Parasites, Hosts and Diseases

"Plasmodium berghei"

Original Articles

Low Fetal Weight is Directly Caused by Sequestration of Parasites and Indirectly by IL-17 and IL-10 Imbalance in the Placenta of Pregnant Mice with Malaria: Loeki Enggar Fitri, Teguh Wahju Sardjono, Zainabur Rahmah, Budi Siswanto, Kusworini Handono, Yoes Prijatna Dachlan; Korean J Parasitol 2015;53(2):189-196.
Published online April 22, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.2.189

Abstract
PDF

The sequestration of infected erythrocytes in the placenta can activate the syncytiotrophoblast to release cytokines that affect the micro-environment and influence the delivery of nutrients and oxygen to fetus. The high level of IL-10 has been reported in the intervillous space and could prevent the pathological effects. There is still no data of Th17 involvement in the pathogenesis of placental malaria. This study was conducted to reveal the influence of placental IL-17 and IL-10 levels on fetal weights in malaria placenta. Seventeen pregnant BALB/C mice were divided into control (8 pregnant mice) and treatment group (9 pregnant mice infected by Plasmodium berghei). Placental specimens stained with hematoxylin and eosin were examined to determine the level of cytoadherence by counting the infected erythrocytes in the intervillous space of placenta. Levels of IL-17 and IL-10 in the placenta were measured using ELISA. All fetuses were weighed by analytical balance. Statistical analysis using Structural Equation Modeling showed that cytoadherence caused an increased level of placental IL-17 and a decreased level of placental IL-10. Cytoadherence also caused low fetal weight. The increased level of placental IL-17 caused low fetal weight, and interestingly low fetal weight was caused by a decrease of placental IL-10. It can be concluded that low fetal weight in placental malaria is directly caused by sequestration of the parasites and indirectly by the local imbalance of IL-17 and IL-10 levels.

Citations

Citations to this article as recorded by

Immunosenescence, immunotolerance and rejection: clinical aspects in solid organ transplantation
Graziella Rubino, Efdal Yörük
Transplant Immunology.2024; 86: 102068. CrossRef
Is TNF alpha a mediator in the co-existence of malaria and type 2 diabetes in a malaria endemic population?
Subulade A. Ademola, Oluwayemi J. Bamikole, Olukemi K. Amodu
Frontiers in Immunology.2023;[Epub] CrossRef
Interleukin-17 promotes proliferation, migration, and invasion of trophoblasts via regulating PPAR-γ/RXR-α/Wnt signaling
Zhuo Zhang, Yuhua Yang, Xiaomei Lv, Hongyuan Liu
Bioengineered.2022; 13(1): 1224. CrossRef
Pregnancy-associated malaria: Effects of cytokine and chemokine expression
Karen E. Sánchez, Lilian M. Spencer
Travel Medicine and Infectious Disease.2022; 47: 102282. CrossRef
Malaria and pregnancy: a Venezuelan approach. Review article
Daniel Ernesto Carvallo Ruiz, Elizabeth Natalia Martínez-Núñez, José Manuel Martín-Castelli, Samantha Margaret Arrizabalo-Seir, Aixa Guadalupe Medina-Gamboa, José Núñez-Troconis
Obstetrics & Gynecology International Journal.2022; 13(5): 311. CrossRef
Impact of placental malaria on maternal, placental and fetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan
Samia Omer, Clara Franco-Jarava, Ali Noureldien, Mona Omer, Mutasim Abdelrahim, Israel Molina, Ishag Adam
Malaria Journal.2021;[Epub] CrossRef
Establishing a conceptual framework of the impact of placental malaria on infant neurodevelopment
Harriet L.S. Lawford, Anne CC Lee, Sailesh Kumar, Helen G. Liley, Samudragupta Bora
International Journal of Infectious Diseases.2019; 84: 54. CrossRef
IL-10 producing B cells rescue mouse fetuses from inflammation-driven fetal death and are able to modulate T cell immune responses
Mandy Busse, Kim-Norina Jutta Campe, Desiree Nowak, Anne Schumacher, Susanne Plenagl, Stefanie Langwisch, Gisa Tiegs, Annegret Reinhold, Ana Claudia Zenclussen
Scientific Reports.2019;[Epub] CrossRef
Trichomonas vaginalis exosome‐like vesicles modify the cytokine profile and reduce inflammation in parasite‐infected mice
L. M. Olmos‐Ortiz, M. A. Barajas‐Mendiola, M. Barrios‐Rodiles, L. E. Castellano, S. Arias‐Negrete, E. E. Avila, P. Cuéllar‐Mata
Parasite Immunology.2017;[Epub] CrossRef
Malaria in pregnancy: the relevance of animal models for vaccine development
Justin Doritchamou, Andrew Teo, Michal Fried, Patrick E Duffy
Lab Animal.2017; 46(10): 388. CrossRef

10,852 View
133 Download
11 Web of Science
Crossref

Age-Related CD4⁺CD25⁺Foxp3⁺ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria: Ying Shan, Jun Liu, Yan-Yan Pan, Yong-Jun Jiang, Hong Shang, Ya-Ming Cao; Korean J Parasitol 2013;51(3):289-295.
Published online June 30, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.3.289

Abstract
PDF

Different functions have been attributed to CD4⁺CD25⁺Foxp3⁺ regulatory T-cells (Tregs) during malaria infection. Herein, we describe the disparity in Treg response and pro- and anti-inflammatory cytokines during infection with Plasmodium berghei ANKA between young (3-week-old) and middle-aged (8-month-old) C57BL/6 mice. Young mice were susceptible to cerebral malaria (CM), while the middle-aged mice were resistant to CM and succumbed to hyperparasitemia and severe anemia. The levels of pro-inflammatory cytokines, such as TNF-α, in young CM-susceptible mice were markedly higher than in middle-aged CM-resistant mice. An increased absolute number of Tregs 3-5 days post-inoculation, co-occurring with elevated IL-10 levels, was observed in middle-aged CM-resistant mice but not in young CM-susceptible mice. Our findings suggest that Treg proliferation might be associated with the suppression of excessive pro-inflammatory Th1 response during early malaria infection, leading to resistance to CM in the middle-aged mice, possibly in an IL-10-dependent manner.

Citations

Citations to this article as recorded by

Contribution of Magnetic Resonance Imaging Studies to the Understanding of Cerebral Malaria Pathogenesis
Alicia Comino Garcia-Munoz, Isabelle Varlet, Georges Emile Grau, Teodora-Adriana Perles-Barbacaru, Angèle Viola
Pathogens.2024; 13(12): 1042. CrossRef
Mechanistic insights into immunopathogenesis of murine cerebral malaria: Cues from “young” C57BL/6J and BALB/c mice
Shweta Rai, Meetali Girdhar, Fouzia Siraj, Sheetal Sharma, Mukesh Kumar, Anju Katyal
Immunology Letters.2023; 256-257: 9. CrossRef
G6pd-Deficient Mice Are Protected From Experimental Cerebral Malaria and Liver Injury by Suppressing Proinflammatory Response in the Early Stage of Plasmodium berghei Infection
Haoan Yi, Weiyang Jiang, Fang Yang, Fan Li, Yirong Li, Wenjing Zhu, Qing Li, Syed Hassam Fakhar, Yaming Cao, Lan Luo, Wen Zhang, Yongshu He
Frontiers in Immunology.2021;[Epub] CrossRef
The role of regulatory T cells during Plasmodium chabaudi chabaudi AS infection in BALB/c mice
W. Pang, X. Sun, H. Feng, J. Wang, L. Cui, Y. Cao
Parasite Immunology.2016; 38(7): 439. CrossRef
Phenylhydrazine administration accelerates the development of experimental cerebral malaria
Xiaotong Zhu, Jun Liu, Yonghui Feng, Wei Pang, Zanmei Qi, Yongjun Jiang, Hong Shang, Yaming Cao
Experimental Parasitology.2015; 156: 1. CrossRef
Myeloid expression of the AP‐1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections
M. F. Fontana, A. Baccarella, D. Kellar, T. K. Oniskey, P. Terinate, S. D. Rosenberg, E. J. Huang, D. R. Herbert, C. C. Kim
Parasite Immunology.2015; 37(9): 470. CrossRef
Parasite densities modulate susceptibility of mice to cerebral malaria during co-infection with Schistosoma japonicum and Plasmodium berghei
Mei-lian Wang, Yong-hui Feng, Wei Pang, Zan-mei Qi, Ying Zhang, Ya-jun Guo, En-jie Luo, Ya-ming Cao
Malaria Journal.2014;[Epub] CrossRef

9,150 View
89 Download
Crossref

Expressed Sequence Tag Analysis of the Erythrocytic Stage of Plasmodium berghei: Ji-Woong Seok, Yong-Seok Lee, Eun-Kyung Moon, Jung-Yub Lee, Bijay Kumar Jha, Hyun-Hee Kong, Dong-Il Chung, Yeonchul Hong; Korean J Parasitol 2011;49(3):221-228.
Published online September 30, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.3.221

Abstract
PDF

Rodent malaria parasites, such as Plasmodium berghei, are practical and useful model organisms for human malaria research because of their analogies to the human malaria in terms of structure, physiology, and life cycle. Exploiting the available genetic sequence information, we constructed a cDNA library from the erythrocytic stages of P. berghei and analyzed the expressed sequence tag (EST). A total of 10,040 ESTs were generated and assembled into 2,462 clusters. These EST clusters were compared against public protein databases and 48 putative new transcripts, most of which were hypothetical proteins with unknown function, were identified. Genes encoding ribosomal or membrane proteins and purine nucleotide phosphorylases were highly abundant clusters in P. berghei. Protein domain analyses and the Gene Ontology functional categorization revealed translation/protein folding, metabolism, protein degradation, and multiple family of variant antigens to be mainly prevalent. The presently-collected ESTs and its bioinformatic analysis will be useful resources to identify for drug target and vaccine candidates and validate gene predictions of P. berghei.

9,146 View
59 Download

Brief Communication

Glutathione Reductase and Thioredoxin Reductase: Novel Antioxidant Enzymes from Plasmodium berghei: Gaurav Kapoor, Harjeet Singh Banyal; Korean J Parasitol 2009;47(4):421-424.
Published online December 1, 2009; DOI: https://doi.org/10.3347/kjp.2009.47.4.421

Abstract
PDF

Malaria parasites adapt to the oxidative stress during their erythrocytic stages with the help of vital thioredoxin redox system and glutathione redox system. Glutathione reductase and thioredoxin reductase are important enzymes of these redox systems that help parasites to maintain an adequate intracellular redox environment. In the present study, activities of glutathione reductase and thioredoxin reductase were investigated in normal and Plasmodium berghei-infected mice red blood cells and their fractions. Activities of glutathione reductase and thioredoxin reductase in P. berghei-infected host erythrocytes were found to be higher than those in normal host cells. These enzymes were mainly confined to the cytosolic part of cell-free P. berghei. Full characterization and understanding of these enzymes may promise advances in chemotherapy of malaria.

Citations

Citations to this article as recorded by

Increased Blood Concentrations of Malondialdehyde in Plasmodium Infection: A Systematic Review and Meta-Analysis
Onchuma Mueangson, Aongart Mahittikorn, Nsoh Godwin Anabire, Wanida Mala, Manas Kotepui
Antioxidants.2023; 12(8): 1502. CrossRef
Genome-Wide CRISPR/Cas9 Screen Identifies New Genes Critical for Defense Against Oxidant Stress in Toxoplasma gondii
Yun Chen, Qi Liu, Jun-Xin Xue, Man-Yu Zhang, Xiao-Ling Geng, Quan Wang, Wei Jiang
Frontiers in Microbiology.2021;[Epub] CrossRef
Differential Effect of Antioxidants Glutathione and Vitamin C on the Hepatic Injuries Induced by Plasmodium berghei ANKA Infection
Nayara Kauffmann, Luana K. R. L. da Penha, Danielle V. Braga, Brenda J. A. Ataíde, Nivia S. F. Mendes, Laiane P. de Sousa, Givago S. da Souza, Adelaide C. F. Passos, Evander J. O. Batista, Anderson M. Herculano, Karen R. H. M. Oliveira, Praveen Bharti
BioMed Research International.2021;[Epub] CrossRef
Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice
Camila Fabbri, Rita de Cássia Mascarenhas-Netto, Pritesh Lalwani, Gisely C Melo, Belisa ML Magalhães, Márcia AA Alexandre, Marcus VG Lacerda, Emerson S Lima
Malaria Journal.2013;[Epub] CrossRef
Cysteine-3 and cysteine-4 are essential for the thioredoxin-like oxidoreductase and antioxidant activities of Plasmodium falciparum macrophage migration inhibitory factor
Athar Alam, Manish Goyal, Mohd. Shameel Iqbal, Samik Bindu, Sumanta Dey, Chinmay Pal, Pallab Maity, Nahren Manuel Mascarenhas, Nanda Ghoshal, Uday Bandyopadhyay
Free Radical Biology and Medicine.2011; 50(11): 1659. CrossRef