Parasites, Hosts and Diseases

"Plasmodium ovale"

Case Reports

A Case of Plasmodium ovale wallikeri Infection in a Chinese Worker Returning from West Africa: Yuchun Li, Guangze Wang, Dingwei Sun, Feng Meng, Shigan Lin, Ximin Hu, Shanqing Wang; Korean J Parasito 2013;51(5):557-562.
Published online October 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.5.557

Abstract
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In contrast to the gradual reduction in the number of locally transmitted malaria cases in China, the number of imported malaria cases has been increasing since 2008. Here, we report a case of a 39-year-old Chinese man who acquired Plasmodium ovale wallikeri infection while staying in Ghana, West Africa for 6 months in 2012. Microscopic examinations of Giemsa-stained thin and thick blood smears indicated Plasmodium vivax infection. However, the results of rapid diagnostic tests, which were conducted 3 times, were not in agreement with P. vivax. To further check the diagnosis, standard PCR analysis of the small-subunit rRNA gene was conducted, based on which a phylogeny tree was constructed. The results of gene sequencing indicated that this malaria is a variant of P. ovale (P. ovale wallikeri). The infection in this patient was not a new infection, but a relapse of the infection from the one that he had contracted in West Africa.

Citations

Citations to this article as recorded by

Geographical origin of Plasmodium vivax in the Hainan Island, China: insights from mitochondrial genome
Yuchun Li, Xiaomin Huang, Ling Qing, Wen Zeng, Xiangjie Zeng, Feng Meng, GuangZe Wang, Yan Chen
Malaria Journal.2023;[Epub] CrossRef
An innovative three-layer strategy in response to a quartan malaria outbreak among forest goers in Hainan Island, China: a retrospective study
Yuchun Li, Yingjuan Huang, Renqiang Chen, Weizhen Huang, Huanzhi Xu, Rongshen Ye, Shaoling Huang, Ji Zhen, Xiaodan Wen, Guoyi Wang, Yong Liu, Haishan Li, Zaichun Zheng, Jian Wang, Guoshen Wang, Chong Chen, Wen Zeng, Feng Meng, Xiaoming Huang, Guangze Wang
Infectious Diseases of Poverty.2022;[Epub] CrossRef
High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana
Charles A. Brown, Prince J. Pappoe-Ashong, Nancy Duah, Anita Ghansah, Harry Asmah, Edwin Afari, Kwadwo A. Koram
Malaria Journal.2021;[Epub] CrossRef
A comparison of two PCR protocols for the differentiation of Plasmodium ovale species and implications for clinical management in travellers returning to Germany: a 10-year cross-sectional study
Hagen Frickmann, Christine Wegner, Stefanie Ruben, Ulrike Loderstädt, Egbert Tannich
Malaria Journal.2019;[Epub] CrossRef
Indel-informed Bayesian analysis suggests cryptic population structure between Plasmodium knowlesi of humans and long-tailed macaques (Macaca fascicularis) in Malaysian Borneo
JustinJ.S. Wilcox, Abigail Kerschner, Hope Hollocher
Infection, Genetics and Evolution.2019; 75: 103994. CrossRef
Detection of malaria with light microscopy and Nested polymerase chain reaction (Nested PCR) methods in peripheral blood expansions and investigation of the genetic diversity of Plasmodium species by 18S rRNA gene in Southeast of Iran
Ahmad Taghdiri, Pooya Ghasemi Nejad Almani, Iraj Sharifi, Mohammad Ali Mohammadi, Samira Salari
Microbial Pathogenesis.2019; 137: 103782. CrossRef
WITHDRAWN: Indel-informed bayesian analysis suggests cryptic divisions between Plasmodium knowlesi of humans and long-tailed macaques (Macaca fascicularis) in Malaysian Borneo
Justin J.S. Wilcox, Abigail Kerschner, Hope Hollocher
Infection, Genetics and Evolution.2018;[Epub] CrossRef
Diagnosis of an imported Plasmodium ovale wallikeri infection in Malaysia
Jonathan Wee Kent Liew, Rohela Mahmud, Lian Huat Tan, Yee Ling Lau
Malaria Journal.2016;[Epub] CrossRef
Clinical implications of a gradual dormancy concept in malaria
Joachim Richter, Gabriele Franken, Martha C. Holtfreter, Susanne Walter, Alfons Labisch, Heinz Mehlhorn
Parasitology Research.2016; 115(6): 2139. CrossRef
Genetic diversity of Plasmodium vivax population before elimination of malaria in Hainan Province, China
Yu-Chun Li, Guang-Ze Wang, Feng Meng, Wen Zeng, Chang-hua He, Xi-Min Hu, Shan-Qing Wang
Malaria Journal.2015;[Epub] CrossRef
Molecular characterization of misidentified Plasmodium ovale imported cases in Singapore
Jean-Marc Chavatte, Sarah Bee Hui Tan, Georges Snounou, Raymond Tzer Pin Valentine Lin
Malaria Journal.2015;[Epub] CrossRef
Characterization of Plasmodium ovale curtisi and P. ovale wallikeri in Western Kenya Utilizing a Novel Species-specific Real-time PCR Assay
Robin H. Miller, Clifford O. Obuya, Elizabeth W. Wanja, Bernhards Ogutu, John Waitumbi, Shirley Luckhart, V. Ann Stewart, Alain Debrabant
PLOS Neglected Tropical Diseases.2015; 9(1): e0003469. CrossRef

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A Case of Plasmodium ovale Malaria Imported from West Africa: Yunjung Kang, Jinyoung Yang; Korean J Parasito 2013;51(2):213-218.
Published online April 25, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.2.213

Abstract
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Malaria is a parasitic infection caused by Plasmodium species. Most of the imported malaria in Korea are due to Plasmodium vivax and Plasmodium falciparum, and Plasmodium ovale infections are very rare. Here, we report a case of a 24-year-old American woman who acquired P. ovale while staying in Ghana, West Africa for 5 months in 2010. The patient was diagnosed with P. ovale malaria based on a Wright-Giemsa stained peripheral blood smear, Plasmodium genus-specific real-time PCR, Plasmodium species-specific nested PCR, and sequencing targeting 18S rRNA gene. The strain identified had a very long incubation period of 19-24 months. Blood donors who have malaria with a very long incubation period could be a potential danger for propagating malaria. Therefore, we should identify imported P. ovale infections not only by morphological findings but also by molecular methods for preventing propagation and appropriate treatment.

Citations

Citations to this article as recorded by

A case of an asymptomatic Plasmodium falciparum infection followed by a symptomatic Plasmodium ovale infection in a soldier deployed to South Sudan
Choon Mee Kim, Jun-Won Seo, Da Young Kim, Na Ra Yun, Beomgi Lee, You Mi Lee, Munawir Muhammad, Dong-Min Kim
Malaria Journal.2025;[Epub] CrossRef
Plasmodium ovale: Exploring an Atypical Presentation
Priscila Lopez, Samah Suleiman, Mario Valdez Imbert, Mark N Sayegh, Tjark Schliep
Cureus.2024;[Epub] CrossRef
Diagnosis and Molecular Analysis on Imported Plasmodium ovale curtisi and P. ovale wallikeri Malaria Cases from West and South Africa during 2013-2016
Hyun-Il Shin, Bora Ku, Yu Jung Kim, Tae Yun Kim, Shin-Hyeong Cho, Sang-Eun Lee
The Korean Journal of Parasitology.2020; 58(1): 61. CrossRef
Clinical implications of a gradual dormancy concept in malaria
Joachim Richter, Gabriele Franken, Martha C. Holtfreter, Susanne Walter, Alfons Labisch, Heinz Mehlhorn
Parasitology Research.2016; 115(6): 2139. CrossRef
A Case ofPlasmodium malariaeInfection Imported from Guinea
Yun-Jung Kang, Moon-Jung Shim, Jung-Yeon Kim, So-Young Ji, Won-Ja Lee, Jinyoung Yang
Laboratory Medicine Online.2015; 5(1): 33. CrossRef
Do hypnozoites cause relapse in malaria?
Miles B. Markus
Trends in Parasitology.2015; 31(6): 239. CrossRef
A molecular survey of acute febrile illnesses reveals Plasmodium vivax infections in Kedougou, southeastern Senegal
Makhtar Niang, Laty Gaye Thiam, Abdourahmane Sow, Cheikh Loucoubar, Ndeye Sakha Bob, Fode Diop, Babacar Diouf, Oumy Niass, Annick Mansourou, Marie Louise Varela, Ronald Perraut, Amadou A Sall, Aissatou Toure-Balde
Malaria Journal.2015;[Epub] CrossRef
New type of SSUrDNA sequence was detected from both Plasmodium ovale curtisi and Plasmodium ovale wallikeri samples
Mei Li, Zhigui Xia, He Yan
Malaria Journal.2014;[Epub] CrossRef
Mixed-species Plasmodium falciparum and Plasmodium ovale malaria in a paediatric returned traveller
Heather Senn, Nadia Alattas, Andrea K Boggild, Shaun K Morris
Malaria Journal.2014;[Epub] CrossRef
A Case of Plasmodium ovale wallikeri Infection in a Chinese Worker Returning from West Africa
Yuchun Li, Guangze Wang, Dingwei Sun, Feng Meng, Shigan Lin, Ximin Hu, Shanqing Wang
The Korean Journal of Parasitology.2013; 51(5): 557. CrossRef

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Original Article

Minor liver profile dysfunctions in Plasmodium vivax, P. malariae and P. ovale patients and normalization after treatment: Noppadon Tangpukdee, Vipa Thanachartwet, Srivicha Krudsood, Nutthanej Luplertlop, Karnchana Pornpininworakij, Kobsiri Chalermrut, Sasikarn Phokham, Shigeyuki Kano, Sornchai Looareesuwan, Polrat Wilairatana; Korean J Parasito 2006;44(4):295-302.
Published online December 20, 2006; DOI: https://doi.org/10.3347/kjp.2006.44.4.295

Abstract
PDF

Liver function tests were performed in 61 vivax, 54 malariae and 15 ovale malaria patients who were admitted to Bangkok Hospital for Tropical Diseases between 2001 and 2004. The
objective
of the study was to evaluate changes in hepatic biochemical indices before and after treatment with artemisinin derivatives. On admission and prior to treatment, hepatic dysfunction was found among the 3 groups. Serum liver function tests and physical examinations were performed weekly during the 28-day follow-up period. Initially elevated serum bilirubin and diminished albumin returned to normal within 2 weeks of treatment. Serum alkaline phosphatase and aminotransferases returned to within normal limits within 3 weeks. We conclude that patients with Plasmodium vivax, P. malariae and P. ovale infections had slightly elevated serum bilirubin, aminotransferase and alkaline phosphatase levels, and hypoalbuminemia. These minor abnormalities returned to normal within a few weeks after treatment with therapies based on artemisinin derivatives.

Citations

Citations to this article as recorded by

The Dynamics of Liver Function Test Abnormalities after Malaria Infection: A Retrospective Observational Study
John Woodford, G. Dennis Shanks, Paul Griffin, Stephan Chalon, James S. McCarthy
The American Journal of Tropical Medicine and Hygiene.2018; 98(4): 1113. CrossRef
Liver injury in uncomplicated malaria: an overlooked phenomenon
Brioni R. Moore
EBioMedicine.2018; 37: 15. CrossRef
Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection
Sandipan Ray, Sandip K. Patel, Apoorva Venkatesh, Gangadhar Chatterjee, Naziya N. Ansari, Nithya J. Gogtay, Urmila M. Thatte, Prajakta Gandhe, Santosh G. Varma, Swati Patankar, Sanjeeva Srivastava
Scientific Reports.2017;[Epub] CrossRef
Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission
Paul Griffin, Cielo Pasay, Suzanne Elliott, Silvana Sekuloski, Maggy Sikulu, Leon Hugo, David Khoury, Deborah Cromer, Miles Davenport, Jetsumon Sattabongkot, Karen Ivinson, Christian Ockenhouse, James McCarthy, Photini Sinnis
PLOS Neglected Tropical Diseases.2016; 10(12): e0005139. CrossRef
Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax — malaria in India and Saudi Arabia
Wajihullah Khan, Haytham Zakai, Umm-e-Asma
Acta Parasitologica.2014;[Epub] CrossRef
Association of Heme Oxygenase 1 with the Restoration of Liver Function after Damage in Murine Malaria by Plasmodium yoelii
Sumanta Dey, Somnath Mazumder, Asim Azhar Siddiqui, M. Shameel Iqbal, Chinmoy Banerjee, Souvik Sarkar, Rudranil De, Manish Goyal, Samik Bindu, Uday Bandyopadhyay, J. H. Adams
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A STUDY OF CLINICAL PROFILE IN PATIENTS WITH P.VIVAX MALARIA
Apte S., Jain J., Parmar A., Apte A., Sinha U, Chanchlani R
Journal of Evolution of Medical and Dental Sciences.2014; 03(03): 575. CrossRef
Mice lacking inducible nitric oxide synthase develop exacerbated hepatic inflammatory responses induced by Plasmodium berghei NK65 infection
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Clinico-laboratory profile of severe Plasmodium vivax malaria in a tertiary care centre in Kolkata
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Effect of artesunate based combination therapy with homeopathic medicine china on liver and kidney of Plasmodium berghei infected mice
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Journal of Parasitic Diseases.2012;[Epub] CrossRef
A Case of Plasmodium ovale Malaria Imported from West Africa
SeJin Moon, Baek-Nam Kim, Eun-Young Kuak, Tae Hee Han
Laboratory Medicine Online.2012; 2(1): 51. CrossRef
Retrospective analysis of vivax malaria patients presenting to tertiary referral centre of Uttarakhand
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Ictericia y hepatopatía en el paciente con malaria
Ana del Mar Cortina, Alberto Tobón
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Clinical Features of Children Hospitalized with Malaria—A Study from Bikaner, Northwest India
Dhanpat Kumar Kochar, Ashish Das, Shilpi Garg, Sanjay Kumar Kochar, Ghanshyam Singh Sengar, Gajanand Singh Tanwar, Anjana Gupta, Abhishek Kochar, Deepak Pakalapati, Vishal Saxena, Poonam Chand Khatri, Sheetal Middha, Jyoti Acharya
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Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species
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