Parasites, Hosts and Diseases

"Jin-Joo Lee"

Brief Communication

STAT6 Expression and IL-13 Production in Association with Goblet Cell Hyperplasia and Worm Expulsion of Gymnophalloides seoi from C57BL/6 Mice: Jin-Joo Lee, Donghee Kim, Kyoung-Ho Pyo, Min-Ki Kim, Hyo-Jin Kim, Jong-Yil Chai, Eun-Hee Shin; Korean J Parasitol 2013;51(5):589-594.
Published online October 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.5.589

Abstract
PDF

In intestinal helminth infections, Th2 immune respones are generally associated with mucin secretion for worm expulsion from the host intestine. In particular, IL-4 and IL-13 are the important cytokines related with intestinal mucus production via STAT6 signalling in nematode infections. However, this perspective has never been studied in Gymnophalloides seoi infection. The present study aimed to observe the STAT6 signalling and cytokine responses in C57BL/6 mice, a mouse strain resistant to infection with this trematode. The results showed that worm expulsion occurred actively during days 1-2 post-infection (PI), when goblet cells began to proliferate in the small intestine. The STAT6 gene expression in the mouse spleen became remarkable from day 2 PI. Moreover, G. seoi infection induced a significant increase of IL-13 from day 4 PI in the spleen of infected mice. Our results suggested that goblet cell hyperplasia and worm expulsion in G. seoi-infected mice should be induced by STAT6 signalling, in which IL-13 may be involved as a dominant triggering cytokine.

Citations

Citations to this article as recorded by

Immune Regulation of Goblet Cell and Mucus Functions in Health and Disease
Jenny K. Gustafsson, Gunnar C. Hansson
Annual Review of Immunology .2025; 43(1): 169. CrossRef
The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis
Franziska Bayer, Olga Dremova, My Phung Khuu, Könül Mammadova, Giulia Pontarollo, Klytaimnistra Kiouptsi, Natalia Soshnikova, Helen Louise May-Simera, Kristina Endres, Christoph Reinhardt
Nutrients.2021; 13(7): 2198. CrossRef
Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
Songwei Yang, Min Yu
Journal of Inflammation Research.2021; Volume 14: 3171. CrossRef
The relationship between intestinal goblet cells and the immune response
Mingming Zhang, Chenchen Wu
Bioscience Reports.2020;[Epub] CrossRef
Developmental expression of STATs, nuclear factor-κB and inflammatory genes in the jejunum of piglets during weaning
Hongbo Yi, Denghu Jiang, Lin Zhang, Haitao Xiong, Feifei Han, Yizhen Wang
International Immunopharmacology.2016; 36: 199. CrossRef
Increased Intestinal Epithelial Cell Turnover and Intestinal Motility in Gymnophalloides seoi-Infected C57BL/6 Mice
Sang Hyub Lee, Bong-Kwang Jung, Jae-Hwan Park, Eun-Hee Shin, Jong-Yil Chai
The Korean Journal of Parasitology.2014; 52(3): 273. CrossRef

9,145 View
89 Download
Crossref

Original Article

Comparative Morphology of Minute Intestinal Fluke Eggs That Can Occur in Human Stools in the Republic of Korea: Jin-Joo Lee, Bong-Kwang Jung, Hyemi Lim, Mi Youn Lee, Sung-Yil Choi, Eun-Hee Shin, Jong-Yil Chai; Korean J Parasitol 2012;50(3):207-213.
Published online August 13, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.3.207

Abstract
PDF

The egg morphology of minute intestinal flukes (MIF) that can occur as human infections in the Republic of Korea, i.e., Metagonimus yokogawai, M. miyatai, M. takahashii, Heterophyes nocens, Heterophyopsis continua, Stellantchasmus falcatus, Stictodora fuscata, Pygidiopsis summa, and Gymnophalloides seoi, was studied in comparison with Clonorchis sinensis. The adult worms were obtained from residents of endemic areas, and their intrauterine eggs were studied and measured using light microscopy; the length, width, length-width ratio (LWR), and Faust-Meleney index (FMI). Several specimens were processed for scanning electron microscopy (SEM), and before gold-coating, the uterine portion of each fluke was etched with a sharp pin in order to expose the eggs. The MIF eggs were ovoid, pyriform, or elliptical with a size range of 21-35×12-21 ?m. S. fuscata eggs revealed the highest FMI (largest in the area) and lowest LWR, whereas P. summa eggs showed the lowest FMI and medium LWR. SEM revealed that G. seoi and S. fuscata had remarkably clean shell surface lacking the muskmelon-like structure which is prominent in C. sinensis eggs. In Metagonimus spp., H. continua, H. nocens, and S. falcatus eggs, minute surface ridges were recognizable though less prominent compared with C. sinensis. On the surface of P. summa eggs, thread-like curly structures were characteristically seen. The results revealed that important differential keys for MIF eggs include the length, width, area (FMI), shape of the eggs, and the extent of the muskmelon-like structure or ridges on their shell surface and operculum.

Citations

Citations to this article as recorded by

Multiparasitism in Spain in a Korean Visiting Friends and Relatives: Case Report and Review of Imported Cases of Clonorchis sinensis in Europe
Paola Cociancic, Jacklyn Comas, J. Guillermo Esteban
Clinical Case Reports.2025;[Epub] CrossRef
Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Men-Bao Qian, Jennifer Keiser, Jürg Utzinger, Xiao-Nong Zhou, Graeme N. Forrest
Clinical Microbiology Reviews.2024;[Epub] CrossRef
Identification of Intestinal Parasites in Spinach at Padamara Market, Padamara District
NABELA PUTRI JANG JAYA, DITA PRATIWI KUSUMA WARDANI, IKHSAN MUJAHID, MUHAMMAD LUTHFI ALMANFALUTHI
International Islamic Medical Journal.2024; 6(1): 1. CrossRef
Diatoms-endoparasite association in fish from the marine pacific coast of Colombia (Buenaventura)
Vanessa Potosi-Pai, Carlos E. Agudelo Morales, Javier Antonio Benavides-Montaño, Shawky M. Aboelhadid
PLOS ONE.2024; 19(12): e0312015. CrossRef
Incidence of fish-borne trematode infections and associated factors: results from a cohort study in highly endemic communities in northern Vietnam
Thao Thi Bich Nguyen, Veronique Dermauw, Dung Thi Bui, Hafid Dahma, Dung Thuy Le, Hien Thi Thu Nguyen, Dung Trung Do, Pierre Dorny, Bertrand Losson, Olivier Vandenberg
Parasitology Research.2023; 122(6): 1415. CrossRef
Morphological and molecular characterization of Prosthogonimus falconis n. sp. (Trematoda; Prosthogonimidae), found in a peregrine falcon (Falco peregrinus) (Aves: Falconidae) in the United Arab Emirates
R.K. Schuster, B. Gajic, M. Procter, G. Wibbelt, B. Arca Ruibal, M. Qablan
Journal of Helminthology.2022;[Epub] CrossRef
A novel use of a geometric morphometric technique to distinguish human parasite eggs of twelve different species
Nantana Suwandittakul, Mathirut Mungthin, Kewarin Kuntawong, Sedthapong Laojun, Siripong Pimsuka, Tanawat Chaiphongpachara
Experimental Parasitology.2022; 238: 108281. CrossRef
Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis
J.-G. Kim, C.-S. Ahn, B. Sripa, K.S. Eom, I. Kang, W.-M. Sohn, Y. Nawa, Y. Kong
Clinical Microbiology and Infection.2019; 25(1): 109.e1. CrossRef
Liver Fluke-Associated Biliary Tract Cancer
Piyapan Prueksapanich, Panida Piyachaturawat, Prapimphan Aumpansub, Wiriyaporn Ridtitid, Roongruedee Chaiteerakij, Rungsun Rerknimitr
Gut and Liver.2018; 12(3): 236. CrossRef
Fishborne zoonotic heterophyid infections: An update
Jong-Yil Chai, Bong-Kwang Jung
Food and Waterborne Parasitology.2017; 8-9: 33. CrossRef
Epidemiological situation and molecular identification of cercarial stage in freshwater snails in Chao-Phraya Basin, Central Thailand
Sothorn Anucherngchai, Thanawan Tejangkura, Thapana Chontananarth
Asian Pacific Journal of Tropical Biomedicine.2016; 6(6): 539. CrossRef
Heterophyid trematodes recovered from people residing along the Boseong River, South Korea
Jong-Yil Chai, Bong-Kwang Jung, Deok-Gyu Kim, Jae-Lip Kim, Hyemi Lim, Eun-Hee Shin, Keon Hoon Lee, Mok Ryeon Kim, Sun Jin Han, Jae Hyun Yeom, Sun Mi Park, Jae-Sun Hwang
Acta Tropica.2015; 148: 142. CrossRef
Microscopic identification of possible Clonorchis/Opisthorchis infection in two Ghanaian women with undiagnosed abdominal discomfort: two case reports
Kwame Kumi Asare, Johnson Nyarko Boampong, Elvis Ofori Ameyaw, Ama Kyeraa Thomford, Richmond Afoakwah, Godwin Kwakye-Nuako, Kwesi Prah Thomford, Neils Ben Quashie
Journal of Medical Case Reports.2014;[Epub] CrossRef
Detection of Clonorchis sinensis Circulating Antigen in Sera from Chinese Patients by Immunomagnetic Bead ELISA Based on IgY
Ge Nie, Ting Wang, Shengjun Lu, Wenqi Liu, Yonglong Li, Jiahui Lei, Lijun Rong
PLoS ONE.2014; 9(12): e113208. CrossRef

18,166 View
177 Download
Crossref

Brief Communication

CD8⁺ T-cell Activation in Mice Injected with a Plasmid DNA Vaccine Encoding AMA-1 of the Reemerging Korean Plasmodium vivax: Hyo-Jin Kim, Bong-Kwang Jung, Jin-Joo Lee, Kyoung-Ho Pyo, Tae Yun Kim, Byung-il Choi, Tae Woo Kim, Hajime Hisaeda, Kunisuke Himeno, Eun-Hee Shin, Jong-Yil Chai; Korean J Parasitol 2011;49(1):85-90.
Published online March 18, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.1.85

Abstract
PDF

Relatively little has been studied on the AMA-1 vaccine against Plasmodium vivax and on the plasmid DNA vaccine encoding P. vivax AMA-1 (PvAMA-1). In the present study, a plasmid DNA vaccine encoding AMA-1 of the reemerging Korean P. vivax has been constructed and a preliminary study was done on its cellular immunogenicity to recipient BALB/c mice. The PvAMA-1 gene was cloned and expressed in the plasmid vector UBpcAMA-1, and a protein band of approximately 56.8 kDa was obtained from the transfected COS7 cells. BALB/c mice were immunized intramuscularly or using a gene gun 4 times with the vaccine, and the proportions of splenic T-cell subsets were examined by fluorocytometry at week 2 after the last injection. The spleen cells from intramuscularly injected mice revealed no significant changes in the proportions of CD8⁺ T-cells and CD4⁺ T-cells. However, in mice immunized using a gene gun, significantly higher (P<0.05) proportions of CD8⁺ cells were observed compared to UB vector-injected control mice. The results indicated that cellular immunogenicity of the plasmid DNA vaccine encoding AMA-1 of the reemerging Korean P. vivax was weak when it was injected intramuscularly; however, a promising effect was observed using the gene gun injection technique.

Citations

Citations to this article as recorded by

Live Vaccination with Blood-Stage Plasmodium yoelii 17XNL Prevents the Development of Experimental Cerebral Malaria
Takashi Imai, Ha Ngo-Thanh, Kazutomo Suzue, Aoi Shimo, Akihiro Nakamura, Yutaka Horiuchi, Hajime Hisaeda, Takashi Murakami
Vaccines.2022; 10(5): 762. CrossRef
Immunotherapeutic Effects of Different Doses of Mycobacterium tuberculosis ag85a/b DNA Vaccine Delivered by Electroporation
Yan Liang, Lei Cui, Li Xiao, Xiao Liu, Yourong Yang, Yanbo Ling, Tong Wang, Lan Wang, Jie Wang, Xueqiong Wu
Frontiers in Immunology.2022;[Epub] CrossRef
Long-Term Humoral and Cellular Immune Responses Elicited by a Heterologous Plasmodium vivax Apical Membrane Antigen 1 Protein Prime/Adenovirus Boost Immunization Protocol
Leoneide Érica Maduro Bouillet, Mariana Oliveira Dias, Natália Alves Dorigo, Andrew Douglas Moura, Bruce Russell, Francois Nosten, Laurent Renia, Érika Martins Braga, Ricardo Tostes Gazzinelli, Maurício M. Rodrigues, Irene S. Soares, Oscar Bruna-Romero, J
Infection and Immunity.2011; 79(9): 3642. CrossRef

10,011 View
74 Download
Crossref

Case Report

Gnathostoma hispidum Infection in a Korean Man Returning from China: Han-Seong Kim, Jin-Joo Lee, Mee Joo, Sun-Hee Chang, Je G. Chi, Jong-Yil Chai; Korean J Parasitol 2010;48(3):259-261.
Published online September 16, 2010; DOI: https://doi.org/10.3347/kjp.2010.48.3.259

Abstract
PDF

Human Gnathostoma hispidum infection is extremely rare in the world literature and has never been reported in the Republic of Korea. A 74-year-old Korean man who returned from China complained of an erythematous papule on his back and admitted to our hospital. Surgical extraction of the lesion and histopathological examination revealed sections of a nematode larva in the deep dermis. The sectioned larva had 1 nucleus in each intestinal cell and was identified as G. hispidum. The patient recalled having eaten freshwater fish when he lived in China. We designated our patient as an imported G. hispidum case from China.

Citations

Citations to this article as recorded by

Imported parasitic diseases in the Republic of Korea: status and issues
Jong-Yil Chai
Journal of the Korean Medical Association.2025; 68(1): 52. CrossRef
A case of vocal cord gnathostomiasis diagnosed with sectional morphologies in a histopathological specimen from a Chinese woman living in Korea
Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
Parasites, Hosts and Diseases.2023; 61(3): 298. CrossRef
Morphology and phylogeny of the parasitic nematode Mooleptus rabuka (Machida, Ogawa & Okiyama, 1982) (Rhabditida, Spirurina: Mooleptinae nom. nov.), with notes on taxonomy of the family Gnathostomatidae
S.G. Sokolov, I.I. Gordeev
Journal of Helminthology.2021;[Epub] CrossRef
Human gnathostomiasis: a neglected food-borne zoonosis
Guo-Hua Liu, Miao-Miao Sun, Hany M. Elsheikha, Yi-Tian Fu, Hiromu Sugiyama, Katsuhiko Ando, Woon-Mok Sohn, Xing-Quan Zhu, Chaoqun Yao
Parasites & Vectors.2020;[Epub] CrossRef
An Overview of Fish-borne Nematodiases among Returned Travelers for Recent 25 Years– Unexpected Diseases Sometimes Far Away from the Origin
Jorge Costa Eiras, Gilberto Cezar Pavanelli, Ricardo Massato Takemoto, Yukifumi Nawa
The Korean Journal of Parasitology.2018; 56(3): 215. CrossRef
Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China
Jing Cui, Ye Wang, Zhong Quan Wang
The Korean Journal of Parasitology.2013; 51(4): 467. CrossRef
Gnathostoma spinigerum Infection in the Upper Lip of a Korean Woman: An Autochthonous Case in Korea
Jae Hee Kim, Hyemi Lim, Young-Sang Hwang, Tae Yeon Kim, Eun Mee Han, Eun-Hee Shin, Jong-Yil Chai
The Korean Journal of Parasitology.2013; 51(3): 343. CrossRef
Imported Intraocular Gnathostomiasis with Subretinal Tracks Confirmed by Western Blot Assay
Ji Ho Yang, Moosang Kim, Eung Suk Kim, Byoung-Kuk Na, Seung-Young Yu, Hyung-Woo Kwak
The Korean Journal of Parasitology.2012; 50(1): 73. CrossRef
Discovery of LarvalGnathostoma nipponicumin Frogs and Snakes from Jeju-do (Province), Republic of Korea
Ho-Choon Woo, Hong-Shik Oh, Shin-Hyeong Cho, Byoung-Kuk Na, Woon-Mok Sohn
The Korean Journal of Parasitology.2011; 49(4): 445. CrossRef
Imported Parasitic Diseases in Korea
Myoung-Hee Ahn
Infection and Chemotherapy.2010; 42(5): 271. CrossRef