Parasites, Hosts and Diseases

"Pyo Yun Cho"

Brief Communications

An Evaluation of Active Case Detection in Malaria Control Program in Kiyuni Parish of Kyankwanzi District, Uganda: Young Yil Bahk, Pyo Yun Cho, Seong Kyu Ahn, Woo-Joo Lee, Tong-Soo Kim, Working Groups in ChildFund Korea , Uganda; Korean J Parasitol 2018;56(6):625-632.
Published online December 31, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.6.625

Abstract
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Malaria remains one of the leading health burdens in the developing world, especially in several sub-Saharan Africa countries; and Uganda has some of the highest recorded measures of malaria transmission intensity in the world. It is evident that the prevalence of malaria infection, the incidence of disease, and mortality from severe malaria remain very high in Uganda. Although the recent stable political and economic situation in the last few decades in Uganda supported for a fairly good appreciation of malaria control, the declines in infection, morbidity, and mortality are not sufficient to interrupt transmission and this country is among the top 4 countries with cases of malaria, especially among children under 5 years of age. In fact, Uganda, which is endemic in over 95% of the country, is a representative of challenges facing malaria control in Africa. In this study, we evaluated an active case detection program in 6 randomly selected villages, Uganda. This program covered a potential target population of 5,017 individuals. Our team screened 12,257 samples of malaria by active case detection, every 4 months, from February 2015 to January 2017 in the 6 villages (a total of 6 times). This study assessed the perceptions and practices on malaria control in Kiyuni Parish of Kyankwanzi district, Uganda. Our study presents that the incidence of malaria is sustained high despite efforts to scale-up and improve the use of LLINs and access to ACDs, based on the average incidence confirmed by RDTs.

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The impact of mass screening and treatment interventions on malaria incidence and prevalence: a retrospective analysis of a malaria elimination programme in eastern Myanmar, and systematic review and meta-analysis
Jade D. Rae, Angela Devine, Chanapat Patekkham, Aung Myint Thu, Gilles Delmas, Daniel M. Parker, Richard J. Maude, Jacher Wiladphaingern, Ladda Kajeechiwa, May Myo Thwin, Saw Win Tun, Julie A. Simpson, François H. Nosten
Malaria Journal.2025;[Epub] CrossRef
The Relationship Between Market Environment Dimensions and Availability of Malaria Pills in Uganda
Pross Nagitta Oluka, Marcia Mkansi, George William Kajjumba
Global Advances in Health and Medicine.2021;[Epub] CrossRef
Malaria vector control strategies. What is appropriate towards sustainable global eradication?
Joanne Atieno Ogunah, Joseph O. Lalah, Karl-Werner Schramm
Sustainable Chemistry and Pharmacy.2020; 18: 100339. CrossRef

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Monitoring of Noxious Protozoa for Management of Natural Water Resources: Young Yil Bahk, Pyo Yun Cho, Sung Kyu Ahn, Sangjung Park, Won Hwa Jheong, Yun-Kyu Park, Ho-Joon Shin, Sang-Seob Lee, Okjae Rhee, Tong-Soo Kim; Korean J Parasitol 2018;56(2):205-210.
Published online April 30, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.2.205

Abstract
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Waterborne parasitic protozoa, particularly Giardia lamblia and Cryptosporidium spp., are common causes of diarrhea and gastroenteritis worldwide. The most frequently identified source of infestation is water, and exposure involves either drinking water or recreation in swimming pools or natural bodies of water. In practice, studies on Cryptosporidium oocysts and Giardia cysts in surface water are challenging owing to the low concentrations of these microorganisms because of dilution. In this study, a 3-year monitoring of Cryptosporidium parvum, Giardia lamblia, and Naegleria fowleri was conducted from August 2014 to June 2016 at 5 surface water sites including 2 lakes, 1 river, and 2 water intake plants. A total of 50 water samples of 40 L were examined. Cryptosporidium oocysts were detected in 22% of samples and Giardia cysts in 32%. Water at the 5 sampling sites was all contaminated with Cryptosporidium oocysts (0-36/L), Giardia cysts (0-39/L), or both. The geometric mean concentrations of Cryptosporidium and Giardia were 1.14 oocysts/L and 4.62 cysts/L, respectively. Thus, effective monitoring plans must take into account the spatial and temporal parameters of contamination because they affect the prevalence and distribution of these protozoan cysts in local water resources.

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Cryptosporidium and cryptosporidiosis: An update of Asian perspectives in humans, water and food, 2015–2025
Shahira Abdelaziz Ali Ahmed, Sonia Boughattas, Mohammad Reza Mahmoudi, Huma Khan, Simuzar Mamedova, Ardra Namboodiri, Frederick R. Masangkay, Panagiotis Karanis
Current Research in Parasitology & Vector-Borne Diseases.2025; 8: 100311. CrossRef
Recent progress of functionalized nanomaterials-based biosensing for monitoring of food- and water-borne pathogens
Piyush Dey, Mohd Jamshaiya Raza, Alisha Khera, Akanksha Sharma, Akhil Khajuria, Ankur Pandey, Chandra Mouli Pandey, Rakesh Kumar Sharma, Gurpal Singh, Ravi Pratap Barnwal
Environmental Nanotechnology, Monitoring & Management.2024; 21: 100914. CrossRef
Performance of sewage treatment technologies for the removal of Cryptosporidium sp. and Giardia sp.: Toward water circularity
Pilar Suarez, José Luis Alonso, Gloria Gómez, Gladys Vidal
Journal of Environmental Management.2022; 324: 116320. CrossRef
Incorporating Microbial Species Interaction in Management of Freshwater Toxic Cyanobacteria: A Systems Science Challenge
Aabir Banerji, Kasey Benesh
Ecologies.2022; 3(4): 570. CrossRef

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Original Articles

Evaluation of the Accuracy of the EasyTest™ Malaria Pf/Pan Ag, a Rapid Diagnostic Test, in Uganda: Chom-Kyu Chong, Pyo Yun Cho, Byoung-Kuk Na, Seong Kyu Ahn, Jin Su Kim, Jin-Soo Lee, Sung-Keun Lee, Eun-Taek Han, Hak-Yong Kim, Yun-Kyu Park, Seok Ho Cha, Tong-Soo Kim; Korean J Parasitol 2014;52(5):501-505.
Published online October 22, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.5.501

Abstract
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In recent years, rapid diagnostic tests (RDTs) have been widely used for malaria detection, primarily because of their simple operation, fast results, and straightforward interpretation. The Asan EasyTest™ Malaria Pf/Pan Ag is one of the most commonly used malaria RDTs in several countries, including Korea and India. In this study, we tested the diagnostic performance of this RDT in Uganda to evaluate its usefulness for field diagnosis of malaria in this country. Microscopic and PCR analyses, and the Asan EasyTest™ Malaria Pf/Pan Ag rapid diagnostic test, were performed on blood samples from 185 individuals with suspected malaria in several villages in Uganda. Compared to the microscopic analysis, the sensitivity of the RDT to detect malaria infection was 95.8% and 83.3% for Plasmodium falciparum and non-P. falciparum, respectively. Although the diagnostic sensitivity of the RDT decreased when parasitemia was ≤500 parasites/?l, it showed 96.8% sensitivity (98.4% for P. falciparum and 93.8% for non-P. falciparum) in blood samples with parasitemia ≥100 parasites/?l. The specificity of the RDT was 97.3% for P. falciparum and 97.3% for non-P. falciparum. These results collectively suggest that the accuracy of the Asan EasyTest™ Malaria Pf/Pan Ag makes it an effective point-of-care diagnostic tool for malaria in Uganda.

Citations

Citations to this article as recorded by

Asymptomatic malaria infection, associated factors and accuracy of diagnostic tests in a historically high transmission setting in Northern Uganda
Bosco B. Agaba, Simon P. Rugera, Ruth Mpirirwe, Martha Atekat, Samuel Okubal, Khalid Masereka, Miseal Erionu, Bosco Adranya, Gertrude Nabirwa, Patrick B. Odong, Yasin Mukiibi, Isaac Ssewanyana, Susan Nabadda, Enoch Muwanguzi
Malaria Journal.2022;[Epub] CrossRef
Genetic diversity of Plasmodium vivax and Plasmodium falciparum lactate dehydrogenases in Myanmar isolates
Jinyoung Lee, Tae Im Kim, Hương Giang Lê, Won Gi Yoo, Jung-Mi Kang, Seong-Kyu Ahn, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim, Byoung-Kuk Na
Malaria Journal.2020;[Epub] CrossRef
Limitations of rapid diagnostic tests in malaria surveys in areas with varied transmission intensity in Uganda 2017-2019: Implications for selection and use of HRP2 RDTs
Agaba B. Bosco, Joaniter I. Nankabirwa, Adoke Yeka, Sam Nsobya, Karryn Gresty, Karen Anderson, Paul Mbaka, Christiane Prosser, David Smith, Jimmy Opigo, Rhoda Namubiru, Emmanuel Arinaitwe, John Kissa, Samuel Gonahasa, Sungho Won, Bora Lee, Chae Seung Lim,
PLOS ONE.2020; 15(12): e0244457. CrossRef
An Update on Malaria Rapid Diagnostic Tests
Avinash N. Mukkala, Jason Kwan, Rachel Lau, David Harris, Dylan Kain, Andrea K. Boggild
Current Infectious Disease Reports.2018;[Epub] CrossRef
Comparative Assessment of Diagnostic Performances of Two Commercial Rapid Diagnostic Test Kits for Detection of Plasmodium spp. in Ugandan Patients with Malaria
Young Yil Bahk, Seo Hye Park, Woojoo Lee, Kyoung Jin, Seong Kyu Ahn, Byoung-Kuk Na, Tong-Soo Kim
The Korean Journal of Parasitology.2018; 56(5): 447. CrossRef
An Evaluation of Active Case Detection in Malaria Control Program in Kiyuni Parish of Kyankwanzi District, Uganda
Young Yil Bahk, Pyo Yun Cho, Seong Kyu Ahn, Woo-Joo Lee, Tong-Soo Kim
The Korean Journal of Parasitology.2018; 56(6): 625. CrossRef
Comparison of the diagnostic performance of microscopic examination with nested polymerase chain reaction for optimum malaria diagnosis in Upper Myanmar
Jung-Mi Kang, Pyo-Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong-Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim, Byoung-Kuk Na
Malaria Journal.2017;[Epub] CrossRef
A Cluster Randomised Trial Introducing Rapid Diagnostic Tests into Registered Drug Shops in Uganda: Impact on Appropriate Treatment of Malaria
Anthony K. Mbonye, Pascal Magnussen, Sham Lal, Kristian S. Hansen, Bonnie Cundill, Clare Chandler, Siân E. Clarke, Roly D Gosling
PLOS ONE.2015; 10(7): e0129545. CrossRef

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Probability of Antibody Formation against Circumsporozoite Protein of Plasmodium vivax among Korean Malaria Patients: Ho-Woo Nam, Kyoung Ju Song, Hye Jin Ahn, Zhaoshou Yang, Chom-Kyu Chong, Pyo Yun Cho, Seong Kyu Ahn, Tong-Soo Kim; Korean J Parasitol 2014;52(2):143-149.
Published online April 18, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.2.143

Abstract
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To evaluate the seroprevalence against circumsporozoite protein (CSP) of Plasmodium vivax in sera of Korean patients, the central repeating domain (CRD) of CSP was cloned and analyzed. From the genomic DNA of patient's blood, 2 kinds of CSPs were identified to belong to a VK210 type, which is the dominant repeating of GDRA(D/A)GQPA, and named as PvCSPA and PvCSPB. Recombinantly expressed his-tagged PvCSPA or PvCSPB in Escherichia coli reacted well against sera of patients in western blot, with the detecting rate of 47.9% (58/121), which included 15 cases positive for PvCSPA, 6 cases positive for PvCSPB, and 37 cases for both. The mixture of PvCSPA and PvCSPB was loaded to a rapid diagnostic test kit (RDT) and applied with the same set of patient sera, which resulted in detection rates of 57.0% (69/121). When the protein sequences of PvCSPA were compared with those of P. vivax in endemic regions of India and Uganda, they were compatibly homologous to PvCSPA with minor mutations. These results suggested that the recombinant PvCSPA and PvCSPB loaded RDT may be a milestone in latent diagnosis which has been a hot issue of domestic malaria and important for radical therapy in overlapped infections with P. falciparum in tropical and subtropical areas. During the biological process of malarial infection, exposure of CSP to antigen-antibody reaction up to 57.0% is the first report in Korea.

Citations

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Using Serological Markers for the Surveillance of Plasmodium vivax Malaria: A Scoping Review
Lejla Kartal, Ivo Mueller, Rhea J. Longley
Pathogens.2023; 12(6): 791. CrossRef
A Dual, Systematic Approach to Malaria Diagnostic Biomarker Discovery
Seda Yerlikaya, Ewurama D A Owusu, Augustina Frimpong, Robert Kirk DeLisle, Xavier C Ding
Clinical Infectious Diseases.2022; 74(1): 40. CrossRef
Structure-genetic diversity and recombinant protein of circumsporozoite protein (CSP) of vivax malaria antigen: A potential malaria vaccine candidate
Vahid Raissi, Soudabeh Etemadi, Muhammad Ibrahim Getso, Ahmad Mehravaran, Omid Raiesi
Gene Reports.2021; 23: 101132. CrossRef
Serological responses to a soluble recombinant circumsporozoite protein-VK210 of Plasmodium vivax (rPvCSP-VK210) among Iranian malaria patients
Mehdi Nateghpour, Soudabeh Etemadi, Afsaneh Motevalli Haghi, Hamid Eslami, Mehdi Mohebali, Leila Farivar
European Journal of Medical Research.2021;[Epub] CrossRef
Recent Advances in the Development of Biosensors for Malaria Diagnosis
Francis D. Krampa, Yaw Aniweh, Prosper Kanyong, Gordon A. Awandare
Sensors.2020; 20(3): 799. CrossRef
Genetic Diversity of Plasmodium vivax Causing Epidemic Malaria in the Republic of Korea
Young Yil Bahk, Jeonga Kim, Seong Kyu Ahn, Byoung-Kuk Na, Jong-Yil Chai, Tong-Soo Kim
The Korean Journal of Parasitology.2018; 56(6): 545. CrossRef
Plasmodium vivax msp-3α polymorphisms: analysis in the Indian subcontinent
Anju Verma, Hema Joshi, Vineeta Singh, Anup Anvikar, Neena Valecha
Malaria Journal.2016;[Epub] CrossRef

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Seroprevalence of Plasmodium vivax in the Republic of Korea (2003-2005) using Indirect Fluorescent Antibody Test: Tong-Soo Kim, Yoon-Joong Kang, Won-Ja Lee, Byoung-Kuk Na, Sung-Ung Moon, Seok Ho Cha, Sung-Keun Lee, Yun-Kyu Park, Jhang-Ho Pak, Pyo Yun Cho, Youngjoo Sohn, Hyeong-Woo Lee; Korean J Parasitol 2014;52(1):1-7.
Published online February 19, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.1.1

Abstract
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Plasmodium vivax reemerged in the Republic of Korea (ROK) in 1993, and is likely to continue to affect public health. The purpose of this study was to measure levels of anti-P. vivax antibodies using indirect fluorescent antibody test (IFAT) in border areas of ROK, to determine the seroprevalence of malaria (2003-2005) and to plan effective control strategies. Blood samples of the inhabitants in Gimpo-si, Paju-si, and Yeoncheon-gun (Gyeonggi-do), and Cheorwon-gun (Gangwon-do) were collected and kept in Korea Centers for Disease Control and Prevention (KCDC). Out of a total of 1,774 serum samples tested, the overall seropositivity was 0.94% (n=17). The seropositivity was the highest in Paju-si (1.9%, 7/372), followed by Gimpo-si (1.4%, 6/425), Yeoncheon-gun (0.67%, 3/451), and Cheorwon-gun (0.19%, 1/526). The annual parasite incidence (API) in these areas gradually decreased from 2003 to 2005 (1.69, 1.09, and 0.80 in 2003, 2004, and 2005, respectively). The highest API was found in Yeoncheon-gun, followed by Cheorwon-gun, Paju-si, and Gimpo-si. The API ranking in these areas did not change over the 3 years. The seropositivity of Gimpo-si showed a strong linear relationship with the API of 2005 (r=0.9983, P=0.036). Seropositivity data obtained using IFAT may be useful for understanding malaria prevalence of relevant years, predicting future transmission of malaria, and for establishing and evaluating malaria control programs in affected areas.

Citations

Citations to this article as recorded by

Using Serological Markers for the Surveillance of Plasmodium vivax Malaria: A Scoping Review
Lejla Kartal, Ivo Mueller, Rhea J. Longley
Pathogens.2023; 12(6): 791. CrossRef

9,615 View
98 Download
1 Web of Science
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Brief Communication

Seroprevalence of Toxoplasmosis in the Residents of Cheorwon-gun, Gangwon-do, Korea: Hye-Jin Ahn, Pyo Yun Cho, Seong Kyu Ahn, Tong-Soo Kim, Chom-Kyu Chong, Sung-Jong Hong, Seok Ho Cha, Ho-Woo Nam; Korean J Parasitol 2012;50(3):225-227.
Published online August 13, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.3.225

Abstract
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The seroepidemiological status of toxoplasmosis was surveyed among the residents of Cheorwon-gun, Gangwon-do by means of ELISA using a crude extract antigen of Toxoplasma gondii. The sera of 1,661 adult residents (866 males and 795 females) were collected and checked for IgG antibody titers, which showed 17.0% positive rate (282 sera). The positive rate was significantly different between the sex; 20.6% for males and 13.1% for females (P<0.05). The positive rates were higher in fifties of males (28.7%) and forties of females (20.0%). This positive rate of toxoplasmosis in Cheorwon-gun residents is regarded as the highest among the surveys of different geographical regions of Korea. This high positive rate may due in part to peculiar geographical locality of the surveyed area near the naturally well preserved demilitarized zone (DMZ) or presumably consumption of the pork imported from high endemic nations. Therefore, it is necessary to study further the epidemiology of toxoplasmosis in Cheorwon-gun.

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Clinical characteristics of toxoplasmosis patients in Korea: A retrospective study using health insurance review and assessment service data and electronic medical records
Do-Won Ham, Bong-Kwang Jung, Ji-Hun Shin, Yong Joon Kim, Kyoung Yul Seo, Seung Mi Lee, Jae Hyoung Im, Jeong-Ran Kwon, Ho-Sung Lee, Kyung-Won Hwang, Eun-Hee Shin
Parasites, Hosts and Diseases.2024; 62(4): 424. CrossRef
Detection of Toxoplasma gondii oocysts in soil and risk mapping in an island environment in the Northeast of Brazil
Pollyanne Raysa Fernandes de Oliveira, Renata Pimentel Bandeira de Melo, Umberto Diego Rodrigues de Oliveira, Fernando Jorge Rodrigues Magalhães, Rivaldo José Ferreira Junior, Müller Ribeiro Andrade, Rinaldo Aparecido Mota
Transboundary and Emerging Diseases.2022; 69(6): 3457. CrossRef
Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea
Jeehi Jung, Jinyoung Lee, Yoon Kyung Chang, Seong Kyu Ahn, Seo Hye Park, Sung-Jong Hong, Jihoo Lee, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam, Tong-Soo Kim, Dongjae Kim
The Korean Journal of Parasitology.2021; 59(1): 9. CrossRef
Clusters of Toxoplasmosis in Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea
Jihye Yu, Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
The Korean Journal of Parasitology.2021; 59(3): 251. CrossRef
Seroprevalence and B1 gene Phylogeny of Toxoplasma gondii of Dogs and Cats in Republic of Korea
Yeojin Park, Jinhyeong Noh, Hyun-Ji Seo, Keun-Ho Kim, Subin Min, Mi-Sun Yoo, Bo-Ram Yun, Jong-Ho Kim, Eun-Jin Choi, Doo-Sung Cheon, Sung-Jong Hong, Soon-Seek Yoon, Yun Sang Cho
The Korean Journal of Parasitology.2020; 58(3): 257. CrossRef
Clusters of Toxoplasmosis in Gyodong-Myeon and Samsan-Myeon, Ganghwa-Gun, Korea
Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
The Korean Journal of Parasitology.2020; 58(5): 493. CrossRef
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Davood Anvari, Mehdi Sharif, Shahabeddin Sarvi, Sargis A. Aghayan, Shirzad Gholami, Abdol Sattar Pagheh, Seyed Abdollah Hosseini, Reza Saberi, Tooran Nayeri Chegeni, Zahra Hosseininejad, Ahmad Daryani
Microbial Pathogenesis.2019; 129: 30. CrossRef
Tissue Fluid Enzyme-Linked Immunosorbant Assay for Piglets Experimentally Infected with Toxoplasma gondii and Survey on Local and Imported Pork in Korean Retail Meat Markets
Won Gi Yoo, Sun-Min Kim, Eun Jeong Won, Ji-Yun Lee, Fuhong Dai, Ho Choon Woo, Ho-Woo Nam, Tae Im Kim, Jeong-Hee Han, Dongmi Kwak, Yun Sang Cho, Seung-Won Kang, Tong-Soo Kim, Xing-Quan Zhu, Chunren Wang, Heejeong Youn, Sung-Jong Hong
The Korean Journal of Parasitology.2018; 56(5): 437. CrossRef
Seroprevalence of Toxoplasmosis with ELISA and Rapid Diagnostic Test among Residents in Gyodong-do, Inchon city, Korea: A Four-Year Follow-up
Yeong Hoon Kim, Ji hoo Lee, Seong kyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
The Korean Journal of Parasitology.2017; 55(3): 247. CrossRef
Seroprevalence of Toxoplasmosis Detected by RDT in Residents near the DMZ (demilitarized zone) of Cheorwon-gun, Gangwon-do, Korea
Yeong Hoon Kim, Jihoo Lee, Young-Eun Kim, Seongkyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
The Korean Journal of Parasitology.2017; 55(4): 385. CrossRef
Seroprevalence of anti-Toxoplasma IgG and IgM among individuals who were referred to medical laboratories in Mazandaran province, northern Iran
Mehdi Sharif, Ahmad Daryani, Zahra Ebrahimnejad, Shirzad Gholami, Ehsan Ahmadpour, Samaneh Borhani, Narges Lamsechi
Journal of Infection and Public Health.2016; 9(1): 75. CrossRef
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Zhaoshou Yang, Hye-Jin Ahn, Young-Hoon Park, Ho-Woo Nam
The Korean Journal of Parasitology.2016; 54(1): 31. CrossRef
First Report of Genotyping ofToxoplasma gondiiin Free-LivingMicrotus fortisin Northeastern China
Xiao-Xuan Zhang, Si-Yang Huang, Ying-Guang Zhang, Yuan Zhang, Xing-Quan Zhu, Quan Liu
Journal of Parasitology.2014; 100(5): 692. CrossRef
Seroepidemiology of Toxoplasma gondii infection in drivers involved in road traffic accidents in the metropolitan area of Guadalajara, Jalisco, Mexico
Ma de la Luz Galván-Ramírez, Laura Verónica Sánchez-Orozco, Laura Rocío Rodríguez, Saúl Rodríguez, Enrique Roig-Melo, Rogelio Troyo Sanromán, Erwin Chiquete, Juan Armendáriz-Borunda
Parasites & Vectors.2013;[Epub] CrossRef
Clinical Features and Treatment of Ocular Toxoplasmosis
Young-Hoon Park, Ho-Woo Nam
The Korean Journal of Parasitology.2013; 51(4): 393. CrossRef
Serologic Survey of Toxoplasmosis in Seoul and Jeju-do, and a Brief Review of Its Seroprevalence in Korea
Hyemi Lim, Sang-Eun Lee, Bong-Kwang Jung, Min-Ki Kim, Mi Youn Lee, Ho-Woo Nam, Jong-Gyun Shin, Cheong-Ha Yun, Han-Ik Cho, Eun-Hee Shin, Jong-Yil Chai
The Korean Journal of Parasitology.2012; 50(4): 287. CrossRef
A Surge in the Seroprevalence of Toxoplasmosis among the Residents of Islands in Gangwha-gun, Incheon, Korea
Zhaoshou Yang, Pyo Yun Cho, Seong Kyu Ahn, Hye-Jin Ahn, Tong-Soo Kim, Chom-Kyu Chong, Sung-Jong Hong, Seok Ho Cha, Ho-Woo Nam
The Korean Journal of Parasitology.2012; 50(3): 191. CrossRef

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Original Article

A Surge in the Seroprevalence of Toxoplasmosis among the Residents of Islands in Gangwha-gun, Incheon, Korea: Zhaoshou Yang, Pyo Yun Cho, Seong Kyu Ahn, Hye-Jin Ahn, Tong-Soo Kim, Chom-Kyu Chong, Sung-Jong Hong, Seok Ho Cha, Ho-Woo Nam; Korean J Parasitol 2012;50(3):191-197.
Published online August 13, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.3.191

Abstract
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Seroepidemiological changes of Toxoplasma gondii infection among the residents of the islands of Gangwha-gun, Incheon for 2 years were surveyed and evaluated by ELISA using a crude extract antigen. In 2010, sera of 919 adult residents in Gyodong-myeon and 313 adults in Samsan-myeon were collected and checked for IgG antibody titers, which showed 14.5% (133 sera) and 19.8% (62 sera) positive rates, respectively. In 2011, sera of 955 adults in Gyodong-myeon and 341 adults in Samsan-myeon were examined, which showed an increase of positive rates to 23.8% (227 sera) and 31.7% (108 sera), respectively. Totally, the seroprevalence of the first year was 15.8% and it increased rapidly to 25.8% in the second year. The positive rates of both sexes increased simultaneously with the significant ratio of males to females by 1.7-2.2 fold (P<0.05). In both myeons, 661 sera were collected every year and showed changes in optical density (OD) in 177 sera; newly found as positives in 73 persons (11.0%), negative conversion in 10 persons (1.5%), and maintained or increased in 94 persons (14.2%). This rapid increase in the prevalence of toxoplasmosis in Gangwha islands may be due to in part peculiar changes in the toxoplasmic environment of the islands and presumably the consumption of the pork bred domestically within the islands or imported from high endemic nations. It is necessary to find out symptomatic toxoplasmic patients and confirm the risk factors for further infection in the islands of Gangwha-gun.

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Is the incidence of congenital toxoplasmosis declining?
Gregory Colin Milne, Joanne P. Webster, Martin Walker
Trends in Parasitology.2023; 39(1): 26. CrossRef
Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea
Jeehi Jung, Jinyoung Lee, Yoon Kyung Chang, Seong Kyu Ahn, Seo Hye Park, Sung-Jong Hong, Jihoo Lee, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam, Tong-Soo Kim, Dongjae Kim
The Korean Journal of Parasitology.2021; 59(1): 9. CrossRef
Cross-sectional survey for Toxoplasma gondii infection in humans in Fernando de Noronha island, Brazil
Maria da Conceição Carvalho, Müller Ribeiro-Andrade, Renata Pimentel Bandeira de Melo, Dandara Matias Guedes, José Wilton Pinheiro Junior, Erika Fernanda Torres Samico Fernandes Cavalcanti, Fernando Jorge Rodrigues Magalhães, Rinaldo Aparecido Mota
Revista Brasileira de Parasitologia Veterinária.2021;[Epub] CrossRef
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Sun Huh
Journal of the Korean Medical Association.2019; 62(8): 437. CrossRef
TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: efficacy study in a single institute in Korea
Mi Hae Chung, Chan Ok Shin, Juyoung Lee
Korean Journal of Pediatrics.2018; 61(4): 114. CrossRef
Tissue Fluid Enzyme-Linked Immunosorbant Assay for Piglets Experimentally Infected with Toxoplasma gondii and Survey on Local and Imported Pork in Korean Retail Meat Markets
Won Gi Yoo, Sun-Min Kim, Eun Jeong Won, Ji-Yun Lee, Fuhong Dai, Ho Choon Woo, Ho-Woo Nam, Tae Im Kim, Jeong-Hee Han, Dongmi Kwak, Yun Sang Cho, Seung-Won Kang, Tong-Soo Kim, Xing-Quan Zhu, Chunren Wang, Heejeong Youn, Sung-Jong Hong
The Korean Journal of Parasitology.2018; 56(5): 437. CrossRef
Seroprevalence of Toxoplasmosis with ELISA and Rapid Diagnostic Test among Residents in Gyodong-do, Inchon city, Korea: A Four-Year Follow-up
Yeong Hoon Kim, Ji hoo Lee, Seong kyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
The Korean Journal of Parasitology.2017; 55(3): 247. CrossRef
Seroprevalence of Toxoplasmosis Detected by RDT in Residents near the DMZ (demilitarized zone) of Cheorwon-gun, Gangwon-do, Korea
Yeong Hoon Kim, Jihoo Lee, Young-Eun Kim, Seongkyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
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Brief Communication

Expression of Exogenous Human Hepatic Nuclear Factor-1α by a Lentiviral Vector and Its Interactions with Plasmodium falciparum Subtilisin-Like Protease 2: Shunyao Liao, Yunqiang Liu, Bing Zheng, Pyo Yun Cho, Hyun Ok Song, Yun-Seok Lee, Suk-Yul Jung, Hyun Park; Korean J Parasitol 2011;49(4):431-436.
Published online December 16, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.4.431

Abstract
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The onset, severity, and ultimate outcome of malaria infection are influenced by parasite-expressed virulence factors as well as by individual host responses to these determinants. In both humans and mice, liver injury follows parasite entry, persisting to the erythrocytic stage in the case of infection with the fatal strain of Plasmodium falciparum. Hepatic nuclear factor (HNF)-1α is a master regulator of not only the liver damage and adaptive responses but also diverse metabolic functions. In this study, we analyzed the expression of host HNF-1α in relation to malaria infection and evaluated its interaction with the 5'-untranslated region of subtilisin-like protease 2 (subtilase, Sub2). Recombinant human HNF-1α expressed by a lentiviral vector (LV HNF-1α) was introduced into mice. Interestingly, differences in the activity of the 5'-untranslated region of the Pf-Sub2 promoter were detected in 293T cells, and LV HNF-1α was observed to influence promoter activity, suggesting that host HNF-1α interacts with the Sub2 gene.

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Original Article

Transcriptional Activity of Plasmodium Subtilisin-like Protease 2 (Pf-Sub2) 5'Untranslated Regions and Its Interaction with Hepatocyte Growth Factor: Shunyao Liao, Yunqiang Liu, Suk-Yul Jung, Pyo Yun Cho, Bing Zheng, Hyun Park; Korean J Parasitol 2010;48(4):291-295.
Published online December 16, 2010; DOI: https://doi.org/10.3347/kjp.2010.48.4.291

Abstract
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The onset, severity, and ultimate outcome of malaria infection are influenced by parasite-expressed virulence factors and individual host responses to these determinants. In both humans and mice, liver injury is involved after parasite entry, which persists until the erythrocyte stage after infection with the fatal strain Plasmodium falciparum (Pf). Hepatocyte growth factor (HGF) has strong anti-apoptotic effects in various kinds of cells, and also has diverse metabolic functions. In this work, Pf-subtilisin-like protease 2 (Pf-Sub2) 5'untranslated region (UTR) was analyzed and its transcriptional activity was estimated by luciferase expression. Fourteen TATA boxes were observed but only one Oct-1 and c-Myb were done. In addition, host HGF interaction with Pf-Sub2 was evaluated by co-transfection of HGF- and Pf-Sub2-cloned vector. Interestingly, -1,422/+12 UTR exhibited the strongest luciferase activity but -329 to +12 UTR did not exhibit luciferase activity. Moreover, as compared with the control of unexpressed HGF, the HGF protein suppressed luciferase expression driven by the 5'untranslated region of the Pf-Sub2 promoter. Taken together, it is suggested that HGF controls and interacts with the promoter region of the Pf-Sub2 gene.

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Characterization of the transcriptome and temperature-induced differential gene expression in QPX, the thraustochytrid parasite of hard clams
Ewelina Rubin, Arnaud Tanguy, Mickael Perrigault, Emmanuelle Pales Espinosa, Bassem Allam
BMC Genomics.2014;[Epub] CrossRef

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Brief Communication

Metacercarial proteins interacting with WD40-repeat protein of Clonorchis sinensis: Pyo Yun Cho, Tae Im Kim, Shunyu Li, Sung-Jong Hong, Min-Ho Choi, Sung-Tae Hong, Yong Je Chung; Korean J Parasitol 2007;45(3):229-232.
Published online September 20, 2007; DOI: https://doi.org/10.3347/kjp.2007.45.3.229

Abstract
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The WD40-repeat proteins serve as a platform coordinating partner proteins and are involved in a range of regulatory cellular functions. A WD40-repeat protein (CsWD1) of Clonorchis sinensis previously cloned is expressed stage-specifically in the tegumental syncytium of C. sinensis metacercariae. In the present study, interacting proteins with the CsWD1 protein was purified by immunoprecipitation and 2 dimension gel electrophoresis from the C. sinensis metacercaria soluble extract, and tryptic peptides were analyzed by LC/ESI-MS. Putative partner proteins were annotated to be actin-2, glyceraldehyde-3-phosphate dehydrogenase, and hypothetical and unmanned proteins. The CsWD1 protein was predicted to contain 3 conserved actin-interacting residues on its functional surface. With these results, the CsWD1 protein is suggested to be an actin-interacting protein of C. sinensis.

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