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"Seung-Young Yu"

Case Report

Imported Intraocular Gnathostomiasis with Subretinal Tracks Confirmed by Western Blot Assay
Ji Ho Yang, Moosang Kim, Eung Suk Kim, Byoung-Kuk Na, Seung-Young Yu, Hyung-Woo Kwak
Korean J Parasitol 2012;50(1):73-78.
Published online March 6, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.1.73

We report a case of intraocular gnathostomiasis diagnosed by western blot assay in a patient with subretinal tracks. A 15-year-old male patient complained of blurred vision in the right eye, lasting for 2 weeks. Eight months earlier, he had traveled to Vietnam for 1 week and ate raw wild boar meat and lobster. His best-corrected visual acuity was 20/20 in both eyes and anterior chamber examination revealed no abnormalities. Fundus examination showed subretinal tracks in the right eye. Fluorescein angiography and indocyanine green angiography showed linear hyperfluorescence of the subretinal lesion observed on fundus in the right eye. Ultrasound examination revealed no abnormalities. Blood tests indicated mild eosinophilia (7.5%), and there was no abnormality found by systemic examinations. Two years later, the patient visited our department again for ophthalmologic evaluation. Visual acuity remained 20/20 in both eyes and the subretinal tracks in the right eye had not changed since the previous examination. Serologic examination was performed to provide a more accurate diagnosis, and the patient's serum reacted strongly to the Gnathostoma nipponicum antigen by western blot assay, which led to a diagnosis of intraocular gnathostomiasis. This is the first reported case of intraocular gnathostomiasis with subretinal tracks confirmed serologically using western blot in Korea.

Citations

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  • Ocular infections in international travelers
    Francesca F. Norman, Julio J. González-López, Diego Gayoso-Cantero, Marta Vicente-Antolin, Maria-Dolores Corbacho-Loarte, Rogelio López-Vélez, Marta González-Sanz
    Travel Medicine and Infectious Disease.2025; 63: 102789.     CrossRef
  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Intracameral gnathostomiasis presenting as neuroretinitis
    Kimhour Lay, Leng Un, Kossama Chukmol, Piseth Kong
    BMJ Case Reports.2025; 18(3): e260393.     CrossRef
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  • Intracameral Gnathostomiasis: A Case Report and Literature Review
    Wijak Kongwattananon, Thanaporn Wiriyabanditkul, Waraluck Supwatjariyakul, Thanapong Somkijrungroj
    Ocular Immunology and Inflammation.2023; 31(5): 1092.     CrossRef
  • A case of vocal cord gnathostomiasis diagnosed with sectional morphologies in a histopathological specimen from a Chinese woman living in Korea
    Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
    Parasites, Hosts and Diseases.2023; 61(3): 298.     CrossRef
  • Subretinal gnathostomiasis: A successful focal laser photocoagulation for a living parasite
    Supalert Prakhunhungsit, Somanus Thoongsuwan, Sutasinee Boonsopon, Thitiyaporn Panawattanawong, Pitchaya Amornvararak, Nuttawut Rodanant, Nopasak Phasukkijwatana
    American Journal of Ophthalmology Case Reports.2022; 26: 101413.     CrossRef
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    Jorge Costa Eiras, Gilberto Cezar Pavanelli, Ricardo Massato Takemoto, Yukifumi Nawa
    The Korean Journal of Parasitology.2018; 56(3): 215.     CrossRef
  • Imported gnathostomiasis manifesting as cutaneous larva migrans and Löffler’s syndrome
    William L. Hamilton, Daniel Agranoff
    BMJ Case Reports.2018; 2018: bcr-2017-223132.     CrossRef
  • Ocular Gnathostomiasis—Update of Earlier Survey
    Kittisak Sawanyawisuth, Yukifumi Nawa, Sandra Fernández Figueiras, Sylvia Paz Diaz Camacho, Verajit Chotmongkol, Masahide Yoshikawa, Maria Benavides
    The American Journal of Tropical Medicine and Hygiene.2017; 97(4): 1232.     CrossRef
  • First reported case of intraocular Gnathostoma spinigerum in Cambodia
    S. Hem, A. Tarantola, R. Chheang, P. Nop, A. Kerléguer
    Bulletin de la Société de pathologie exotique.2015; 108(5): 312.     CrossRef
  • Three-dimensional spectral domain optical coherence tomography and light microscopy of an intravitreal parasite
    Aziz A. Khanifar, Michael J. Espiritu, Jane S. Myung, Grant D. Aaker, Audrey N. Schuetz, Donald J. D’Amico, R. V. Paul Chan
    Journal of Ophthalmic Inflammation and Infection.2015;[Epub]     CrossRef
  • Toxocara Optic Neuropathy after Ingestion of Raw Meat Products
    Hee Kyung Yang, Se Joon Woo, Jeong-Min Hwang
    Optometry and Vision Science.2014; 91(11): e267.     CrossRef
  • Gnathostoma spinigerum Infection in the Upper Lip of a Korean Woman: An Autochthonous Case in Korea
    Jae Hee Kim, Hyemi Lim, Young-Sang Hwang, Tae Yeon Kim, Eun Mee Han, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2013; 51(3): 343.     CrossRef
  • Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China
    Jing Cui, Ye Wang, Zhong Quan Wang
    The Korean Journal of Parasitology.2013; 51(4): 467.     CrossRef
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Brief Communication
Suppression of CD4+ T-Cells in the Spleen of Mice Infected with Toxoplasma gondii KI-1 Tachyzoites
Won-Hee Kim, Eun-Hee Shin, Jae-Lip Kim, Seung-Young Yu, Bong-Kwang Jung, Jong-Yil Chai
Korean J Parasitol 2010;48(4):325-329.
Published online December 16, 2010
DOI: https://doi.org/10.3347/kjp.2010.48.4.325

Toxoplasma gondii KI-1, a recent new isolate from Korea, shows similar pathogenicity and infectivity to mice compared to the virulent RH strain. To understand characteristics of host immunity, including immune enhancement or suppression, we investigated proliferative responses and phenotypes of spleen cells. In addition, kinetics of IFN-γ, a Th1 cytokine, was examined in BALB/c mice up to day 6 post-infection (PI). Intraperitoneal injection of mice with 103 KI-1 tachyzoites induced significant decreases (P < 0.05) in proliferative responses of spleen cells. This occurred at days 2-6 PI even when concanavalin A (con A) was added and when stimulated with KI-1 antigen, suggesting suppression of the immunity. CD4+ T-cells decreased markedly at day 2 PI (P < 0.05), whereas CD8+ T-cells, NK cells, and macrophages did not show significant changes, except a slight, but significant, increase of CD8+ T-cells at day 6 PI. The capacity of splenocytes to produce IFN-γ by con A stimulation dropped significantly at days 2-6 PI. These results demonstrate that intraperitoneal injection of KI-1 tachyzoites can induce immunosuppression during the early stage of infection, as revealed by the decrease of CD4+ T-cells and IFN-γ.

Citations

Citations to this article as recorded by  Crossref logo
  • Exploring the potential of Toxoplasma gondii in drug development and as a delivery system
    Chanjin Yoon, Yu Seong Ham, Woo Jin Gil, Chul-Su Yang
    Experimental & Molecular Medicine.2024; 56(2): 289.     CrossRef
  • Toxoplasma gondii macrophage migration inhibitory factor shows anti– Mycobacterium tuberculosis potential via AZIN1/STAT1 interaction
    Chanjin Yoon, Hyo Keun Kim, Yu Seong Ham, Woo Jin Gil, Seok-Jun Mun, Euni Cho, Jae-Min Yuk, Chul-Su Yang
    Science Advances.2024;[Epub]     CrossRef
  • The effects of toxoplasmosis on sex ratio at birth
    Jaroslav Flegr, Šárka Kaňková
    Early Human Development.2020; 141: 104874.     CrossRef
  • Reactive Oxygen Species-Triggered Trophoblast Apoptosis Is Initiated by Endoplasmic Reticulum Stress via Activation of Caspase-12, CHOP, and the JNK Pathway in Toxoplasma gondii Infection in Mice
    Xiucai Xu, Tingting Liu, Aimei Zhang, Xingxing Huo, Qingli Luo, Zhaowu Chen, Li Yu, Qing Li, Lili Liu, Zhao-rong Lun, Jilong Shen, J. H. Adams
    Infection and Immunity.2012; 80(6): 2121.     CrossRef
  • 8,380 View
  • 63 Download
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