Parasites, Hosts and Diseases

"Wagner Welber Arrais-Silva"

Brief Communication

Evaluation of Boldine Activity against Intracellular Amastigotes of Leishmania amazonensis: Isabel Cristina Salama, Cristina Arrais-Lima, Wagner Welber Arrais-Silva; Korean J Parasitol 2017;55(3):337-340.
Published online June 30, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.3.337

Abstract
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Leishmaniasis is a neglected and endemic disease that affects poorest population mainly in developing countries. A lack of adequate and definitive chemotherapeutic agents to fight against this infection has led to the investigation of numerous compounds. The aim of this study was to investigate in vitro activity of boldine against Leishmania amazonensis murine cell infection. Boldine ((S)-2,9-dihydroxy-1,10-dimethoxy-aporphine) is an aporphine alkaloid found abundantly in the leaves/bark of boldo (Peumus boldus Molina), a widely distributed tree native to Chile. The in vitro system consisted of murine macrophage infection with amastigotes of L. amazonensis treated with different concentrations from 50 to 600 μg/ml of boldine for 24 hr. Intracellular parasite destruction was assessed by morphological examination and boldine cytotoxicity to macrophages was tested by the MTT viability assay. When cells were treated with 100 μg/ml of boldine the reduction of parasite infection was 81% compared with untreated cultures cells. Interestingly, boldine-treatment caused a concentration-dependent decrease of macrophage infection that culminated with 96% of reduction when cells were submitted to 600 μg/ml of boldine. Cell cultures exposed to 100 μg/ml of boldine and 300 μg/ml of Glucantime^® during 24 hr showed a significant reduction of 50% in parasitized cells compared with cell cultures exposed just to Glucantime^®. The study showed that treatment with boldine produces a better effect than treatment with the reference antimonial drug, glucantime, in L. amazonensis infected macrophage. Our results suggest that boldine is a potentially useful agent for the treatment of leishmaniasis.

Citations

Citations to this article as recorded by

Boldine: a narrative review of the bioactive compound with versatile biological and pharmacological potential
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Frontiers in Molecular Biosciences.2021;[Epub] CrossRef
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Original Article

A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent: Camila B?rbara Cantalupo Lima, Wagner Welber Arrais-Silva, Rodrigo Luiz Oliveira Rodrigues Cunha, Selma Giorgio; Korean J Parasitol 2009;47(3):213-218.
Published online August 28, 2009; DOI: https://doi.org/10.3347/kjp.2009.47.3.213

Abstract
PDF

Leishmaniasis is a neglected disease and endemic in developing countries. A lack of adequate and definitive chemotherapeutic agents to fight against this infection has led to the investigation of numerous compounds. The aim of this study was to investigate the effect of RT-01, an organotellurane compound presenting biological activities, in 2 experimental systems against Leishmania amazonensis. The in vitro system consisted of promastigotes and amastigotes forms of the parasite, and the in vivo system consisted of L. amazonensis infected BALB/c mice, an extremely susceptible mouse strain. The compound proved to be toxic against promastigotes and amastigotes. The study also showed that treatment with RT-01 produces an effect similar to that treatment with the reference antimonial drug, Glucantime, in L. amazonensis infected mice. The best results were obtained following RT-01 intralesional administration (720 ?g/kg/day); mice showed significant delay in the development of cutaneous lesions and decreased numbers of parasites obtained from the lesions. Significant differences in tissue pathology consisted mainly of no expressive accumulation of inflammatory cells and well-preserved structures in the skin tissue of RT-01-treated mice compared with expressive infiltration of infected cells replacing the skin tissue in lesions of untreated mice. These findings highlight the fact that the apparent potency of organotellurane compounds, together with their relatively simple structure, may represent a new avenue for the development of novel drugs to combat parasitic diseases.

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