Schistosoma haematobium is one of the most prevalent parasitic flatworms, infecting over 112 million people in Africa. However, little is known about the genetic diversity of natural S. haematobium populations from the human host because of the inaccessible location of adult worms in the host. We used 4 microsatellite loci to genotype individually pooled S. haematobium eggs directly from each patient sampled at 4 endemic locations in Africa. We found that the average allele number of individuals from Mali was significantly higher than that from Nigeria. In addition, no significant difference in allelic composition was detected among the populations within Nigeria; however, the allelic composition was significantly different between Mali and Nigeria populations. This study demonstrated a high level of genetic variability of S. haematobium in the populations from Mali and Nigeria, the 2 major African endemic countries, suggesting that geographical population differentiation may occur in the regions.
Citations
Citations to this article as recorded by
Evidence of high genetic diversity among parasite populations in a schistosomiasis hotspot Yvonne Aryeetey Ashong, Emmanuel Odartei Armah, Jewelna Akorli, Frank Twum Aboagye, Isaac Owusu-Frimpong, Linda Batsa Debrah, Rhoda Lims Diyie, Samuel Armoo, Alexander Yaw Debrah, Mike Yaw Osei-Atweneboana, Clinton J. Jones, Marcello Otake Sato Microbiology Spectrum.2025;[Epub] CrossRef
Geographical Influence on Morphometric Variability of Genetically “Pure” Schistosoma haematobium Eggs from Sub-Saharan Migrants in Spain Marta Reguera-Gómez, Maria Adela Valero, Patricio Artigas, Alejandra De Elías-Escribano, Maria Cecilia Fantozzi, Maria Pilar Luzón-García, Joaquín Salas-Coronas, Jérôme Boissier, Santiago Mas-Coma, Maria Dolores Bargues Tropical Medicine and Infectious Disease.2023; 8(3): 144. CrossRef
Genetic Diversity of Schistosoma haematobium in Sub-Saharan Africa: A Systematic Review Rabecca Tembo, Panji Nkhoma, Mildred Zulu, Florence Mwaba, John Yabe, Hikabasa Halwiindi, Moses Kamwela, King S Nalubamba, Chummy S Sikasunge, Andrew M Phri University of Zambia Journal of Agricultural and Biomedical Sciences.2022;[Epub] CrossRef
Membrane Technology for Rapid Point-of-Care Diagnostics for Parasitic Neglected Tropical Diseases Madeleine J. Rogers, Donald P. McManus, Stephen Muhi, Catherine A. Gordon Clinical Microbiology Reviews.2021;[Epub] CrossRef
Detection of Schistosoma DNA in genital specimens and urine: A comparison between five female African study populations originating from S. haematobium and/or S. mansoni endemic areas P. Pillay, J.A. Downs, J.M. Changalucha, E.A.T. Brienen, C.E. Ramarokoto, P.D.C. Leutscher, B.J. Vennervald, M. Taylor, E.F. Kjetland, L. Van Lieshout Acta Tropica.2020; 204: 105363. CrossRef
RETRACTED: Diversity and Compatibility of Human Schistosomes and Their Intermediate Snail Hosts Benjamin Sanogo, Dongjuan Yuan, Xin Zeng, Yanhua Zhang, Zhongdao Wu Trends in Parasitology.2018; 34(6): 493. CrossRef
Geographic strain differentiation of Schistosoma japonicum in the Philippines using microsatellite markers Kharleezelle J. Moendeg, Jose Ma M. Angeles, Ryo Nakao, Lydia R. Leonardo, Ian Kendrich C. Fontanilla, Yasuyuki Goto, Masashi Kirinoki, Elena A. Villacorte, Pilarita T. Rivera, Noboru Inoue, Yuichi Chigusa, Shin-ichiro Kawazu, Aaron R. Jex PLOS Neglected Tropical Diseases.2017; 11(7): e0005749. CrossRef
Genetic Diversity of <i>Schistosoma haematobium</i> Eggs Isolated from Human Urine in Sudan Juan-Hua Quan, In-Wook Choi, Hassan Ahmed Hassan Ahmed Ismail, Abdoelohab Saed Mohamed, Hoo-Gn Jeong, Jin-Su Lee, Sung-Tae Hong, Tai-Soon Yong, Guang-Ho Cha, Young-Ha Lee The Korean Journal of Parasitology.2015; 53(3): 271. CrossRef
First
Prev
