Parasites, Hosts and Diseases

"Mathirut Mungthin"

Original Articles

Prevalence and Alternative Treatment of Head-Lice Infestation in Rural Thailand: A Community-Based Study: On-uma Singhasivanon, Saranath Lawpoolsri, Mathirut Mungthin, Surapon Yimsamran, Ngamphol Soonthornworasiri, Srivicha Krudsood; Korean J Parasitol 2019;57(5):499-504.
Published online October 31, 2019; DOI: https://doi.org/10.3347/kjp.2019.57.5.499

Abstract
PDF

Head-lice infestation, pediculosis capitis, remains a public-health burden in many countries. The widely used first-line pediculicides and alternative treatments are often too costly for use in poor socio-economic settings. Ivermectin has been considered an alternate treatment for field practice. This study was composed of 2 parts, a cross-sectional survey and an intervention study. The main
objective
s were to determine the prevalence and potential factors associated with head-lice infestation, and to evaluate the effectiveness and safety of oral ivermectin administration. A community-based cross-sectional survey was conducted among 890 villagers in rural areas along Thai-Myanmar border. Females with infestations were eligible for the intervention study, and 181 participated in the intervention study. A post-treatment survey was conducted to assess acceptance of ivermectin as a treatment choice. Data analysis used descriptive statistics and a generalized-estimation-equation model adjusted for cluster effect. The study revealed the prevalence of head-lice infestation was 50% among females and only 3% among males. Age stratification showed a high prevalence among females aged <20 years, and among 50% of female school-children. The prevalence was persistent among those with a history of infestation. The major risk factors were residing in a setting with other infected cases, and sharing a hair comb. The study also confirmed that ivermectin was safe and effective for field-based practice. It was considered a preferable treatment option. In conclusion, behavior-change communication should be implemented to reduce the observed high prevalence of headlice infestation. Ivermectin may be an alternative choice for head-lice treatment, especially in remote areas.

Citations

Citations to this article as recorded by

Comparative Efficacy of Commercial Antilice Shampoos Against Head Lice in a High‐Prevalence Primary School in Thailand
Sirima Kitvatanachai, Utsanee Supcharoengoon, Nutnicha Suphakhonchuwong, Aree Taylor, Pochong Rhongbutsri, Semonti Nandi
Journal of Parasitology Research.2025;[Epub] CrossRef
Correlates of pediculosis preventive behaviors among female adolescents using a theoretical framework: A case of health belief model
Masumeh Naseri, Mohtasham Ghaffari, Sakineh Rakhshanderou
Journal of Education and Health Promotion.2025;[Epub] CrossRef
Impact factors and genetic characteristics of head lice infestation in schoolchildren: a cross-sectional study from 2018 to 2023 in central China
Yi-Tian Fu, Yuan-Ping Deng, Yue Xie, Hui-Mei Wang, Yan-Yan Peng, Guo-Hua Liu, Xiang Wu
Parasites & Vectors.2025;[Epub] CrossRef
Prevalence and Intensity of Pediculus humanus capitis in Kindergarten and Primary School Children in Poland
Marcin Padzik, Gabriela Olędzka, Anita Gromala-Milaniuk, Ewa Kopeć, Edyta Beata Hendiger-Rizo
Journal of Clinical Medicine.2025; 14(11): 3942. CrossRef
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Journal of Southeast Asian Medical Research.2025; 9: e0248. CrossRef
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M.A. Valero, J. Haidamak, T.C. de Oliveira Santos, I. Cristine Prüss, A. Bisson, C. Santosdo Rosário, M.C. Fantozzi, M. Morales-Suárez-Varela, D.R. Klisiowicz
Acta Tropica.2024; 249: 107075. CrossRef
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The association between knockdown resistance and treatment outcome of 1% permethrin lotion in head lice infestations in Nonthaburi province, Thailand
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Archives of Dermatological Research.2024;[Epub] CrossRef
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Christian Kositz, John Bradley, Harry Hutchins, Anna Last, Umberto D'Alessandro, Michael Marks
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Daniel Morgado-Carrasco, Jaime Piquero-Casals, Sebastian Podlipnik
Piel.2022; 37(2): 113. CrossRef
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Ave Kutman, Ülle Parm, Anna-Liisa Tamm, Birgit Hüneva, Diana Jesin
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Narisa Brownell, Sakone Sunantaraporn, Kobpat Phadungsaksawasdi, Nirin Seatamanoch, Switt Kongdachalert, Atchara Phumee, Padet Siriyasatien, Kosta Y. Mumcuoglu
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Drug Resistance and in Vitro Susceptibility of Plasmodium falciparum in Thailand during 1988-2003: Nantana Suwandittakul, Wanna Chaijaroenkul, Pongchai Harnyuttanakorn, Mathirut Mungthin, Kesara Na Bangchang; Korean J Parasitol 2009;47(2):139-144.
Published online May 27, 2009; DOI: https://doi.org/10.3347/kjp.2009.47.2.139

Abstract
PDF

The aim of the present study was to investigate antimalarial drug pressure resulting from the clinical use of different antimalarials in Thailand. The phenotypic diversity of the susceptibility profiles of antimalarials, i.e., chloroquine (CQ), quinine (QN), mefloquine (MQ), and artesunate (ARS) in Plasmodium falciparum isolates collected during the period from 1988 to 2003 were studied. P. falciparum isolates from infected patients were collected from the Thai-Cambodian border area at different time periods (1988-1989, 1991-1992, and 2003), during which 3 different patterns of drug use had been implemented: MQ + sulphadoxine (S) + pyrimethamine (P), MQ alone and MQ + ARS, respectively. The in vitro drug susceptibilities were investigated using a method based on the incorporation of [³H] hypoxanthine. A total of 50 isolates were tested for susceptibilities to CQ, QN, MQ, and ARS. Of these isolates, 19, 16, and 15 were adapted during the periods 1988-1989, 1991-1993, and 2003, respectively. P. falciparum isolates collected during the 3 periods were resistant to CQ. Sensitivities to MQ declined from 1988 to 2003. In contrast, the parasite was sensitive to QN, and similar sensitivity profile patterns were observed during the 3 time periods. There was a significantly positive but weak correlation between the IC₅₀ values of CQ and QN, as well as between the IC₅₀ values of QN and MQ. Drug pressure has impact on sensitivity of P. falciparum to MQ. A combination therapy of MQ and ARS is being applied to reduce the parasite resistance, and also increasing the efficacy of the drug.

Citations

Citations to this article as recorded by

In vitro sensitivity of antimalarial drugs and correlation with clinico-parasitological response following treatment with a 3-day artesunate-mefloquine combination in patients with falciparum malaria along the Thai-Myanmar border
Phunuch Muhamad, Artitaya Thiengsusuk, Papichaya Phompradit, Kesara Na-Bangchang
Acta Tropica.2017; 166: 257. CrossRef
Ex vivo drug sensitivity profiles of Plasmodium falciparum field isolates from Cambodia and Thailand, 2005 to 2010, determined by a histidine-rich protein-2 assay
Stuart D Tyner, Chanthap Lon, Youry Se, Delia Bethell, Doung Socheat, Harald Noedl, Darapiseth Sea, Wichai Satimai, Kurt Schaecher, Wiriya Rutvisuttinunt, Mark M Fukuda, Suwanna Chaorattanakawee, Kritsanai Yingyuen, Siratchana Sundrakes, Panjaporn Chaicha
Malaria Journal.2012;[Epub] CrossRef
Pyronaridine-Artesunate versus Chloroquine in Patients with Acute Plasmodium vivax Malaria: A Randomized, Double-Blind, Non-Inferiority Trial
Yi Poravuth, Duong Socheat, Ronnatrai Rueangweerayut, Chirapong Uthaisin, Aung Pyae Phyo, Neena Valecha, B. H. Krishnamoorthy Rao, Emiliana Tjitra, Asep Purnama, Isabelle Borghini-Fuhrer, Stephan Duparc, Chang-Sik Shin, Lawrence Fleckenstein, Lorenz von S
PLoS ONE.2011; 6(1): e14501. CrossRef
Is it too soon to eliminate quinine?
Hubert Barennes, Leila M Srour, Eric Pussard
The Lancet Infectious Diseases.2010; 10(3): 141. CrossRef