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Volume 52(6); December 2014

Mini Review

Recent Advances in Toxoplasma gondii Immunotherapeutics
Sherene Swee-Yin Lim, Rofina Yasmin Othman
Korean J Parasitol 2014;52(6):581-593.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.581

Toxoplasmosis is an opportunistic infection caused by the protozoan parasite Toxoplasma gondii. T. gondii is widespread globally and causes severe diseases in individuals with impaired immune defences as well as congenitally infected infants. The high prevalence rate in some parts of the world such as South America and Africa, coupled with the current drug treatments that trigger hypersensitivity reactions, makes the development of immunotherapeutics intervention a highly important research priority. Immunotherapeutics strategies could either be a vaccine which would confer a pre-emptive immunity to infection, or passive immunization in cases of disease recrudescence or recurrent clinical diseases. As the severity of clinical manifestations is often greater in developing nations, the development of well-tolerated and safe immunotherapeutics becomes not only a scientific pursuit, but a humanitarian enterprise. In the last few years, much progress has been made in vaccine research with new antigens, novel adjuvants, and innovative vaccine delivery such as nanoparticles and antigen encapsulations. A literature search over the past 5 years showed that most experimental studies were focused on DNA vaccination at 52%, followed by protein vaccination which formed 36% of the studies, live attenuated vaccinations at 9%, and heterologous vaccination at 3%; while there were few on passive immunization. Recent progress in studies on vaccination, passive immunization, as well as insights gained from these immunotherapeutics is highlighted in this review.

Citations

Citations to this article as recorded by  Crossref logo
  • In silico analysis and structural vaccinology prediction of Toxoplasma gondii ROP41 gene via immunoinformatics methods as a vaccine candidate
    Masoumeh Asadi, Ali Dalir Ghaffari, Fatemeh Mohammadhasani
    Current Research in Translational Medicine.2025; 73(1): 103475.     CrossRef
  • Toxoplasma gondii (GRA10): A Closer Glance Into Immunogenic and Biochemical Characteristics Using In Silico Approach
    Mahdi Khadem Mohammadi, Ali Dalir Ghaffari
    Parasite Immunology.2025;[Epub]     CrossRef
  • Design and immunological evaluation of a multi-epitope vaccine candidate against Toxoplasma gondii incorporating MIC13, GRA1, and SAG1 antigens in BALB/c mice
    Zahra Hosseininejad, Ahmad Daryani, Mahdi Fasihi-Ramandi, Hossein Asgarian-Omran, Tooran Nayeri, Samira Dodangeh, Afsaneh Amouei, Javad Javidnia, Sabah Mayahi, Shahabeddin Sarvi, Sargis A. Aghayan
    Food and Waterborne Parasitology.2025; 40: e00269.     CrossRef
  • Effective factors in the pathogenesis of Toxoplasma gondii
    Tooran Nayeri, Shahabeddin Sarvi, Ahmad Daryani
    Heliyon.2024; 10(10): e31558.     CrossRef
  • Nanoparticles as a Delivery System of Antigens for the Development of an Effective Vaccine against Toxoplasma gondii
    Carina Brito, Camila Lourenço, Joana Magalhães, Salette Reis, Margarida Borges
    Vaccines.2023; 11(4): 733.     CrossRef
  • Metallic Nanoparticles and Core-Shell Nanosystems in the Treatment, Diagnosis, and Prevention of Parasitic Diseases
    Grzegorz Król, Kamila Fortunka, Michał Majchrzak, Ewelina Piktel, Paulina Paprocka, Angelika Mańkowska, Agata Lesiak, Maciej Karasiński, Agnieszka Strzelecka, Bonita Durnaś, Robert Bucki
    Pathogens.2023; 12(6): 838.     CrossRef
  • Toxoplasmosis: stages of the protozoan life cycle and risk assessment in humans and animals for an enhanced awareness and an improved socio-economic status
    Esam S. Al-Malki
    Saudi Journal of Biological Sciences.2021; 28(1): 962.     CrossRef
  • Synergistic effect of GRA7 and profilin proteins in vaccination against chronic Toxoplasma gondii infection
    Nadia Arcon, Mariano S. Picchio, Ignacio M. Fenoy, Rosalía E. Moretta, Ariadna S. Soto, Matías D. Perrone Sibilia, Vanesa R. Sánchez, Cecilia A. Prato, María Virginia Tribulatti, Alejandra Goldman, Valentina Martin
    Vaccine.2021; 39(6): 933.     CrossRef
  • Evaluation of immunogenicity and protection of the Mic1-3 knockout Toxoplasma gondii live attenuated strain in the feline host
    Delphine Le Roux, Vitomir Djokic, Solen Morisse, Clément Chauvin, Vanessa Doré, Anne-Claire Lagrée, Déborah Voisin, Yohan Villain, Aurélie Grasset-Chevillot, Fanny Boursin, Chunlei Su, Sébastien Perrot, Isabelle Vallée, Edouard Seche, Radu Blaga
    Vaccine.2020; 38(6): 1457.     CrossRef
  • A Review on the Prevalence of Toxoplasma gondii in Humans and Animals Reported in Malaysia from 2008–2018
    Mohammed Nasiru Wana, Mohamad Aris Mohd Moklas, Malaika Watanabe, Norshariza Nordin, Ngah Zasmy Unyah, Sharif Alhassan Abdullahi, Ashraf Ahmad Issa Alapid, Tijjani Mustapha, Rusliza Basir, Roslaini Abd. Majid
    International Journal of Environmental Research and Public Health.2020; 17(13): 4809.     CrossRef
  • In Silico Prediction of T and B Cell Epitopes of SAG1-Related Sequence 3 (SRS3) Gene for Developing Toxoplasma gondii Vaccine
    Abolfazl Mirzadeh, Geita Saadatnia, Majid Golkar, Jalal Babaie, Samira Amiri, Asiyeh Yoosefy
    Archives of Clinical Infectious Diseases.2020;[Epub]     CrossRef
  • Rhoptry antigens asToxoplasma gondiivaccine target
    Masoud Foroutan, Fatemeh Ghaffarifar, Zohreh Sharifi, Abdolhosein Dalimi, Ogholniaz Jorjani
    Clinical and Experimental Vaccine Research.2019; 8(1): 4.     CrossRef
  • Treatment of toxoplasmosis: Current options and future perspectives
    Neda Konstantinovic, Hélène Guegan, Tijana Stäjner, Sorya Belaz, Florence Robert-Gangneux
    Food and Waterborne Parasitology.2019; 15: e00036.     CrossRef
  • In silico analysis and expression of a novel chimeric antigen as a vaccine candidate against Toxoplasma gondii
    Samira Dodangeh, Mahdi Fasihi-Ramandi, Ahmad Daryani, Reza Valadan, Shahabeddin Sarvi
    Microbial Pathogenesis.2019; 132: 275.     CrossRef
  • Evaluation of Anti-Toxoplasma gondii Immune Responses in BALB/c Mice Induced by DNA Vaccines Encoding Surface Antigen 1 (SAG1) and 3 (SAG3)
    H. Sobati, A. Dalimi, B. Kazemi, F. Ghaffarifar
    Molecular Genetics, Microbiology and Virology.2019; 34(1): 59.     CrossRef
  • The course of infection with Toxoplasma gondii RH strain in mice pre-vaccinated with gamma irradiated tachyzoites
    Ahmed M. Gomaa, Nora L. El-Tantawy, Aliaa M. Elsawey, Ramy A. Abdelsalam, Manar S. Azab
    Experimental Parasitology.2019; 205: 107733.     CrossRef
  • Plant-derived chimeric antibodies inhibit the invasion of human fibroblasts byToxoplasma gondii
    Sherene Swee Yin Lim, Kek Heng Chua, Greta Nölke, Holger Spiegel, Wai Leong Goh, Sek Chuen Chow, Boon Pin Kee, Rainer Fischer, Stefan Schillberg, Rofina Yasmin Othman
    PeerJ.2018; 6: e5780.     CrossRef
  • Characterization of a multi-epitope peptide with selective MHC-binding capabilities encapsulated in PLGA nanoparticles as a novel vaccine candidate against Toxoplasma gondii infection
    Mona Roozbehani, Reza Falak, Mohsen Mohammadi, Andrew Hemphill, Elham Razmjou, Ahmad reza Meamar, Leila Masoori, Majid Khoshmirsafa, Maryam Moradi, Mohammad Javad Gharavi
    Vaccine.2018; 36(41): 6124.     CrossRef
  • Synergic in vitro combinations of artemisinin, pyrimethamine and methylene blue against Neospora caninum
    Luiz Miguel Pereira, Gabriela de Luca, Nathália de Lima Martins Abichabki, Cássia Mariana Bronzon da Costa, Ana Patrícia Yatsuda
    Veterinary Parasitology.2018; 249: 92.     CrossRef
  • Vaccine potential of antigen cocktails composed of recombinant Toxoplasma gondii TgPI-1, ROP2 and GRA4 proteins against chronic toxoplasmosis in C3H mice
    Mariano S. Picchio, Vanesa R. Sánchez, Nadia Arcon, Ariadna S. Soto, Matías Perrone Sibilia, María de los Angeles Aldirico, Mariela Urrutia, Rosalía Moretta, Ignacio M. Fenoy, Alejandra Goldman, Valentina Martin
    Experimental Parasitology.2018; 185: 62.     CrossRef
  • Calcium-dependent protein kinases are potential targets forToxoplasma gondiivaccine
    Masoud Foroutan, Fatemeh Ghaffarifar
    Clinical and Experimental Vaccine Research.2018; 7(1): 24.     CrossRef
  • Recent progress in microneme-based vaccines development againstToxoplasma gondii
    Masoud Foroutan, Leila Zaki, Fatemeh Ghaffarifar
    Clinical and Experimental Vaccine Research.2018; 7(2): 93.     CrossRef
  • A Systematic Review of In vitro and In vivo Activities of Anti-Toxoplasma Drugs and Compounds (2006–2016)
    Mahbobeh Montazeri, Mehdi Sharif, Shahabeddin Sarvi, Saeed Mehrzadi, Ehsan Ahmadpour, Ahmad Daryani
    Frontiers in Microbiology.2017;[Epub]     CrossRef
  • The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates
    Nicola Palmieri, Aruna Shrestha, Bärbel Ruttkowski, Tomas Beck, Claus Vogl, Fiona Tomley, Damer P. Blake, Anja Joachim
    International Journal for Parasitology.2017; 47(4): 189.     CrossRef
  • Immunization with Toxoplasma gondii aspartic protease 3 increases survival time of infected mice
    Guanghui Zhao, Xiaojie Song, Xiangnan Kong, Ning Zhang, Shaoling Qu, Wei Zhu, Yanyan Yang, Qian Wang
    Acta Tropica.2017; 171: 17.     CrossRef
  • Vaccination with recombinant adenovirus expressing multi-stage antigens ofToxoplasma gondiiby the mucosal route induces higher systemic cellular and local mucosal immune responses than with other vaccination routes
    Ting Wang, Huiquan Yin, Yan Li, Lingxiao Zhao, Xiahui Sun, Hua Cong
    Parasite.2017; 24: 12.     CrossRef
  • An evaluation of a recombinant multiepitope based antigen for detection of Toxoplasma gondii specific antibodies
    Khalid Hajissa, Robaiza Zakaria, Rapeah Suppian, Zeehaida Mohamed
    BMC Infectious Diseases.2017;[Epub]     CrossRef
  • Vaccination against parasites – status quo and the way forward
    Anja Joachim
    Porcine Health Management.2016;[Epub]     CrossRef
  • Immunization of Wistar female rats with 255-Gy-irradiated Toxoplasma gondii: Tissue parasitic load and lactogenic quantification
    Lucilene Granuzzio Camossi, Felipe Fornazari, Virgínia Bodelão Richini-Pereira, Rodrigo Costa da Silva, Daniel Fontana Ferreira Cardia, Helio Langoni
    Experimental Parasitology.2015; 154: 163.     CrossRef
  • Homologous prime-boost strategy with TgPI-1 improves the immune response and protects highly susceptible mice against chronic Toxoplasma gondii infection
    Vanesa R. Sánchez, Ignacio M. Fenoy, Mariano S. Picchio, Ariadna S. Soto, Nadia Arcon, Alejandra Goldman, Valentina Martin
    Acta Tropica.2015; 150: 159.     CrossRef
  • Seroprevalence of <i>Toxoplasma gondii</i> Among Primary School Children in Shandong Province, China
    Ke-Sheng Xin, Hui Liu, Hong-Bing Wang, Zong-Liang Yao
    The Korean Journal of Parasitology.2015; 53(4): 489.     CrossRef
  • In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum
    Pablo Winzer, Joachim Müller, Adriana Aguado-Martínez, Mahbubur Rahman, Vreni Balmer, Vera Manser, Luis Miguel Ortega-Mora, Kayode K. Ojo, Erkang Fan, Dustin J. Maly, Wesley C. Van Voorhis, Andrew Hemphill
    Antimicrobial Agents and Chemotherapy.2015; 59(10): 6361.     CrossRef
  • Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity
    Andrew J. Neville, Sydney J. Zach, Xiaofang Wang, Joshua J. Larson, Abigail K. Judge, Lisa A. Davis, Jonathan L. Vennerstrom, Paul H. Davis
    Antimicrobial Agents and Chemotherapy.2015; 59(12): 7161.     CrossRef
  • 14,430 View
  • 150 Download
  • 37 Web of Science
  • Crossref

Original Articles

Trichomonas vaginalis Metalloproteinase Induces mTOR Cleavage of SiHa Cells
Juan-Hua Quan, In-Wook Choi, Jung-Bo Yang, Wei Zhou, Guang-Ho Cha, Yu Zhou, Jae-Sook Ryu, Young-Ha Lee
Korean J Parasitol 2014;52(6):595-603.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.595

Trichomonas vaginalis secretes a number of proteases which are suspected to be the cause of pathogenesis; however, little is understood how they manipulate host cells. The mammalian target of rapamycin (mTOR) regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. We detected various types of metalloproteinases including GP63 protein from T. vaginalis trophozoites, and T. vaginalis GP63 metalloproteinase was confirmed by sequencing and western blot. When SiHa cells were stimulated with live T. vaginalis, T. vaginalis excretory-secretory products (ESP) or T. vaginalis lysate, live T. vaginalis and T. vaginalis ESP induced the mTOR cleavage in both time- and parasite load-dependent manner, but T. vaginalis lysate did not. Pretreatment of T. vaginalis with a metalloproteinase inhibitor, 1,10-phenanthroline, completely disappeared the mTOR cleavage in SiHa cells. Collectively, T. vaginalis metallopeptidase induces host cell mTOR cleavage, which may be related to survival of the parasite.

Citations

Citations to this article as recorded by  Crossref logo
  • Chromatin accessibility and gene expression in the parasite Trichomonas vaginalis
    Agustina Prat, Daniela Muñoz, Ayelen Lizarraga, Julieta Seifert-Gorzycki, Estefania Sanchez-Vazquez, Patricia J. Johnson, Pablo H. Strobl-Mazzulla, Natalia de Miguel
    BMC Infectious Diseases.2025;[Epub]     CrossRef
  • Metallopeptidases as Key Virulence Attributes of Clinically Relevant Protozoa: New Discoveries, Perspectives, and Frontiers of Knowledge
    Graziela Vargas Rigo, Fernanda Gomes Cardoso, Giulia Bongiorni Galego, Deisiane Fernanda da Rosa, André Luis Souza dos Santos, Tiana Tasca
    Current Protein & Peptide Science.2023; 24(4): 307.     CrossRef
  • VPS32, a member of the ESCRT complex, modulates adherence to host cells in the parasite Trichomonas vaginalis by affecting biogenesis and cargo sorting of released extracellular vesicles
    Nehuén Salas, Veronica M. Coceres, Tuanne dos Santos Melo, Antonio Pereira-Neves, Vanina G. Maguire, Tania M. Rodriguez, Bruna Sabatke, Marcel I. Ramirez, Jihui Sha, James A. Wohlschlegel, Natalia de Miguel
    Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
  • Adherent Bacteria and Parasiticidal Secretion Products of Human Cervicovaginal Microbiota-Associated Lactobacillus gasseri Confer Non-Identical Cell Protection against Trichomonas vaginalis-Induced Cell Detachment
    Bénédicte Pradines, Séverine Domenichini, Vanessa Lievin-Le Moal
    Pharmaceuticals.2022; 15(11): 1350.     CrossRef
  • The 50 kDa metalloproteinase TvMP50 is a zinc-mediated Trichomonas vaginalis virulence factor
    Jonathan Puente-Rivera, José Luis Villalpando, Alma Villalobos-Osnaya, Laura Isabel Vázquez-Carrillo, Gloria León-Ávila, María Dolores Ponce-Regalado, César López-Camarillo, Jose Miguel Elizalde-Contreras, Eliel Ruiz-May, Rossana Arroyo, María Elizbeth Al
    Molecular and Biochemical Parasitology.2017; 217: 32.     CrossRef
  • Regulation of exosomes released from normal ovarian epithelial cells and ovarian cancer cells
    Wei Zhang, Jiaxin Yang, Dongyan Cao, Yan You, Keng Shen, Peng Peng
    Tumor Biology.2016; 37(12): 15763.     CrossRef
  • Involvement of PI3K/AKT and MAPK Pathways for TNF-α Production in SiHa Cervical Mucosal Epithelial Cells Infected with <i>Trichomonas vaginalis</i>
    Jung-Bo Yang, Juan-Hua Quan, Ye-Eun Kim, Yun-Ee Rhee, Byung-Hyun Kang, In-Wook Choi, Guang-Ho Cha, Jae-Min Yuk, Young-Ha Lee
    The Korean Journal of Parasitology.2015; 53(4): 371.     CrossRef
  • 11,446 View
  • 103 Download
  • 7 Web of Science
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Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment
Kyoung-Ho Pyo, Bong-Kwang Jung, Chun-Feng Xin, You-Won Lee, Jong-Yil Chai, Eun-Hee Shin
Korean J Parasitol 2014;52(6):605-612.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.605

Toxoplasma gondii is an intracellular protozoan parasite that causes a Th1 cellular immunity. Our previous study showed that T. gondii lysate antigen (TLA) treatment in S180 tumor-bearing mice resulted in tumor reduction by suppressing CD31 expression, a marker of angiogenesis. In the present study, to investigate tumor suppressive effect of TLA under the absence of T lymphocytes, athymic nude mice were compared with euthymic mice in the anti-tumorigenic effect triggered by TLA in CT26 tumors. According to the results, intratumorally injected TLA reduced tumor growth and TIMP-1 level, a metastatic marker, in both euthymic and athymic mice. TLA treatment led to a sharp increase in IL-12 expression in serum cytokine profiling of athymic mice, and increased MyD88 signals in macrophages derived from the bone marrow, implying the activation of innate immunity. The selective induction of IL-12 by TLA treatment had an anti-tumorigenic effect.

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  • An Overview of the Dichotomous Role of Microbiota in Cancer Progression and Management
    Pooja Jain, Sradhanjali Mohapatra, Uzma Farooq, Nazia Hassan, Mohd. Aamir Mirza, Zeenat Iqbal
    Current Cancer Drug Targets.2025; 25(1): 38.     CrossRef
  • Bug as a drug: Unveiling anti-cancer properties of Toxoplasma gondii and its therapeutic prospects in cancer immunotherapy
    Yie Wei Chua, Sek Chuen Chow
    Acta Tropica.2025; 267: 107684.     CrossRef
  • From pathogen to cure: exploring the antitumor potential of Toxoplasma gondii
    Parisa Alipanahi, Arezou Khosrojerdi, Abdol Satar Pagheh, Kareem Hatam-Nahavandi, Ehsan Ahmadpour
    Infectious Agents and Cancer.2025;[Epub]     CrossRef
  • Bridging the gap for diverse applications of parasites as advanced cancer therapeutics: current progress and future directions
    Maha M. Eissa, Marwa H. El-Faham, Nahla El Skhawy
    Infectious Agents and Cancer.2025;[Epub]     CrossRef
  • Evaluation of Antitumor Effects of Toxoplasma gondii Different Antigens on Ehrlich Solid Carcinoma in Mice
    Salwa S. Younis, Basma M. Elmansory, Hend A. Elrefaey, Nahla A. Nasef, Sara H. Elakshar, Radwa A. Awad, Ghada A. Gamea
    Parasite Immunology.2025;[Epub]     CrossRef
  • A novel enemy of cancer: recent investigations into protozoan anti-tumor properties
    Zhi Zheng, Xiao Lu, Dong Zhou, Xu-feng Deng, Quan-xing Liu, Xiao-bing Liu, Jiao Zhang, Yan-qi Li, Hong Zheng, Ji-gang Dai
    Frontiers in Cellular and Infection Microbiology.2024;[Epub]     CrossRef
  • Parasite-enhanced immunotherapy: transforming the “cold” tumors to “hot” battlefields
    Yujun Xie, Jinyan Wang, Yafei Wang, Yalin Wen, Yanping Pu, Benfan Wang
    Cell Communication and Signaling.2024;[Epub]     CrossRef
  • Parasites revive hope for cancer therapy
    Maha M. Eissa, Ahmed Ebada Salem, Nahla El Skhawy
    European Journal of Medical Research.2024;[Epub]     CrossRef
  • Toxoplasma gondii-Derived Exosomes: A Potential Immunostimulant and Delivery System for Tumor Immunotherapy Superior to Toxoplasma gondii
    Lai-Xi Zhao, Qiong Sun, Chong Wang, Jia-Jia Liu, Xiao-Rong Yan, Meng-Ci Shao, Li Yu, Wen-Hua Xu, Rui Xu
    International Journal of Nanomedicine.2024; Volume 19: 12421.     CrossRef
  • Association of Neuroblastoma (NB) SH-SY5Y Cells with Antibodies of Parasitic Origin (Anti-Acanthamoeba and Anti-Toxocara canis)
    Víctor Alberto Maravelez Acosta, Maria de Lourdes Caballero Garcia, Genaro Patiño López, María del Pilar Crisóstomo Vázquez, Luz Ofelia Franco Sandoval, Leticia Eligio García
    International Journal of Molecular Sciences.2024; 25(24): 13577.     CrossRef
  • Promising effects of parasite-derived compounds on tumor regression: a systematic review of in vitro and in vivo studies
    Ali Asghari, Hassan Nourmohammadi, Hamidreza Majidiani, Seyyed Ali Shariatzadeh, Davood Anvari, Sadegh Shamsinia, Ezatollah Ghasemi, Morteza Shams, Gholam Basati
    Environmental Science and Pollution Research.2022; 29(22): 32383.     CrossRef
  • Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth
    Jiating Chen, Wenzhong Liao, HongJuan Peng
    Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
  • Neospora caninum inhibits tumor development by activating the immune response and destroying tumor cells in a B16F10 melanoma model
    Xiaojin Li, Meng Qi, Kai He, Haiyan Liu, Wenlan Yan, Lizhuo Zhao, Yanyan Jia, Lei He, Chaochao Lv, Min Zhang, Zhiguo Wei, Wenchao Yan, Tianqi Wang, Fuchang Yu, Weifeng Qian
    Parasites & Vectors.2022;[Epub]     CrossRef
  • Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections
    Ragab M. Fereig, Mosaab A. Omar, Abdullah F. Alsayeqh
    Vaccines.2022; 10(12): 2082.     CrossRef
  • Toxoplasma GRA16 Inhibits NF-κB Activation through PP2A-B55 Upregulation in Non-Small-Cell Lung Carcinoma Cells
    Seung-Hwan Seo, Sang-Gyun Kim, Ji-Hun Shin, Do-Won Ham, Eun-Hee Shin
    International Journal of Molecular Sciences.2020; 21(18): 6642.     CrossRef
  • Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53‐dependent apoptosis and anticancer effect
    Sang‐Gyun Kim, Seung‐Hwan Seo, Ji‐Hun Shin, Jung‐Pyo Yang, Sang Hyung Lee, Eun‐Hee Shin
    Journal of Cellular and Molecular Medicine.2019; 23(5): 3234.     CrossRef
  • Characteristics of Infection Immunity Regulated by Toxoplasma gondii to Maintain Chronic Infection in the Brain
    Young Sang Hwang, Ji-Hun Shin, Jung-Pyo Yang, Bong-Kwang Jung, Sang Hyung Lee, Eun-Hee Shin
    Frontiers in Immunology.2018;[Epub]     CrossRef
  • Microorganisms in the Treatment of Cancer: Advantages and Limitations
    Klaudia Łukasiewicz, Marek Fol
    Journal of Immunology Research.2018; 2018: 1.     CrossRef
  • The Neurotropic Parasite Toxoplasma gondii Induces Sustained Neuroinflammation with Microvascular Dysfunction in Infected Mice
    Vanessa Estato, Joice Stipursky, Fabiana Gomes, Tally C. Mergener, Edwards Frazão-Teixeira, Silvana Allodi, Eduardo Tibiriçá, Helene S. Barbosa, Daniel Adesse
    The American Journal of Pathology.2018; 188(11): 2674.     CrossRef
  • Puzzling and ambivalent roles of malarial infections in cancer development and progression
    ERIC FAURE
    Parasitology.2016; 143(14): 1811.     CrossRef
  • NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells
    Ya Hong Yuan, Chun Fang Zhou, Jiang Yuan, Li Liu, Xing Rong Guo, Xiao Li Wang, Yan Ding, Xiao Nan Wang, Dong Sheng Li, Han Jun Tu
    Oncology Letters.2016; 12(5): 3167.     CrossRef
  • Immune adjuvant effect of aToxoplasma gondiiprofilin-like protein in autologous whole-tumor-cell vaccination in mice
    Kyoung-Ho Pyo, You-Won Lee, Sun Min Lim, Eun-Hee Shin
    Oncotarget.2016; 7(45): 74107.     CrossRef
  • 14,300 View
  • 87 Download
  • 23 Web of Science
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Flavonoids Modulate the Proliferation of Neospora caninum in Glial Cell Primary Cultures
Rosan Barbosa de Matos, Suzana Braga-de-Souza, Bruno Pena Seara Pitanga, Victor Di?genes Amaral da Silva, Erica Etelvina Viana de Jesus, Alexandre Morales Pinheiro, Maria de F?tima Dias Costa, Ramon dos Santos El-Bacha, C?tia Suse de Oliveira Ribeiro, Silvia Lima Costa
Korean J Parasitol 2014;52(6):613-619.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.613

Neospora caninum (Apicomplexa; Sarcocystidae) is a protozoan that causes abortion in cattle, horses, sheep, and dogs as well as neurological and dermatological diseases in dogs. In the central nervous system of dogs infected with N. caninum, cysts were detected that exhibited gliosis and meningitis. Flavonoids are polyphenolic compounds that exhibit antibacterial, antiparasitic, antifungal, and antiviral properties. In this study, we investigated the effects of flavonoids in a well-established in vitro model of N. caninum infection in glial cell cultures. Glial cells were treated individually with 10 different flavonoids, and a subset of cultures was also infected with the NC-1 strain of N. caninum. All of the flavonoids tested induced an increase in the metabolism of glial cells and many of them increased nitrite levels in cultures infected with NC-1 compared to controls and uninfected cultures. Among the flavonoids tested, 3',4'-dihydroxyflavone, 3',4',5,7-tetrahydroxyflavone (luteolin), and 3,3',4',5,6-pentahydroxyflavone (quercetin), also inhibited parasitophorous vacuole formation. Taken together, our findings show that flavonoids modulate glial cell responses, increase NO secretion, and interfere with N. caninum infection and proliferation.

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  • A Dietary Plant Extract Formulation Helps Reduce Flea Populations in Cats: A Double-Blind Randomized Study
    Damien Banuls, Jessie Brun, Jean-Louis Blua, Marie Christine Cadiergues
    Pharmaceuticals.2023; 16(2): 195.     CrossRef
  • Nitric Oxide Production in mixed cultures of infected rats with Neospora caninum and treated with Jataí Honey (Tetragonisca angustula)
    Ângela Cristina de Oliveira Lima, Luciana dos Santos Freitas, Carlos Alfredo Lopes De Carvalho, Alexandre Moraes Pinheiro
    Archives of Health.2023; 4(1): 166.     CrossRef
  • The immunomodulatory activity of Chenopodium ambrosioides reduces the parasite burden and hepatic granulomatous inflammation in Schistosoma mansoni-infection
    João Gustavo Mendes Rodrigues, Paula Sibelly Veras Albuquerque, Johnny R Nascimento, Jaianna Andressa Viana Campos, Andressa S S Godinho, Sulayne Janayna Araújo, Jefferson Mesquita Brito, Caroline M Jesus, Guilherme Silva Miranda, Michelle C Rezende, Debo
    Journal of Ethnopharmacology.2021; 264: 113287.     CrossRef
  • Anti-helminthic activity of Momordica charantia L. against Fasciola hepatica eggs after twelve days of incubation in vitro
    Cíntia A.J. Pereira, Laura L.S. Oliveira, Aytube L. Coaglio, Fernanda S.O. Santos, Rodolfo S.M. Cezar, Tiago Mendes, Fernando L.P. Oliveira, Gustavo Conzensa, Walter S. Lima
    Veterinary Parasitology.2016; 228: 160.     CrossRef
  • Docking studies of flavonoid compounds as inhibitors of β-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli
    Ghalia Sabbagh, Noura Berakdar
    Journal of Molecular Graphics and Modelling.2015; 61: 214.     CrossRef
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  • 4 Web of Science
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Prevalence and Clinical Manifestations of Malaria in Aligarh, India
Umm-e Asma, Farha Taufiq, Wajihullah Khan
Korean J Parasitol 2014;52(6):621-629.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.621

Malaria is one of the most widespread infectious diseases of tropical countries with an estimated 207 million cases globally. In India, there are endemic pockets of this disease, including Aligarh. Hundreds of Plasmodium falciparum and P. vivax cases with severe pathological conditions are recorded every year in this district. The aim of this study is to find out changes in liver enzymes and kidney markers. Specific diagnosis for P. falciparum and P. vivax was made by microscopic examination of Giemsa stained slides. Clinical symptoms were observed in both of these infections. Liver enzymes, such as AST, ALT, and ALP, and kidney function markers, such as creatinine and urea, were estimated by standard biochemical techniques. In Aligarh district, P. vivax, P. falciparum, and mixed infections were 64%, 34%, and 2%, respectively. In case of P. falciparum infection, the incidences of anemia, splenomegaly, renal failure, jaundice, and neurological sequelae were higher compared to those in P. vivax infection. Recrudescence and relapse rates were 18% and 20% in P. falciparum and P. vivax infections, respectively. Liver dysfunctions and renal failures were more common in P. falciparum patients, particularly in elderly patients. Artesunate derivatives must, therefore, be introduced for the treatment of P. falciparum as they resist to chloroquine as well as sulfadoxine-pyrimethamine combinations.

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    Rika Bur, Erni Juwita Nelwan, Ira Danasasmita, Gardian Lukman Hakim, Syukrini Bahri, Febby Elvanesa Sandra Dewi, Rana Zara Athaya, Leonard Nainggolan
    Tropical Diseases, Travel Medicine and Vaccines.2024;[Epub]     CrossRef
  • Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses
    Xueyan Hu, Jie Zhao, Junhui Zhao, Ence Yang, Mozhi Jia
    Parasites & Vectors.2023;[Epub]     CrossRef
  • Clinical profile and severity of Plasmodium vivax and falciparum malaria in hospitalized children from North India
    Venkatesh Badugu, Bablu Kumar Gaur, Baljeet Maini
    Journal of Vector Borne Diseases.2023; 60(3): 252.     CrossRef
  • Antimalarial activity of solvent fractions of a leaf of Eucalyptus globulus labill against Plasmodium berghei infected mice
    Mihret Ayalew, Seyfe Asrade Atnafie, Azmeraw Bekele
    BMC Complementary Medicine and Therapies.2022;[Epub]     CrossRef
  • Predictors of treatment failures of plasmodium falciparum malaria in Vietnam: a 4-year single‐centre retrospective study
    Minh Cuong Duong, Oanh Kieu Nguyet Pham, Phong Thanh Nguyen, Van Vinh Chau Nguyen, Phu Hoan Nguyen
    Malaria Journal.2021;[Epub]     CrossRef
  • Clinical profile of malaria at a tertiary care teaching hospital in North India
    Ritu Karoli, Shobhit Shakya, Nikhil Gupta, Vineeta Mittal, Anil Kumar Upadhyay
    Tropical Parasitology.2021; 11(1): 25.     CrossRef
  • Anti-Malarial and Anti-Lipid Peroxidation Activities of Deferiprone-Resveratrol Hybrid in Plasmodium berghei-Infected Mice
    Hataichanok Chuljerm, Supawadee Maneekesorn, Voravuth Somsak, Yongmin Ma, Somdet Srichairatanakool, Pimpisid Koonyosying
    Biology.2021; 10(9): 911.     CrossRef
  • Clinical features and haematological parameters among malaria patients in Mangaluru city area in the southwestern coastal region of India
    Kishore Punnath, Kiran K. Dayanand, Valleesha N. Chandrashekar, Rajeshwara N. Achur, Srinivas B. Kakkilaya, Susanta K. Ghosh, Benudhar Mukhi, Vishal Midya, Suchetha N. Kumari, D. Channe Gowda
    Parasitology Research.2020; 119(3): 1043.     CrossRef
  • A micro-epidemiological report on the unstable transmission of malaria in Aligarh, India
    Sana Aqeel, Ansari Naheda, Adil Raza, Wajihullah Khan
    Parasite Epidemiology and Control.2020; 11: e00161.     CrossRef
  • Phenotypic characterization of acute headache attributed to SARS-CoV-2: An ICHD-3 validation study on 106 hospitalized patients
    Javier Trigo López, David García-Azorín, Álvaro Planchuelo-Gómez, Cristina García-Iglesias, Carlos Dueñas-Gutiérrez, Ángel L Guerrero
    Cephalalgia.2020; 40(13): 1432.     CrossRef
  • Comparative study of clinical presentation and hematological indices in hospitalized sickle cell patients with severe Plasmodium falciparum malaria
    Prasanta Purohit, Pradeep K. Mohanty, Siris Patel, Padmalaya Das, Jogeswar Panigrahi, Kishalaya Das
    Journal of Infection and Public Health.2018; 11(3): 321.     CrossRef
  • Severe thrombocytopaenia in patients with vivax malaria compared to falciparum malaria: a systematic review and meta-analysis
    Cho Naing, Maxine A. Whittaker
    Infectious Diseases of Poverty.2018;[Epub]     CrossRef
  • On the epidemiology of Plasmodium vivax malaria: past and present with special reference to the former USSR
    Anatoly V. Kondrashin, Lola F. Morozova, Ekaterina V. Stepanova, Natalia A. Turbabina, Maria S. Maksimova, Evgeny N. Morozov
    Malaria Journal.2018;[Epub]     CrossRef
  • Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon
    Petra F. Mens, Rik B. J. Kraan, Benjamin J. Visser, Sophia G. de Vries, Selidji T. Agnandji, Peter G. Kremsner, Rosanne W. Wieten, Danielle Kroon, François Danion, Lídia Ciudad Aguilar, Michèle van Vugt, Barbara Sjouke, Martin P. Grobusch, Akim A. Adegnik
    The American Journal of Tropical Medicine and Hygiene.2017; 96(5): 1205.     CrossRef
  • Utility of nested polymerase chain reaction over the microscopy and immuno-chromatographic test in the detection of Plasmodium species and their clinical spectrum
    P. Ranjan, U. Ghoshal
    Parasitology Research.2016; 115(9): 3375.     CrossRef
  • 11,721 View
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Plasmodium falciparum Genotype Diversity in Artemisinin Derivatives Treatment Failure Patients along the Thai-Myanmar Border
Kanungnit Congpuong, Thirasak Hoonchaiyapoom, Kornnarin Inorn
Korean J Parasitol 2014;52(6):631-637.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.631

Genetic characteristics of Plasmodium falciparum may play a role in the treatment outcome of malaria infection. We have studied the association between diversity at the merozoite surface protein-1 (msp-1), msp-2, and glutamate-rich protein (glurp) loci and the treatment outcome of uncomplicated falciparum malaria patients along the Thai-Myanmar border who were treated with artemisinin derivatives combination therapy. P. falciparum isolates were collected prior to treatment from 3 groups of patients; 50 cases of treatment failures, 50 recrudescences, and 56 successful treatments. Genotyping of the 3 polymorphic markers was analyzed by nested PCR. The distribution of msp-1 alleles was significantly different among the 3 groups of patients but not the msp-2 and glurp alleles. The allelic frequencies of K1 and MAD20 alleles of msp1 gene were higher while RO33 allele was significantly lower in the successful treatment group. Treatment failure samples had a higher median number of alleles as compared to the successful treatment group. Specific genotypes of msp-1, msp-2, and glurp were significantly associated with the treatment outcomes. Three allelic size variants were significantly higher among the isolates from the treatment failure groups, i.e., K1270-290, 3D7610-630, G650-690, while 2 variants, K1150-170, and 3D7670-690 were significantly lower. In conclusion, the present study reports the differences in multiplicity of infection and distribution of specific alleles of msp-1, msp-2, and glurp genes in P. falciparum isolates obtained from treatment failure and successful treatment patients following artemisinin derivatives combination therapy.

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  • Size and sequence polymorphisms in the glutamate-rich protein gene of the human malaria parasite Plasmodium falciparum in Thailand
    Sittiporn Pattaradilokrat, Chawinya Trakoolsoontorn, Phumin Simpalipan, Natapot Warrit, Morakot Kaewthamasorn, Pongchai Harnyuttanakorn
    Parasites & Vectors.2018;[Epub]     CrossRef
  • Genome-wide association analysis identifies genetic loci associated with resistance to multiple antimalarials in Plasmodium falciparum from China-Myanmar border
    Zenglei Wang, Mynthia Cabrera, Jingyun Yang, Lili Yuan, Bhavna Gupta, Xiaoying Liang, Karen Kemirembe, Sony Shrestha, Awtum Brashear, Xiaolian Li, Stephen F. Porcella, Jun Miao, Zhaoqing Yang, Xin-zhuan Su, Liwang Cui
    Scientific Reports.2016;[Epub]     CrossRef
  • 8,550 View
  • 89 Download
  • 2 Web of Science
  • Crossref
Congenital Malaria in Newborns Selected for Low Birth-Weight, Anemia, and Other Possible Symptoms in Maumere, Indonesia
Loeki Enggar Fitri, Natalia Erica Jahja, Irene Ratridewi Huwae, Mario B. Nara, Nicole Berens-Riha
Korean J Parasitol 2014;52(6):639-644.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.639

Congenital malaria is assumed to be a risk factor for infant morbidity and mortality in endemic areas like Maumere, Indonesia. Infected infants are susceptible to its impact such as premature labor, low birth weight, anemia, and other unspecified symptoms. The aim of this study was to investigate the prevalence of congenital malaria and the influence of mother-infant paired parasite densities on the clinical outcome of the newborns at TC Hillers Hospital, Maumere. An analytical cross sectional study was carried out in newborns which showed criteria associated with congenital malaria. A thick and thin blood smear confirmed by nested PCR was performed in both mothers and infants. The association of congenital malaria with the newborn's health status was then assessed. From 112 mother-infant pairs included in this study, 92 were evaluated further. Thirty-nine infants (42.4%) were found to be infected and half of them were asymptomatic. Infected newborns had a 4.7 times higher risk in developing anemia compared to uninfected newborns (95% CI, 1.3-17.1). The hemoglobin level, erythrocyte amount, and hematocrit level were affected by the infants' parasite densities (P<0.05). Focusing on newborns at risk of congenital malaria, the prevalence is almost 3 times higher than in an unselected collective. Low birth weight, anemia, and pre-term birth were the most common features. Anemia seems to be significantly influenced by infant parasite densities but not by maternal parasitemia.

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  • Physiologically based pharmacokinetic modelling to predict artemether and lumefantrine exposure in neonates weighing less than 5 kg treated with artemether–lumefantrine to supplement the clinical data from the CALINA study
    Helen Gu, Nada Abla, Vinay Kumar Venishetty, Birgit Schoeberl, Julia Zack, Heidi J. Einolf
    Tropical Medicine and Health.2025;[Epub]     CrossRef
  • Molecular prevalence and risk factors of plasmodial infection among parturients in Abengourou, Ivory Coast
    A. V. Bedia-Tanoh, A. Konaté-Touré, P. C. M. Kiki-Barro, A. P. Gnagne, A. J. S. Miezan, E. G. M. Koné, K. F. Kassi, K. E. Angora, V. H. Bosson, V. Djohan, E. I. H. Menan, W. Yavo
    Journal of Parasitology and Vector Biology.2025; 17(1): 1.     CrossRef
  • Pharmacokinetics, safety and efficacy of an optimized dose of artemether–lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in neonates and infants of less than 5 kg body weight: a multicentre, open-label, single-arm phase
    Gildas Wounounou, Alfred B. Tiono, Bernhards Ogutu, Christine Manyando, Issaka Sagara, Stefan Schneitter, Quique Bassat, Myriam El Gaaloul, Anne Claire Marrast, Ivan Demin, Cornelis Winnips, Celine Risterucci, Sophie Hugot, Georg Hofstetter, Zhiyan Qian,
    Tropical Medicine and Health.2025;[Epub]     CrossRef
  • Prospective study of malaria in pregnancy, placental and congenital malaria in Northwest Colombia
    Jaiberth Antonio Cardona-Arias, Jaime Carmona-Fonseca
    Malaria Journal.2024;[Epub]     CrossRef
  • Clinical and Parasitological Profiles of Gestational, Placental and Congenital Malaria in Northwestern Colombia
    Jaiberth Antonio Cardona-Arias, Luis Felipe Higuita-Gutiérrez, Jaime Carmona-Fonseca
    Tropical Medicine and Infectious Disease.2023; 8(6): 292.     CrossRef
  • Prevalence and proportion estimate of asymptomatic Plasmodium infection in Asia: a systematic review and meta-analysis
    Manas Kotepui, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Aongart Mahittikorn, Polrat Wilairatana
    Scientific Reports.2023;[Epub]     CrossRef
  • Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020
    Jaiberth Antonio Cardona-Arias, Jaime Carmona-Fonseca, Luzia Helena Carvalho
    PLOS ONE.2022; 17(2): e0263451.     CrossRef
  • Global prevalence of congenital malaria: A systematic review and meta-analysis
    Jalal A. Bilal, Elfatih E. Malik, Abdullah Al-Nafeesah, Ishag Adam
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2020; 252: 534.     CrossRef
  • Congenital Malaria and Its Associated Factors at Issaka Gazobi Maternity of Niamey in Niger
    I. Tahirou, M. O. Zara, M. L. Moustapha, M. Kamayé, D. Mahamadou, A. Ibrahim, M. Daou, A. Soumana, M. L. Ibrahim, Samuel Menahem
    International Journal of Pediatrics.2020; 2020: 1.     CrossRef
  • Congenital Malaria in Newborns Presented at Tororo General Hospital in Uganda: A Cross-Sectional Study
    Mumbere Hangi, Jane Achan, Aimé Saruti, Jacklyn Quinlan, Richard Idro
    The American Journal of Tropical Medicine and Hygiene.2019; 100(5): 1158.     CrossRef
  • Cotransmission of Malaria and HIV to Infants of Mothers Coinfected With Malaria and HIV in the HAART Era in Benin City, Nigeria
    Ayebo Sadoh, Fidelis E. Eki-Udoko
    JAIDS Journal of Acquired Immune Deficiency Syndromes.2018; 79(2): 255.     CrossRef
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Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR
Hwang-Yong Kim, In-Wook Choi, Yeon-Rok Kim, Juan-Hua Quan, Hassan Ahmed Hassan Ahmed Ismail, Guang-Ho Cha, Sung-Jong Hong, Young-Ha Lee
Korean J Parasitol 2014;52(6):645-652.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.645

Fasciola hepatica is a trematode that causes zoonosis mainly in cattle and sheep and occasionally in humans. Fascioliasis has been reported in Korea; however, determining F. hepatica infection in snails has not been done recently. Thus, using PCR, we evaluated the prevalence of F. hepatica infection in snails at 4 large water-dropwort fields. Among 349 examined snails, F. hepatica-specific internal transcribed space 1 (ITS-1) and/or ITS-2 markers were detected in 12 snails and confirmed using sequence analysis. Morphologically, 213 of 349 collected snails were dextral shelled, which is the same aperture as the lymnaeid snail, the vectorial host for F. hepatica. Among the 12 F. hepatica-infected snails, 6 were known first intermediate hosts in Korea (Lymnaea viridis and L. ollula) and the remaining 6 (Lymnaea sp.) were potentially a new first intermediate host in Korea. It has been shown that the overall prevalence of the snails contaminated with F. hepatica in water-dropwort fields was 3.4%; however, the prevalence varied among the fields. This is the first study to estimate the prevalence of F. hepatica infection using the vectorial capacity of the snails in Korea.

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  • Distribution and Fasciola infection rates of Lymnaea snails and cattle in high-salinity areas of Mekong Delta, Vietnam
    Dang Thi LOAN, Lam Thanh NGUYEN, Tran Ngoc BICH, Nguyen Thuy Y VI, Yasunobu MATSUMOTO
    Journal of Veterinary Medical Science.2025; 87(3): 291.     CrossRef
  • Susceptibility of lymnaeid snails to Fasciola hepatica and Fasciola gigantica (Digenea: Fasciolidae): a systematic review and meta-analysis
    Philile Ignecious Ngcamphalala, Ignore Nyagura, Mokgadi Pulane Malatji, Samson Mukaratirwa
    PeerJ.2025; 13: e18976.     CrossRef
  • Green vegetable juice as a potential source of human fascioliasis in Korea
    Sungim Choi, Sunghee Park, Sooji Hong, Hyejoo Shin, Bong-Kwang Jung, Min Jae Kim
    One Health.2022; 15: 100441.     CrossRef
  • Snail-borne parasitic diseases: an update on global epidemiological distribution, transmission interruption and control methods
    Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
    Infectious Diseases of Poverty.2018;[Epub]     CrossRef
  • Morphological Characterization of Emerging Cercariae among Lymnaeid Snails from Barangay Cawongan, Padre Garcia, Batangas, Philippines
    Gregorio L. Martin I, Esperanza C. Cabrera
    Journal of Parasitology Research.2018; 2018: 1.     CrossRef
  • A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea
    Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong
    The Korean Journal of Parasitology.2018; 56(4): 375.     CrossRef
  • Monitoring of Fasciola Species Contamination in Water Dropwort by COX1 Mitochondrial and ITS-2 rDNA Sequencing Analysis
    In-Wook Choi, Hwang-Yong Kim, Juan-Hua Quan, Jae-Gee Ryu, Rubing Sun, Young-Ha Lee
    The Korean Journal of Parasitology.2015; 53(5): 641.     CrossRef
  • Ectopic Human <i>Fasciola hepatica</i> Infection by an Adult Worm in the Mesocolon
    Ah Jin Kim, Chang Hwan Choi, Sun Keun Choi, Yong Woon Shin, Yun-Kyu Park, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, In Suh Park
    The Korean Journal of Parasitology.2015; 53(6): 725.     CrossRef
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  • 139 Download
  • 9 Web of Science
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Scolicidal Effects of Black Cumin Seed (Nigella sativa) Essential Oil on Hydatid Cysts
Hossein Mahmoudvand, Ebrahim Saedi Dezaki, Farnaz Kheirandish, Behrouz Ezatpour, Sareh Jahanbakhsh, Majid Fasihi Harandi
Korean J Parasitol 2014;52(6):653-659.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.653

Surgery remains the preferred treatment for hydatid cyst (cystic echinococcosis, CE). Various scolicidal agents have been used for inactivation of protoscolices during surgery, but most of them are associated with adverse side effects. The present study aimed to evaluate the in vitro scolicidal effect of Nigella sativa (Ranunculaceae) essential oil and also its active principle, thymoquinone, against protoscolices of hydatid cysts. Protoscolices were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (0.01-10 mg/ml) and thymoquinone (0.125-1.0 mg/ml) were used for 5 to 60 min. Viability of protoscolices was confirmed by 0.1% eosin staining. Furthermore, the components of the N. sativa essential oil were identified by gas chromatography/mass spectroscopy (GC/MS). Our study revealed that the essential oil of N. sativa at the concentration of 10 mg/ml and its main component, thymoquinone, at the concentration of 1 mg/ml had potent scolicidal activities against protoscolices of Echinococcus granulosus after 10 min exposure. Moreover, thymoquinone (42.4%), p-cymene (14.1%), carvacrol (10.3%), and longifolene (6.1%) were found to be the major components of N. sativa essential oil by GC/MS analysis. The results of this study indicated the potential of N. sativa as a natural source for production of a new scolicidal agent for use in hydatid cyst surgery. However, further studies will be needed to confirm these results by checking the essential oil and its active component in in vivo models.

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    Biomedicine & Pharmacotherapy.2022; 153: 113349.     CrossRef
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    Hao Wen, Lucine Vuitton, Tuerhongjiang Tuxun, Jun Li, Dominique A. Vuitton, Wenbao Zhang, Donald P. McManus
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  • 49 Web of Science
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Prevalence of Intestinal Helminths among Inhabitants of Cambodia (2006-2011)
Tai-Soon Yong, Jong-Yil Chai, Woon-Mok Sohn, Keeseon S. Eom, Hoo-Gn Jeoung, Eui-Hyug Hoang, Cheong-Ha Yoon, Bong-Kwang Jung, Soon-Hyung Lee, Muth Sinuon, Duong Socheat
Korean J Parasitol 2014;52(6):661-666.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.661

In order to investigate the status of intestinal helminthic infections in Cambodia, epidemiological surveys were carried out on a national scale, including 19 provinces. A total of 32,201 fecal samples were collected from schoolchildren and adults between 2006 and 2011 and examined once by the Kato-Katz thick smear technique. The overall egg positive rate of intestinal helminths was 26.2%. The prevalence of hookworms was the highest (9.6%), followed by that of Opisthorchis viverrini/minute intestinal flukes (Ov/MIF) (5.7%), Ascaris lumbricoides (4.6%), and Trichuris trichiura (4.1%). Other types of parasites detected were Enterobius vermicularis (1.1%), Taenia spp. (0.4%), and Hymenolepis spp. (0.2%). The northwestern regions such as the Siem Reap, Oddar Meanchey, and Banteay Meanchey Provinces showed higher prevalences (17.4-22.3%) of hookworms than the other localities. The southwestern areas, including Koh Kong and Preah Sihanouk Provinces showed higher prevalences of A. lumbricoides (17.5-19.2%) and T. trichiura (6.1-21.0%). Meanwhile, the central and southern areas, in particular, Takeo and Kampong Cham Provinces, showed high prevalences of Ov/MIF (23.8-24.0%). The results indicate that a considerably high prevalence of intestinal helminths has been revealed in Cambodia, and thus sustained national parasite control projects are necessary to reduce morbidity due to parasitic infections in Cambodia.

Citations

Citations to this article as recorded by  Crossref logo
  • Prevalence and Epidemiological Patterns of Enterobius vermicularis Infection in Thailand: A Systematic Review and Meta-Analysis
    Jurairat Jongthawin, Aongart Mahittikorn, Apiporn Thinkhamrop Suwannatrai, Chutima Rattanawan, Kinley Wangdi, Frederick Ramirez Masangkay, Manas Kotepui
    Medical Sciences.2025; 13(4): 207.     CrossRef
  • Prevalence of Foodborne Trematodes in Small Indigenous Fish Species in Local Markets of Phnom Penh, Cambodia
    Domenico Caruso, Lin Kong, Samnang Keo, Sreyni Yoeurn, Samphal Seng
    Vector-Borne and Zoonotic Diseases.2024; 24(3): 141.     CrossRef
  • Prevalence of Intestinal Helminths Among Mogadishu Residents Attending Somali Sudanese Specialized Hospital, Mogadishu, Somalia
    Motaz Mohammed
    American Journal of Laboratory Medicine.2024; 9(1): 8.     CrossRef
  • Evaluation of the diagnostic techniques in the detection of hookworm infestation among school children in Ethiopia: Cross-sectional study design
    Abebe Fenta, Destaw Kebede, Adane Tilahun, Bewket Mesganaw, Adane Adugna, Wubetu Yihunie, Habtamu Belew, Desalegn Abebaw, Gashaw Azanaw Amare
    Heliyon.2024; 10(21): e39936.     CrossRef
  • A study protocol for a multi-country cluster randomized controlled trial of the impact of a multi-component One Health strategy to eliminate Opisthorchis viverrini and soil transmitted helminths in the Lower Mekong Basin
    Mary Lorraine Mationg, Archie C. A. Clements, Gail M. Williams, Matthew Kelly, Donald E. Stewart, Catherine A. Gordon, Kinley Wangdi, Sirikachorn Tangkawattana, Apiporn T. Suwannatrai, Vanathom Savathdy, Visal Khieu, Sangduan Wannachart, Suji Yoo O’Connor
    Trials.2024;[Epub]     CrossRef
  • An Integrated Coproscopic and Molecular Method Provides Insights into the Epidemiology of Zoonotic Intestinal Helminths of Dogs across Cambodia
    Patsy A. Zendejas-Heredia, Vito Colella, Lucas G. Huggins, Roland Schaper, Bettina Schunack, Rebecca J. Traub, Long-Xian Zhang
    Transboundary and Emerging Diseases.2023; 2023: 1.     CrossRef
  • Global prevalence of 4 neglected foodborne trematodes targeted for control by WHO: A scoping review to highlight the gaps
    Rachel Tidman, Kaushi S. T. Kanankege, Mathieu Bangert, Bernadette Abela-Ridder, Paul R. Torgerson
    PLOS Neglected Tropical Diseases.2023; 17(3): e0011073.     CrossRef
  • High endemicity of Opisthorchis viverrini infection among people in northern Cambodia confirmed by adult worm expulsion
    Bong-Kwang Jung, Sooji Hong, Taehee Chang, Jaeeun Cho, Seungwan Ryoo, Keon Hoon Lee, Jeonggyu Lee, Woon-Mok Sohn, Sung-Jong Hong, Virak Khieu, Rekol Huy, Jong-Yil Chai
    Scientific Reports.2023;[Epub]     CrossRef
  • General overview of the current status of human foodborne trematodiasis
    Jong-Yil Chai, Bong-Kwang Jung
    Parasitology.2022; 149(10): 1262.     CrossRef
  • Prevalence and Associated Risk Factors of Human Intestinal Helminths Parasitic Infections in Ethiopia: A Systematic Review and Meta-Analysis
    Minichil Liyih, Destaw Damtie, Dires Tegen, Ahmad Mansour
    The Scientific World Journal.2022; 2022: 1.     CrossRef
  • Model-based spatial-temporal mapping of opisthorchiasis in endemic countries of Southeast Asia
    Ting-Ting Zhao, Yi-Jing Feng, Pham Ngoc Doanh, Somphou Sayasone, Virak Khieu, Choosak Nithikathkul, Men-Bao Qian, Yuan-Tao Hao, Ying-Si Lai
    eLife.2021;[Epub]     CrossRef
  • Prevalence of meat-transmitted Taenia and Trichinella parasites in the Far East countries
    Yi Liu, Zijian Dong, Jianda Pang, Mingyuan Liu, Xuemin Jin
    Parasitology Research.2021; 120(12): 4145.     CrossRef
  • Current status of human liver fluke infections in the Greater Mekong Subregion
    Banchob Sripa, Apiporn T. Suwannatrai, Somphou Sayasone, Dung Trung Do, Virak Khieu, Yichao Yang
    Acta Tropica.2021; 224: 106133.     CrossRef
  • Prevalence and Intensity of Opisthorchis viverrini Metacercarial Infection in Fish from Phnom Penh, Takeo, and Kandal Provinces, Cambodia
    Woon-Mok Sohn, Seung-Ho Choi, Bong-Kwang Jung, Sooji Hong, Seungwan Ryoo, Taehee Chang, Keon Hoon Lee, Byoung-Kuk Na, Sung-Jong Hong, Virak Khieu, Jong-Yil Chai
    The Korean Journal of Parasitology.2021; 59(5): 531.     CrossRef
  • Epidemiology of Taenia saginata taeniosis/cysticercosis: a systematic review of the distribution in East, Southeast and South Asia
    Ramon M. Eichenberger, Lian F. Thomas, Sarah Gabriël, Branco Bobić, Brecht Devleesschauwer, Lucy J. Robertson, Anastasios Saratsis, Paul R. Torgerson, Uffe C. Braae, Veronique Dermauw, Pierre Dorny
    Parasites & Vectors.2020;[Epub]     CrossRef
  • Morphological and Molecular Diagnosis of Necator americanus and Ancylostoma ceylanicum Recovered from Villagers in Northern Cambodia
    Taehee Chang, Bong-Kwang Jung, Woon-Mok Sohn, Sooji Hong, Hyejoo Shin, Seungwan Ryoo, Jeonggyu Lee, Keon Hoon Lee, Virak Khieu, Rekol Huy, Jong-Yil Chai
    The Korean Journal of Parasitology.2020; 58(6): 619.     CrossRef
  • Low-Grade Endemicity of Opisthorchiasis, Yangon, Myanmar
    Woon-Mok Sohn, Bong-Kwang Jung, Sung-Jong Hong, Keon-Hoon Lee, Jong-Bok Park, Hyun-Seung Kim, Seon Cho, Thi Thi Htoon, Htay Htay Tin, Jong-Yil Chai
    Emerging Infectious Diseases.2019; 25(7): 1435.     CrossRef
  • Thiamine dose response in human milk with supplementation among lactating women in Cambodia: study protocol for a double-blind, four-parallel arm randomised controlled trial
    Kyly C Whitfield, Hou Kroeun, Tim Green, Frank T Wieringa, Mam Borath, Prak Sophonneary, Jeffrey R Measelle, Dare Baldwin, Lisa N Yelland, Shalem Leemaqz, Kathleen Chan, Jelisa Gallant
    BMJ Open.2019; 9(7): e029255.     CrossRef
  • Molecular Identification of Trichuris suis and Trichuris trichiura Eggs in Human Populations from Thailand, Lao PDR, and Myanmar
    Rutchanee Rodpai, Issarapong Phosuk, Penchom Janwan, Tongjit Thanchomnang, Pewpan M. Intapan, Sakhone Laymanivong, Win Pa Pa Aung, Witthaya Anamnart, Oranuch Sanpool, Adulsak Wijit, Wanchai Maleewong, Lakkhana Sadaow
    The American Journal of Tropical Medicine and Hygiene.2018; 98(1): 39.     CrossRef
  • Strongyloides stercoralis and hookworm co-infection: spatial distribution and determinants in Preah Vihear Province, Cambodia
    Armelle Forrer, Virak Khieu, Fabian Schär, Penelope Vounatsou, Frédérique Chammartin, Hanspeter Marti, Sinuon Muth, Peter Odermatt
    Parasites & Vectors.2018;[Epub]     CrossRef
  • Prevalence of Intestinal Parasites and Associated Risk Factors for Infection among Rural Communities of Chachoengsao Province, Thailand
    Pisit Suntaravitun, Amornrat Dokmaikaw
    The Korean Journal of Parasitology.2018; 56(1): 33.     CrossRef
  • Concurrent infection of a young tourist by hookworm and Strongyloides stercoralis during low budget travel in Southeast Asia
    M. Wesołowska, W. Rymer, M. Kicia, M. Popiołek
    Helminthologia.2018; 55(2): 166.     CrossRef
  • Human liver fluke Opisthorchis viverrini (Trematoda, Opisthorchiidae) in Central Myanmar: New records of adults and metacercariae identified by morphology and molecular analysis
    Oranuch Sanpool, Win Pa Pa Aung, Rutchanee Rodpai, Wanchai Maleewong, Pewpan M. Intapan
    Acta Tropica.2018; 185: 149.     CrossRef
  • First report and molecular identification of Opisthorchis viverrini infection in human communities from Lower Myanmar
    Win Pa Pa Aung, Thi Thi Htoon, Htay Htay Tin, Kyi Kyi Thinn, Oranuch Sanpool, Jurairat Jongthawin, Lakkhana Sadaow, Issarapong Phosuk, Rutchanee Rodpai, Pewpan M. Intapan, Wanchai Maleewong, Petr Heneberg
    PLOS ONE.2017; 12(5): e0177130.     CrossRef
  • Molecular Characterization of Cryptosporidium Species and Giardia duodenalis from Symptomatic Cambodian Children
    Catrin E. Moore, Kristin Elwin, Nget Phot, Chanthou Seng, Saroeun Mao, Kuong Suy, Varun Kumar, Johanna Nader, Rachel Bousfield, Sanuki Perera, J. Wendi Bailey, Nicholas J. Beeching, Nicholas P. J. Day, Christopher M. Parry, Rachel M. Chalmers, James S McC
    PLOS Neglected Tropical Diseases.2016; 10(7): e0004822.     CrossRef
  • Improved Sanitation Facilities are Associated with Higher Body Mass Index and Higher Hemoglobin Concentration Among Rural Cambodian Women in the First Trimester of Pregnancy
    Timothy J. Green, Crystal D. Karakochuk, Judy McLean, Amynah Janmohamed
    The American Journal of Tropical Medicine and Hygiene.2016; 95(5): 1211.     CrossRef
  • A 13-Year Retrospective Study on Primary Liver Cancer in Cambodia: A Strikingly High Hepatitis C Occurrence among Hepatocellular Carcinoma Cases
    François Chassagne, Teresa Rojas Rojas, Stéphane Bertani, Geneviève Bourdy, Sokha Eav, Eloy Ruiz, Pascal Pineau, Eric Deharo
    Oncology.2016; 91(2): 106.     CrossRef
  • 12,148 View
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Case Reports

An Imported Case of Severe Falciparum Malaria with Prolonged Hemolytic Anemia Clinically Mimicking a Coinfection with Babesiosis
Young Ju Na, Jong-Yil Chai, Bong-Kwang Jung, Hyun Jung Lee, Ji Young Song, Ji Hye Je, Ji Hye Seo, Sung Hun Park, Ji Seon Choi, Min Ja Kim
Korean J Parasitol 2014;52(6):667-672.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.667

While imported falciparum malaria has been increasingly reported in recent years in Korea, clinicians have difficulties in making a clinical diagnosis as well as in having accessibility to effective anti-malarial agents. Here we describe an unusual case of imported falciparum malaria with severe hemolytic anemia lasting over 2 weeks, clinically mimicking a coinfection with babesiosis. A 48-year old Korean man was diagnosed with severe falciparum malaria in France after traveling to the Republic of Benin, West Africa. He received a 1-day course of intravenous artesunate and a 7-day course of Malarone (atovaquone/proguanil) with supportive hemodialysis. Coming back to Korea 5 days after discharge, he was readmitted due to recurrent fever, and further treated with Malarone for 3 days. Both the peripheral blood smears and PCR test were positive for Plasmodium falciparum. However, he had prolonged severe hemolytic anemia (Hb 5.6 g/dl). Therefore, 10 days after the hospitalization, Babesia was considered to be potentially coinfected. A 7-day course of Malarone and azithromycin was empirically started. He became afebrile within 3 days of this babesiosis treatment, and hemolytic anemia profiles began to improve at the completion of the treatment. He has remained stable since his discharge. Unexpectedly, the PCR assays failed to detect DNA of Babesia spp. from blood. In addition, during the retrospective review of the case, the artesunate-induced delayed hemolytic anemia was considered as an alternative cause of the unexplained hemolytic anemia.

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    Hyun Jung Kim, BoGyeong Han, Hee-Il Lee, Jung-Won Ju, Hyun-Il Shin
    Animals.2024; 14(7): 989.     CrossRef
  • Imported human babesiosis in the Republic of Korea, 2019: two case reports
    Hyun Jung Kim, Min Jae Kim, Hyun-Il Shin, Jung-Won Ju, Hee-Il Lee
    Parasites, Hosts and Diseases.2023; 61(1): 72.     CrossRef
  • Babesia microti alleviates disease manifestations caused by Plasmodium berghei ANKA in murine co-infection model of complicated malaria
    Iqra Zafar, Tomoyo Taniguchi, Hanadi B. Baghdadi, Daisuke Kondoh, Mohamed Abdo Rizk, Eloiza May Galon, Shengwei Ji, Shimaa Abd El-Salam El-Sayed, Thom Do, Hang Li, Moaz M. Amer, Ma Zhuowei, Ma Yihong, Jinlin Zhou, Noboru Inoue, Xuenan Xuan
    Frontiers in Cellular and Infection Microbiology.2023;[Epub]     CrossRef
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    Yao Wang, Qianqian Zhang, Wanruo Zhang, Junhu Chen, Jianfeng Dai, Xia Zhou
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    Artemis Efstratiou, Eloiza May S. Galon, Guanbo Wang, Kousuke Umeda, Daisuke Kondoh, Mohamad Alaa Terkawi, Aiko Kume, Mingming Liu, Aaron Edmond Ringo, Huanping Guo, Yang Gao, Seung-Hun Lee, Jixu Li, Paul Franck Adjou Moumouni, Yoshifumi Nishikawa, Hirosh
    Frontiers in Cellular and Infection Microbiology.2020;[Epub]     CrossRef
  • Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea
    Hea Yoon Kwon, Jae Hyoung Im, Yun-Kyu Park, Areum Durey, Jin-Soo Lee, Ji Hyeon Baek
    The Korean Journal of Parasitology.2018; 56(6): 609.     CrossRef
  • Delayed Diagnosis of Falciparum Malaria with Acute Kidney Injury
    Iee Ho Choi, Pyoung Han Hwang, Sam Im Choi, Dae-Yeol Lee, Min Sun Kim
    Journal of Korean Medical Science.2016; 31(9): 1499.     CrossRef
  • Malaria endemicity and co-infection with tissue-dwelling parasites in Sub-Saharan Africa: a review
    Nyamongo W. Onkoba, Moses J. Chimbari, Samson Mukaratirwa
    Infectious Diseases of Poverty.2015;[Epub]     CrossRef
  • Artesunate

    Reactions Weekly.2015; 1574(1): 36.     CrossRef
  • 10,643 View
  • 107 Download
  • 9 Web of Science
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Three Cases of Diphyllobothrium nihonkaiense Infection in Korea
Hong-Ja Kim, Keeseon S. Eom, Min Seo
Korean J Parasitol 2014;52(6):673-676.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.673

Until 2012, a total of 48 cases of diphyllobothriasis had been reported in Korea, all of which were morphologically identified as Diphyllobothrium latum. However, some of these specimens were analyzed by nucleotide sequencing of the mitochondrial cox1 gene, which showed that all were D. nihonkaiense, not D. latum. After that, 3 further cases of diphyllobothriasis were confirmed as D. nihonkaiense. In the present study, 3 new cases of D. nihonkaiense were detected from 2011 through 2013. The hosts were infected through consumption of salmonid fishes, such as the trout or salmon, and 2 of them experienced severe diarrhea prior to proglottid passage. All of the tapeworms were confirmed to be D. nihonkaiense by genetic identification. This proved again that most diphyllobothriasis in Korea have been caused by D. nihonkaiense.

Citations

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  • Locally acquired infection with Dibothriocephalus nihonkaiense (=Diphyllobothrium nihonkaiense) in France: the importance of molecular diagnosis
    Valentin Greigert, Julie Brunet, Alexander W. Pfaff, Jean-Philippe Lemoine, Ermanno Candolfi, Ahmed Abou-Bacar
    Parasitology Research.2020; 119(2): 513.     CrossRef
  • Epidemiology ofDiphyllobothrium nihonkaienseDiphyllobothriasis, Japan, 2001–2016
    Hiroshi Ikuno, Shinkichi Akao, Hiroshi Yamasaki
    Emerging Infectious Diseases.2018;[Epub]     CrossRef
  • Molecular Identification of Diphyllobothrium latum from a Pediatric Case in Taiwan
    Yu-Chin An, Chia-Cheng Sung, Chih-Chien Wang, Hsin-Chung Lin, Kuang-Yao Chen, Fu-Man Ku, Ruei-Min Chen, Mei-Li Chen, Kuo-Yang Huang
    The Korean Journal of Parasitology.2017; 55(4): 425.     CrossRef
  • Eggs as a Suitable Tool for Species Diagnosis of Causative Agents of Human Diphyllobothriosis (Cestoda)
    Kateřina Leštinová, Miroslava Soldánová, Tomáš Scholz, Roman Kuchta, Ricardo Toshio Fujiwara
    PLOS Neglected Tropical Diseases.2016; 10(5): e0004721.     CrossRef
  • Diphyllobothrium nihonkaiense: wide egg size variation in 32 molecularly confirmed adult specimens from Korea
    Seoyun Choi, Jaeeun Cho, Bong-Kwang Jung, Deok-Gyu Kim, Sarah Jiyoun Jeon, Hyeong-Kyu Jeon, Keeseon S. Eom, Jong-Yil Chai
    Parasitology Research.2015; 114(6): 2129.     CrossRef
  • Molecular Identification of <i>Diphyllobothrium nihonkaiense</i> from 3 Human Cases in Heilongjiang Province with a Brief Literature Review in China
    Weizhe Zhang, Fei Che, Song Tian, Jing Shu, Xiaoli Zhang
    The Korean Journal of Parasitology.2015; 53(6): 683.     CrossRef
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  • 8 Web of Science
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Extracorporeal Worm Extraction of Diphyllobothrium nihonkaiense with Amidotrizoic Acid in a Child
Hye Kyung Shin, Joo-Hyung Roh, Jae-Won Oh, Jae-Sook Ryu, Youn-Kyoung Goo, Dong-Il Chung, Yong Joo Kim
Korean J Parasitol 2014;52(6):677-680.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.677

Infection cases of diphyllobothriid tapeworms are not much in the below teen-age group. We report a case of Diphyllobothrium nihonkaiense infection in a 13-year-old boy. He presented with severe fatigue, occasional abdominal pain at night time. He also had several episodes of tapeworm segment discharge in his stools. By his past history, he had frequently eaten raw fish including salmon and trout with his families. Numerous eggs of diphyllobothriid tapeworm were detected in the fecal examination. We introduced amidotrizoic acid as a cathartic agent through nasogastroduodenal tube and let nearly whole length (4.75 m) of D. nihonkaiense be excreted through his anus. After a single dose of praziquantel, the child's stool showed no further eggs, and his symptoms disappeared. The evacuated worm was identified as D. nihonkaiense by mitochondrial cox1 gene analysis. Here we report a successful extracorporeal worm extraction from an infection case of D. nihonkaiense by the injection of amidotrizoic acid.

Citations

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  • Diphyllobothrium nihonkaiense: wide egg size variation in 32 molecularly confirmed adult specimens from Korea
    Seoyun Choi, Jaeeun Cho, Bong-Kwang Jung, Deok-Gyu Kim, Sarah Jiyoun Jeon, Hyeong-Kyu Jeon, Keeseon S. Eom, Jong-Yil Chai
    Parasitology Research.2015; 114(6): 2129.     CrossRef
  • 17,089 View
  • 115 Download
  • 2 Web of Science
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Human Sting of Cephalonomia gallicola (Hymenoptera: Bethylidae) in Korea
In-Yong Lee, Chang-Seob Shin, Seobo Sim, Jung-Won Park, Tai-Soon Yong
Korean J Parasitol 2014;52(6):681-684.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.681

Hymenoptera stings can cause serious injury to humans. We report the clinical findings of 6 cases of Hymenoptera stings. All patients developed painful erythematous papules at the sting sites and had a past history of parasitoid wasp sting. This is the first clinical report of the parasitoid wasp, Cephalonomia gallicola, causing human stings in Korea.

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  • Human ectoparasitoses caused by flat wasps of the genera Sclerodermus and Cephalonomia (Hymenoptera: Bethylidae)
    Paolo Masini, Luca Stingeni, Gianandrea Salerno, Valerio Saitta, Celso O Azevedo, Manuela Rebora, Matteo Ornielli, Katharina Hansel, Leonardo Bianchi, Gabriele Casciola
    Clinical and Experimental Dermatology.2025; 50(8): 1508.     CrossRef
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    Hassan Ghahari, Jongok Lim
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    Jan Hubert, Vaclav Stejskal, Christos G. Athanassiou, James E. Throne
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    Michael J Skvarla
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  • Bethylids attacking stored‐product pests: an overview
    Marco Amante, Matthias Schöller, Pompeo Suma, Agatino Russo
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  • Dermatitis caused by arthropods in domestic environment: an Italian multicentre study
    L. Stingeni, L. Bianchi, K. Hansel, D. Neve, C. Foti, M. Corazza, V. Bini, I. Moretta, M. Principato
    Journal of the European Academy of Dermatology and Venereology.2017; 31(9): 1526.     CrossRef
  • 17,753 View
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Perianal Tick-Bite Lesion Caused by a Fully Engorged Female Amblyomma testudinarium
Jin Kim, Haeng An Kang, Sung Sun Kim, Hyun Soo Joo, Won Seog Chong
Korean J Parasitol 2014;52(6):685-690.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.685

A perianal tick and the surrounding skin were surgically excised from a 73-year-old man residing in a southwestern costal area of the Korean Peninsula. Microscopically a deep penetrating lesion was formed beneath the attachment site. Dense and mixed inflammatory cell infiltrations occurred in the dermis and subcutaneous tissues around the feeding lesion. Amorphous eosinophilic cement was abundant in the center of the lesion. The tick had Y-shaped anal groove, long mouthparts, ornate scutum, comma-shaped spiracular plate, distinct eyes, and fastoons. It was morphologically identified as a fully engorged female Amblyomma testudinarium. This is the third human case of Amblyomma tick infection in Korea.

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  • A checklist of the ticks of Malaysia (Acari: Argasidae, Ixodidae), with lists of known associated hosts, geographical distribution, type localities, human infestations and pathogens
    ABDUL-RAHMAN KAZIM, JAMAL HOUSSAINI, DENNIS TAPPE, CHONG CHIN HEO
    Zootaxa.2022; 5190(4): 485.     CrossRef
  • Geographic distribution and modeling of ticks in the Republic of Korea and the application of tick models towards understanding the distribution of associated pathogenic agents
    Heidi K. St. John, Penny Masuoka, Ju Jiang, Ratree Takhampunya, Terry A. Klein, Heung-Chul Kim, Sung-Tae Chong, Jin-Won Song, Yu-Jin Kim, Christina M. Farris, Allen L. Richards
    Ticks and Tick-borne Diseases.2021; 12(4): 101686.     CrossRef
  • Francisella-Like Endosymbiont Detected in Haemaphysalis Ticks (Acari: Ixodidae) From the Republic of Korea
    Ratree Takhampunya, Heung-Chul Kim, Sung-Tae Chong, Achareeya Korkusol, Bousaraporn Tippayachai, Silas A Davidson, Jeannine M Petersen, Terry A Klein
    Journal of Medical Entomology.2017; 54(6): 1735.     CrossRef
  • Detection of SFTS Virus inIxodes nipponensisandAmblyomma testudinarium(Ixodida: Ixodidae) Collected From Reptiles in the Republic of Korea
    Jae-Hwa Suh, Heung-Chul Kim, Seok-Min Yun, Jae-Won Lim, Jin-Han Kim, Sung-Tae Chong, Dae-Ho Kim, Hyun-Tae Kim, Hyun Kim, Terry A. Klein, Jaree L. Johnson, Won-Ja Lee
    Journal of Medical Entomology.2016; 53(3): 584.     CrossRef
  • Tick Bite by NymphalAmblyomma testudinarium
    Yeong Ho Kim, Ji Hyun Lee, Young Min Park, Jun Young Lee
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  • Modulation of host immunity by tick saliva
    Jan Kotál, Helena Langhansová, Jaroslava Lieskovská, John F. Andersen, Ivo M.B. Francischetti, Triantafyllos Chavakis, Jan Kopecký, Joao H.F. Pedra, Michail Kotsyfakis, Jindřich Chmelař
    Journal of Proteomics.2015; 128: 58.     CrossRef
  • 12,305 View
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  • 10 Web of Science
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Brief Communications
Prevalence of Dirofilaria immitis Infection in Stray Cats by Nested PCR in Korea
Hyung-Jin Park, Sang-Eun Lee, Won-Ja Lee, Jung-Hyun Oh, Easwaran Maheswaran, Kyoung-Won Seo, Kun-Ho Song
Korean J Parasitol 2014;52(6):691-694.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.691

The purpose of this study was to conduct a survey of Dirofilaria immitis infection among stray cats in Korea using nested PCR. We included 235 stray cats (121 females and 114 males) and evaluated each for the presence of feline heartworm infection. Blood samples were collected from 135 cats in Daejeon, 50 cats in Seoul, and 50 cats from Gyeonggi-do (Province). Of the 235 DNA samples, 14 (6.0%) were positive for D. immitis. The prevalence of infection in male cats (8/114, 7.0%) tended to be higher than that in female cats (6/121, 5.0%), but the difference was not statistically significant. In each location, 8, 2, and 4 cats were positive for infection, respectively, based on DNA testing. No significant differences in the prevalence were observed among the geographic regions, although the rate of infection was higher in Gyeonggi-do (8.0%) than Daejeon (5.9%) and Seoul (4.0%). We submitted 7 of the 14 D. immitis DNA-positive samples for sequencing analysis. All samples corresponded to partial D. immitis cytochrome c oxidase subunit I gene sequences with 99% homology to the D. immitis sequence deposited in GenBank (accession no. FN391553). To the best of our knowledge, this is the first survey using nested PCR to analyze the prevalence of D. immitis in stray cats in Korea.

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  • Status of selected feline infectious diseases in Gwangju, Korea
    Juyeon Choi, Kyu-Sung Ahn, Ah-Jin Ahn, SungShik Shin
    Korean Journal of Veterinary Research.2023; 63(4): e31.     CrossRef
  • Evidence of Dirofilaria immitis in Felids in North-Eastern Italy
    Marika Grillini, Antonio Frangipane di Regalbono, Cinzia Tessarin, Paola Beraldo, Rudi Cassini, Erica Marchiori, Giulia Simonato
    Pathogens.2022; 11(10): 1216.     CrossRef
  • Prevalence of infection with Dirofilaria immitis in cats in Townsville, Australia
    Carl Adagra, Richard Squires, Angela Adagra, Jennifer Elliman, Constantin Constantinoiu
    Veterinary Parasitology: Regional Studies and Reports.2021; 24: 100580.     CrossRef
  • Seroprevalence of Dirofilaria immitis in Cats from Liaoning Province, Northeastern China
    Honglie Hou, Lili Cao, Wenzhi Ren, Dansheng Wang, He Ding, Juan You, Xinhua Yao, Hang Dong, Yanbing Guo, Shuxian Yuan, Xichen Zhang, Pengtao Gong
    The Korean Journal of Parasitology.2017; 55(6): 673.     CrossRef
  • Toxoplasma gondii, Dirofilaria immitis, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections in stray and pet cats (Felis catus) in northwest China: co-infections and risk factors
    Wei Cong, Qing-Feng Meng, Radu Blaga, Isabelle Villena, Xing-Quan Zhu, Ai-Dong Qian
    Parasitology Research.2016; 115(1): 217.     CrossRef
  • 11,310 View
  • 104 Download
  • 6 Web of Science
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Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.

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  • Liver Fluke-Derived Molecules Accelerate Skin Repair Processes in a Mouse Model of Type 2 Diabetes Mellitus
    Anna Kovner, Yaroslav Kapushchak, Oxana Zaparina, Dmitry Ponomarev, Maria Pakharukova
    International Journal of Molecular Sciences.2024; 25(22): 12002.     CrossRef
  • Exploring the role of macrophages in determining the pathogenesis of liver fluke infection
    Susel Loli Quinteros, Bronwyn O'Brien, Sheila Donnelly
    Parasitology.2022; 149(10): 1364.     CrossRef
  • Wound healing approach based on excretory-secretory product and lysate of liver flukes
    Anna V. Kovner, Alena A. Tarasenko, Oxana Zaparina, Olga V. Tikhonova, Maria Y. Pakharukova, Viatcheslav A. Mordvinov
    Scientific Reports.2022;[Epub]     CrossRef
  • The pathogenic potential of the combined action of chronic Opisthorchis felineus infection and repeated social defeat stress in C57BL/6 mice
    Damira Avgustinovich, Anna Kovner, Elena Kashina, Natalia Shatskaya, Galina Vishnivetskaya, Natalia Bondar, Maria Lvova
    International Journal for Parasitology.2021; 51(5): 353.     CrossRef
  • High macrophage activities are associated with advanced periductal fibrosis in chronic Opisthorchis viverrini infection
    Kanin Salao, Krongkarn Watakulsin, Eimorn Mairiang, Sutas Suttiprapa, Sirikachorn Tangkawattana, Steven W. Edwards, Banchob Sripa
    Parasite Immunology.2019;[Epub]     CrossRef
  • Chronic hepatitis C infection–induced liver fibrogenesis is associated with M2 macrophage activation
    Moses T. Bility, Kouki Nio, Feng Li, David R. McGivern, Stanley M. Lemon, Eoin R. Feeney, Raymond T. Chung, Lishan Su
    Scientific Reports.2016;[Epub]     CrossRef
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  • 8 Web of Science
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Molecular Characterization of Gastrothylax crumenifer (Platyhelminthes: Gastrothylacidae) from Goats in the Western Part of India by LSU of Nuclear Ribosomal DNA
Ashwani Kumar, Anshu Chaudhary, Chandni Verma, Hridaya Shanker Singh
Korean J Parasitol 2014;52(6):701-705.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.701

The rumen parasite, Gastrothylax crumenifer (Platyhelminthes: Gastrothylacidae), is a highly pathogenic trematode parasite of goat (Capra hircus). It sucks blood that causes acute disease like anemia, and severe economic losses occur due to morbidity and mortality of the ruminant infected by these worms. The study of these rumen paramphistomes, their infection, and public health importance remains unclear in India especially in the western part of state Uttar Pradesh (U.P.), Meerut, India, where the goat meat consumption is very high. This paper provides the molecular characterization of G. crumenifer recovered from the rumen of Capra hircus from Meerut, U.P., India by the partial sequence of 28S rDNA. Nucleotide sequence similarity searching on BLAST of 28S rDNA from parasites showed the highest identity with those of G. crumenifer from the same host Capra hircus. This is the first report of molecular identification of G. crumenifer from this part of India.

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  • A Universal Approach to Molecular Identification of Rumen Fluke Species Across Hosts, Continents, and Sample Types
    Gillian Mitchell, Ruth N. Zadoks, Philip J. Skuce
    Frontiers in Veterinary Science.2021;[Epub]     CrossRef
  • Rumen fluke, Fischoederius elongatus (Trematoda: Gastrothylacidae): Preliminary investigation of suitable conditions for egg hatching
    Sirapat Nak-on, Thapana Chontananarth
    Veterinary Parasitology.2020; 282: 109135.     CrossRef
  • Incidence of amphistome infection in sheep from Mhow, Madhya Pradesh
    D. K. Bansal, V. Agrawal, A. K. Jayraw, U. K. Garg, G. P Jatav, N. Jamra, Nidhi Singh
    Journal of Parasitic Diseases.2018; 42(1): 19.     CrossRef
  • First genetic evidence for the presence of the rumen fluke Paramphistomum epiclitum in Pakistan
    Qasim Ali, Imran Rashid, Muhammad Zubair Shabbir, Haroon Akbar, Kashif Shahzad, Kamran Ashraf, Neil Sargison, Umer Chaudhry
    Parasitology International.2018; 67(5): 533.     CrossRef
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  • 102 Download
  • 3 Web of Science
  • Crossref