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"Echinococcus multilocularis"

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"Echinococcus multilocularis"

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A Rapid and Convenient Method for in Vivo Fluorescent Imaging of Protoscolices of Echinococcus multilocularis
Tao Yang, Sibo Wang, Xuyong Zhang, Jie Xia, Jun Guo, Jixue Hou, Hongwei Zhang, Xueling Chen, Xiangwei Wu
Korean J Parasitol 2016;54(2):225-231.
Published online April 30, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.2.225
Human and animal alveolar echinococcosis (AE) are important helminth infections endemic in wide areas of the Northern hemisphere. Monitoring Echinococcus multilocularis viability and spread using real-time fluorescent imaging in vivo provides a fast method to evaluate the load of parasite. Here, we generated a kind of fluorescent protoscolices in vivo imaging model and utilized this model to assess the activity against E. multilocularis protoscolices of metformin (Met). Results indicated that JC-1 tagged E. multilocularis can be reliably and confidently used to monitor protoscolices in vitro and in vivo. The availability of this transient in vivo fluorescent imaging of E. multilocularis protoscolices constitutes an important step toward the long term bio-imaging research of the AE-infected mouse models. In addition, this will be of great interest for further research on infection strategies and development of drugs and vaccines against E. multilocularis and other cestodes.

Citations

Citations to this article as recorded by  Crossref logo
  • NIR-II fluorescence microscopic bioimaging for intrahepatic angiography and the early detection of Echinococcus multilocularis microlesions
    Nuernisha Alifu, Ting Yan, Jun Li, Lijun Zhu, Abudusalamu Aini, Siyiti Amuti, Juan Wu, Wenjing Qi, Gang Guo, Wenbao Zhang, Xueliang Zhang
    Frontiers in Bioengineering and Biotechnology.2023;[Epub]     CrossRef
  • In Vitro and In Vivo Efficacy of Albendazole Chitosan Microspheres with Intensity-Modulated Radiation Therapy in the Treatment of Spinal Echinococcosis
    Sibo Wang, Shan Wang, Weishan Wang, Yi Dai, Zhongpeng Qiu, Wei Ke, Minghao Geng, Jing Li, Ke Li, Qingyuan Ma, Feng Li
    Antimicrobial Agents and Chemotherapy.2021;[Epub]     CrossRef
  • Small animal in vivo imaging of parasitic infections: A systematic review
    Adam Novobilský, Johan Höglund
    Experimental Parasitology.2020; 214: 107905.     CrossRef
  • 8,478 View
  • 89 Download
  • 3 Web of Science
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Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai
Korean J Parasitol 2013;51(5):595-597.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.595

In December 2011, we reported an autochthonous case of Echinococcus multilocularis infection in a 42-year-old woman in Korea. The diagnosis was based on histopathological findings of the surgically resected liver cyst. In the present study, we evaluated the serological and molecular characteristics of this Korean E. multilocularis case. The patient's serum strongly reacted with affinity-purified native Em18 and recombinant Em18 antigens (specific for E. multilocularis) but negative for recombinant antigen B8/1 (reactive for Echinococcus granulosus). In immunoaffinity chromatography, the serum also strongly reacted with E. multilocularis and only weakly positive for E. granulosus. We determined the whole nucleotide sequence of cox1 (1,608 bp) using the paraffin-embedded cystic tissue which was compared with E. multilocularis isolates from China, Japan, Kazakhstan, Austria, France, and Slovakia. The Korean case showed 99.8-99.9% similarity with isolates from Asia (the highest similarity with an isolate from Sichuan, China), whereas the similarity with European isolates ranged from 99.5 to 99.6%.

Citations

Citations to this article as recorded by  Crossref logo
  • Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
    Sven Baumann, Rong Shi, Wenya Liu, Haihua Bao, Julian Schmidberger, Wolfgang Kratzer, Weixia Li, Thomas F. E. Barth, Sven Baumann, Johannes Bloehdorn, Iris Fischer, Tilmann Graeter, Natalja Graf, Beate Gruener, Doris Henne-Bruns, Andreas Hillenbrand, Tanj
    Infection.2019; 47(5): 703.     CrossRef
  • Lasiopodomys fuscus as an important intermediate host for Echinococcus multilocularis: isolation and phylogenetic identification of the parasite
    Qi-Gang Cai, Xiu-Min Han, Yong-Hai Yang, Xue-Yong Zhang, Li-Qing Ma, Panagiotis Karanis, Yong-Hao Hu
    Infectious Diseases of Poverty.2018;[Epub]     CrossRef
  • Assessment of the global pattern of genetic diversity in Echinococcus multilocularis inferred by mitochondrial DNA sequences
    Adel Spotin, Belgees Boufana, Ehsan Ahmadpour, Adriano Casulli, Mahmoud Mahami-Oskouei, Soheila Rouhani, Amirreza Javadi-Mamaghani, Firooz Shahrivar, Paria Khoshakhlagh
    Veterinary Parasitology.2018; 262: 30.     CrossRef
  • The echinococcoses in Asia: The present situation
    Akira Ito, Christine M. Budke
    Acta Tropica.2017; 176: 11.     CrossRef
  • 8,868 View
  • 98 Download
  • Crossref
Case Reports
A Case of Budd-Chiari Syndrome Associated with Alveolar Echinococcosis
Erol ?akmak, Hakan Alagozlu, Cesur Gumus, Celiks?z Al?
Korean J Parasitol 2013;51(4):475-477.
Published online August 30, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.4.475

Although alveolar echinococcosis (AE) can cause a serious disease with high mortality and morbidity similar to malign neoplasms. A 62-year-old woman admitted to a hospital located in Sivas, Turkey, with the complaints of fatigue and right upper abdominal pain. On contrast abdominal CT, a 54×70×45 mm sized cystic lesion was detected in the left lobe of the liver that was seen to extend to the posterior mediastinum and invade the diaphragm, esophagus, and pericardium. The cystic lesion was seen to be occluding the inferior vena cava and left hepatic vein at the level where the hepatic veins poured into the inferior vena cava. Bilateral pleural effusion was also detected. We discussed this secondary Budd-Chiari Syndrome (BCS) case, resulting from the AE occlusion of the left hepatic vein and inferior vena cava, in light of the information in literature.

Citations

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  • A Case Series and Literature Review of Alveolar Echinococcosis in Kashmir, India: An Emerging Endemic Zone for Echinococcus multilocularis
    Mohammad Sultan Khuroo, Naira Sultan Khuroo, Ajaz Ahmad Rather
    Life.2024; 14(7): 794.     CrossRef
  • Role of the radiologist in the diagnosis and management of the two forms of hepatic echinococcosis
    Paul Calame, Mathieu Weck, Andreas Busse-Cote, Eleonore Brumpt, Carine Richou, Celia Turco, Alexandre Doussot, Solange Bresson-Hadni, Eric Delabrousse
    Insights into Imaging.2022;[Epub]     CrossRef
  • Intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis: a multicenter cohort study
    Tilmann Graeter, Rong Shi, Haihua Bao, Wenya Liu, Weixia Li, Yi Jiang, Julian Schmidberger, Eleonore Brumpt, Eric Delabrousse, Wolfgang Kratzer
    Acta Radiologica.2021; 62(8): 997.     CrossRef
  • Evaluation of intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis
    Tilmann Graeter, Hai-Hua Bao, Rong Shi, Wen-Ya Liu, Wei-Xia Li, Yi Jiang, Julian Schmidberger, Eleonore Brumpt, Eric Delabrousse, Wolfgang Kratzer, the XUUB Consortium
    World Journal of Gastroenterology.2020; 26(29): 4302.     CrossRef
  • Left trisectionectomy and supra-hepatic caval reconstruction with vascular prosthesis for chronic Budd-Chiari syndrome caused by hepatic alveolar echinococcosis
    Bo Ran, Tie-Min Jiang, Aimaiti Yasen, Abudusalamu Aini, Qiang Guo, Rui-Qing Zhang, Ying-Mei Shao, Hao Wen, Aji Tuerganaili
    Chinese Medical Journal.2019; 132(23): 2886.     CrossRef
  • A report on three patients with Echinococcus multilocularis: Lessons learned
    Nalini Bansal, Vivek Vij, Mukul Rastogi, Manav Wadhawan, Ajay Kumar
    Indian Journal of Gastroenterology.2018; 37(4): 353.     CrossRef
  • Diagnosis and treatment guidelines for aberrant portal hemodynamics

    Hepatology Research.2017; 47(5): 373.     CrossRef
  • Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients
    Leilei Xu, Sikandaer Siyiti, Xinghua Song, Hao Wen, Liwen Ding, Akbar Yunus, Zheng Tian, Chong Wang, Jiangtao Chen
    Medicine.2017; 96(42): e7632.     CrossRef
  • Orage pour ce foie mais pas de désespoir…
    C. Bernard, F. Bailly, F. Craigherot, B. Bancel, M. Brevet, C. Broussolle, P. Sève, P. Bélénotti
    La Revue de Médecine Interne.2015; 36(10): 706.     CrossRef
  • Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study
    Tilmann Graeter
    World Journal of Gastroenterology.2015; 21(16): 4925.     CrossRef
  • 8,589 View
  • 73 Download
  • Crossref
Recurrent Hepatic Alveolar Echinococcosis: Report of The First Case in Korea with Unproven Infection Route
Su-Jin Kim, Jong-Han Kim, Sang-Young Han, Young-Hoon Kim, Jin-Han Cho, Jong-Yil Chai, Jin-Sook Jeong
Korean J Parasitol 2011;49(4):413-418.
Published online December 16, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.4.413

Human alveolar echinococcosis (AE), a hepatic disorder that resembles liver cancer, is a highly aggressive and lethal zoonotic infection caused by the larval stage of the fox tapeworm, Echinococcus multilocularis. E. multilocularis is widely distributed in the northern hemisphere; the disease-endemic area stretches from north America through Europe to central and east Asia, including northern parts of Japan, but it has not been reported in Korea. Herein, we represent a first case of AE in Korea. A 41-year-old woman was found to have a large liver mass on routine medical examination. The excised mass showed multinodular, necrotic, and spongiform appearance with small irregular pseudocystic spaces. Microscopically, the mass was composed of chronic granulomatous inflammation with extensive coagulation necrosis and parasite-like structure, which was revealed as parasitic vesicles and laminated layer delineated by periodic acid-Schiff (PAS) stain. Clinical and histologic features were consistent with AE. After 8 years, a new liver mass and multiple metastatic pulmonary nodules were found and the recurred mass showed similar histologic features to the initial mass. She had never visited endemic areas of AE, and thus the exact infection route is unclear.

Citations

Citations to this article as recorded by  Crossref logo
  • Delayed Diagnosis of Imported Cystic Echinococcosis and Successful Treatment With Percutaneous Drainage and Albendazole in Korea: A Case Report
    Won Jun Choi, Hanna Jin, Hyeon Jae Jo, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Min-Ho Choi
    Journal of Korean Medical Science.2025;[Epub]     CrossRef
  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Comparative analysis of host immune responses to Hydatid cyst in human and ovine hepatic cystic Echinococcosis
    Bnar S. Hamad, Bushra H. Shnawa, Rafal A. Alrawi, Mukhtar H. Ahmed
    Veterinary Immunology and Immunopathology.2024; 273: 110775.     CrossRef
  • Investigation of Echinococcus multilocularis in foxes and dogs in Pakistan by detection of copro-DNA
    Aisha Khan, Gérald Umhang, Zaib Ullah, Franck Boué, Vanessa Bastid, Ikram Ullah, Sajid Mahmood, Muhammad Sohail Afzal, Haroon Ahmed
    Parasitology Research.2021; 120(2): 731.     CrossRef
  • Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
    Sven Baumann, Rong Shi, Wenya Liu, Haihua Bao, Julian Schmidberger, Wolfgang Kratzer, Weixia Li, Thomas F. E. Barth, Sven Baumann, Johannes Bloehdorn, Iris Fischer, Tilmann Graeter, Natalja Graf, Beate Gruener, Doris Henne-Bruns, Andreas Hillenbrand, Tanj
    Infection.2019; 47(5): 703.     CrossRef
  • An Imported Case of Disseminated Echinococcosis in Korea
    Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
    The Korean Journal of Parasitology.2019; 57(4): 429.     CrossRef
  • The echinococcoses in Asia: The present situation
    Akira Ito, Christine M. Budke
    Acta Tropica.2017; 176: 11.     CrossRef
  • Alveolar Echinococcosis of the Liver: A Diagnostic Problem in a Nonendemic Area
    Kumble S. Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthruimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
    Current Problems in Diagnostic Radiology.2016; 45(1): 80.     CrossRef
  • Alveolar Echinococcosis of Liver: A Diagnostic Problem in a Nonendemic Area
    Kumble Seetharama Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthurimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
    Current Problems in Diagnostic Radiology.2015; 44(2): 221.     CrossRef
  • Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
    Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai
    The Korean Journal of Parasitology.2013; 51(5): 595.     CrossRef
  • Serodiagnosis of Echinococcosis by ELISA Using Cystic Fluid from Uzbekistan Sheep
    Yan Jin, Khikmat Anvarov, Abdukhakim Khajibaev, Samin Hong, Sung-Tae Hong
    The Korean Journal of Parasitology.2013; 51(3): 313.     CrossRef
  • In VitroandIn VivoActivities of Dicationic Diguanidino Compounds against Echinococcus multilocularis Metacestodes
    Tatiana Küster, Nadja Kriegel, David W. Boykin, Chad E. Stephens, Andrew Hemphill
    Antimicrobial Agents and Chemotherapy.2013; 57(8): 3829.     CrossRef
  • An Imported Case of Cystic Echinococcosis in the Liver
    Keun Soo Ahn, Sung-Tae Hong, Yu Na Kang, Jung Hyeok Kwon, Mi Jeong Kim, Tae Jun Park, Yong Hoon Kim, Tae Jin Lim, Koo Jeong Kang
    The Korean Journal of Parasitology.2012; 50(4): 357.     CrossRef
  • 10,352 View
  • 109 Download
  • Crossref