Parasites, Hosts and Diseases

"Sang-Young Han"

Brief Communication

Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis: Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai; Korean J Parasitol 2013;51(5):595-597.
Published online October 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.5.595

Abstract
PDF

In December 2011, we reported an autochthonous case of Echinococcus multilocularis infection in a 42-year-old woman in Korea. The diagnosis was based on histopathological findings of the surgically resected liver cyst. In the present study, we evaluated the serological and molecular characteristics of this Korean E. multilocularis case. The patient's serum strongly reacted with affinity-purified native Em18 and recombinant Em18 antigens (specific for E. multilocularis) but negative for recombinant antigen B8/1 (reactive for Echinococcus granulosus). In immunoaffinity chromatography, the serum also strongly reacted with E. multilocularis and only weakly positive for E. granulosus. We determined the whole nucleotide sequence of cox1 (1,608 bp) using the paraffin-embedded cystic tissue which was compared with E. multilocularis isolates from China, Japan, Kazakhstan, Austria, France, and Slovakia. The Korean case showed 99.8-99.9% similarity with isolates from Asia (the highest similarity with an isolate from Sichuan, China), whereas the similarity with European isolates ranged from 99.5 to 99.6%.

Citations

Citations to this article as recorded by

Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
Sven Baumann, Rong Shi, Wenya Liu, Haihua Bao, Julian Schmidberger, Wolfgang Kratzer, Weixia Li, Thomas F. E. Barth, Sven Baumann, Johannes Bloehdorn, Iris Fischer, Tilmann Graeter, Natalja Graf, Beate Gruener, Doris Henne-Bruns, Andreas Hillenbrand, Tanj
Infection.2019; 47(5): 703. CrossRef
Lasiopodomys fuscus as an important intermediate host for Echinococcus multilocularis: isolation and phylogenetic identification of the parasite
Qi-Gang Cai, Xiu-Min Han, Yong-Hai Yang, Xue-Yong Zhang, Li-Qing Ma, Panagiotis Karanis, Yong-Hao Hu
Infectious Diseases of Poverty.2018;[Epub] CrossRef
Assessment of the global pattern of genetic diversity in Echinococcus multilocularis inferred by mitochondrial DNA sequences
Adel Spotin, Belgees Boufana, Ehsan Ahmadpour, Adriano Casulli, Mahmoud Mahami-Oskouei, Soheila Rouhani, Amirreza Javadi-Mamaghani, Firooz Shahrivar, Paria Khoshakhlagh
Veterinary Parasitology.2018; 262: 30. CrossRef
The echinococcoses in Asia: The present situation
Akira Ito, Christine M. Budke
Acta Tropica.2017; 176: 11. CrossRef

8,868 View
98 Download
Crossref

Case Report

Recurrent Hepatic Alveolar Echinococcosis: Report of The First Case in Korea with Unproven Infection Route: Su-Jin Kim, Jong-Han Kim, Sang-Young Han, Young-Hoon Kim, Jin-Han Cho, Jong-Yil Chai, Jin-Sook Jeong; Korean J Parasitol 2011;49(4):413-418.
Published online December 16, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.4.413

Abstract
PDF

Human alveolar echinococcosis (AE), a hepatic disorder that resembles liver cancer, is a highly aggressive and lethal zoonotic infection caused by the larval stage of the fox tapeworm, Echinococcus multilocularis. E. multilocularis is widely distributed in the northern hemisphere; the disease-endemic area stretches from north America through Europe to central and east Asia, including northern parts of Japan, but it has not been reported in Korea. Herein, we represent a first case of AE in Korea. A 41-year-old woman was found to have a large liver mass on routine medical examination. The excised mass showed multinodular, necrotic, and spongiform appearance with small irregular pseudocystic spaces. Microscopically, the mass was composed of chronic granulomatous inflammation with extensive coagulation necrosis and parasite-like structure, which was revealed as parasitic vesicles and laminated layer delineated by periodic acid-Schiff (PAS) stain. Clinical and histologic features were consistent with AE. After 8 years, a new liver mass and multiple metastatic pulmonary nodules were found and the recurred mass showed similar histologic features to the initial mass. She had never visited endemic areas of AE, and thus the exact infection route is unclear.

Citations

Citations to this article as recorded by

Delayed Diagnosis of Imported Cystic Echinococcosis and Successful Treatment With Percutaneous Drainage and Albendazole in Korea: A Case Report
Won Jun Choi, Hanna Jin, Hyeon Jae Jo, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Min-Ho Choi
Journal of Korean Medical Science.2025;[Epub] CrossRef
Imported parasitic diseases in the Republic of Korea: status and issues
Jong-Yil Chai
Journal of the Korean Medical Association.2025; 68(1): 52. CrossRef
Comparative analysis of host immune responses to Hydatid cyst in human and ovine hepatic cystic Echinococcosis
Bnar S. Hamad, Bushra H. Shnawa, Rafal A. Alrawi, Mukhtar H. Ahmed
Veterinary Immunology and Immunopathology.2024; 273: 110775. CrossRef
Investigation of Echinococcus multilocularis in foxes and dogs in Pakistan by detection of copro-DNA
Aisha Khan, Gérald Umhang, Zaib Ullah, Franck Boué, Vanessa Bastid, Ikram Ullah, Sajid Mahmood, Muhammad Sohail Afzal, Haroon Ahmed
Parasitology Research.2021; 120(2): 731. CrossRef
Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
Sven Baumann, Rong Shi, Wenya Liu, Haihua Bao, Julian Schmidberger, Wolfgang Kratzer, Weixia Li, Thomas F. E. Barth, Sven Baumann, Johannes Bloehdorn, Iris Fischer, Tilmann Graeter, Natalja Graf, Beate Gruener, Doris Henne-Bruns, Andreas Hillenbrand, Tanj
Infection.2019; 47(5): 703. CrossRef
An Imported Case of Disseminated Echinococcosis in Korea
Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
The Korean Journal of Parasitology.2019; 57(4): 429. CrossRef
The echinococcoses in Asia: The present situation
Akira Ito, Christine M. Budke
Acta Tropica.2017; 176: 11. CrossRef
Alveolar Echinococcosis of the Liver: A Diagnostic Problem in a Nonendemic Area
Kumble S. Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthruimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
Current Problems in Diagnostic Radiology.2016; 45(1): 80. CrossRef
Alveolar Echinococcosis of Liver: A Diagnostic Problem in a Nonendemic Area
Kumble Seetharama Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthurimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
Current Problems in Diagnostic Radiology.2015; 44(2): 221. CrossRef
Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai
The Korean Journal of Parasitology.2013; 51(5): 595. CrossRef
Serodiagnosis of Echinococcosis by ELISA Using Cystic Fluid from Uzbekistan Sheep
Yan Jin, Khikmat Anvarov, Abdukhakim Khajibaev, Samin Hong, Sung-Tae Hong
The Korean Journal of Parasitology.2013; 51(3): 313. CrossRef
In VitroandIn VivoActivities of Dicationic Diguanidino Compounds against Echinococcus multilocularis Metacestodes
Tatiana Küster, Nadja Kriegel, David W. Boykin, Chad E. Stephens, Andrew Hemphill
Antimicrobial Agents and Chemotherapy.2013; 57(8): 3829. CrossRef
An Imported Case of Cystic Echinococcosis in the Liver
Keun Soo Ahn, Sung-Tae Hong, Yu Na Kang, Jung Hyeok Kwon, Mi Jeong Kim, Tae Jun Park, Yong Hoon Kim, Tae Jin Lim, Koo Jeong Kang
The Korean Journal of Parasitology.2012; 50(4): 357. CrossRef