatography from the petroleum ether extract, using benzene (90 percent) and acetone (10 percent) as a solvent. The anthelmintic activity was observed in vitro on the cercaria, the excysted metacercaria and the adult of Clonorchis sinensis. On the silica gel thin layer chromatography with the wormicidal substance in benzene:acetone/90:10, five spots were observed in iodine chamber and the spot of Rf. 0.18 value of them appeared the most strong wormicidal effect on the cercaria of C.
sinensis. Afterward, a substance which was equivalent to the Rf. 0.18 value spot was isolated from the wormicidal substance by means of silica gel column chromatography using 1 part of ethyl acetate and 6 parts of chloroform carrier, and the excysted matacercaria and the adult of C. sinensis were killed within 14 minutes and 128 minutes in the substance.
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The wormicidal substances of fresh water fishes on Clonorchis sinensis VII. The effect of linoleic acid and ethyl linoleate on parasite viability Jae Ku Rhee, Sang Bork Lee, Pyung Gil Kim The Korean Journal of Parasitology.1988; 26(3): 175. CrossRef
Larvicidal action of liquid nitrogen against metacercariae of Clonorchis sinensis Soo Bok Song The Korean Journal of Parasitology.1987; 25(2): 123. CrossRef
The wormicidal substance of fresh water fishes on Clonorchis sinensis V. Purification and chemical characterization of clonorchicidal substance from epidermal mucus of Cyprinus carpio Jae Ku Rhee, Sang Bork Lee, Byung Zun Ahn The Korean Journal of Parasitology.1984; 22(1): 127. CrossRef
Experimental Infection of Clonorchis sinensis to Cyprinus carpio nudus Jae Ku Rhee, Pyung Gil Kim, Byeong Kirl Baek, Sang Bork Lee, Byung Zun Ahn The Korean Journal of Parasitology.1983; 21(1): 11. CrossRef
The wormicidal substance of fresh water fishes on Clonorchis sinensis IV. Preliminary research on the wormicidal substance from mucus of Cyprinus carpio nudus Jae Ku Rhee, Pyung Gil Kim, Byeong Kirl Baek, Sang Bork Lee, Byung Zun Ahn The Korean Journal of Parasitology.1983; 21(1): 21. CrossRef
In an attempt to determine the incidence of the cercarial larvae of trematodes, Semisulcospira snails collected in Judong stream, an endemic area of Paragonimus westermani, in Kyungpook Province, Korea, were examined from 1965 to 1980.
The infestation rate for cercariae in the snails was 5.4 per cent, but in 1970 dropped to 4.0 per cent and remained at the same level, 4.2 per cent, in 1975. It then decreased to 3.5 per cent in 1980. Seven species of cercariae, Cercaria incerta(Kobayashi, 1992) Faust, 1924, Cercaria nipponensis(Ando, 1915) Faust, 1924, Cercaria yoshidae(Osafune, 1898) Cort et Nichols, 1920, Centrocestus armatus(Tanabe, 1922) Yamaguti, 1934, Metagonimus species, Notocotylus magniovatus Yamaguti, 1934, and Paragonimus westermani(Kerbert, 1878), and five kinds of undeterminced cercariae were found. Of these, the most freqently emerged cercaria was Metagonimus species, folllowed by Notocotylus magniovatus. The least freqently emerged was Paragonimus westermani, with the rate of 0.04 per cent. The liberation rates in the five kinds of undetermined species varied from 0.04 to 0.15 per cent. In the monthly liberaton rates for cercariae, the highest rate was encountered in May, and decreased in the period from June to November. It then somewhat increased again in December. There was no correlation in the liberation rate for cercariae and length of snails. The results of this study indicate that the infestation of Semisulcospira snails with the cercariae of trematodes has decreased over the fifteen year period from 1965 to 1980.
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Paragonimus and paragonimiasis in Korea D W Choi The Korean Journal of Parasitology.1990; 28(Suppl): 79. CrossRef
Studies on the Metagonimus fluke in the Daecheong reservoir and the upper stream of Geum river, Korea Chong Hwan Kim, Nam Man Kim, Chan Hyun Lee, Jin Suk Park The Korean Journal of Parasitology.1987; 25(1): 69. CrossRef
Epidemiological survey of Paragonimus westermani in Ulchin County, Kyungpook Province, Korea Chong Yoon Joo, Sung Hoon Ahn, Young Choon Park The Korean Journal of Parasitology.1985; 23(1): 102. CrossRef
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Changes of abdominal organs in early paragonimiasis are described in dogs and cats. Experimental infection was induced by feeding 40-50 and 20-30 metacercariae of Paragonimus westermani to 15 dogs and 15 cats respectively.
These animals were killed sequentially starting from 8 days to 120 days after infection. Complete autopsies were carried out in all animals and the tissues were examined microscopically with the main emphasis on changes of the liver and the diaphragm. A definite bout of acute diffuse fibrinoexudative peritonitis with ascites ranging from 5 to 20 ml was present in both dogs and cats at the time of 20 days after infection. This was also the period of the maximum liver damage and diaphragmatic injuries. The peritonitic changes became minimized after 45 days of infection. The liver changes were of two folds. The first one was characterized by numerous pin-point or linear tissue defects on the surface of the lobes, which were often covered with fibrin clots. Some of these defects were impacted by the larvae. These 'scratch' marks appeared to be of mechanical effect, and the margins were often banal without a significant inflammatory reaction. The scratch marks were no longer observed in animals examined after 45 days. The second was noted in the Kupffer cells of the liver. A large amount of hemosiderin pigment was noted in the Kupffer cells and became prominent by 20 days through 45 days. Hemosiderin-laden macrophages were found also in the spleens of these animals. Some animals in 30 days group showed the most Kupffer cells heavily loaded with hemosiderin. However, no associated degenerative changes were noted in these cells. The diaphragm was quite unique in early phase of infection in all animals examined. Numerous pinpoint perforative lesions could definitely be seen grossly, and some of these lesions included migrating larval worms inside the tunnels. These lesions were microscopically characterized by tract or tunnel formation with accompanying tissue reaction. The diaphragmatic changes were manifest by 20 days after infection. The tracts of tunnels appeared to have been made by pressure necrosis and surrounding edema, and subsequently were associated with a massive eosinophilic influx and myocytolysis. The eosinophilic abscess and multinucleated giant cells were often observed in the animals of the 30 days group. The diaphragmatic changes seemed to be repaired with or without fibrous scar formation which was occasionally seen in 45 days and later.
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A total of 28 adult cases who were confirmed cysticercosis with or without cerebral involvements were treated with praziquantel at the daily dose of 3 x 25mg/kg for 3 to 7 consecutive days and was evaluated for tolerance and therapeutic effects in the trials clinically performed.The assessment of drug efficacy of praziquantel in the dermal cysticercosis was made by comparing the numbers of cysticercus nodules and histopathological findings of the biopsied parasites by means of light, scanning and transmission electron microscope. In the cerebral cysticercosis, the assessment was considered by the frequency of the episodes of convulsive seizure before and after treatment with praziquantel and by the findings of the disapearance or decreased densities of the lesions in C.T.
scan in comparison with those of before and after treatment.
The results were as follows: The cysticerci in the subcutaneous tissues began to disappear within one month of drug administration of 3 x 25mg/kg praziquantel over 3 to 7 days. Within 3 to 6 months most of the cysticerci had disappeared, although in some case a small number of cysticercus nodules remained even one year after treatment.
Histological observation of the cysticerci biopsied at different times during the course of treatment revealed that morphological changes were already taking place within two weeks after the treatment. At the early stage of the treatment, small vacuoles were scattered along the basement layer in the tegumental syncytium of the scolex and neck regions. In the scanning electron microscopic observation, marked surface changes were present in the neck region with many bleb-like structures formed by the bursting of the large vacuoles in the tegumental syncytium. In the specimens biopsied at 2 or 5 weeks after treatment, the degenerations and necrosis of the tegumental syncytium were seen in all parts of cysticercus. In 12 cases of cerebral cysticercosis treated with praziquantel at the daily dose of 3 x 35 mg/kg for 3 or 4 consecutive days, there were no ceasing of the convulsive seizures during the 6 months follow-up. Among them 9 cases were given again the same doses of the drug for 4 or 7 days. In 7 of 9 cases, no more convulsive seizure was experienced over one or two years after the second time. At the same treatment the lesions of the brain C.T. scan disappeared, decreasd in size or calcified after treatment.
In other 3 cerebral cysticercosis cases, complete cure was also obtained after the oral medication of praziquantel at the daily dose of 3 x 25 mg/kg for 7 consecutive days. In the treatment of cerebral cysticercosis with praziquantel, it was found that the concomitant oral medication of dexamethasone during the course of treatment was effective for preventing and minimizing the side-effects.
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A case of ectopic fascioliasis involving cecum and ascending colon was reported. This case was a 19-year old Korean female who had a history of postprandial aggravation of intermittent abdominal pain of 3 weeks duration. She was presented with an abdominal mass in the right upper quadrant, for which an operation(right hemicolectomy) was performed. Whole cecum and ascending colon showed multifocal tunnel-like necrotizing granulmas with central cavitations.
Numerous Charcot-Leyden crystals were seen along tracts of the worm. The lesion was distributed throughout the entire thickness of the wall. Parasitological examination confirmed the worm found in the intestinal wall to be juvenile form of Fasciola species. Possibilities were discussed on the localization of the fluke and the mode of infection of present case.
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The wormicidal substances of fresh water fishes on Clonorchis sinensis VII. The effect of linoleic acid and ethyl linoleate on parasite viability Jae Ku Rhee, Sang Bork Lee, Pyung Gil Kim The Korean Journal of Parasitology.1988; 26(3): 175. CrossRef
The wormicidal substance of fresh water fishes on Clonorchis sinensis V. Purification and chemical characterization of clonorchicidal substance from epidermal mucus of Cyprinus carpio Jae Ku Rhee, Sang Bork Lee, Byung Zun Ahn The Korean Journal of Parasitology.1984; 22(1): 127. CrossRef
Experimental Infection of Clonorchis sinensis to Cyprinus carpio nudus Jae Ku Rhee, Pyung Gil Kim, Byeong Kirl Baek, Sang Bork Lee, Byung Zun Ahn The Korean Journal of Parasitology.1983; 21(1): 11. CrossRef
The wormicidal substance of fresh water fishes on Clonorchis sinensis IV. Preliminary research on the wormicidal substance from mucus of Cyprinus carpio nudus Jae Ku Rhee, Pyung Gil Kim, Byeong Kirl Baek, Sang Bork Lee, Byung Zun Ahn The Korean Journal of Parasitology.1983; 21(1): 21. CrossRef
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