Acanthamoeba castellanii has ubiquitous distribution and causes primary acanthamoebic keratitis (AK). AK is a common disease in contact lens wearers and results in permanent visual impairment or blindness. In this study, we observed the cytopathic effect, in vitro cytotoxicity, and secretion pattern of cytokines in human corneal epithelial cells (HCECs) induced by A. castellanii trophozoites and/or cysts. Morphological observation revealed that panked dendritic HCECs co-cultured with amoeba cysts had changed into round shape and gradually died. Such changes were more severe in co-culture with cyst than those of co-cultivation with trophozoites. In vitro cytotoxicity assay revealed the highest cytotoxicity to HCECs in the co-culture system with amoeba cysts. A. castellanii induced the expression of IL-1α, IL-6, IL-8, and CXCL1 in HCECs. Secreted levels of IL-1α, IL-6, and IL-8 in HCECs co-cultured with both trophozoites and cysts were increased at an early incubation time (3 and 6 hr). These results suggested that cytopathic changes and pro-inflammatory cytokines release of HCECs in response to A. castellanii, especially amoebic cysts, are an important mechanism for AK development.
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Comparative analysis of essential oil efficacy against the Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae) Mohammad Saiful Islam, Md. Samiul Haque, Myung-Jo You Parasites, Hosts and Diseases.2024; 62(2): 217. CrossRef
Molecular cloning, identification, transcriptional analysis, and silencing of enolase on the life cycle of Haemaphysalis longicornis (Acari, Ixodidae) tick Md. Samiul Haque, Md. Khalesur Rahman, Mohammad Saiful Islam, Myung-Jo You Parasites, Hosts and Diseases.2024; 62(2): 226. CrossRef
Haemaphysalis flava ticks as a competent vector of severe fever with thrombocytopenia syndrome virus Li-Zhu Fang, Xiao Xiao, Si-Cong Lei, Jian-Wei Liu, Xue-Jie Yu Ticks and Tick-borne Diseases.2023; 14(2): 102100. CrossRef
Detailed new insights about tick infestations in domestic ruminant groups: a global systematic review and meta-analysis Hassan Nasirian Journal of Parasitic Diseases.2022; 46(2): 526. CrossRef
Utility of ultra-rapid real-time PCR for detection and prevalence of Rickettsia spp. in ticks A-Tai Truong, Bo-Ram Yun, Mi-Sun Yoo, Jiyeon Lim, Subin Min, Soon-Seek Yoon, Young-Min Yun, Jong-Taek Kim, Yun Sang Cho BMC Veterinary Research.2022;[Epub] CrossRef
Geographic distribution and modeling of ticks in the Republic of Korea and the application of tick models towards understanding the distribution of associated pathogenic agents Heidi K. St. John, Penny Masuoka, Ju Jiang, Ratree Takhampunya, Terry A. Klein, Heung-Chul Kim, Sung-Tae Chong, Jin-Won Song, Yu-Jin Kim, Christina M. Farris, Allen L. Richards Ticks and Tick-borne Diseases.2021; 12(4): 101686. CrossRef
Real-time PCR biochip for on-site detection of Coxiella burnetii in ticks A.-Tai Truong, Bo-Ram Yun, Jiyeon Lim, Subin Min, Mi-Sun Yoo, Soon-Seek Yoon, Young-Min Yun, Jong-Taek Kim, Yun Sang Cho Parasites & Vectors.2021;[Epub] CrossRef
Transmission Dynamics of African Swine Fever Virus, South Korea, 2019 Dae Sung Yoo, Younjung Kim, Eune Sub Lee, Jun Sik Lim, Seong Keun Hong, Il Seob Lee, Chung Sik Jung, Ha Chung Yoon, Sung Hwan Wee, Dirk U. Pfeiffer, Guillaume Fournié Emerging Infectious Diseases.2021; 27(7): 1909. CrossRef
Hard Ticks as Vectors Tested Negative for Severe Fever with Thrombocytopenia Syndrome in Ganghwa-do, Korea during 2019-2020 Kyoung Jin, Yeon-Ja Koh, Seong Kyu Ahn, Joonghee Cho, Junghwan Lim, Jaeyong Song, Jinyoung Lee, Young Woo Gong, Mun Ju Kwon, Hyung Wook Kwon, Young Yil Bahk, Tong-Soo Kim The Korean Journal of Parasitology.2021; 59(3): 281. CrossRef
iSeq 100 for metagenomic pathogen screening in ticks Ju Yeong Kim, Myung-hee Yi, Alghurabi Areej Sabri Mahdi, Tai-Soon Yong Parasites & Vectors.2021;[Epub] CrossRef
Microbiome of Haemaphysalis longicornis Tick in Korea Myungjun Kim, Ju Yeong Kim, Myung-hee Yi, In-Yong Lee, Dongeun Yong, Bo-Young Jeon, Tai-Soon Yong The Korean Journal of Parasitology.2021; 59(5): 489. CrossRef
Estimating severe fever with thrombocytopenia syndrome transmission using machine learning methods in South Korea Giphil Cho, Seungheon Lee, Hyojung Lee Scientific Reports.2021;[Epub] CrossRef
Molecular and Phylogenetic Analysis of Tick-Borne Pathogens in Ticks Parasitizing Native Korean Goats (Capra hircus coreanae) in South Korea Min-Goo Seo, Oh-Deog Kwon, Dongmi Kwak Pathogens.2020; 9(2): 71. CrossRef
Four Year Surveillance of the Vector Hard Ticks for SFTS, Ganghwa-do, Republic of Korea Myung-Deok Kim-Jeon, Seung Jegal, Hojong Jun, Haneul Jung, Seo Hye Park, Seong Kyu Ahn, Jinyoung Lee, Young Woo Gong, Kwangsig Joo, Mun Ju Kwon, Jong Yul Roh, Wook-Gyo Lee, Young Yil Bahk, Tong-Soo Kim The Korean Journal of Parasitology.2019; 57(6): 691. CrossRef
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