Parasites, Hosts and Diseases

"Jin-Sook Jeong"

Brief Communication

Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis: Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai; Korean J Parasitol 2013;51(5):595-597.
Published online October 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.5.595

Abstract
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In December 2011, we reported an autochthonous case of Echinococcus multilocularis infection in a 42-year-old woman in Korea. The diagnosis was based on histopathological findings of the surgically resected liver cyst. In the present study, we evaluated the serological and molecular characteristics of this Korean E. multilocularis case. The patient's serum strongly reacted with affinity-purified native Em18 and recombinant Em18 antigens (specific for E. multilocularis) but negative for recombinant antigen B8/1 (reactive for Echinococcus granulosus). In immunoaffinity chromatography, the serum also strongly reacted with E. multilocularis and only weakly positive for E. granulosus. We determined the whole nucleotide sequence of cox1 (1,608 bp) using the paraffin-embedded cystic tissue which was compared with E. multilocularis isolates from China, Japan, Kazakhstan, Austria, France, and Slovakia. The Korean case showed 99.8-99.9% similarity with isolates from Asia (the highest similarity with an isolate from Sichuan, China), whereas the similarity with European isolates ranged from 99.5 to 99.6%.

Citations

Citations to this article as recorded by

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Qi-Gang Cai, Xiu-Min Han, Yong-Hai Yang, Xue-Yong Zhang, Li-Qing Ma, Panagiotis Karanis, Yong-Hao Hu
Infectious Diseases of Poverty.2018;[Epub] CrossRef
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Adel Spotin, Belgees Boufana, Ehsan Ahmadpour, Adriano Casulli, Mahmoud Mahami-Oskouei, Soheila Rouhani, Amirreza Javadi-Mamaghani, Firooz Shahrivar, Paria Khoshakhlagh
Veterinary Parasitology.2018; 262: 30. CrossRef
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Akira Ito, Christine M. Budke
Acta Tropica.2017; 176: 11. CrossRef

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Case Report

Recurrent Hepatic Alveolar Echinococcosis: Report of The First Case in Korea with Unproven Infection Route: Su-Jin Kim, Jong-Han Kim, Sang-Young Han, Young-Hoon Kim, Jin-Han Cho, Jong-Yil Chai, Jin-Sook Jeong; Korean J Parasitol 2011;49(4):413-418.
Published online December 16, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.4.413

Abstract
PDF

Human alveolar echinococcosis (AE), a hepatic disorder that resembles liver cancer, is a highly aggressive and lethal zoonotic infection caused by the larval stage of the fox tapeworm, Echinococcus multilocularis. E. multilocularis is widely distributed in the northern hemisphere; the disease-endemic area stretches from north America through Europe to central and east Asia, including northern parts of Japan, but it has not been reported in Korea. Herein, we represent a first case of AE in Korea. A 41-year-old woman was found to have a large liver mass on routine medical examination. The excised mass showed multinodular, necrotic, and spongiform appearance with small irregular pseudocystic spaces. Microscopically, the mass was composed of chronic granulomatous inflammation with extensive coagulation necrosis and parasite-like structure, which was revealed as parasitic vesicles and laminated layer delineated by periodic acid-Schiff (PAS) stain. Clinical and histologic features were consistent with AE. After 8 years, a new liver mass and multiple metastatic pulmonary nodules were found and the recurred mass showed similar histologic features to the initial mass. She had never visited endemic areas of AE, and thus the exact infection route is unclear.

Citations

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Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
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