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"Hyung Suk Kim"

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"Hyung Suk Kim"

Case Report

Sparganosis of the Unilateral Breast: A Case Report
Hyung Suk Kim, Man Sik Shin, Chang Jong Kim, Sun Hyung You, Yong Hwa Eom, Tae Kyung Yoo, Ahwon Lee, Byung Joo Song, Byung Joo Chae
Korean J Parasitol 2017;55(4):421-424.
Published online August 31, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.4.421
Sparganosis is a parasitic infection caused by the sparganum, the plercercoid of the genus Spirometra. The preoperative diagnosis of breast sparganosis is difficult in most cases because it is a rare parasitic infection less than 2% of all cases. We report a 62-year-old woman case of breast sparganosis that were confirmed by surgical removal of worms from the right breast. The radiologic images of the patient also revealed characteristic features of breast sparganosis. The patient described the migrating palpable breast mass, which strongly suggested the possibility of breast sparganosis. The treatment of choice and confirmative diagnosis for sparganosis are complete surgical extraction of the sparganum irrespective of infected site. Inspection of the mass site with detailed medical history and radiological examinations are important for preoperative diagnosis of sparganosis patients.

Citations

Citations to this article as recorded by  Crossref logo
  • A Painful Breast Mass
    Samkeliso Blundell, Manjiri Deshmukh, Alastair McGregor
    Clinical Infectious Diseases.2022; 75(12): 2275.     CrossRef
  • 11,618 View
  • 189 Download
  • 1 Web of Science
  • Crossref
Original Article
Development of Urinary Bladder Pre-Neoplasia by Schistosoma haematobium Eggs and Chemical Carcinogen in Mice
Bayissa Chala, Min-Ho Choi, Kyung Chul Moon, Hyung Suk Kim, Cheol Kwak, Sung-Tae Hong
Korean J Parasitol 2017;55(1):21-29.
Published online February 28, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.1.21
Schistosoma haematobium is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting S. haematobium eggs into the bladder wall and introduction of chemical carcinogens. Histopathological findings showed mild hyperplasia to epithelial vacuolar change, and high grade dysplasia. Squamous metaplasia was observed in the S. haematobium eggs+NDMA group at week 12 but not in other groups. Immunohistochemistry revealed significantly high expression of Ki-67 in urothelial epithelial cells of the S. haematobium eggs+BBN group at week 20. The qRT-PCR showed high expression of p53 gene in S. haematobium eggs group at week 4 and S. haematobium eggs+BBN group at week 20. E-cadherin and vimentin showed contrasting expression in S. haematobium eggs+BBN group. Such inverse expression of E-cadherin and vimentin may indicate epithelial mesenchymal transition in the UB tissue. In conclusion, S. haematobium eggs and nitrosamines may transform UB cells into squamous metaplasia and dysplasia in correlation with increased expression of Ki-67. Marked decrease in E-cadherin and increase in p53 and vimentin expressions may support the transformation. The present study introduces a promising modified animal model for UB cancer study using S. haematobium eggs.

Citations

Citations to this article as recorded by  Crossref logo
  • Reinventing type 2 immunity in cancer
    Marek Wagner, Hiroyoshi Nishikawa, Shigeo Koyasu
    Nature.2025; 637(8045): 296.     CrossRef
  • Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review
    Anna M. Mertelsmann, Sheridan F. Bowers, Drew Wright, Jane K. Maganga, Humphrey D. Mazigo, Lishomwa C. Ndhlovu, John M. Changalucha, Jennifer A. Downs, Hamed Kalani
    PLOS Neglected Tropical Diseases.2024; 18(9): e0012456.     CrossRef
  • Development of an automated artificial intelligence-based system for urogenital schistosomiasis diagnosis using digital image analysis techniques and a robotized microscope
    Carles Rubio Maturana, Allisson Dantas de Oliveira, Francesc Zarzuela, Edurne Ruiz, Elena Sulleiro, Alejandro Mediavilla, Patricia Martínez-Vallejo, Sergi Nadal, Tomàs Pumarola, Daniel López-Codina, Alberto Abelló, Elisa Sayrol, Joan Joseph-Munné, David J
    PLOS Neglected Tropical Diseases.2024; 18(11): e0012614.     CrossRef
  • Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis
    Ana Gabriela Leija-Montoya, Javier González-Ramírez, Gustavo Martínez-Coronilla, María Esther Mejía-León, Mario Isiordia-Espinoza, Fausto Sánchez-Muñoz, Elda Georgina Chávez-Cortez, Viviana Pitones-Rubio, Nicolas Serafín-Higuera
    International Journal of Molecular Sciences.2022; 23(15): 8173.     CrossRef
  • The role of helminths in the development of non-communicable diseases
    Yifan Wu, Megan Duffey, Saira Elizabeth Alex, Charlie Suarez-Reyes, Eva H. Clark, Jill E. Weatherhead
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Pathogens and Carcinogenesis: A Review
    Muhammad Nur Adam Hatta, Ezanee Azlina Mohamad Hanif, Siok-Fong Chin, Hui-min Neoh
    Biology.2021; 10(6): 533.     CrossRef
  • E-cadherin and N-cadherin Immunohistochemical Expression in Proliferating Urothelial Lesions: Potential Novel Cancer Predictive EMT Profiles
    Lobna S. Shash, Riham A. Ibrahim, Shimaa A. Elgohary
    Applied Immunohistochemistry & Molecular Morphology.2021; 29(9): 657.     CrossRef
  • Parasite–bacteria interrelationship
    Dalia S. Ashour, Ahmad A. Othman
    Parasitology Research.2020; 119(10): 3145.     CrossRef
  • Urinary schistosomiasis and the associated bladder cancer: update
    Mohamed S. Zaghloul, Tarek M. Zaghloul, Mai K. Bishr, Brian C. Baumann
    Journal of the Egyptian National Cancer Institute.2020;[Epub]     CrossRef
  • Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni
    Rafael Nacif-Pimenta, Alessandra da Silva Orfanó, Ilana A. Mosley, Shannon E. Karinshak, Kenji Ishida, Victoria H. Mann, Paulo Marcos Zech Coelho, José M. Correia da Costa, Michael H. Hsieh, Paul J. Brindley, Gabriel Rinaldi
    Scientific Reports.2019;[Epub]     CrossRef
  • Cytological and Wet Mount Microscopic Observations Made in Urine ofSchistosoma haematobium-Infected Children: Hint of the Implication in Bladder Cancer
    Patience B. Tetteh-Quarcoo, Benjamin K. Akuetteh, Irene A. Owusu, Solomon E. Quayson, Simon K. Attah, Robert Armah, Emmanuel Afutu, Ama Afrah, Kantanka Addo-Osafo, Cecilia Smith, Richard K. Gyasi, Patrick F. Ayeh-Kumi
    Canadian Journal of Infectious Diseases and Medical Microbiology.2019; 2019: 1.     CrossRef
  • Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy
    Naina Arora, Rimanpreet Kaur, Farhan Anjum, Shweta Tripathi, Amit Mishra, Rajiv Kumar, Amit Prasad
    Frontiers in Cellular and Infection Microbiology.2019;[Epub]     CrossRef
  • Understanding Urogenital Schistosomiasis-Related Bladder Cancer: An Update
    Kenji Ishida, Michael H. Hsieh
    Frontiers in Medicine.2018;[Epub]     CrossRef
  • Helminth infection–induced malignancy
    Paul J. Brindley, Alex Loukas, Laura J Knoll
    PLOS Pathogens.2017; 13(7): e1006393.     CrossRef
  • 17,001 View
  • 239 Download
  • 16 Web of Science
  • Crossref