Parasites, Hosts and Diseases

"Ki Uk Kim"

Original Articles

Comparison of Functional Gene Annotation of Toxascaris leonina and Toxocara canis using CLC Genomics Workbench: Ki Uk Kim, Sang Kyun Park, Shin Ae Kang, Mi Kyung Park, Min Kyoung Cho, Ho-jin Jung, Kyung-Yun Kim, Hak Sun Yu; Korean J Parasitol 2013;51(5):525-530.
Published online October 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.5.525

The ascarids, Toxocara canis and Toxascaris leonina, are probably the most common gastrointestinal helminths encountered in dogs. In order to understand biological differences of 2 ascarids, we analyzed gene expression profiles of female adults of T. canis and T. leonina using CLC Genomics Workbench, and the results were compared with those of free-living nematode Caenorhabditis elegans. A total of 2,880 and 7,949 ESTs were collected from T. leonina and T. canis, respectively. The length of ESTs ranged from 106 to 4,637 bp with an average insert size of 820 bp. Overall, our results showed that most functional gene annotations of 2 ascarids were quite similar to each other in 3 major categories, i.e., cellular component, biological process, and molecular function. Although some different transcript expression categories were found, the distance was short and it was not enough to explain their different lifestyles. However, we found distinguished transcript differences between ascarid parasites and free-living nematodes. Understanding evolutionary genetic changes might be helpful for studies of the lifestyle and evolution of parasites.

Citations

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CRISPR-Cas9 genome editing reveals that the Pgs gene of Fusarium circinatum is involved in pathogenicity, growth and sporulation
Alida van Dijk, Andi M. Wilson, Bianke Marx, Bianca Hough, Benedicta Swalarsk-Parry, Lieschen De Vos, Michael J. Wingfield, Brenda D. Wingfield, Emma T. Steenkamp
Fungal Genetics and Biology.2025; 177: 103970. CrossRef
Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi
Jiayu Li, Yingying Fan, Na Li, Yaqiong Guo, Weijian Wang, Kangli Feng, Wei He, Falei Li, Jianbo Huang, Yanhua Xu, Lihua Xiao, Yaoyu Feng
International Journal for Parasitology.2024; 54(7): 379. CrossRef
Chromosome-level genome assembly of Cryptosporidium parvum by long-read sequencing of ten oocysts
Yuancai Chen, Jianying Huang, Huikai Qin, Kaihui Zhang, Yin Fu, Junqiang Li, Rongjun Wang, Kai Chen, Jie Xiong, Wei Miao, Guangying Wang, Longxian Zhang
Scientific Data.2024;[Epub] CrossRef
High subtelomeric GC content in the genome of a zoonotic Cryptosporidium species
Jiayu Li, Na Li, Dawn M. Roellig, Wentao Zhao, Yaqiong Guo, Yaoyu Feng, Lihua Xiao
Microbial Genomics .2023;[Epub] CrossRef
The Combination of Phages and Faecal Microbiota Transplantation Can Effectively Treat Mouse Colitis Caused by Salmonella enterica Serovar Typhimurium
Xinwu Wang, Yating Xing, Yalu Ji, Hengyu Xi, Xiaohe Liu, Li Yang, Liancheng Lei, Wenyu Han, Jingmin Gu
Frontiers in Microbiology.2022;[Epub] CrossRef
Complete Plastome of Physalis angulata var. villosa, Gene Organization, Comparative Genomics and Phylogenetic Relationships among Solanaceae
Xiaori Zhan, Zhenhao Zhang, Yong Zhang, Yadi Gao, Yanyun Jin, Chenjia Shen, Huizhong Wang, Shangguo Feng
Genes.2022; 13(12): 2291. CrossRef
Mitochondrial genes associated with pyrethroid resistance revealed by mitochondrial genome and transcriptome analyses in the malaria vector Anopheles sinensis (Diptera: Culicidae)
Yi‐Ran Ding, Zhen‐Tian Yan, Feng‐Ling Si, Xu‐Dong Li, Qi‐Meng Mao, Sana Asghar, Bin Chen
Pest Management Science.2020; 76(2): 769. CrossRef
Environmental microbiology: Perspectives for legal and occupational medicine
Saverio Giampaoli, Federica Alessandrini, Giovanni Vanni Frajese, Giovanni Guglielmi, Adriano Tagliabracci, Andrea Berti
Legal Medicine.2018; 35: 34. CrossRef

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A 24 kDa Excretory-Secretory Protein of Anisakis simplex Larvae Could Elicit Allergic Airway Inflammation in Mice: Hye-Kyung Park, Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Yun Seong Kim, Ki Uk Kim, Min Ki Lee, Mee Sun Ock, Hee Jae Cha, Hak Sun Yu; Korean J Parasitol 2011;49(4):373-380.
Published online December 16, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.4.373

Abstract
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We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means that As22U may play a role as an allergen. In order to determine the contribution of As22U to allergic reactions, we treated mice with 6 times intra-nasal application of recombinant As22U (rAs22U). In the group challenged with rAs22U and ovalbumin (OVA), the number of eosinophils in the bronchial alveolar lavage fluid (BALF) was significantly increased, as compared to the group receiving only OVA. In addition, mice treated with rAs22U and OVA showed significantly increased airway hyperresponsiveness. Thus, severe inflammation around the airway and immune cell recruitment was observed in mice treated with rAs22U plus OVA. The levels of IL-4, IL-5, and IL-13 cytokines in the BALF increased significantly after treatment with rAs22U and OVA. Similarly, the levels of anti-OVA specific IgE and IgG1 increased in mice treated with rAs22U and OVA, compared to those treated only with OVA. The Gro-α (CXCL1) gene expression in mouse lung epithelial cells increased instantly after treatment with rAs22U, and allergy-specific chemokines eotaxin (CCL11) and thymus-and-activation-regulated-chemokine (CCL17) gene expressions significantly increased at 6 hr after treatment. In conclusion, rAs22U may induce airway allergic inflammation, as the result of enhanced Th2 and Th17 responses.

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Anisakis pegreffii Extract Induces Airway Inflammation with Airway Remodeling in a Murine Model System
Jun Ho Choi, Ju Yeong Kim, Myung-hee Yi, Myungjun Kim, Tai-Soon Yong, Kalman Imre
BioMed Research International.2021;[Epub] CrossRef
Allergen-like Molecules from Parasites
Ju Yeong Kim, Myung-Hee Yi, Tai-Soon Yong
Current Protein & Peptide Science.2020; 21(2): 186. CrossRef
Research Note. Prevalence, protein analysis and possible preventive measures against zoonotic anisakid larvae isolated from marine Atherina fish
M. Samir, M. A. Amin, A. O. Hassan, A. M. Merwad, M. A. I. Awadallah
Helminthologia.2015; 52(4): 375. CrossRef
Allergenicity of two Anisakis simplex allergens evaluated in vivo using an experimental mouse model
Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Maria Luisa Caballero, Teresa Perez-Pinar, Rosa Rodriguez-Perez, Mee Sun Ock, Hee Jae Cha, Yeon Chul Hong, Hak Sun Yu
Experimental Parasitology.2014; 146: 71. CrossRef
Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice
Shin Ae Kang, Mi-Kyung Park, Min Kyoung Cho, Hak Sun Yu
The Korean Journal of Parasitology.2013; 51(5): 583. CrossRef

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Protease-Activated Receptor 2 Is Involved in Th2 Responses against Trichinella spiralis Infection: Mi Kyung Park, Min Kyoung Cho, Shin Ae Kang, Hye-Kyung Park, Yun Seong Kim, Ki Uk Kim, Soon Cheol Ahn, Dong-Hee Kim, Hak Sun Yu; Korean J Parasitol 2011;49(3):235-243.
Published online September 30, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.3.235

Abstract
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In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2 responses in T. spiralis-infected PAR2 knockout (KO) mice. The levels of the Th2 cell-secreted cytokines, IL-4, IL-5, and IL-13 were markedly reduced in the PAR2 KO mice as compared to the wild type mice following infection with T. spiralis. The serum levels of parasite-specific IgE increased significantly in the wild type mice as the result of T. spiralis infection, but this level was not significantly increased in PAR2 KO mice. The expression level of thymic stromal lymphopoietin, IL-25, and eotaxin gene (the genes were recently known as Th2 response initiators) of mouse intestinal epithelial cells were increased as the result of treatment with T. spiralis excretory-secretory proteins. However, the expression of these chemokine genes was inhibited by protease inhibitor treatments. In conclusion, PAR2 might involve in Th2 responses against T. spiralis infection.

Citations

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Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models
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The induction of the collagen capsule synthesis by Trichinella spiralis is closely related to protease-activated receptor 2
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Parasitic Nematode-Induced CD4+Foxp3+T Cells Can Ameliorate Allergic Airway Inflammation
Shin Ae Kang, Mi-Kyung Park, Min Kyoung Cho, Sang Kyun Park, Min Seong Jang, Bo-Gie Yang, Myoung Ho Jang, Dong-Hee Kim, Hak Sun Yu, Edward Mitre
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Coinfection with Clonorchis sinensis modulates murine host response against Trichinella spiralis infection
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Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice
Shin Ae Kang, Mi-Kyung Park, Min Kyoung Cho, Hak Sun Yu
The Korean Journal of Parasitology.2013; 51(5): 583. CrossRef
Toward Drugs for Protease-Activated Receptor 2 (PAR2)
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Molecular characterization of 45kDa aspartic protease of Trichinella spiralis
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Case Report

A Pulmonary Paragonimiasis Case Mimicking Metastatic Pulmonary Tumor: Ki Uk Kim, Kwangha Lee, Hye-Kyung Park, Yeon Joo Jeong, Hak Sun Yu, Min Ki Lee; Korean J Parasitol 2011;49(1):69-72.
Published online March 18, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.1.69

Abstract
PDF

Pulmonary paragonimiasis is a relatively rare cause of lung disease revealing a wide variety of radiologic findings, such as air-space consolidation, nodules, and cysts. We describe here a case of pulmonary paragonimiasis in a 27-year-old woman who presented with a 2-month history of cough and sputum. Based on chest computed tomography (CT) scans and fluorodeoxyglucose positron emission tomography (FDG-PET) findings, the patient was suspected to have a metastatic lung tumor. However, she was diagnosed as having Paragonimus westermani infection by an immunoserological examination using ELISA. Follow-up chest X-ray and CT scans after chemotherapy with praziquantel showed an obvious improvement. There have been several reported cases of pulmonary paragonimiasis mimicking lung tumors on FDG-PET. However, all of them were suspected as primary lung tumors. To our knowledge, this patient represents the first case of paragonimiasis mimicking metastatic lung disease on FDG-PET CT imaging.

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