Parasites, Hosts and Diseases

"Majid Fasihi Harandi"

Original Articles

Differential Expression of Hox and Notch Genes in Larval and Adult Stages of Echinococcus granulosus: Ebrahim Saedi Dezaki, Mohammad Mehdi Yaghoobi, Elham Taheri, Pooya Ghaseminejad Almani, Farideh Tohidi, Bruno Gottstein, Majid Fasihi Harandi; Korean J Parasitol 2016;54(5):653-658.
Published online October 31, 2016; DOI: https://doi.org/10.3347/kjp.2016.54.5.653

Abstract
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This investigation aimed to evaluate the differential expression of HoxB7 and notch genes in different developmental stages of Echinococcus granulosus sensu stricto. The expression of HoxB7 gene was observed at all developmental stages. Nevertheless, significant fold differences in the expression level was documented in the juvenile worm with 3 or more proglottids, the germinal layer from infected sheep, and the adult worm from an experimentally infected dog. The notch gene was expressed at all developmental stages of E. granulosus; however, the fold difference was significantly increased at the microcysts in monophasic culture medium and the germinal layer of infected sheep in comparison with other stages. The findings demonstrated that the 2 aforementioned genes evaluated in the present study were differentially expressed at different developmental stages of the parasite and may contribute to some important biological processes of E. granulosus.

Citations

Citations to this article as recorded by

Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective
Yan Lv, Xuan Pang, Zhonghong Cao, Changping Song, Baohua Liu, Weiwei Wu, Qiuxiang Pang
International Journal of Molecular Sciences.2024; 25(6): 3322. CrossRef
Echinococcus multilocularis delta/notch signalling components are expressed in post-mitotic cells
Chris Speicher, Monika Bergmann, Klaus Brehm
Parasitology Research.2024;[Epub] CrossRef
Notch signaling pathway involved in Echinococcus granulosus infection regulates dendritic cell development and differentiation
Mingxia Wang, Zailing Shang, Fei Qiao, Junhu Hei, Xueling Ma, Yana Wang
Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef
Proteomic profiling of hydatid fluid from pulmonary cystic echinococcosis
Guilherme Brzoskowski dos Santos, Edileuza Danieli da Silva, Eduardo Shigueo Kitano, Maria Eduarda Battistella, Karina Mariante Monteiro, Jeferson Camargo de Lima, Henrique Bunselmeyer Ferreira, Solange Maria de Toledo Serrano, Arnaldo Zaha
Parasites & Vectors.2022;[Epub] CrossRef
The Genomes of Two Strains of Taenia crassiceps the Animal Model for the Study of Human Cysticercosis
Raúl J. Bobes, Karel Estrada, Diana G. Rios-Valencia, Arturo Calderón-Gallegos, Patricia de la Torre, Julio C. Carrero, Alejandro Sanchez-Flores, Juan P. Laclette
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Bioinformatics analysis and experimental verification of Notch signalling pathway-related miRNA–mRNA subnetwork in extracellular vesicles during Echinococcus granulosus encystation
Jian Gao, Xuan Zhou, Ling Liu, Guodong Lv, Qiulian Hou, Xiaofan Zhang, Yujuan Shen
Parasites & Vectors.2022;[Epub] CrossRef
Screening, construction, and serological identification of the diagnostic antigen molecule EG-06283 for the diagnosis of Echinococcus granulosus
Yazhou Zhu, Tingrui Zhang, Yinqi Zhao, Yin Wang, Yongxue Lv, Shasha Li, Songhao Yang, Mingxing Zhu, Wei Zhao, Qiang Wang
Parasitology Research.2021; 120(7): 2557. CrossRef
Evolutionary Transformations of the Metazoan Body Plan: Genomic-Morphogenetic Correlations
V. V. Isaeva, S. V. Rozhnov
Paleontological Journal.2021; 55(7): 811. CrossRef
In vitro effects of glutathione on Transforming Growth Factor beta and Epidermal Growth Factor Receptor genes expression in the protoscoleces and strobilated worms of Echinococcus granulosus
Seyyed Jafar Nosratabadi, Nasim Hayati Roodbari, Ali Afgar, Mohammad Hossein Modarressi, Alireza Farsinejad, Majid Fasihi Harandi
Gene Reports.2020; 20: 100786. CrossRef
Transcriptomic profile of two developmental stages of the cestode parasite Mesocestoides corti
T. Basika, G.P. Paludo, F.M. Araujo, A.C. Salim, F. Pais, L. Maldonado, N. Macchiaroli, J. Camargo de Lima, M. Rosenzvit, G.C. Oliveira, L. Kamenetzky, H.B. Ferreira
Molecular and Biochemical Parasitology.2019; 229: 35. CrossRef
Calmodulin-specific small interfering RNA induces consistent expression suppression and morphological changes in Echinococcus granulosus
Seyed Mohammad Mousavi, Ali Afgar, Mohammad Ali Mohammadi, Seifollah Mortezaei, Balal Sadeghi, Majid Fasihi Harandi
Scientific Reports.2019;[Epub] CrossRef
The effect of albendazole sulfoxide on the expression of miR-61 and let-7 in different in vitro developmental stages of Echinococcus granulosus
Seifollah Mortezaei, Ali Afgar, Mohammad Ali Mohammadi, Seyed Mohammad Mousavi, Balal Sadeghi, Majid Fasihi Harandi
Acta Tropica.2019; 195: 97. CrossRef
Comparative Transcriptomic Analysis of the Larval and Adult Stages of Taenia pisiformis
Shaohua Zhang
Genes.2019; 10(7): 507. CrossRef

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Scolicidal Effects of Black Cumin Seed (Nigella sativa) Essential Oil on Hydatid Cysts: Hossein Mahmoudvand, Ebrahim Saedi Dezaki, Farnaz Kheirandish, Behrouz Ezatpour, Sareh Jahanbakhsh, Majid Fasihi Harandi; Korean J Parasitol 2014;52(6):653-659.
Published online December 23, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.6.653

Abstract
PDF

Surgery remains the preferred treatment for hydatid cyst (cystic echinococcosis, CE). Various scolicidal agents have been used for inactivation of protoscolices during surgery, but most of them are associated with adverse side effects. The present study aimed to evaluate the in vitro scolicidal effect of Nigella sativa (Ranunculaceae) essential oil and also its active principle, thymoquinone, against protoscolices of hydatid cysts. Protoscolices were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (0.01-10 mg/ml) and thymoquinone (0.125-1.0 mg/ml) were used for 5 to 60 min. Viability of protoscolices was confirmed by 0.1% eosin staining. Furthermore, the components of the N. sativa essential oil were identified by gas chromatography/mass spectroscopy (GC/MS). Our study revealed that the essential oil of N. sativa at the concentration of 10 mg/ml and its main component, thymoquinone, at the concentration of 1 mg/ml had potent scolicidal activities against protoscolices of Echinococcus granulosus after 10 min exposure. Moreover, thymoquinone (42.4%), p-cymene (14.1%), carvacrol (10.3%), and longifolene (6.1%) were found to be the major components of N. sativa essential oil by GC/MS analysis. The results of this study indicated the potential of N. sativa as a natural source for production of a new scolicidal agent for use in hydatid cyst surgery. However, further studies will be needed to confirm these results by checking the essential oil and its active component in in vivo models.

Citations

Citations to this article as recorded by

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BMC Veterinary Research.2025;[Epub] CrossRef
Chemical compositions, and biological activities of essential oils from Gomphrena nitida ROTHR from Nigeria
A.A. Sotade, O.O. Aiyelaagbe, O.O. Luchen
Journal of Essential Oil Bearing Plants.2025; 28(3): 564. CrossRef
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PLOS ONE.2021; 16(11): e0259290. CrossRef
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Parasitology Research.2016; 115(1): 379. CrossRef
Efficacy ofMyrtus communisL. to Inactivate the Hydatid Cyst Protoscoleces
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Journal of Investigative Surgery.2016; 29(3): 137. CrossRef
Hidatidosis hepática: todavía un problema
Victoria Busto Bea, Jesús Barrio Andrés, Carolina Almohalla Álvarez
Medicina Clínica.2016; 146(8): 367. CrossRef
Antileishmanial, antioxidant, and cytotoxic activities of Quercus infectoria Olivier extract
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Biomedicine & Pharmacotherapy.2016; 82: 208. CrossRef
Chemical composition, efficacy and safety of Pistacia vera (var. Fandoghi) to inactivate protoscoleces during hydatid cyst surgery
Hossein Mahmoudvand, Farnaz Kheirandish, Ebrahim Saedi Dezaki, Saeedeh Shamsaddini, Majid Fasihi Harandi
Biomedicine & Pharmacotherapy.2016; 82: 393. CrossRef
Liver hydatid disease: Still a problem
Victoria Busto Bea, Jesús Barrio Andrés, Carolina Almohalla Álvarez
Medicina Clínica (English Edition).2016; 146(8): 367. CrossRef
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Phytochemical Compositions and Biological Activities of Essential Oil from Xanthium strumarium L.
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