Parasites, Hosts and Diseases

"Schistosoma mansoni"

Articles from Symposium on Controls of NTDs around Lake Victoria, Tanzania

Improved Perceptions and Practices Related to Schistosomiasis and Intestinal Worm Infections Following PHAST Intervention on Kome Island, North-Western Tanzania: Joseph R. Mwanga, Godfrey M. Kaatano, Julius E. Siza, Su Young Chang, Yunsuk Ko, Cyril M. Kullaya, Jackson Nsabo, Keeseon S. Eom, Tai-Soon Yong, Jong-Yil Chai, Duk-Young Min, Han-Jong Rim, John M. Changalucha; Korean J Parasitol 2015;53(5):561-569.
Published online October 29, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.5.561

Abstract
PDF

Schistosomiasis and intestinal worm infections are widespread diseases of public health importance in Tanzania. A study on perceptions and practices related to schistosomiasis and intestinal worm infections was undertaken among a community population of Kome Island in Sengerema District, north-western Tanzania, where intestinal schistosomiasis and intestinal worm infections are endemic. Schistosomiasis and intestinal worm-related perceptions and practices were assessed before and 3 years after implementation of a participatory hygiene and sanitation transformation (PHAST) intervention as a control measure. Data were obtained from baseline and post-intervention knowledge, attitudes, and practices (KAP) questionnaire surveys conducted twice in 2009 and 2012 among 82 individuals aged ≥15 years. We found significant increases in respondents’ knowledge of the cause, transmission, symptoms, health consequences, and prevention of schistosomiasis and intestinal worm infections after PHAST intervention. The increase in respondents’ knowledge on almost all aspects of the said infections was translated into actions to control schistosomiasis and intestinal worm infections. This has not been achieved by chance, but due to well-designed and locally-adapted PHAST intervention. We conclude that despite criticisms, PHAST approach is still useful in empowering communities to control water, sanitation, and hygiene related infectious diseases such as schistosomiasis and intestinal worm infections.

Citations

Citations to this article as recorded by

Effects of an integrated intervention on schistosomiasis prevalence in a rural area of Tanzania
Yoonho Cho, Jungim Lee, Humphrey Deogratias Mazigo, Leah Elisha Salamba, Seungman Cha, Sutas Suttiprapa
PLOS Neglected Tropical Diseases.2025; 19(7): e0013215. CrossRef
Awareness, Attitude, and Perception of Port Health to Customers and Other Regulatory Authorities at Rusumo OSBP
Masunga Simon Tryphone, Kassim Moh’d Ali, Edward Joseph Macha
European Journal of Theoretical and Applied Sciences.2024; 2(5): 676. CrossRef
Contextual factors influencing schistosomiasis treatment and identification of delivery platforms for arpraziquantel in hard-to-reach areas and populations in Homa Bay County, Kenya
Phyllis Munyiva Isaiah, Doris Osei Afriyie, Mary Maghanga, Donna Obare Ogeto, Mary Amuyunzu Nyamongo, Peter Steinmann, Julia Robinson
PLOS Global Public Health.2024; 4(12): e0004035. CrossRef
Subclinical vascular damage in Schistosoma spp. endemic regions
Valeria Silvestri, Mwanahawa Idavas Mshana, Vivian Mushi, Witness M. Bonaventura, Nyanda C. Justine, Clemence Kinabo, Abdallah Zacharia, Giuseppe La Torre, Billy Ngasala
Vasa.2023; 52(4): 275. CrossRef
Behaviour change interventions for the control and elimination of schistosomiasis: A systematic review of evidence from low- and middle-income countries
Carlos A. Torres-Vitolas, Suzan C. M. Trienekens, Willemijn Zaadnoordijk, Anouk N. Gouvras, Alberto Novaes Ramos
PLOS Neglected Tropical Diseases.2023; 17(5): e0011315. CrossRef
Interventions to improve water, sanitation, and hygiene for preventing soil-transmitted helminth infection
Joshua V Garn, Jennifer L Wilkers, Ashley A Meehan, Lisa M Pfadenhauer, Jacob Burns, Rubina Imtiaz, Matthew C Freeman
Cochrane Database of Systematic Reviews.2022;[Epub] CrossRef
A novel theatre-based behaviour change approach for influencing community uptake of schistosomiasis control measures
May N. Sule, Justina Mosha, Teshome Emana Soboka, Safari M. Kinung’hi, Chrysoula Sfynia, Kamran Rafiq, Alex Dower, Marianne Comparet, Emma Bewley, Teckla Angelo, Feleke Zewge Beshah, Michael R. Templeton
Parasites & Vectors.2022;[Epub] CrossRef
Molecular Detection of Haplorchis pumilio Eggs in Schoolchildren, Kome Island, Lake Victoria, Tanzania
Hyejoo Shin, Bong-Kwang Jung, Seungwan Ryoo, Sooji Hong, Heonwoo Jeong, Hoo-Gn Jeoung, Sunhye Kim, Sun Kim, Min-Jae Kim, Hansol Park, Keeseon S. Eom, Godfrey M. Kaatano, Jong-Yil Chai
Emerging Infectious Diseases.2022; 28(11): 2298. CrossRef
Blood Flukes and Arterial Damage: A Review of Aneurysm Cases in Patients with Schistosomiasis
Valeria Silvestri, Vivian Mushi, Mwanahawa Idavas Mshana, Witness M. Bonaventura, Nyanda C. Justine, Deodatus Sabas, Billy Ngasala, Arif Siddiqui
Canadian Journal of Infectious Diseases and Medical Microbiology.2022; 2022: 1. CrossRef
Water, sanitation, and hygiene for schistosomiasis prevention: a qualitative analysis of experiences of stakeholders in rural KwaZulu-Natal
Chanelle Mulopo, Moses J. Chimbari
Journal of Water, Sanitation and Hygiene for Development.2021; 11(2): 255. CrossRef
From the One Health Perspective: Schistosomiasis Japonica and Flooding
Su-Ying Guo, Lu Li, Li-Juan Zhang, Yin-Long Li, Shi-Zhu Li, Jing Xu
Pathogens.2021; 10(12): 1538. CrossRef
Village Response to Mass Drug Administration for Schistosomiasis in Mwanza Region, Northwestern Tanzania: Are We Missing Socioeconomic, Cultural, and Political Dimensions?
Joseph R. Mwanga, Safari M. Kinung’hi, Justina Mosha, Teckla Angelo, Jane Maganga, Carl H. Campbell
The American Journal of Tropical Medicine and Hygiene.2020; 103(5): 1969. CrossRef
Parasitic infections in relation to practices and knowledge in a rural village in Northern Thailand with emphasis on fish-borne trematode infection
K. Chaisiri, C. Jollivet, P. Della Rossa, S. Sanguankiat, D. Wattanakulpanich, C. Lajaunie, A. Binot, M. Tanita, S. Rattanapikul, D. Sutdan, S. Morand, A. Ribas
Epidemiology and Infection.2019;[Epub] CrossRef
Community knowledge, perceptions and water contact practices associated with transmission of urinary schistosomiasis in an endemic region: a qualitative cross-sectional study
Teckla Angelo, Safari M. Kinung’hi, Jorum Buza, Joseph R. Mwanga, Henry Curtis Kariuki, Shona Wilson
BMC Public Health.2019;[Epub] CrossRef
Assessment of urogenital schistosomiasis knowledge among primary and junior high school students in the Eastern Region of Ghana: A cross-sectional study
Rachel A. Martel, Bernard Gyamfi Osei, Alexandra V. Kulinkina, Elena N. Naumova, Abdul Aziz Abdulai, David Tybor, Karen Claire Kosinski, Abdallah M. Samy
PLOS ONE.2019; 14(6): e0218080. CrossRef
Role of ecological approaches to eliminating schistosomiasis in Eryuan County evaluated by system modelling
Yi Dong, Chun-Hong Du, Yun Zhang, Li-Fang Wang, Jing Song, Ming-Shou Wu, Wen-Can Yang, Shan Lv, Xiao-Nong Zhou
Infectious Diseases of Poverty.2018;[Epub] CrossRef
Knowledge, practices and perceptions of geo-helminthes infection among parents of pre-school age children of coastal region, Kenya
Janet Masaku, Faith Mwende, Gladys Odhiambo, Rosemary Musuva, Elizabeth Matey, Jimmy H. Kihara, Isaac G. Thuita, Doris W. Njomo, Aaron R. Jex
PLOS Neglected Tropical Diseases.2017; 11(3): e0005514. CrossRef
Community Mobilization for Slum Upgrading through Sanitation in Roma Informal Settlements in the Paris Region
Ipsita Nita Chaudhuri
Frontiers in Public Health.2017;[Epub] CrossRef
Approaches to promote handwashing and sanitation behaviour change in low‐ and middle‐income countries: a mixed method systematic review
Emmy De Buck, Hans Van Remoortel, Karin Hannes, Thashlin Govender, Selvan Naidoo, Bert Avau, Axel Vande Veegaete, Alfred Musekiwa, Vittoria Lutje, Margaret Cargo, Hans‐Joachim Mosler, Philippe Vandekerckhove, Taryn Young
Campbell Systematic Reviews.2017; 13(1): 1. CrossRef
Integrated Schistosomiasis and Soil-Transmitted Helminthiasis Control over Five Years on Kome Island, Tanzania
Godfrey M. Kaatano, Julius E. Siza, Joseph R. Mwanga, Duk-Yong Min, Tai-Soon Yong, Jong-Yil Chai, Yunsuk Ko, Su Young Chang, Cyril M. Kullaya, Han-Jong Rim, John M. Changalucha, Keeseon S. Eom
The Korean Journal of Parasitology.2015; 53(5): 535. CrossRef

11,717 View
123 Download
17 Web of Science
Crossref

Schistosoma mansoni-Related Hepatosplenic Morbidity in Adult Population on Kome Island, Sengerema District, Tanzania: Godfrey M. Kaatano, Duk-Young Min, Julius E. Siza, Tai-Soon Yong, Jong-Yil Chai, Yunsuk Ko, Su-Young Chang, John M. Changalucha, Keeseon S. Eom, Han-Jong Rim; Korean J Parasitol 2015;53(5):545-551.
Published online October 29, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.5.545

Abstract
PDF

Schistosomiasis is one of the important neglected tropical diseases (NTDs) in Tanzania, particularly in Lake Victoria zone. This baseline survey was a part of the main study of integrated control of schistosomiasis and soil-transmitted helminths (STHs) aimed at describing morbidity patterns due to intestinal schistosomiasis among adults living on Kome Island, Sengerema District, Tanzania. Total 388 adults from Kome Islands (about 50 people from each village) aged between 12 and 85 years, were examined by abdominal ultrasound according to the Niamey protocol. Liver image patterns (LIPs) A and B were considered normal, and C-F as distinct periportal fibrosis (PPF). The overall prevalence of PPF was 42.2%; much higher in males than in females (47.0% in male vs 34.4% in females, P=0.007). Abnormal increase of segmental branch wall thickness (SBWT) and dilated portal vein diameter (PVD) were also more common in males than in females. Hepatosplenomegaly was frequently encountered; 68.1% had left liver lobe hepatomegaly and 55.2% had splenomegaly. Schistosoma mansoni-related morbidity is quite high among adults in this community justifying the implementation of integrated control strategies through mass drug administration, improved water supply (pumped wells), and health education that had already started in the study area.

Citations

Citations to this article as recorded by

Parasites of the liver: A global problem?
Vladislav V Tsukanov, Alexander V Vasyutin, Julia L Tonkikh
World Journal of Gastroenterology.2024; 30(30): 3554. CrossRef
Prevalence of human schistosomiasis in various regions of Tanzania Mainland and Zanzibar: A systematic review and meta-analysis of studies conducted for the past ten years (2013–2023)
Nicolaus Omari Mbugi, Hudson Laizer, Musa Chacha, Ernest Mbega, Uwem Friday Ekpo
PLOS Neglected Tropical Diseases.2024; 18(9): e0012462. CrossRef
Prevalence of human Schistosoma mansoni infection in endemic regions (2010–2024): a systematic review and meta-analysis
Ali Tavakoli Pirzaman, Mahdi Sepidarkish, Faezeh Alizadeh, Sarah Al-Obidy, Pouyan Ebrahimi, Nazanin Kianifard, Morteza Sheikhi Nooshabadi, Mehradad Jafari Tadi, Maryam Zolfaghari Dehkharghani, Safa Mousavi, Nassim Rezapour, Sara Mohammadnia, Andarz Fazlol
eClinicalMedicine.2024; 77: 102855. CrossRef
Prevalence of Schistosoma mansoni, soil-transmitted helminths and intestinal protozoa in orphans and street children in Mwanza city, Northern Tanzania
Anemone Franz, Antje Fuss, Humphrey D. Mazigo, Deodatus Ruganuza, Andreas Müller
Infection.2023; 51(5): 1399. CrossRef
Parasites of the liver – epidemiology, diagnosis and clinical management in the European context
Lynn Peters, Sanne Burkert, Beate Grüner
Journal of Hepatology.2021; 75(1): 202. CrossRef
Schistosoma mansoni-related periportal fibrosis; can we use APRI and PSDR levels in the real-time selection of patients for targeted endoscopy in a resource-limited setting? A case–control study
Daniel W. Gunda, Elizabeth F. Mtui, Paulina M. Manyiri, David C. Majinge, Semvua B. Kilonzo, Humphrey D. Mazigo, Benson R. Kidenya
BMC Gastroenterology.2021;[Epub] CrossRef
Morbidity associated with Schistosoma mansoni infection in north-eastern Democratic Republic of the Congo
Maurice M. Nigo, Peter Odermatt, David Wully Nigo, Georgette B. Salieb-Beugelaar, Manuel Battegay, Patrick R. Hunziker, Amadou Garba
PLOS Neglected Tropical Diseases.2021; 15(12): e0009375. CrossRef
Morbidity and Mortality Due to Schistosoma mansoni Related Periportal Fibrosis: Could Early Diagnosis of Varices Improve the Outcome Following Available Treatment Modalities in Sub Saharan Africa? A Scoping Review
Daniel W. Gunda, Semvua B. Kilonzo, Paulina M. Manyiri, Robert N. Peck, Humphrey D. Mazigo
Tropical Medicine and Infectious Disease.2020; 5(1): 20. CrossRef
A cross-sectional study of periportal fibrosis and Schistosoma mansoni infection among school-aged children in a hard-to-reach area of Madagascar
Hannah J Russell, James M StJ Penney, Cortland Linder, Elizabeth C Joekes, Amaya L Bustinduy, J Russell Stothard, Daniel A L Rakotomampianina, Emmanuel H Andriamasy, Lalarizo R Mahary, Elodie P Ranjanoro, Alain M Rahetilahy, Stephen A Spencer
Transactions of The Royal Society of Tropical Medicine and Hygiene.2020; 114(4): 315. CrossRef
Prevalence and pattern of waterborne parasitic infections in eastern Africa: A systematic scoping review
Helena A. Ngowi
Food and Waterborne Parasitology.2020; 20: e00089. CrossRef
Intestinal schistosomiasis of Ijinga Island, north-western Tanzania: prevalence, intensity of infection, hepatosplenic morbidities and their associated factors
Andreas Mueller, Antje Fuss, Uwe Ziegler, Godfrey M. Kaatano, Humphrey D. Mazigo
BMC Infectious Diseases.2019;[Epub] CrossRef
Integrating use of point-of-care circulating cathodic antigen rapid diagnostic tests by community health workers during mass drug administration campaigns to improve uptake of praziquantel treatment among the adult population at Kome Island, North-Western
Humphrey D. Mazigo, John H. Amuasi, Isaac Osei, Safari M. Kinung’hi
BMC Public Health.2018;[Epub] CrossRef
Association Between Polymorphisms of the Mannose-Binding Lectin and Severity of Periportal Fibrosis in Schistosomiasis, in the Northeast of Brazil
Taynan da Silva Constantino, Elker Lene Santos de Lima, Lidiane Régia Pereira Braga de Brito, Jamile Luciana Silva, Maria Rosângela Cunha Duarte Coêlho, Maria Tereza Cartaxo Muniz, Paula Carolina Valença Silva, Ana Lúcia Coutinho Domingues
Genetic Testing and Molecular Biomarkers.2017; 21(9): 571. CrossRef
Schistosoma mansoni Infection and Its Related Morbidity among Adults Living in Selected Villages of Mara Region, North-Western Tanzania: A Cross-Sectional Exploratory Study
Humphrey D. Mazigo, Fred Nuwaha, David W. Dunne, Godfrey M. Kaatano, Tekla Angelo, Stella Kepha, Safari M. Kinung’hi
The Korean Journal of Parasitology.2017; 55(5): 533. CrossRef
Ultrasonography of gallbladder abnormalities due to schistosomiasis
Joachim Richter, Daniel Azoulay, Yi Dong, Martha C. Holtfreter, Robert Akpata, Julien Calderaro, Tarik El-Scheich, Matthias Breuer, Andreas Neumayr, Christoph Hatz, Gerald Kircheis, Monica C. Botelho, Christoph F. Dietrich
Parasitology Research.2016; 115(8): 2917. CrossRef
Is ultrasonography useful for population studies on schistosomiasis mansoni? An evaluation based on a survey on a population from Kome Island, Tanzania
Mats SL Asztely, Bo Eriksson, Reverianus M Gabone, Lars-Åke Nilsson
Acta Radiologica Open.2016;[Epub] CrossRef

11,594 View
124 Download
18 Web of Science
Crossref

Integrated Schistosomiasis and Soil-Transmitted Helminthiasis Control over Five Years on Kome Island, Tanzania: Godfrey M. Kaatano, Julius E. Siza, Joseph R. Mwanga, Duk-Yong Min, Tai-Soon Yong, Jong-Yil Chai, Yunsuk Ko, Su Young Chang, Cyril M. Kullaya, Han-Jong Rim, John M. Changalucha, Keeseon S. Eom; Korean J Parasitol 2015;53(5):535-543.
Published online October 29, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.5.535

Abstract
PDF

Integrated control strategies are important for sustainable control of schistosomiasis and soil-transmitted helminthiasis, despite their challenges for their effective implementation. With the support of Good Neighbors International in collaboration with National Institute of Medical Research, Mwanza, Tanzania, integrated control applying mass drug administration (MDA), health education using PHAST, and improved safe water supply has been implemented on Kome Island over 5 years for controlling schistosomiasis and soil-transmitted helminths (STHs). Baseline surveys for schistosomiasis and STHs was conducted before implementation of any integrated control strategies, followed by 4 cross-sectional follow-up surveys on randomly selected samples of schoolchildren and adults in 10 primary schools and 8 villages, respectively, on Kome islands. Those follow-up surveys were conducted for impact evaluation after introduction of control strategies interventions in the study area. Five rounds of MDA have been implemented from 2009 along with PHAST and improved water supply with pumped wells as other control strategies for complementing MDA. A remarkable steady decline of schistosomiasis and STHs was observed from 2009 to 2012 with significant trends in their prevalence decline, and thereafter infection rate has remained at a low sustainable control. By the third follow-up survey in 2012, Schistosoma mansoni infection prevalence was reduced by 90.5% and hookworm by 93.3% among schoolchildren while in adults the corresponding reduction was 83.2% and 56.9%, respectively. Integrated control strategies have successfully reduced S. mansoni and STH infection status to a lower level. This study further suggests that monitoring and evaluation is a crucial component of any large-scale STH and schistosomiasis intervention.

Citations

Citations to this article as recorded by

Effects of an integrated intervention on schistosomiasis prevalence in a rural area of Tanzania
Yoonho Cho, Jungim Lee, Humphrey Deogratias Mazigo, Leah Elisha Salamba, Seungman Cha, Sutas Suttiprapa
PLOS Neglected Tropical Diseases.2025; 19(7): e0013215. CrossRef
Investigating the effect of a school-based WASH intervention on soil-transmitted helminth and schistosome infections and nutritional status of school children in Ethiopia: a quasi-experimental study
Gemechu Tadesse, Yonas Wuletaw, Kalkidan Mekete, Heven Sime, Elodie Yard, Laura Appleby, Jack Grimes, Nigussie Dejene, Iain Gardiner, Adama Kazienga, Souheila Abbeddou, Michael French, Bruno Levecke, Lesley Drake
Parasites & Vectors.2024;[Epub] CrossRef
Validating a questionnaire to identify women in the first trimester of pregnancy during preventive chemotherapy interventions against soil-transmitted helminths in northwestern Tanzania
Humphrey D. Mazigo, Antonio Montresor
IJID Regions.2024; 10: 214. CrossRef
Burden and factors associated with ongoing transmission of soil-transmitted helminths infections among the adult population: A community-based cross-sectional survey in Muleba district, Tanzania
Franco Zacharia, Valeria Silvestri, Vivian Mushi, George Ogweno, Twilumba Makene, Lwidiko E. Mhamilawa, David Zadock Munisi
PLOS ONE.2023; 18(7): e0288936. CrossRef
Esquistossomose, geo-helmintíases e condições sanitárias na América Latina e Caribe: uma revisão sistemática
Mariana Cristina Silva Santos, Léo Heller
Revista Panamericana de Salud Pública.2023; 47: 1. CrossRef
Adherence to diagnosis followed by selective treatment of schistosomiasis mansoni and related knowledge among schoolchildren in an endemic area of Minas Gerais, Brazil, prior to and after the implementation of educational actions
Tereza Cristina Favre, Cristiano Lara Massara, Lilian Christina N?brega Holsbach Beck, Roc?o Karina Saavedra Acero Cabello, Otavio Sarmento Pieri
Parasite Epidemiology and Control.2021; 13: e00208. CrossRef
How can we better integrate the prevention, treatment, control and elimination of neglected tropical diseases with other health interventions? A systematic review
Gift Treighcy Banda, Kebede Deribe, Gail Davey
BMJ Global Health.2021; 6(10): e006968. CrossRef
National mapping of soil-transmitted helminth and schistosome infections in Ethiopia
Gemechu Tadesse Leta, Kalkidan Mekete, Yonas Wuletaw, Abeba Gebretsadik, Heven Sime, Sindew Mekasha, Adugna Woyessa, Oumer Shafi, Jozef Vercruysse, Jack E. T. Grimes, Iain Gardiner, Michael French, Bruno Levecke, Lesley Drake, Wendy Harrison, Alan Fenwick
Parasites & Vectors.2020;[Epub] CrossRef
Interventions to improve disposal of child faeces for preventing diarrhoea and soil-transmitted helminth infection
Fiona Majorin, Belen Torondel, Gabrielle Ka Seen Chan, Thomas Clasen
Cochrane Database of Systematic Reviews.2019;[Epub] CrossRef
Differential impact of mass and targeted praziquantel delivery on schistosomiasis control in school-aged children: A systematic review and meta-analysis
Danielle M. Cribb, Naomi E. Clarke, Suhail A. R. Doi, Susana Vaz Nery, Amadou Garba
PLOS Neglected Tropical Diseases.2019; 13(10): e0007808. CrossRef
Factors associated with relevant knowledge of intestinal schistosomiasis and intention to participate in treatment campaigns: a cross sectional survey among school children at Ijinga Island on Lake Victoria, North-Western Tanzania
Sandra Parisi, Humphrey D. Mazigo, Saskia Kreibich, Karl Puchner, Christa Kasang, Andreas Mueller
BMC Public Health.2019;[Epub] CrossRef
Integrating use of point-of-care circulating cathodic antigen rapid diagnostic tests by community health workers during mass drug administration campaigns to improve uptake of praziquantel treatment among the adult population at Kome Island, North-Western
Humphrey D. Mazigo, John H. Amuasi, Isaac Osei, Safari M. Kinung’hi
BMC Public Health.2018;[Epub] CrossRef
Intersectoral collaboration for the prevention and control of vector borne diseases to support the implementation of a global strategy: A systematic review
Herdiana Herdiana, Jana Fitria Kartika Sari, Maxine Whittaker, Basil Brooke
PLOS ONE.2018; 13(10): e0204659. CrossRef
The impact of sanitation on infectious disease and nutritional status: A systematic review and meta-analysis
Matthew C. Freeman, Joshua V. Garn, Gloria D. Sclar, Sophie Boisson, Kate Medlicott, Kelly T. Alexander, Gauthami Penakalapati, Darcy Anderson, Amrita G. Mahtani, Jack E.T. Grimes, Eva A. Rehfuess, Thomas F. Clasen
International Journal of Hygiene and Environmental Health.2017; 220(6): 928. CrossRef
Baseline prevalence and intensity of schistosomiasis at sentinel sites in Madagascar: Informing a national control strategy
Clara Fabienne Rasoamanamihaja, Alain Marcel Rahetilahy, Bruno Ranjatoarivony, Neerav Dhanani, Luciano Andriamaro, Samuel Hermas Andrianarisoa, Peter Mark Jourdan
Parasites & Vectors.2016;[Epub] CrossRef
Schistosoma mansoni infection and related knowledge among schoolchildren in an endemic area of Minas Gerais, Brazil, prior to educational actions
Rocio Karina S.A.A. Cabello, Lilian C.N.H. Beck, Cristiano L. Massara, Felipe L.G. Murta, Ricardo J.P.S. Guimarães, Otávio S. Pieri, Virginia T. Schall, Tereza C. Favre
Acta Tropica.2016; 164: 208. CrossRef

11,847 View
148 Download
20 Web of Science
Crossref

Prevalence of Schistosomes and Soil-Transmitted Helminths and Morbidity Associated with Schistosomiasis among Adult Population in Lake Victoria Basin, Tanzania: Julius E. Siza, Godfrey M. Kaatano, Jong-Yil Chai, Keeseon S. Eom, Han-Jong Rim, Tai-Soon Yong, Duk-Young Min, Su Young Chang, Yunsuk Ko, John M. Changalucha; Korean J Parasitol 2015;53(5):525-533.
Published online October 29, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.5.525

Abstract
PDF

The
objective
of this study was to carry out a community survey on schistosomiais and soil-transmitted helminth (STH) infections in order to suggest feasible and effective intervention strategies in Lake Victoria basin, Tanzania. A total of 37 communities selected from 23 districts of the 4 regions in the Lake Victoria basin of Tanzania were involved in the study. From each of the selected locality, 50 adult community members, 25 males and 25 females, were recruited for the study. Each study participant was requested to submit stool and urine specimens. From each stool specimen, duplicate Kato-Katz thick smears were prepared and microscopically examined for Schistosoma mansoni and STH eggs. Urine specimens were processed by the filtration technique and microscopically examined for Schistosoma haematobium eggs. Ultrasound examination for morbidity due to schistosomiasis was performed. Mass treatment was done using praziquantel and albendazole for schistosome and STHs infections, respectively. Out of 1,606 adults who provided stool specimens, 199 (12.4%) were positive for S. mansoni, 349 (21.7%) for hookworms, 133 (8.3%) for Ascaris lumbricoides, and 33 (2.0%) for Trichuris trichiura. Out of 1,400 participants who provided urine specimens, 25 (1.8%) were positive for S. haematobium eggs. Because of the co-endemicity of these afflictions and their impact on vulnerable population groups, the helminthiasis could be simultaneously treated with 2 drugs, praziquantel for schistosomiasis and albendazole for STHs.

Citations

Citations to this article as recorded by

Prevalence and determinants of Soil-Transmitted Helminths among urban vegetable farmers in Ghana
Gerard Quarcoo, Samuel Armoo, Augustina Angelina Sylverken, Matthew Glover Addo, Nils Pilotte,
PLOS One.2025; 20(5): e0323486. CrossRef
Prevalence, intensity, and associated factors of soil-transmitted helminth and schistosome infections after multiple rounds of preventive chemotherapy among schoolchildren in five selected district councils in Tanzania
Clarer Jones, Mohamed Nyati, Abdallah Zacharia, Stephen Gabriel Mbwambo, Huda Omary, Billy Ngasala, Edward Mitre
PLOS Neglected Tropical Diseases.2025; 19(7): e0013310. CrossRef
Vaccine value profile for Hookworm
Karl Philipp Puchner, Maria Elena Bottazzi, Victoria Periago, Martin Grobusch, Rick Maizels, James McCarthy, Bruce Lee, Erika Gaspari, David Diemert, Peter Hotez
Vaccine.2024; 42(19): S25. CrossRef
Is a mass drug administration deworming programme for school-aged children enough to reduce the prevalence of soil-transmitted helminths and Schistosoma mansoni in adults: a cross-sectional study from Togo
Hombamane Christelle Simfele, Gnatoulma Katawa, Kathrin Arndts, Christèle Nguepou Tchopba, Oukoe Marthe Amessoudji, Edlom Pélagie Tchadie, Simplice Damintoti Karou, Yaovi Ameyapoh, Achim Hoerauf, Malewe Kolou, Laura Layland-Heni, Manuel Ritter
Frontiers in Tropical Diseases.2024;[Epub] CrossRef
Prevalence of human schistosomiasis in various regions of Tanzania Mainland and Zanzibar: A systematic review and meta-analysis of studies conducted for the past ten years (2013–2023)
Nicolaus Omari Mbugi, Hudson Laizer, Musa Chacha, Ernest Mbega, Uwem Friday Ekpo
PLOS Neglected Tropical Diseases.2024; 18(9): e0012462. CrossRef
Cultural adaption and validation of the Explanatory Model Interview Catalogue–Community Stigma Scale in the assessment of public stigma related to schistosomiasis in lakeshore areas of Mwanza region, Tanzania
Laura Klinker, Anne Boeckler, Saskia Kreibich, Humphrey Mazigo, David Joseph Diemert
PLOS Neglected Tropical Diseases.2023; 17(8): e0011534. CrossRef
Intestinal schistosomiasis among secondary school students in Northern Tanzania: prevalence, infection intensity and associated risk factors
Lilian G Samweli, Angel J Sesera, Vivian Mushi, Valeria Silvestri, Hoseenu Palilo, Winfrida John, Yonah Eliud Yangaza, Donath Tarimo
IJID Regions.2023; 6: 125. CrossRef
Routine health check-ups for adolescents in Mwanza City, Tanzania: stakeholders’ recommendations on its content, venue, and mode of delivery
Yovitha Sedekia, Gerry Mshana, Mussa K. Nsanya, Kid Kohl, Mwita Wambura, Heiner Grosskurth, David A. Ross, Saidi Kapiga
BMC Public Health.2023;[Epub] CrossRef
Burden and factors associated with ongoing transmission of soil-transmitted helminths infections among the adult population: A community-based cross-sectional survey in Muleba district, Tanzania
Franco Zacharia, Valeria Silvestri, Vivian Mushi, George Ogweno, Twilumba Makene, Lwidiko E. Mhamilawa, David Zadock Munisi
PLOS ONE.2023; 18(7): e0288936. CrossRef
Assessing risk factors for malaria and schistosomiasis among children in Misungwi, Tanzania, an area of co-endemicity: A mixed methods study
Claudia Duguay, Jacklin F. Mosha, Eliud Lukole, Doris Mangalu, Charles Thickstun, Elizabeth Mallya, Tatu Aziz, Cindy Feng, Natacha Protopopoff, Franklin Mosha, Alphaxard Manjurano, Alison Krentel, Manisha A. Kulkarni, Everton Falcão de Oliveira
PLOS Global Public Health.2023; 3(11): e0002468. CrossRef
High Specificity but Low Sensitivity of Lab-on-a-Disk Technique in Detecting Soil-Transmitted Helminth Eggs among Pre- and School-Aged Children in North-Western Tanzania
Humphrey D. Mazigo, Nyanda C. Justine, Jeffer Bhuko, Sarah Rubagumya, Namanya Basinda, Maria M. Zinga, Deodatus Ruganuza, Vyacheslav R. Misko, Matthieu Briet, Filip Legein, Wim De Malsche
Tropical Medicine and Infectious Disease.2023; 9(1): 5. CrossRef
Prevalence of Schistosomiasis and Soil-Transmitted Helminthiasis and Their Risk Factors: A Cross-Sectional Study in Itilima District, North-Western Tanzania
Jungim Lee, Seungman Cha, Yoonho Cho, Anold Musiba, Boniphace Marwa, Humphrey Mazigo
Life.2023; 13(12): 2333. CrossRef
Hand hygiene intervention to optimise soil-transmitted helminth infection control among primary school children: the Mikono Safi cluster randomised controlled trial in northwestern Tanzania
Kenneth Makata, Jeroen Ensink, Philip Ayieko, Christian Hansen, Simon Sichalwe, Julius Mngara, Onike Mcharo, Humphrey Mazigo, Jeremiah Seni, Robert Dreibelbis, Sarah Rockowitz, Elialilia Okello, Heiner Grosskurth, Safari Kinung’hi, Saidi Kapiga
BMC Medicine.2021;[Epub] CrossRef
Malaria infection and anemia status in under-five children from Southern Tanzania where seasonal malaria chemoprevention is being implemented
Richard O. Mwaiswelo, Bruno P. Mmbando, Frank Chacky, Fabrizio Molteni, Ally Mohamed, Samwel Lazaro, Sylvia F. Mkalla, Bushukatale Samuel, Billy Ngasala, Luzia Helena Carvalho
PLOS ONE.2021; 16(12): e0260785. CrossRef
Growth Status, Inflammation, and Enteropathy in Young Children in Northern Tanzania
James P. Wirth, Brenda Kitilya, Nicolai Petry, George PrayGod, Stephen Veryser, Julius Mngara, Christian Zwahlen, Frank Wieringa, Jacques Berger, Mercedes de Onis, Fabian Rohner, Elodie Becquey
The American Journal of Tropical Medicine and Hygiene.2019; 100(1): 192. CrossRef
Analysis of Schistosomiasis and soil-transmitted helminths mixed infections among pupils in Enugu State, Nigeria: Implications for control
Dennis N. Aribodor, Simon A. Bassey, Tippayarat Yoonuan, Sammy O. Sam-Wobo, Ogechukwu B. Aribodor, Ifeoma K. Ugwuanyi
Infection, Disease & Health.2019; 24(2): 98. CrossRef
Comparison of sensitivity and specificity of three diagnostic tests to detect Schistosoma mansoni infections in school children in Mwanza region, Tanzania
Antje Fuss, Humphrey Deogratias Mazigo, Dennis Tappe, Christa Kasang, Andreas Mueller, Ryan E. Wiegand
PLOS ONE.2018; 13(8): e0202499. CrossRef
Geographical and behavioral risks associated with Schistosoma haematobium infection in an area of complex transmission
Teckla Angelo, Joram Buza, Safari Methusela Kinung’hi, Henry Curtis Kariuki, Joseph Rogathe Mwanga, David Zadock Munisi, Shona Wilson
Parasites & Vectors.2018;[Epub] CrossRef
Prevalence and distribution of soil-transmitted helminth infections in Nigerian children: a systematic review and meta-analysis
Solomon Ngutor Karshima
Infectious Diseases of Poverty.2018;[Epub] CrossRef
Longitudinal survey on the distribution of Biomphalaria sudanica and B. choanomophala in Mwanza region, on the shores of Lake Victoria, Tanzania: implications for schistosomiasis transmission and control
Anouk N. Gouvras, Fiona Allan, Safari Kinung’hi, Muriel Rabone, Aidan Emery, Teckla Angelo, Tom Pennance, Bonnie Webster, Honest Nagai, David Rollinson
Parasites & Vectors.2017;[Epub] CrossRef
Trichuris trichiura infection and its relation to environmental factors in Mbeya region, Tanzania: A cross-sectional, population-based study
Kirsi M. Manz, Petra Clowes, Inge Kroidl, Dickens O. Kowuor, Christof Geldmacher, Nyanda E. Ntinginya, Leonard Maboko, Michael Hoelscher, Elmar Saathoff, David Joseph Diemert
PLOS ONE.2017; 12(4): e0175137. CrossRef
Risk factors for mortality among patients admitted with upper gastrointestinal bleeding at a tertiary hospital: a prospective cohort study
Sibtain M. Moledina, Ewaldo Komba
BMC Gastroenterology.2017;[Epub] CrossRef
Baseline prevalence and intensity of schistosomiasis at sentinel sites in Madagascar: Informing a national control strategy
Clara Fabienne Rasoamanamihaja, Alain Marcel Rahetilahy, Bruno Ranjatoarivony, Neerav Dhanani, Luciano Andriamaro, Samuel Hermas Andrianarisoa, Peter Mark Jourdan
Parasites & Vectors.2016;[Epub] CrossRef

14,806 View
165 Download
26 Web of Science
Crossref

Prevalence of Schistosomes and Soil-Transmitted Helminths among Schoolchildren in Lake Victoria Basin, Tanzania: Julius E. Siza, Godfrey M. Kaatano, Jong-Yil Chai, Keeseon S. Eom, Han-Jong Rim, Tai-Soon Yong, Duk-Young Min, Su Young Chang, Yunsuk Ko, John M. Changalucha; Korean J Parasitol 2015;53(5):515-524.
Published online October 29, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.5.515

Abstract
PDF

The
objective
s of this study was to conduct a survey on schistosomiasis and soil-transmitted helminth (STH) infections in order to come up with feasible control strategies in Lake Victoria basin, Tanzania. Depending on the size of the school, 150-200 schoolchildren were recruited for the study. Duplicate Kato-Katz stool smears were prepared from each child and microscopically examined for Schistosoma mansoni and STHs. Urine specimens were examined for Schistosoma haematobium eggs using the filtration technique. After the survey, mass drug administration was done using praziquantel and albendazole for schistosomiasis and STHs infections, respectively. A total of 5,952 schoolchildren from 36 schools were recruited for the study and had their stool and urine specimens examined. Out of 5,952 schoolchildren, 898 (15.1%) were positive for S. mansoni, 754 (12.6%) for hookworms, 188 (3.2%) for Ascaris lumblicoides, and 5 (0.008%) for Trichuris trichiura. Out of 5,826 schoolchildren who provided urine samples, 519 (8.9%) were positive for S. haematobium eggs. The results revealed that intestinal schistosomiasis, urogenital schistosomiasis, and STH infections are highly prevalent throughought the lake basin. The high prevalence of intestinal and urogenital schistosomisiasis in the study area was a function of the distance from Lake Victoria, the former being more prevalent at localities close to the lake, whilst the latter is more so away from it. Control of schistosomiasis and STHs in the study area requires an integrated strategy that involves provision of health education to communities, regular treatments, and provision of adequate safe water supply and sanitation facilities.

Citations

Citations to this article as recorded by

Determinants of uptake of deworming medication during pregnancy in Tanzania: insights from 2022 demographic and health survey
Vivian P. Mushi, Pankras Luoga, Elia Nyangi, Valeria Silvestri, Jiayan Huang
Journal of Health, Population and Nutrition.2025;[Epub] CrossRef
Prevalence of human schistosomiasis in various regions of Tanzania Mainland and Zanzibar: A systematic review and meta-analysis of studies conducted for the past ten years (2013–2023)
Nicolaus Omari Mbugi, Hudson Laizer, Musa Chacha, Ernest Mbega, Uwem Friday Ekpo
PLOS Neglected Tropical Diseases.2024; 18(9): e0012462. CrossRef
Burden and risk factors for Schistosoma mansoni infection among primary school children: A quantitative school-based cross-sectional survey in Busega district, Northern Tanzania
George Ogweno, Vivian Mushi, Valeria Silvestri, Witness Bonaventura, Nyanda C. Justine, Mololo Noah, Furahini Yoram, Hussein Mohamed, Donath Tarimo, Matty Knight
PLOS ONE.2023; 18(1): e0280180. CrossRef
Discovering new pathways toward integration between health and sustainable development goals with natural language processing and network science
Thomas Bryan Smith, Raffaele Vacca, Luca Mantegazza, Ilaria Capua
Globalization and Health.2023;[Epub] CrossRef
Burden and factors associated with ongoing transmission of soil-transmitted helminths infections among the adult population: A community-based cross-sectional survey in Muleba district, Tanzania
Franco Zacharia, Valeria Silvestri, Vivian Mushi, George Ogweno, Twilumba Makene, Lwidiko E. Mhamilawa, David Zadock Munisi
PLOS ONE.2023; 18(7): e0288936. CrossRef
Soil-transmitted helminths: A critical review of the impact of co-infections and implications for control and elimination
Sarah Lebu, Winnie Kibone, Chimdi C. Muoghalu, Stephen Ochaya, Aaron Salzberg, Felix Bongomin, Musa Manga, Alberto Novaes Ramos
PLOS Neglected Tropical Diseases.2023; 17(8): e0011496. CrossRef
Does a school-based intervention to engage parents change opportunity for handwashing with soap at home? Practical experience from the Mikono Safi trial in Northwestern Tanzania
Yovitha Sedekia, Saidi Kapiga, Onike Mcharo, Kenneth Makata, Belen Torondel, Robert Dreibelbis, Elialilia Okello, Poppy H. L. Lamberton
PLOS Neglected Tropical Diseases.2022; 16(6): e0010438. CrossRef
Prevalence of Schistosoma mansoni infection among fishermen in Busega district, Tanzania
Revocatus J. L. Mang’ara, Billy Ngasala, Winfrida John, Wannaporn Ittiprasert
PLOS ONE.2022; 17(11): e0276395. CrossRef
Soil transmitted helminth infection in primary school children varies with ecozone in the Ngorongoro Conservation Area, Tanzania
Manar Eltantawy, Karin Orsel, Ashley Schroeder, Domenica Morona, Humphrey D. Mazigo, Susan Kutz, Jennifer Hatfield, Mange Manyama, Frank van der Meer
Tropical Medicine and Health.2021;[Epub] CrossRef
Schistosomiasis with a Focus on Africa
Oyime Poise Aula, Donald P. McManus, Malcolm K. Jones, Catherine A. Gordon
Tropical Medicine and Infectious Disease.2021; 6(3): 109. CrossRef
Prevalence and associated factors of soil transmitted helminthiasis among school-age children in wetland and non-wetland areas of Blue Nile Basins, northwest Ethiopia: A community-based comparative study
Almaw Genet, Achenef Motbainor, Tsion Samuel, Muluken Azage
SAGE Open Medicine.2021;[Epub] CrossRef
Prevalence and Intensity of Soil-Transmitted Helminths and Associated Factors among Adolescents and Adults in Bibugn Woreda, Northwest Ethiopia: A Community-Based Cross-Sectional Study
Abrham Goshu, Getaneh Alemu, Animen Ayehu, Alemayehu Toma
Journal of Tropical Medicine.2021; 2021: 1. CrossRef
Epidemiology of Schistosoma mansoni infection and associated risk factors among school children attending primary schools nearby rivers in Jimma town, an urban setting, Southwest Ethiopia
Azalech Tefera, Tariku Belay, Mitiku Bajiro, David Joseph Diemert
PLOS ONE.2020; 15(2): e0228007. CrossRef
Assessing the diversity and distribution of potential intermediate hosts snails for urogenital schistosomiasis: Bulinus spp. (Gastropoda: Planorbidae) of Lake Victoria
Fred D. Chibwana, Immaculate Tumwebaze, Anna Mahulu, Arthur F. Sands, Christian Albrecht
Parasites & Vectors.2020;[Epub] CrossRef
Evaluation of Occurrence, Concentration, and Removal of Pathogenic Parasites and Fecal Coliforms in Three Waste Stabilization Pond Systems in Tanzania
Abdallah Zacharia, Wajihu Ahmada, Anne H. Outwater, Billy Ngasala, Rob Van Deun
The Scientific World Journal.2019; 2019: 1. CrossRef
Comparison of sensitivity and specificity of three diagnostic tests to detect Schistosoma mansoni infections in school children in Mwanza region, Tanzania
Antje Fuss, Humphrey Deogratias Mazigo, Dennis Tappe, Christa Kasang, Andreas Mueller, Ryan E. Wiegand
PLOS ONE.2018; 13(8): e0202499. CrossRef
Prevalence of Soil-Transmitted Helminthiases and Schistosomiasis in Preschool Age Children in Mwea Division, Kirinyaga South District, Kirinyaga County, and Their Potential Effect on Physical Growth
Stephen Sifuna Wefwafwa Sakari, Amos K. Mbugua, Gerald M. Mkoji
Journal of Tropical Medicine.2017; 2017: 1. CrossRef
Coinfection of intestinal schistosomiasis and malaria and association with haemoglobin levels and nutritional status in school children in Mara region, Northwestern Tanzania: a cross-sectional exploratory study
Safari M. Kinung’hi, Humphrey D. Mazigo, David W. Dunne, Stella Kepha, Godfrey Kaatano, Coleman Kishamawe, Samuel Ndokeji, Teckla Angelo, Fred Nuwaha
BMC Research Notes.2017;[Epub] CrossRef

14,503 View
206 Download
19 Web of Science
Crossref

Original Articles

Ameliorative Effect of Bone Marrow-Derived Stem Cells on Injured Liver of Mice Infected with Schistosoma mansoni: Magda M. El-Mahdi, Wafaa A. Mansour, Olfat Hammam, Noha A. Mehana, Taghreed M. Hussein; Korean J Parasitol 2014;52(2):151-162.
Published online April 18, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.2.151

Abstract
PDF

The technique of stem cells or hepatocytes transplantation has recently improved in order to bridge the time before whole-organ liver transplantation. In the present study, unfractionated bone marrow stem cells (BMSCs) were harvested from the tibial and femoral marrow compartments of male mice, which were cultured in Dulbecco's modified Eagle's medium (DMEM) with and without hepatocyte growth factor (HGF), and then transplanted into Schistosoma mansoni-infected female mice on their 8th week post-infection. Mice were sacrificed monthly until the third month of bone marrow transplantation, serum was collected, and albumin concentration, ALT, AST, and alkaline phosphatase (ALP) activities were assayed. On the other hand, immunohistopathological and immunohistochemical changes of granuloma size and number, collagen content, and cells expressing OV-6 were detected for identification of liver fibrosis. BMSCs were shown to differentiate into hepatocyte-like cells. Serum ALT, AST, and ALP were markedly reduced in the group of mice treated with BMSCs than in the untreated control group. Also, granuloma showed a marked decrease in size and number as compared to the BMSCs untreated group. Collagen content showed marked decrease after the third month of treatment with BMSCs. On the other hand, the expression of OV-6 increased detecting the presence of newly formed hepatocytes after BMSCs treatment. BMSCs with or without HGF infusion significantly enhanced hepatic regeneration in S. mansoni-induced fibrotic liver model and have pathologic and immunohistopathologic therapeutic effects. Also, this new therapeutic trend could generate new hepatocytes to improve the overall liver functions.

Citations

Citations to this article as recorded by

Anti-fibrotic Effect of Oral Versus Intraperitoneal Administration of Gold Nanoparticles in Hepatic Schistosoma mansoni-Infected Mice
Shahira Abdelaziz Ali Ahmed, Samer Eid Mohamed Gad, Omima Mohamed Eida, Laila Mohamed Makhlouf
Acta Parasitologica.2024; 69(1): 190. CrossRef
The Role of Praziquantel in the Prevention and Treatment of Fibrosis Associated with Schistosomiasis: A Review
Xuehua Niu, Tao Hu, Ye Hong, Xiaoyan Li, Yuzhou Shen, Wei Wang
Journal of Tropical Medicine.2022; 2022: 1. CrossRef
Cell therapy as a new approach on hepatic fibrosis of murine model of Schistosoma mansoni-infection
Muslimah Alsulami, Rewaida Abdel-Gaber
Acta Parasitologica.2021; 66(1): 136. CrossRef
hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
Liyang Dong, Yanan Pu, Xiaojun Chen, Xin Qi, Lina Zhang, Lei Xu, Wei Li, Yongbin Ma, Sha Zhou, Jifeng Zhu, Yalin Li, Xuefeng Wang, Chuan Su
Stem Cell Research & Therapy.2020;[Epub] CrossRef
Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration
Xiaoping Qi, S. Louise Pay, Yuanqing Yan, James Thomas, Alfred S. Lewin, Lung-Ji Chang, Maria B. Grant, Michael E. Boulton
Molecular Therapy.2017; 25(4): 917. CrossRef
Therapeutic Potential of Mesenchymal Stem Cells on Early and Late Experimental Hepatic Schistosomiasis Model
Shahinaz F. El-Shennawy, Heba E. Abdel Aaty, Nehal A. Radwan, Dina M. Abdel-Hameed, Yosra H. Alam-Eldin, Ayman M. El-Ashkar, Fatma A. Abu-Zahra
Journal of Parasitology.2015; 101(5): 587. CrossRef

10,469 View
75 Download
9 Web of Science
Crossref

Effect of Ketoconazole, a Cytochrome P450 Inhibitor, on the Efficacy of Quinine and Halofantrine against Schistosoma mansoni in Mice: Sayed Hassan Seif el-Din, Abdel-Nasser Abdel-Aal Sabra, Olfat Ali Hammam, Naglaa Mohamed El-Lakkany; Korean J Parasitol 2013;51(2):165-175.
Published online April 25, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.2.165

Abstract
PDF

The fear that schistosomes will become resistant to praziquantel (PZQ) motivates the search for alternatives to treat schistosomiasis. The antimalarials quinine (QN) and halofantrine (HF) possess moderate antischistosomal properties. The major metabolic pathway of QN and HF is through cytochrome P450 (CYP) 3A4. Accordingly, this study investigates the effects of CYP3A4 inhibitor, ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver. QN and HF significantly (P<0.05) elevated malondialdehyde levels when used alone or with KTZ. Meanwhile, KTZ plus QN or HF restored serum levels of ALT, albumin, and reduced hepatic glutathione (KTZ+HF) to their control values. KTZ enhanced the therapeutic antischistosomal potential of QN and HF over each drug alone. Moreover, the effect of KTZ+QN was more evident than KTZ+HF.

Citations

Citations to this article as recorded by

Surface-grafted MoS₂ for ketoconazole sensing in biological and aqua samples
Krishnapandi Alagumalai, Balamurugan Muthukutty, Mani Sivakumar, Daeho Lee, Seong-Cheol Kim
Colloids and Surfaces A: Physicochemical and Engineering Aspects.2025; 706: 135808. CrossRef
Indirect Modeling of Post-Prandial Intestinal Lymphatic Uptake of Halofantrine Using PBPK Approaches: Limitations and Implications
Malaz Yousef, Farag E. S. Mosa, Khaled H. Barakat, Neal M. Davies, Raimar Löbenberg
Pharmaceutics.2025; 17(9): 1228. CrossRef
Anti-fibrotic Effect of Oral Versus Intraperitoneal Administration of Gold Nanoparticles in Hepatic Schistosoma mansoni-Infected Mice
Shahira Abdelaziz Ali Ahmed, Samer Eid Mohamed Gad, Omima Mohamed Eida, Laila Mohamed Makhlouf
Acta Parasitologica.2024; 69(1): 190. CrossRef
Evaluation of the prophylactic and therapeutic efficacies of mucus and tissue nucleoproteins extracted from Biomphalaria alexandrina snails on schistosomiasis mansoni
Esraa H. Nafie, Maha M. Abou-Gamra, Hanan S. Mossalem, Rania M. Sarhan, Olfat A. Hammam, Sami M. Nasr, Mona M. Anwar
Journal of Parasitic Diseases.2024; 48(3): 551. CrossRef
Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma
Jin-man Liu, Jun-mei Chen, Ming-jun Lin, Fan-chang Wu, Cui-ru Ma, Xue Zuo, Wen-qian Yu, Ming-jun Huang, Jian-song Fang, Wei-rong Li, Qi Wang, Yong Liang
Journal of Ethnopharmacology.2022; 282: 114643. CrossRef
The effect of ivermectin alone and in combination with cobicistat or elacridar in experimental Schistosoma mansoni infection in mice
Belén Vicente, Julio López-Abán, Juliane Chaccour, Juan Hernández-Goenaga, Patricia Nicolas, Pedro Fernández-Soto, Antonio Muro, Carlos Chaccour
Scientific Reports.2021;[Epub] CrossRef
Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis
Mark C. Howell, Ryan Green, Roukiah Khalil, Elspeth Foran, Waise Quarni, Rajesh Nair, Stanley Stevens, Aleksandr Grinchuk, Andrew Hanna, Shyam Mohapatra, Subhra Mohapatra
FASEB BioAdvances.2020; 2(2): 90. CrossRef
Anti‐neurotoxic evaluation of synthetic and characterized metal complexes of thiosemicarbazone derivatives
Fathy A. El‐Saied, Tarek A. Salem, Mohamad M.E. Shakdofa, Ahmed N. Al‐Hakimi
Applied Organometallic Chemistry.2018;[Epub] CrossRef
Anthelmintic activity of cytochrome P450 inhibitors miconazole and clotrimazole: in-vitro effect on the liver fluke Opisthorchis felineus
Viatcheslav A. Mordvinov, Alexander G. Shilov, Maria Y. Pakharukova
International Journal of Antimicrobial Agents.2017; 50(1): 97. CrossRef
Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in Anopheles gambiae
Carlos J. Chaccour, Felix Hammann, Marta Alustiza, Sandra Castejon, Brian B. Tarimo, Gloria Abizanda, Ángel Irigoyen Barrio, Helena Martí Soler, Rafael Moncada, José Ignacio Bilbao, Azucena Aldaz, Marta Maia, José Luis Del Pozo
Scientific Reports.2017;[Epub] CrossRef
Dietary accumulation of tetrabromobisphenol A and its effects on the scallop Chlamys farreri
Fengxiao Hu, Luqing Pan, Meng Xiu, Dong Liu
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology.2015; 167: 7. CrossRef

10,561 View
70 Download
Crossref

Protective and Anti-Pathology Effects of Sm Fructose-1,6-Bisphosphate Aldolase-Based DNA Vaccine against Schistosoma mansoni by Changing Route of Injection: Mohamed Saber, Tarek Diab, Olft Hammam, Amr Karim, Amina Medhat, Mamdouh Khela, Ehab El-Dabaa; Korean J Parasitol 2013;51(2):155-163.
Published online April 25, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.2.155

Abstract
PDF

This study aimed to evaluate the efficacy of fructose-1,6-bis phosphate aldolase (SMALDO) DNA vaccination against Schistosoma mansoni infection using different routes of injection. The SMALDO has been cloned into the eukaryotic expression vector pcDNA3.1/V5-His TOPO-TA and was used in injecting Swiss albino mice intramuscularly (IM), subcutaneously (SC), or intraperitoneally (IP) (50 ?g/mouse). Mice vaccinated with non-recombinant pcDNA3.1 served as controls. Each group was immunized 4 times at weeks 0, 2, 4, and 6. Two weeks after the last booster dose, all mice groups were infected with 80 S. mansoni cercariae via tail immersion. At week 8 post-infection, animals were sacrificed for assessment of parasitological and histopathological parameters. High anti-SMALDO IgG antibody titers were detected in sera of all vaccinated groups (P<0.01) compared to the control group. Both the IP and SC vaccination routes resulted in a significant reduction in worm burden (46.2% and 28.9%, respectively, P<0.01). This was accompanied by a significant reduction in hepatic and intestinal egg counts (41.7% and 40.2%, respectively, P<0.01) in the IP group only. The number of dead eggs was significantly increased in both IP and IM groups (P<0.01). IP vaccination recorded the highest significant reduction in granuloma number and diameter (54.7% and 29.2%, respectively, P<0.01) and significant increase in dead miracidia (P<0.01). In conclusion, changing the injection route of SMALDO DNA vaccination significantly influenced the efficacy of vaccination. SMALDO DNA vaccination via IP route could be a promising protective and anti-pathology vaccine candidate against S. mansoni infection.

Citations

Citations to this article as recorded by

Glycolytic Enzymes as Vaccines Against Schistosomiasis: Testing Schistosoma mansoni Phosphoglycerate Mutase in Mice
David B. Pirovich, Akram A. Da'dara, Patrick J. Skelly
Journal of Parasitology.2024;[Epub] CrossRef
Multifunctional Fructose 1,6-Bisphosphate Aldolase as a Therapeutic Target
David B. Pirovich, Akram A. Da’dara, Patrick J. Skelly
Frontiers in Molecular Biosciences.2021;[Epub] CrossRef
Characterization of Fructose-1,6-Bisphosphate Aldolase 1 of Echinococcus multilocularis
Xuedong He, Jing Zhang, Yue Sun, Tianyan Lan, Xiaola Guo, Xiaoqiang Wang, Omnia M. Kandil, Mazhar Ayaz, Xuenong Luo, Houhui Song, Yadong Zheng
Veterinary Sciences.2021; 9(1): 4. CrossRef
Proteomic analysis of adult Schistosoma mekongi somatic and excretory-secretory proteins
Onrapak Reamtong, Nattapon Simanon, Tipparat Thiangtrongjit, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Songtham Anuntakarun, Sunchai Payungporn, Orawan Phuphisut, Poom Adisakwattana
Acta Tropica.2020; 202: 105247. CrossRef
Amelioration of type 1 diabetes by recombinant fructose-1,6-bisphosphate aldolase and cystatin derived from Schistosoma japonicum in a murine model
Ke Yan, Bo Wang, Huabang Zhou, Qingli Luo, Jilong Shen, Yunxia Xu, Zhengrong Zhong
Parasitology Research.2020; 119(1): 203. CrossRef
Linking murine resistance to secondary cystic echinococcosis with antibody responses targeting Echinococcus granulosus tegumental antigens
Sebastián Miles, Javier Magnone, Marek Cyrklaff, Paula Arbildi, Friedrich Frischknecht, Sylvia Dematteis, Gustavo Mourglia-Ettlin
Immunobiology.2020; 225(3): 151916. CrossRef
Interactome analysis of CD5 and CD6 ectodomains with tegumental antigens from the helminth parasite Echinococcus granulosus sensu lato
Sebastián Miles, María Velasco-de-Andrés, Francisco Lozano, Gustavo Mourglia-Ettlin
International Journal of Biological Macromolecules.2020; 164: 3718. CrossRef
Protein extract from head-foot tissue of Oncomelania hupensis promotes the growth and development of mother sporocysts of Schistosoma japonicum via upregulation of parasite aldolase gene
Ting Chai, Sijing Zhu, Huifen Dong, Zhenping Ming
Parasitology Research.2019; 118(6): 1821. CrossRef
Comparative study of excretory–secretory proteins released by Schistosoma mansoni-resistant, susceptible and naïve Biomphalaria glabrata
Conor E. Fogarty, Min Zhao, Donald P. McManus, Mary G. Duke, Scott F. Cummins, Tianfang Wang
Parasites & Vectors.2019;[Epub] CrossRef
Why Do Intravascular Schistosomes Coat Themselves in Glycolytic Enzymes?
David Pirovich, Akram A. Da'dara, Patrick J. Skelly
BioEssays.2019;[Epub] CrossRef
Schistosomiasis in Egypt: A never-ending story?
Ahmad A. Othman, Rasha H. Soliman
Acta Tropica.2015; 148: 179. CrossRef
Cloning, expression, and partial characterization of FBPA from Schistosoma japonicum, a molecule on that the fluke may develop nutrition competition and immune evasion from human
Qiping Hu, Huiqiong Xie, Shuyu Zhu, Dejun Liao, Tingzheng Zhan, Dengyu Liu
Parasitology Research.2015; 114(9): 3459. CrossRef
Evaluation of Echinostoma liei worm, metacercaria and redia antigens for schistosomiasis control
G. Abdel-Monaem, A. Farid, I. Rabia, A. El-Amir
Experimental Parasitology.2015; 157: 23. CrossRef

9,969 View
72 Download
Crossref

Monoclonal Antibody-Based Dipstick Assay: A Reliable Field Applicable Technique for Diagnosis of Schistosoma mansoni Infection Using Human Serum and Urine Samples: Zeinab Demerdash, Salwa Mohamed, Mohamed Hendawy, Ibrahim Rabia, Mohy Attia, Zeinab Shaker, Tarek M Diab; Korean J Parasitol 2013;51(1):93-98.
Published online February 18, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.1.93

Abstract
PDF

A field applicable diagnostic technique, the dipstick assay, was evaluated for its sensitivity and specificity in diagnosing human Schistosoma mansoni infection. A monoclonal antibody (mAb) against S. mansoni adult worm tegumental antigen (AWTA) was employed in dipstick and sandwich ELISA for detection of circulating schistosome antigen (CSA) in both serum and urine samples. Based on clinical and parasitological examinations, 60 S. mansoni-infected patients, 30 patients infected with parasites other than schistosomiasis, and 30 uninfected healthy individuals were selected. The sensitivity and specificity of dipstick assay in urine samples were 86.7% and 90.0%, respectively, compared to 90.0% sensitivity and 91.7% specificity of sandwich ELISA. In serum samples, the sensitivity and specificity were 88.3% and 91.7% for dipstick assay vs. 91.7% and 95.0% for sandwich ELISA, respectively. The diagnostic efficacy of dipstick assay in urine and serum samples was 88.3% and 90.0%, while it was 90.8% and 93.3% for sandwich ELISA, respectively. The diagnostic indices of dipstick assay and ELISA either in serum or in urine were statistically comparable (P>0.05). In conclusion, the dipstick assay offers an alternative simple, rapid, non-invasive technique in detecting CSA or complement to stool examinations especially in field studies.

Citations

Citations to this article as recorded by

Construction of Camelus dromedaries Immune Single Domain Antibodies Library for Development of Schistosoma mansoni Specific Nanobodies Using Phage Display Strategy
Hadeer Adel El-Kalamawy, Mohammed H. Awwad, Tarek M. Diab, Hend Okasha, Amal M. Abdel-Kareim, Marawan A. Marawan, Salma A. Shoulah, Ehab El-Dabaa
Recent Patents on Biotechnology.2025; 19(1): 69. CrossRef
Membrane Technology for Rapid Point-of-Care Diagnostics for Parasitic Neglected Tropical Diseases
Madeleine J. Rogers, Donald P. McManus, Stephen Muhi, Catherine A. Gordon
Clinical Microbiology Reviews.2021;[Epub] CrossRef
Serum low replacement medium versus serum rich replacement medium for production of Anti-Schistosoma Monoclonal antibody: A comparative study
Faten S. Mahmoud, Zeinab A. Demerdash, Sherihan M. Elmotawakel, Salwa Hassan, Mohamed Hendawy, Shimaa A. Atta, Shereen M. Shawky, Engy M. Alkhateeb, Hanaa I. Hassanin
Clinical Epidemiology and Global Health.2020; 8(2): 423. CrossRef
A protease-based biosensor for the detection of schistosome cercariae
A. J. Webb, R. Kelwick, M. J. Doenhoff, N. Kylilis, J. T. MacDonald, K. Y. Wen, C. McKeown, G. Baldwin, T. Ellis, K. Jensen, P. S. Freemont
Scientific Reports.2016;[Epub] CrossRef
Diagnostic Tests to Support Late-Stage Control Programs for Schistosomiasis and Soil-Transmitted Helminthiases
Kenneth R. Hawkins, Jason L. Cantera, Helen L. Storey, Brandon T. Leader, Tala de los Santos, Justin V. Remais
PLOS Neglected Tropical Diseases.2016; 10(12): e0004985. CrossRef
Comparative Study of the Accuracy of Different Techniques for the Laboratory Diagnosis of Schistosomiasis Mansoni in Areas of Low Endemicity in Barra Mansa City, Rio de Janeiro State, Brazil
Maria Cristina Carvalho Espírito-Santo, Mónica Viviana Alvarado-Mora, Pedro Luiz Silva Pinto, Maria Carmen Arroyo Sanchez, Emmanuel Dias-Neto, Vera Lúcia Pagliusi Castilho, Elenice Messias do Nascimento Gonçalves, Pedro Paulo Chieffi, Expedito José de Alb
BioMed Research International.2015; 2015: 1. CrossRef
Diagnosis of Parasitic Infections: What’s Going On?
Alessandra Ricciardi, Momar Ndao
SLAS Discovery.2015; 20(1): 6. CrossRef

10,738 View
84 Download
8 Web of Science
Crossref

Potential Correlation between Carboxylic Acid Metabolites in Biomphalaria alexandrina Snails after Exposure to Schistosoma mansoni Infection: Salwa M. F. Abou Elseoud, Nashwa S. Abdel Fattah, Hayam M. Ezz El Din, Hala Abdel Al, Hanan Mossalem, Noha Elleboudy; Korean J Parasitol 2012;50(2):119-126.
Published online May 24, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.2.119

Abstract
PDF

Carboxylic acids play an important role in both aerobic and anaerobic metabolic pathways of both the snail and the parasite. Monitoring the effects of infection by schistosome on Biomphalaria alexandrina carboxylic acids metabolic profiles represents a promising additional source of information about the state of metabolic system. We separated and quantified pyruvic, fumaric, malic, oxalic, and acetic acids using ion-suppression reversed-phase high performance liquid chromatography (HPLC) to detect correlations between these acids in both hemolymph and digestive gland gonad complex (DGG's) samples in a total of 300 B. alexandrina snails (150 infected and 150 controls) at different stages of infection. The results showed that the majority of metabolite pairs did not show significant correlations. However, some high correlations were found between the studied acids within the control group but not in other groups. More striking was the existence of reversed correlations between the same acids at different stages of infection. Some possible explanations of the underlying mechanisms were discussed. Ultimately, however, further data are required for resolving the responsible regulatory events. These findings highlight the potential of metabolomics as a novel approach for fundamental investigations of host-pathogen interactions as well as disease surveillance and control.

Citations

Citations to this article as recorded by

Novel insights into the glucose metabolic alterations of freshwater snails: a pathway to molluscicide innovation and snail control strategies
Tao Zheng, Jia Hao Liu, Ting Yao Zhu, Bin Li, Jia Shan Li, Yun Yang Gu, Juan Nie, Tao Xiong, Fang Guo Lu
Parasitology Research.2024;[Epub] CrossRef

8,195 View
60 Download
Crossref

Fasciola gigantica Fatty Acid Binding Protein (FABP) as a Prophylactic Agent against Schistosoma mansoni Infection in CD1 Mice: Ibrahim Rabia Aly, M. Diab, A. M. El-Amir, M. Hendawy, S. Kadry; Korean J Parasitol 2012;50(1):37-43.
Published online March 6, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.1.37

Abstract
PDF

Although schistosomicidal drugs and other control measures exist, the advent of an efficacious vaccine remains the most potentially powerful means for controlling this disease. In this study, native fatty acid binding protein (FABP) from Fasciola gigantica was purified from the adult worm's crude extract by saturation with ammonium sulphate followed by separation on DEAE-Sephadex A-50 anion exchange chromatography and gel filtration using Sephacryl HR-100, respectively. CD1 mice were immunized with the purified, native F. gigantica FABP in Freund's adjuvant and challenged subcutaneously with 120 Schistosoma mansoni cercariae. Immunization of CD1 mice with F. gigantica FABP has induced heterologous protection against S. mansoni, evidenced by the significant reduction in mean worm burden (72.3%), liver and intestinal egg counts (81.3% and 80.8%, respectively), and hepatic granuloma counts (42%). Also, it elicited mixed IgG₁/IgG_2b immune responses with predominant IgG1 isotype, suggesting that native F. gigantica FABP is mediated by a mixed Th1/Th2 response. However, it failed to induce any significant differences in the oogram pattern or in the mean granuloma diameter. This indicated that native F. gigantica FABP could be a promising vaccine candidate against S. mansoni infection.

Citations

Citations to this article as recorded by

Investigating the Taenia solium Fatty Acid Binding Protein Superfamily for Their Immunological Outlook and Prospect for Therapeutic Targets
Suraj S. Rawat, Gagandeep Singh, Amit Prasad
ACS Omega.2024; 9(21): 22557. CrossRef
Potential Utility of Systemic Plasma Biomarkers for Evaluation of Pediatric Schistosomiasis in Western Kenya
Bartholomew N. Ondigo, Rachael E. Hamilton, Edwin O. Magomere, Isaac O. Onkanga, Pauline N. Mwinzi, Maurice R. Odiere, Lisa Ganley-Leal
Frontiers in Immunology.2022;[Epub] CrossRef
Effect of regulatory T cells on the efficacy of the fatty acid-binding protein vaccine against Schistosoma japonicum
Chun-lian Tang, Rong-hui Zhang, Zhi-ming Liu, Huang Jin, Long He
Parasitology Research.2019; 118(2): 559. CrossRef
Protection against Schistosoma mansoni infection using a Fasciola hepatica-derived fatty acid binding protein from different delivery systems
Belén Vicente, Julio López-Abán, Jose Rojas-Caraballo, Esther del Olmo, Pedro Fernández-Soto, Antonio Muro
Parasites & Vectors.2016;[Epub] CrossRef
Schistosomiasis in Egypt: A never-ending story?
Ahmad A. Othman, Rasha H. Soliman
Acta Tropica.2015; 148: 179. CrossRef
Development of the Brazilian Anti Schistosomiasis Vaccine Based on the Recombinant Fatty Acid Binding Protein Sm14 Plus GLA-SE Adjuvant
Miriam Tendler, Marilia Almeida, Andrew Simpson
Frontiers in Immunology.2015;[Epub] CrossRef
The transcriptome of Echinostoma caproni adults: Further characterization of the secretome and identification of new potential drug targets
Gagan Garg, Dolores Bernal, Maria Trelis, Javier Forment, Javier Ortiz, M. Luz Valero, Laia Pedrola, Juan Martinez-Blanch, J. Guillermo Esteban, Shoba Ranganathan, Rafael Toledo, Antonio Marcilla
Journal of Proteomics.2013; 89: 202. CrossRef
Molecular characterization, functional expression, tissue localization and protective potential of a Taenia solium fatty acid-binding protein
Oscar Illescas, Julio C. Carrero, Raúl J. Bobes, Ana Flisser, Gabriela Rosas, Juan P. Laclette
Molecular and Biochemical Parasitology.2012; 186(2): 117. CrossRef

9,036 View
95 Download
Crossref

T Regulatory Cell Responses to Immunization with a Soluble Egg Antigen in Schistosoma mansoni-Infected Mice: Eman El-Ahwany, Ibrahim Rabia Bauiomy, Faten Nagy, Rabab Zalat, Ola Mahmoud, Suher Zada; Korean J Parasitol 2012;50(1):29-35.
Published online March 6, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.1.29

Abstract
PDF

The aim of the study is to characterize the phenotypes of CD4⁺ CD25⁺ T regulatory cells within the liver granulomas and association with both Foxp-3 gene expression and splenic cytokines. Na?ve C57BL/6 mice were intravenously injected with multiple doses of the soluble egg antigen (SEA) 7 days before cercarial infection. The immunized and infected control groups were sacrificed 8 and 16 weeks post-infection (PI). Histopathology, parasitological parameters, splenic phenotypes for T regulatory cells, the FOXP-3 expression in hepatic granuloma using real-time PCR, and the associated splenic cytokines were studied. Histopathological examination of the liver revealed remarkable increase in degenerated ova within hepatic granuloma which decreased in diameter at weeks 8 and 16 PI (P<0.01). The percentage of T regulatory cells (CD4⁺ CD25⁺) increased significantly (P<0.01) in the immunized group compared to the infected control at weeks 8 and 16 PI. The FOXP-3 expression in hepatic granulomas increased from 10 at week 8 to 30 fold at week 16 PI in the infected control group. However, its expression in the immunized group showed an increase from 30 at week 8 to 70 fold at week 16 PI. The splenic cytokine levels of pro-inflammatory cytokines, IFN-γ, IL-4, and TNF-α, showed significant decreases (P<0.05) compared to the infected control group. In conclusion, the magnitude and phenotype of the egg-induced effects on T helper responses were found to be controlled by a parallel response within the T regulatory population which provides protection in worm parasite-induced immunopathology.

Citations

Citations to this article as recorded by

Micromorphological Changes in the Parenchymatous Organs of Muskrats Infected with Quinqueserialis quinqueserialis (Trematoda: Notocotilidae)
O. E. Mazur, A. S. Fomina
Biology Bulletin.2024; 51(2): 371. CrossRef
Micromorphological changes in the parenchymatous organs of the muskrat infected with Quinqueserialis quinqueserialis (Trematoda: Notocotilidae)
O. E. Mazur, A. S. Fomina
Известия Российской академии наук. Серия биологическая.2024;[Epub] CrossRef
Evaluation of schistosomula lung antigen preparation and soluble egg antigen vaccines on experimental schistosomiasis mansoni
Nagwa S. M. Aly, Hye-Sook Kim, Maysa A. Eraky, Asmaa A. El Kholy, Basma T. Ali, Shin-ichi Miyoshi, Rabab E. Omar
Parasites, Hosts and Diseases.2023; 61(3): 251. CrossRef
Protective effect and mechanism of Schistosoma japonicum soluble egg antigen against type 1 diabetes in NOD mice
Li-xia Wang, Yan-ru Gao, Qun Pan, Chun-lian Tang, Rong-hui Zhang, Yan-hong Li, Chun-lan Zheng
International Journal of Diabetes in Developing Countries.2022; 42(2): 363. CrossRef
Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice
Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang, Luiz Felipe Domingues Passero
Journal of Immunology Research.2021; 2021: 1. CrossRef
Role of regulatory T cells in Schistosoma-mediated protection against type 1 diabetes
Chun-lian Tang, Yan-ru Gao, Li-xia Wang, Ya-wen Zhu, Qun Pan, Rong-hui Zhang, Ying Xiong
Molecular and Cellular Endocrinology.2019; 491: 110434. CrossRef
Schistosoma japonicum Soluble Egg Antigen Protects Against Type 2 Diabetes in Leprdb/db Mice by Enhancing Regulatory T Cells and Th2 Cytokines
Chun-lian Tang, Xiao-hong Yu, Yan Li, Rong-hui Zhang, Jun Xie, Zhi-ming Liu
Frontiers in Immunology.2019;[Epub] CrossRef
Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Erica de Souza Fernandes, Virgínia Maria de Barros Lorena, Iana Rafaela Fernandes Sales, Mônica Camelo Pessoa de Azevedo Albuquerque, Yara de Miranda Gomes, Vlaudia Maria Assis Costa, Valdênia Maria Oliveira de Souza
Revista da Sociedade Brasileira de Medicina Tropical.2018; 51(4): 546. CrossRef
Heat Shock Protein 60 in Eggs Specifically Induces Tregs and Reduces Liver Immunopathology in Mice with Schistosomiasis Japonica
Sha Zhou, Xin Jin, Xiaojun Chen, Jifeng Zhu, Zhipeng Xu, Xuefeng Wang, Feng Liu, Wei Hu, Liang Zhou, Chuan Su, Susmit Suvas
PLOS ONE.2015; 10(9): e0139133. CrossRef
Morphological features of cellular responses to different rates of trematode Quinqueserialis quinqueserialis (Trematoda: Notocotilidae) invasion in muskrat (Ondatra zibethicus)
O. E. Mazur, A. S. Fomina
Biology Bulletin.2014; 41(5): 444. CrossRef

9,315 View
94 Download
Crossref

Carboxylic Acids as Biomarkers of Biomphalaria alexandrina Snails Infected with Schistosoma mansoni: Salwa M. F. Abou Elseoud, Nashwa S. Abdel Fattah, Hayam M. Ezz El Din, Hala Abdel Al, Hanan Mossalem, Noha Elleboudy; Korean J Parasitol 2010;48(2):127-132.
Published online June 17, 2010; DOI: https://doi.org/10.3347/kjp.2010.48.2.127

Abstract
PDF

Biomphalaria alexandrina snails play an indispensable role in transmission of schistosomiasis. Infection rates in field populations of snails are routinely determined by cercarial shedding neglecting prepatent snail infections, because of lack of a suitable method for diagnosis. The present study aimed at separation and quantification of oxalic, malic, acetic, pyruvic, and fumaric acids using ion-suppression reversed-phase high performance liquid chromatography (HPLC) to test the potentiality of these acids to be used as diagnostic and therapeutic biomarkers. The assay was done in both hemolymph and digestive gland-gonad complex (DGG) samples in a total of 300 B. alexandrina snails. All of the studied acids in both the hemolymph and tissue samples except for the fumaric acid in hemolymph appeared to be good diagnostic biomarkers as they provide not only a good discrimination between the infected snails from the control but also between the studied stages of infection from each other. The most sensitive discriminating acid was malic acid in hemolymph samples as it showed the highest F-ratio. Using the Z-score, malic acid was found to be a good potential therapeutic biomarker in the prepatency stage, oxalic acid and acetic acid in the stage of patency, and malic acid and acetic acid at 2 weeks after patency. Quantification of carboxylic acids, using HPLC strategy, was fast, easy, and accurate in prediction of infected and uninfected snails and possibly to detect the stage of infection. It seems also useful for detection of the most suitable acids to be used as drug targets.

Citations

Citations to this article as recorded by

Novel insights into the glucose metabolic alterations of freshwater snails: a pathway to molluscicide innovation and snail control strategies
Tao Zheng, Jia Hao Liu, Ting Yao Zhu, Bin Li, Jia Shan Li, Yun Yang Gu, Juan Nie, Tao Xiong, Fang Guo Lu
Parasitology Research.2024;[Epub] CrossRef
NMR-based metabolomic responses of freshwater gastropod Bellamya aeruginosa to MC-producing and non MC-producing Microcystis aeruginosa
Wen Yang, Yangfang Ye, Kaihong Lu, Zhongming Zheng, Jinyong Zhu
Journal of Oceanology and Limnology.2022; 40(1): 260. CrossRef
UHPLC-MS-Based Metabolomics Analysis Reveals the Process of Schistosomiasis in Mice
Yuzheng Huang, Qiong Wu, Liang Zhao, Chunrong Xiong, Yongliang Xu, Xin Dong, Yan Wen, Jun Cao
Frontiers in Microbiology.2020;[Epub] CrossRef
Unveiling the oxidative metabolism of Achatina fulica (Mollusca: Gastropoda) experimentally infected to Angiostrongylus cantonensis (Nematoda: Metastrongylidae)
Vinícius Menezes Tunholi-Alves, Victor Menezes Tunholi, Juberlan Garcia, Esther Maria Mota, Rosane Nora Castro, Emerson Guedes Pontes, Jairo Pinheiro
Parasitology Research.2018; 117(6): 1773. CrossRef
Advances in the Diagnosis of Human Schistosomiasis
Kosala G. A. D. Weerakoon, Geoffrey N. Gobert, Pengfei Cai, Donald P. McManus
Clinical Microbiology Reviews.2015; 28(4): 939. CrossRef
Potential Correlation between Carboxylic Acid Metabolites in Biomphalaria alexandrina Snails after Exposure to Schistosoma mansoni Infection
Salwa M. F. Abou Elseoud, Nashwa S. Abdel Fattah, Hayam M. Ezz El Din, Hala Abdel Al, Hanan Mossalem, Noha Elleboudy
The Korean Journal of Parasitology.2012; 50(2): 119. CrossRef

8,894 View
59 Download
Crossref

Brief Communications

Intestinal helminthiases and schistosomiasis among school children in an urban center and some rural communities in southwest Nigeria: Olufemi Moses Agbolade, Ndubuisi Chinweike Agu, Oluseyi Olusegun Adesanya, Adedayo Olugbenga Odejayi, Aliu Adekunle Adigun, Emmanuel Babatunde Adesanlu, Flourish George Ogunleye, Adetoun Omolayo Sodimu, Stella Ajoke Adeshina, Ganiyat Olusola Bisiriyu, Oluwatosin Ibiyemi Omotoso, Karen Mfon Udia; Korean J Parasitol 2007;45(3):233-238.
Published online September 20, 2007; DOI: https://doi.org/10.3347/kjp.2007.45.3.233

Abstract
PDF

Intestinal helminths and schistosomiasis among school children were investigated in an urban and some rural communities of Ogun State, southwest Nigeria. Fecal samples of 1,059 subjects (524 males, 535 females) aged 3-18 years were examined using direct smear and brine concentration methods between June 2005 and November 2006. The pooled prevalence of infection was 66.2%. Ascaris lumbricoides showed the highest prevalence (53.4%) (P < 0.001) followed by hookworms (17.8%), Trichuris trichiura (10.4%), Taenia sp. (9.6%), Schistosoma mansoni (2.3%), Strongyloides stercoralis (0.7%), Schistosoma haematobium (0.6%), and Enterobius vermicularis (0.3%). The prevalences of A. lumbricoides, hookworms, Taenia sp., S. mansoni, and S. stercoralis in the urban centre were similar (P > 0.05) to those in the rural communities. The fertile and infertile egg ratios of A. lumbricoides in the urban centre and the rural communities were 13: 1 and 3.7: 1, respectively. Each helminth had similar prevalences among both genders (P > 0.05). The prevalence of A. lumbricoides increased significantly with age (P < 0.001). The commonest double infections were Ascaris and hookworms, while the commonest triple infections were Ascaris, hookworms, and Trichuris. The study demonstrates the need for urgent intervention programmes against intestinal helminthiases and schistosomiasis in the study area.

Citations

Citations to this article as recorded by

Cystic echinococcosis and Taenia spp. infections in Nigeria: A systematic review and meta-analysis of prevalence and geographical distribution
Tharheer Oluwashola Amuda, Li Li, Li-Qun Wang, Guo-Dong Dai, Yao-Dong Wu, Olajumoke Abimbola Morenikeji, Gui-Ting Pu, Dossêh Jean Apôtre Afayibo, Ke-Ke Wu, Wan-Zhong Jia, Xue-Nong Luo, Hong-Bin Yan
Acta Tropica.2025; 271: 107826. CrossRef
Strongyloides stercoralis Infection in Humans in West Africa, 1975–2024: Systematic Review and Meta-Analysis
Rufin K. Assaré, Mamadou Ouattara, Sören L. Becker, Fidèle K. Bassa, Nana R. Diakité, Jürg Utzinger, Eliézer K. N’Goran
Tropical Medicine and Infectious Disease.2025; 10(11): 321. CrossRef
Prevalence of Human Intestinal Parasitic Infections and Associated Risk Factors among School Children in Hakim District, Harari Regional State, Eastern Ethiopia
Eshetu Mekonnen, Nuredin Sadik, Hadi Tehrani
Advances in Public Health.2024;[Epub] CrossRef
PREVALENCE OF HELMINTH INFECTIONS AMONG PRIMARY SCHOOL CHILDREN IN GUSAU LOCAL GOVERNMENT AREA, ZAMFARA STATE
KHADIJAT OYIBO-USMAN, M. T. Abdulazeez, M. Mohammed, A. S. Lawal
FUDMA JOURNAL OF SCIENCES.2023; 6(5): 180. CrossRef
Prevalence of Schistosoma haematobium and Intestinal Helminth Infections among Nigerian School Children
Tolulope Alade, Thuy-Huong Ta-Tang, Sulaiman Adebayo Nassar, Akeem Abiodun Akindele, Raquel Capote-Morales, Tosin Blessing Omobami, Pedro Berzosa
Diagnostics.2023; 13(4): 759. CrossRef
Soil-transmitted helminth infection among school-age children in Ogoja, Nigeria: implication for control
Edema Enogiomwan Imalele, Ekanem Ikpi Braide, Ubleni Etta Emanghe, Emmanuel Offiong Effanga, Anok Ukam Usang
Parasitology Research.2023; 122(4): 1015. CrossRef
Evaluating the awareness of female genital schistosomiasis among women in Ebonyi, Nigeria
Anorue Chioma Ogochukwu, Onu Christiana Ukamaka, Anyanwu Ihuoma Ngozi, Mark Ericson, Ebenyi Hyacinth Okwe, Okesanya Olalekan John
Journal of Global Health Science.2023;[Epub] CrossRef
Establishing and Integrating a Female Genital Schistosomiasis Control Programme into the Existing Health Care System
Takalani Girly Nemungadi, Tsakani Ernica Furumele, Mary Kay Gugerty, Amadou Garba Djirmay, Saloshni Naidoo, Eyrun Flörecke Kjetland
Tropical Medicine and Infectious Disease.2022; 7(11): 382. CrossRef
Immunological Considerations for Schistosoma Vaccine Development: Transitioning to Endemic Settings
Emmanuella Driciru, Jan Pieter R. Koopman, Stephen Cose, Afzal A. Siddiqui, Maria Yazdanbakhsh, Alison M. Elliott, Meta Roestenberg
Frontiers in Immunology.2021;[Epub] CrossRef
Epidemiology of intestinal parasitic infections in preschool and school-aged Ethiopian children: a systematic review and meta-analysis
Legese Chelkeba, Zeleke Mekonnen, Yonas Alemu, Daniel Emana
BMC Public Health.2020;[Epub] CrossRef
Prevalence of Intestinal Parasitic Infections and Associated Risk Factors among the First-Cycle Primary Schoolchildren in Sasiga District, Southwest Ethiopia
Baye Sitotaw, Wakgari Shiferaw
Journal of Parasitology Research.2020; 2020: 1. CrossRef
Prevalence of intestinal helminths and their effects on anthropometric, haematological and metabolic parameters among patients of two teaching hospitals in NDjamena (Chad)
M. A. Hamit, R. A Issa, Ndifor Fombotioh, J. Nack, S. Kemba, M. M. Ali, F. Bilong Bilong C.
Journal of Public Health and Epidemiology.2020; 12(4): 277. CrossRef
Analysis of Schistosomiasis and soil-transmitted helminths mixed infections among pupils in Enugu State, Nigeria: Implications for control
Dennis N. Aribodor, Simon A. Bassey, Tippayarat Yoonuan, Sammy O. Sam-Wobo, Ogechukwu B. Aribodor, Ifeoma K. Ugwuanyi
Infection, Disease & Health.2019; 24(2): 98. CrossRef
Prevalence and clinical outcomes of Plasmodium falciparum and intestinal parasitic infections among children in Kiryandongo refugee camp, mid-Western Uganda: a cross sectional study
Paul Oboth, Yahaya Gavamukulya, Banson John Barugahare
BMC Infectious Diseases.2019;[Epub] CrossRef
Epidemiology of Taenia saginata taeniosis/cysticercosis: a systematic review of the distribution in West and Central Africa
Emilie Hendrickx, Lian F. Thomas, Pierre Dorny, Branko Bobić, Uffe Christian Braae, Brecht Devleesschauwer, Ramon M. Eichenberger, Sarah Gabriël, Anastasios Saratsis, Paul R. Torgerson, Lucy J. Robertson, Veronique Dermauw
Parasites & Vectors.2019;[Epub] CrossRef
Prevalence and distribution of soil-transmitted helminth infections in Nigerian children: a systematic review and meta-analysis
Solomon Ngutor Karshima
Infectious Diseases of Poverty.2018;[Epub] CrossRef
Geohelminth Infections and Nutritional Status of Preschool Aged Children in a Periurban Settlement ofOgun State
O. O. Omitola, H. O. Mogaji, A. S. Oluwole, A. A. Adeniran, O. M. Alabi, U. F. Ekpo
Scientifica.2016; 2016: 1. CrossRef
Trends in prevalence of soil‐transmitted helminth and major intestinal protozoan infections among school‐aged children in Nepal
Ritu Kunwar, Lokendra Acharya, Surendra Karki
Tropical Medicine & International Health.2016; 21(6): 703. CrossRef
Decreasing prevalence of intestinal parasitic infections among school-aged children in Nepal: a systematic review and meta-analysis
Ritu Kunwar, Lokendra Acharya, Surendra Karki
Transactions of The Royal Society of Tropical Medicine and Hygiene.2016; 110(6): 324. CrossRef
PREVALENCE AND RISK FACTORS OF SCHISTOSOMIASIS AMONG HAUSA COMMUNITIES IN KANO STATE, NIGERIA
Salwa DAWAKI, Hesham Mahyoub AL-MEKHLAFI, Init ITHOI, Jamaiah IBRAHIM, Awatif Mohammed ABDULSALAM, Abdulhamid AHMED, Hany SADY, Wahib Mohammed ATROOSH, Mona Abdullah AL-AREEQI, Fatin Nur ELYANA, Nabil Ahmed NASR, Johari SURIN
Revista do Instituto de Medicina Tropical de São Paulo.2016;[Epub] CrossRef
Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa
Uffe Christian Braae, Christopher F. L. Saarnak, Samson Mukaratirwa, Brecht Devleesschauwer, Pascal Magnussen, Maria Vang Johansen
Parasites & Vectors.2015;[Epub] CrossRef
Prevalence and its associated risk factors of intestinal parasitic infections among Yadot primary school children of South Eastern Ethiopia: a cross-sectional study
Begna Tulu, Solomon Taye, Eden Amsalu
BMC Research Notes.2014; 7(1): 848. CrossRef
Assessment of the prevalence of intestinal parasitosis and associated risk factors among primary school children in Chencha town, Southern Ethiopia
Ashenafi Abossie, Mohammed Seid
BMC Public Health.2014;[Epub] CrossRef
Genital schistosomiasis and its unacknowledged role on HIV transmission in the STD intervention studies
Eyrun F Kjetland, Ingrid EA Hegertun, Marc FD Baay, Mathias Onsrud, Patricia D Ndhlovu, Myra Taylor
International Journal of STD & AIDS.2014; 25(10): 705. CrossRef
Parasitic Prevalence in a Suburban School of Famaillá, Tucumán, Argentina
Julián Dib, Juana Oquilla, Silvia G. Lazarte, Silvia N. Gonzalez
ISRN Microbiology.2012; 2012: 1. CrossRef
Current status of soil-transmitted helminthiases among pre-school and school-aged children from Ile-Ife, Osun State, Nigeria
O.A. Sowemimo, S.O. Asaolu
Journal of Helminthology.2011; 85(3): 234. CrossRef
Helminthic Infections in School Children in Puducherry, South India
Latha Ragunathan, Senthil Kumar Kalivaradhan, Sasikala Ramadass, Muruganandam Nagaraj, Karthikeyan Ramesh
Journal of Microbiology, Immunology and Infection.2010; 43(3): 228. CrossRef
Freshwater snail diversity in Benin (West Africa) with a focus on human schistosomiasis
M. Ibikounlé, G. Mouahid, N.G. Sakiti, A. Massougbodji, H. Moné
Acta Tropica.2009; 111(1): 29. CrossRef

10,059 View
101 Download
Crossref

Effects of exogenous glucose on survival and infectivity of Schistosoma mansoni cercariae: Bernard Fried, Robert Laterra, Yonghyun Kim; Korean J Parasitol 2002;40(1):55-58.
Published online March 31, 2002; DOI: https://doi.org/10.3347/kjp.2002.40.1.55

Abstract
PDF

The effects of exogenous glucose in artificial spring water (ASW) were studied on the survival and infectivity of Schistosoma mansoni cercariae. The mean percent survival of cercariae maintained in 1% glucose in ASW for 36 and 48hr was significantly greater than that of cercariae maintained identically in ASW. Cercariae maintained in ASW with or without glucose for 24hr, fixed in neutral buffered formalin, and stained in Oil Red O, showed an accumulation of neutral lipid in the tail. Cercariae maintained as described above and stained in periodic acid-Schiff exhibited depleted glycogen, mainly from the tail. Cercariae maintained in ASW with glucose for 24hr did not resynthesize glycogen. Cercariae maintained in ASW with glucose for 24hr were as capable of infecting male FVBN202 mice as were freshly emerged cercariae, and increased the percent of worm recovery. Exogeneous glucose added to ASW prolonged the survival of S. mansoni cercariae and increased infectivity in terms of worm recovery.

Citations

Citations to this article as recorded by

Heads or tails? Differential translational regulation in cercarial heads and tails of schistosome worms
James R. Hagerty, Emmitt R. Jolly, Salah A. Sheweita
PLOS ONE.2019; 14(10): e0224358. CrossRef
In Vitro Maintenance of Clonorchis sinensis Adult Worms
Md. Hafiz Uddin, Shunyu Li, Young Mee Bae, Min-Ho Choi, Sung-Tae Hong
The Korean Journal of Parasitology.2012; 50(4): 309. CrossRef
Bile components and amino acids affect survival of the newly excysted juvenile Clonorchis sinensis in maintaining media
Shunyu Li, Tae Im Kim, Won Gi Yoo, Pyo Yun Cho, Tong-Soo Kim, Sung-Jong Hong
Parasitology Research.2008; 103(5): 1019. CrossRef
Effects of glucose on survival, infectivity and linear movement of the cercariae of Echinostoma caproni
E.L. Ponder, B. Fried
Journal of Helminthology.2004; 78(2): 185. CrossRef
Emergence of cercariae of Echinostoma caproni and Schistosoma mansoni from Biomphalaria glabrata under different laboratory conditions
B. Fried, R. Laterra, Y. Kim
Journal of Helminthology.2002; 76(4): 369. CrossRef