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"Soon Cheol Ahn"

Brief Communication

Trichinella spiralis Infection Suppressed Gut Inflammation with CD4+CD25+Foxp3+ T Cell Recruitment
Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Seon Hee Choi, Soon Cheol Ahn, Hak Sun Yu
Korean J Parasitol 2012;50(4):385-390.
Published online November 26, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.4.385

In order to know the effect of pre-existing Trichinella spiralis infection on experimentally induced intestinal inflammation and immune responses, we induced colitis in T. spiralis-infected mice and observed the severity of colitis and the levels of Th1, Th2, and regulatory cytokines and recruitment of CD4+CD25+Foxp3+ T (regulatory T; Treg) cells. Female C57BL/6 mice were infected with 250 muscle larvae; after 4 weeks, induction of experimental colitis was performed using 3% dextran sulfate sodium (DSS). During the induction period, we observed severity of colitis, including weight loss and status of stool, and evaluated the disease activity index (DAI). A significantly low DAI and degree of weight loss were observed in infected mice, compared with uninfected mice. In addition, colon length in infected mice was not contracted, compared with uninfected mice. We also observed a significant increase in production of pro-inflammatory cytokines, IL-6 and IFN-γ, in spleen lymphocytes treated with DSS; however, such an increase was not observed in infected mice treated with DSS. Of particular interest, production of regulatory cytokines, IL-10 and transforming growth factor (TGF)-β, in spleen lymphocytes showed a significant increase in mice infected with T. spiralis. A similar result was observed in mesenteric lymph nodes (MLN). Subsets of the population of Treg cells in MLN and spleen showed significant increases in mice infected with T. spiralis. In conclusion, T. spiralis infection can inhibit the DSS-induced colitis in mice by enhancing the regulatory cytokine and Treg cells recruitment.

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Original Articles
Parasitic Helminth Cystatin Inhibits DSS-Induced Intestinal Inflammation Via IL-10+F4/80+ Macrophage Recruitment
Sung Won Jang, Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Byoung-Kuk Na, Soon Cheol Ahn, Dong-Hee Kim, Hak Sun Yu
Korean J Parasitol 2011;49(3):245-254.
Published online September 30, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.3.245

Many immune down-regulatory molecules have been isolated from parasites, including cystatin (cystain protease inhibitor). In a previous study, we isolated and characterized Type I cystatin (CsStefin-1) of the liver fluke, Clonorchis sinensis. To investigate whether the CsStefin-1 might be a new host immune modulator, we induced intestinal inflammation in mice by dextran sodium sulfate (DSS) and treated them with recombinant CsStefin-1 (rCsStefin-1). The disease activity index (DAI) increased in DSS only-treated mice. In contrast, the DAI value was significantly reduced in rCsStefin-1-treated mice than DSS only-treated mice. In addition, the colon length of DSS only-treated mice was shorter than that of rCsStefin-1 treated mice. The secretion levels of IFN-γ and TNF-α in the spleen and mesenteric lymph nodes (MLNs) were significantly increased by DSS treatment, but the level of TNF-α in MLNs was significantly decreased by rCsStefin-1 treatment. IL-10 production in both spleen and MLNs was significantly increased, and IL-10+F4/80+ macrophage cells were significantly increased in the spleen and MLNs of rCsStefin-1 treated mice after DSS treatment. In conclusion, rCsStefin-1 could reduce the intestinal inflammation occurring after DSS treatment, these effects might be related with recruitment of IL-10 secreting macrophages.

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    International Journal for Parasitology.2013; 43(3-4): 301.     CrossRef
  • Helminth Infections and Host Immune Regulation
    Henry J. McSorley, Rick M. Maizels
    Clinical Microbiology Reviews.2012; 25(4): 585.     CrossRef
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Protease-Activated Receptor 2 Is Involved in Th2 Responses against Trichinella spiralis Infection
Mi Kyung Park, Min Kyoung Cho, Shin Ae Kang, Hye-Kyung Park, Yun Seong Kim, Ki Uk Kim, Soon Cheol Ahn, Dong-Hee Kim, Hak Sun Yu
Korean J Parasitol 2011;49(3):235-243.
Published online September 30, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.3.235

In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2 responses in T. spiralis-infected PAR2 knockout (KO) mice. The levels of the Th2 cell-secreted cytokines, IL-4, IL-5, and IL-13 were markedly reduced in the PAR2 KO mice as compared to the wild type mice following infection with T. spiralis. The serum levels of parasite-specific IgE increased significantly in the wild type mice as the result of T. spiralis infection, but this level was not significantly increased in PAR2 KO mice. The expression level of thymic stromal lymphopoietin, IL-25, and eotaxin gene (the genes were recently known as Th2 response initiators) of mouse intestinal epithelial cells were increased as the result of treatment with T. spiralis excretory-secretory proteins. However, the expression of these chemokine genes was inhibited by protease inhibitor treatments. In conclusion, PAR2 might involve in Th2 responses against T. spiralis infection.

Citations

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  • Innate Immune Recognition of Helminths: TLRs and Beyond
    Camila de Almeida Lopes, Linda Djune Yemeli, Pedro Gazzinelli‐Guimaraes
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  • A novel trypsin of Trichinella spiralis mediates larval invasion of gut epithelium via binding to PAR2 and activating ERK1/2 pathway
    Lu Lu Han, Qi Qi Lu, Wen Wen Zheng, Yang Li Li, Yan Yan Song, Xin Zhuo Zhang, Shao Rong Long, Ruo Dan Liu, Zhong Quan Wang, Jing Cui, Krystyna Cwiklinski
    PLOS Neglected Tropical Diseases.2024; 18(1): e0011874.     CrossRef
  • Pathogenesis ofBrucellaepididymoorchitis-game ofBrucelladeath
    Jiuwang Yu, Sha Li, Lu Wang, Zhiheng Dong, Lengge Si, Lidao Bao, Lan Wu
    Critical Reviews in Microbiology.2022; 48(1): 96.     CrossRef
  • Cytokines and beyond: Regulation of innate immune responses during helminth infection
    Oyebola O. Oyesola, Simon P. Früh, Lauren M. Webb, Elia D. Tait Wojno
    Cytokine.2020; 133: 154527.     CrossRef
  • Animal Models for Functional Gastrointestinal Disorders
    Alison Accarie, Tim Vanuytsel
    Frontiers in Psychiatry.2020;[Epub]     CrossRef
  • Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models
    Shin Ae Kang, Mi-Kyung Park, Sang Kyun Park, Jun Ho Choi, Da In Lee, So Myong Song, Hak Sun Yu
    Scientific Reports.2019;[Epub]     CrossRef
  • The role of rare innate immune cells in Type 2 immune activation against parasitic helminths
    LAUREN M. WEBB, ELIA D. TAIT WOJNO
    Parasitology.2017; 144(10): 1288.     CrossRef
  • The induction of the collagen capsule synthesis by Trichinella spiralis is closely related to protease-activated receptor 2
    Mi Kyung Park, Min Kyoung Cho, Shin Ae Kang, Bo Young Kim, Hak Sun Yu
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  • Human Helminths and Allergic Disease: The Hygiene Hypothesis and Beyond
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    E. V. Svirshchevskaya, E. V. Matushevskaya, D. B. Chudakov, Yu. I. Matushevskaya
    Klinicheskaya dermatologiya i venerologiya.2015; 14(2): 4.     CrossRef
  • Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics
    Elena S. Gusareva, Iryna Kurey, Igor Grekov, Marie Lipoldová
    Biological Reviews.2014; 89(2): 375.     CrossRef
  • Thymic stromal lymphopoietin and atopic diseases
    J.M. Leyva-Castillo, M. Li
    Revue Française d'Allergologie.2014; 54(5): 364.     CrossRef
  • Parasitic Nematode-Induced CD4+Foxp3+T Cells Can Ameliorate Allergic Airway Inflammation
    Shin Ae Kang, Mi-Kyung Park, Min Kyoung Cho, Sang Kyun Park, Min Seong Jang, Bo-Gie Yang, Myoung Ho Jang, Dong-Hee Kim, Hak Sun Yu, Edward Mitre
    PLoS Neglected Tropical Diseases.2014; 8(12): e3410.     CrossRef
  • Coinfection with Clonorchis sinensis modulates murine host response against Trichinella spiralis infection
    Ying Chen, Bo Huang, Shiguang Huang, Xinbing Yu, Yonglong Li, Wenjian Song, Yongxiang Li, Fangli Lu
    Parasitology Research.2013; 112(9): 3167.     CrossRef
  • Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice
    Shin Ae Kang, Mi-Kyung Park, Min Kyoung Cho, Hak Sun Yu
    The Korean Journal of Parasitology.2013; 51(5): 583.     CrossRef
  • Toward Drugs for Protease-Activated Receptor 2 (PAR2)
    Mei-Kwan Yau, Ligong Liu, David P. Fairlie
    Journal of Medicinal Chemistry.2013; 56(19): 7477.     CrossRef
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    Masanori Nakayama, Yasuo Niki, Toshiki Kawasaki, Yuki Takeda, Hiroyasu Ikegami, Yoshiaki Toyama, Takeshi Miyamoto
    Scientific Reports.2013;[Epub]     CrossRef
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    Seema Shrivastava, Liang Ma, El‐Li Tham, John H. McVey, Daxin Chen, Anthony Dorling
    Immunology.2013; 139(2): 219.     CrossRef
  • Molecular characterization of 45kDa aspartic protease of Trichinella spiralis
    Jong Nam Park, Sang Kyun Park, Min Kyoung Cho, Mi-Kyung Park, Shin Ae Kang, Dong-Hee Kim, Hak Sun Yu
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    Rajita Pappu, Sascha Rutz, Wenjun Ouyang
    Trends in Immunology.2012; 33(7): 343.     CrossRef
  • Regulation of type 2 immunity to helminths by mast cells
    Matthew R. Hepworth, Marcus Maurer, Susanne Hartmann
    Gut Microbes.2012; 3(5): 476.     CrossRef
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Endosymbionts of Acanthamoeba Isolated from Domestic Tap Water in Korea
Seon Hee Choi, Min Kyoung Cho, Soon Cheol Ahn, Ji Eun Lee, Jong Soo Lee, Dong-Hee Kim, Ying-Hua Xuan, Yeon Chul Hong, Hyun Hee Kong, Dong Il Chung, Hak Sun Yu
Korean J Parasitol 2009;47(4):337-344.
Published online December 1, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.4.337

In a previous study, we reported our discovery of Acanthamoeba contamination in domestic tap water; in that study, we determined that some Acanthamoeba strains harbor endosymbiotic bacteria, via our molecular characterization by mitochondrial DNA restriction fragment length polymorphism (Mt DNA RFLP). Five (29.4%) among 17 Acanthamoeba isolates contained endosymbionts in their cytoplasm, as demonstrated via orcein staining. In order to estimate their pathogenicity, we conducted a genetic characterization of the endosymbionts in Acanthamoeba isolated from domestic tap water via 16S rDNA sequencing. The endosymbionts of Acanthamoeba sp. KA/WP3 and KA/WP4 evidenced the highest level of similarity, at 97% of the recently published 16S rDNA sequence of the bacterium, Candidatus Amoebophilus asiaticus. The endosymbionts of Acanthamoeba sp. KA/WP8 and KA/WP12 shared a 97% sequence similarity with each other, and were also highly similar to Candidatus Odyssella thessalonicensis, a member of the α-proteobacteria. The endosymbiont of Acanthamoeba sp. KA/WP9 exhibits a high degree of similarity (85-95%) with genus Methylophilus, which is not yet known to harbor any endosymbionts. This is the first report, to the best of our knowledge, to show that Methylophilus spp. can live in the cytoplasm of Acanthamoeba.

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    BMC Evolutionary Biology.2011;[Epub]     CrossRef
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