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"alveolar echinococcosis"

Original Article

Echinococcus granulosus Protoscolex DM9 Protein Shows High Potential for Serodiagnosis of Alveolar Echinococcosis
Jeong-Geun Kim, Xiumin Han, Yoon Kong
Korean J Parasitol 2022;60(1):25-34.
Published online February 23, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.1.25
Alveolar echinococcosis (AE) caused by infection with E. multilocularis metacestode, represents one of the most fatal helminthic diseases. AE is principally manifested with infiltrative, proliferating hepatic mass, resembling primary hepatocellular carcinoma. Sometimes metastatic lesions are found in nearby or remote tissue. AE diagnosis largely depends on imaging studies, but atypical findings of imaging features frequently require differential diagnosis from other hepatic lesions. Serological tests may provide further evidence, while obtaining reliable AE materials is not easy. In this study, alternative antigens, specific to AE were identified by analyzing E. granulosus protoscolex proteins. An immunoblot analysis of E. granulosus protoscolex showed that a group of low-molecular-weight proteins in the range from 14 kDa to 16 kDa exhibited a sensitive and specific immune response to AE patient sera. Partial purification and proteomic analysis indicated that this protein group contained myosin, tubulin polymerization promoting protein, fatty-acid binding protein, uncharacterized DM9, heat shock protein 90 cochaperone tebp P-23, and antigen S. When the serological applicability of recombinant forms of these proteins was assessed using enzyme-linked immunosorbent assay, DM9 protein (rEgDM9) showed 90.1% sensitivity (73/81 sera tested) and 94.5% specificity (172/181 sera tested), respectively. rEgDM9 showed weak cross-reactions with patient sera from the transitional and chronic stages of cystic echinococcosis (3 to 5 stages). rEgDM9 would serve as a useful alternative antigen for serodiagnosis of both early- and advanced-stage AE cases.
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  • 185 Download

Case Reports

A Case of Human Hepatic Alveolar Echinococcosis Accompanied by Lung and Brain Metastases
Chuanchuan Liu, Haining Fan, Ri-li Ge
Korean J Parasitol 2021;59(3):291-296.
Published online June 21, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.3.291
Alveolar echinococcosis (AE) is considered as a fatal zoonosis caused by the larvae of Echinococcus multilocularis. The lungs and brain are the most common metastatic organs. We report a human case of hepatic alveolar echinococcosis accompanied by lung and brain metastasis. In particular, the patient had a history of tuberculosis and the lung lesions were easily misdiagnosed as lung abscesses. The lesions of liver and lung underwent radical resection and confirmed as alveolar echinococcosis by pathological examination. The patient had no surgical complications after operation and was discharged after symptomatic treatment. Unfortunately, the patient later developed multiple intracerebral AE metastases. We required the patient to take albendazole orally for life and follow up.

Citations

Citations to this article as recorded by  Crossref logo
  • Alveolar Echinococcosis in 11-Month-Old Dog—Clinical Case
    Zuzana Šufliarska, Štefan Tóth, Michaela Gentil, Filip Humeník
    Pathogens.2025; 14(5): 450.     CrossRef
  • Surgical Approach in the Pulmonary Alveolar Echinococcus
    Yener Aydin, Ali Bilal Ulas, Nurhak Aksungur, Atilla Eroglu
    Archivos de Bronconeumología.2024; 60(6): 385.     CrossRef
  • Epididymal alveolar echinococcosis and tuberculosis co-infection: A case report
    Chuanchuan Liu, Hainin Fan
    IDCases.2024; 36: e01966.     CrossRef
  • Study on the mechanism of miRNAs on liver injury in the condition of Protoscocephalus alveolarus transhepatic portal vein infection
    Yazhou Zhu, Ming Li, Zihua Li, Jiahui Song, Wei Zhao
    Immunity, Inflammation and Disease.2024;[Epub]     CrossRef
  • Echinococcosis: An Uncommon Cause of Thoracic Pain
    Beatriz Sampaio, Felisbela Gomes, Mafalda Leal, Rita Bernardino
    Cureus.2024;[Epub]     CrossRef
  • Diagnosis and comparative analysis of surgical treatment of patients with liver alveococcosis
    V. S. Panteleev, M. A. Nartaylakov, I. Z. Salimgareev, A. S. Petrov
    Acta Biomedica Scientifica.2023; 8(2): 214.     CrossRef
  • A Surgically Resected Case of Multiple Pulmonary Metastases of Echinococcosis Presented with Bloody Phlegm
    Ryota NAGASHIMA, Yasushi CHO, Kenji WAKAYAMA, Shusaku TAKAHASHI, Hiroyuki ISHIZU, Shin ICHIHARA
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2023; 84(9): 1442.     CrossRef
  • The Role of the Intestinal Epithelium in the “Weep and Sweep” Response during Gastro—Intestinal Helminth Infections
    Piotr Bąska, Luke James Norbury
    Animals.2022; 12(2): 175.     CrossRef
  • 4,888 View
  • 85 Download
  • 8 Web of Science
  • Crossref
A Case of Alveolar Echinococcosis Occurring in the Hilar Bile Duct
Jinyu Yang, Zhanxue Zhao, Shuai Li, Hekai Chen
Korean J Parasitol 2019;57(5):517-520.
Published online October 31, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.5.517
Echinococcosis is a disease caused by the Echinococcus species that parasitizes in humans. Alveolar echinococcosis (AE) which is caused by Echinococcus multilocularis is harmful to humans. AE mainly occurs in the liver and can be transferred to retroperitoneal lymph nodes, lung, brain, bone, spleen and other organs through lymphatic and blood vessels. Cholangiocarcinoma can occur in the intrahepatic and extrahepatic bile ducts and is more common in the hilar. We reported a case of hilar bile duct alveolar echinococcosis which was originally misdiagnosed an cholangiocarcinoma.

Citations

Citations to this article as recorded by  Crossref logo
  • An innovative mathematical approach to the evaluation of susceptibility in liver disorder based on fuzzy parameterized complex fuzzy hypersoft set
    Atiqe Ur Rahman, Muhammad Saeed, Mazin Abed Mohammed, Karrar Hameed Abdulkareem, Jan Nedoma, Radek Martinek
    Biomedical Signal Processing and Control.2023; 86: 105204.     CrossRef
  • In vivo and in vitro efficacy of crocin against Echinococcus multilocularis
    Chuanchuan Liu, Haining Fan, Lu Guan, Ri-li Ge, Lan Ma
    Parasites & Vectors.2021;[Epub]     CrossRef
  • 6,857 View
  • 91 Download
  • 3 Web of Science
  • Crossref

Brief Communication

Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai
Korean J Parasitol 2013;51(5):595-597.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.595

In December 2011, we reported an autochthonous case of Echinococcus multilocularis infection in a 42-year-old woman in Korea. The diagnosis was based on histopathological findings of the surgically resected liver cyst. In the present study, we evaluated the serological and molecular characteristics of this Korean E. multilocularis case. The patient's serum strongly reacted with affinity-purified native Em18 and recombinant Em18 antigens (specific for E. multilocularis) but negative for recombinant antigen B8/1 (reactive for Echinococcus granulosus). In immunoaffinity chromatography, the serum also strongly reacted with E. multilocularis and only weakly positive for E. granulosus. We determined the whole nucleotide sequence of cox1 (1,608 bp) using the paraffin-embedded cystic tissue which was compared with E. multilocularis isolates from China, Japan, Kazakhstan, Austria, France, and Slovakia. The Korean case showed 99.8-99.9% similarity with isolates from Asia (the highest similarity with an isolate from Sichuan, China), whereas the similarity with European isolates ranged from 99.5 to 99.6%.

Citations

Citations to this article as recorded by  Crossref logo
  • Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
    Sven Baumann, Rong Shi, Wenya Liu, Haihua Bao, Julian Schmidberger, Wolfgang Kratzer, Weixia Li, Thomas F. E. Barth, Sven Baumann, Johannes Bloehdorn, Iris Fischer, Tilmann Graeter, Natalja Graf, Beate Gruener, Doris Henne-Bruns, Andreas Hillenbrand, Tanj
    Infection.2019; 47(5): 703.     CrossRef
  • Lasiopodomys fuscus as an important intermediate host for Echinococcus multilocularis: isolation and phylogenetic identification of the parasite
    Qi-Gang Cai, Xiu-Min Han, Yong-Hai Yang, Xue-Yong Zhang, Li-Qing Ma, Panagiotis Karanis, Yong-Hao Hu
    Infectious Diseases of Poverty.2018;[Epub]     CrossRef
  • Assessment of the global pattern of genetic diversity in Echinococcus multilocularis inferred by mitochondrial DNA sequences
    Adel Spotin, Belgees Boufana, Ehsan Ahmadpour, Adriano Casulli, Mahmoud Mahami-Oskouei, Soheila Rouhani, Amirreza Javadi-Mamaghani, Firooz Shahrivar, Paria Khoshakhlagh
    Veterinary Parasitology.2018; 262: 30.     CrossRef
  • The echinococcoses in Asia: The present situation
    Akira Ito, Christine M. Budke
    Acta Tropica.2017; 176: 11.     CrossRef
  • 8,868 View
  • 98 Download
  • Crossref
Case Reports
A Case of Budd-Chiari Syndrome Associated with Alveolar Echinococcosis
Erol ?akmak, Hakan Alagozlu, Cesur Gumus, Celiks?z Al?
Korean J Parasitol 2013;51(4):475-477.
Published online August 30, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.4.475

Although alveolar echinococcosis (AE) can cause a serious disease with high mortality and morbidity similar to malign neoplasms. A 62-year-old woman admitted to a hospital located in Sivas, Turkey, with the complaints of fatigue and right upper abdominal pain. On contrast abdominal CT, a 54×70×45 mm sized cystic lesion was detected in the left lobe of the liver that was seen to extend to the posterior mediastinum and invade the diaphragm, esophagus, and pericardium. The cystic lesion was seen to be occluding the inferior vena cava and left hepatic vein at the level where the hepatic veins poured into the inferior vena cava. Bilateral pleural effusion was also detected. We discussed this secondary Budd-Chiari Syndrome (BCS) case, resulting from the AE occlusion of the left hepatic vein and inferior vena cava, in light of the information in literature.

Citations

Citations to this article as recorded by  Crossref logo
  • A Case Series and Literature Review of Alveolar Echinococcosis in Kashmir, India: An Emerging Endemic Zone for Echinococcus multilocularis
    Mohammad Sultan Khuroo, Naira Sultan Khuroo, Ajaz Ahmad Rather
    Life.2024; 14(7): 794.     CrossRef
  • Role of the radiologist in the diagnosis and management of the two forms of hepatic echinococcosis
    Paul Calame, Mathieu Weck, Andreas Busse-Cote, Eleonore Brumpt, Carine Richou, Celia Turco, Alexandre Doussot, Solange Bresson-Hadni, Eric Delabrousse
    Insights into Imaging.2022;[Epub]     CrossRef
  • Intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis: a multicenter cohort study
    Tilmann Graeter, Rong Shi, Haihua Bao, Wenya Liu, Weixia Li, Yi Jiang, Julian Schmidberger, Eleonore Brumpt, Eric Delabrousse, Wolfgang Kratzer
    Acta Radiologica.2021; 62(8): 997.     CrossRef
  • Evaluation of intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis
    Tilmann Graeter, Hai-Hua Bao, Rong Shi, Wen-Ya Liu, Wei-Xia Li, Yi Jiang, Julian Schmidberger, Eleonore Brumpt, Eric Delabrousse, Wolfgang Kratzer, the XUUB Consortium
    World Journal of Gastroenterology.2020; 26(29): 4302.     CrossRef
  • Left trisectionectomy and supra-hepatic caval reconstruction with vascular prosthesis for chronic Budd-Chiari syndrome caused by hepatic alveolar echinococcosis
    Bo Ran, Tie-Min Jiang, Aimaiti Yasen, Abudusalamu Aini, Qiang Guo, Rui-Qing Zhang, Ying-Mei Shao, Hao Wen, Aji Tuerganaili
    Chinese Medical Journal.2019; 132(23): 2886.     CrossRef
  • A report on three patients with Echinococcus multilocularis: Lessons learned
    Nalini Bansal, Vivek Vij, Mukul Rastogi, Manav Wadhawan, Ajay Kumar
    Indian Journal of Gastroenterology.2018; 37(4): 353.     CrossRef
  • Diagnosis and treatment guidelines for aberrant portal hemodynamics

    Hepatology Research.2017; 47(5): 373.     CrossRef
  • Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients
    Leilei Xu, Sikandaer Siyiti, Xinghua Song, Hao Wen, Liwen Ding, Akbar Yunus, Zheng Tian, Chong Wang, Jiangtao Chen
    Medicine.2017; 96(42): e7632.     CrossRef
  • Orage pour ce foie mais pas de désespoir…
    C. Bernard, F. Bailly, F. Craigherot, B. Bancel, M. Brevet, C. Broussolle, P. Sève, P. Bélénotti
    La Revue de Médecine Interne.2015; 36(10): 706.     CrossRef
  • Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study
    Tilmann Graeter
    World Journal of Gastroenterology.2015; 21(16): 4925.     CrossRef
  • 8,589 View
  • 73 Download
  • Crossref
Recurrent Hepatic Alveolar Echinococcosis: Report of The First Case in Korea with Unproven Infection Route
Su-Jin Kim, Jong-Han Kim, Sang-Young Han, Young-Hoon Kim, Jin-Han Cho, Jong-Yil Chai, Jin-Sook Jeong
Korean J Parasitol 2011;49(4):413-418.
Published online December 16, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.4.413

Human alveolar echinococcosis (AE), a hepatic disorder that resembles liver cancer, is a highly aggressive and lethal zoonotic infection caused by the larval stage of the fox tapeworm, Echinococcus multilocularis. E. multilocularis is widely distributed in the northern hemisphere; the disease-endemic area stretches from north America through Europe to central and east Asia, including northern parts of Japan, but it has not been reported in Korea. Herein, we represent a first case of AE in Korea. A 41-year-old woman was found to have a large liver mass on routine medical examination. The excised mass showed multinodular, necrotic, and spongiform appearance with small irregular pseudocystic spaces. Microscopically, the mass was composed of chronic granulomatous inflammation with extensive coagulation necrosis and parasite-like structure, which was revealed as parasitic vesicles and laminated layer delineated by periodic acid-Schiff (PAS) stain. Clinical and histologic features were consistent with AE. After 8 years, a new liver mass and multiple metastatic pulmonary nodules were found and the recurred mass showed similar histologic features to the initial mass. She had never visited endemic areas of AE, and thus the exact infection route is unclear.

Citations

Citations to this article as recorded by  Crossref logo
  • Delayed Diagnosis of Imported Cystic Echinococcosis and Successful Treatment With Percutaneous Drainage and Albendazole in Korea: A Case Report
    Won Jun Choi, Hanna Jin, Hyeon Jae Jo, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Min-Ho Choi
    Journal of Korean Medical Science.2025;[Epub]     CrossRef
  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Comparative analysis of host immune responses to Hydatid cyst in human and ovine hepatic cystic Echinococcosis
    Bnar S. Hamad, Bushra H. Shnawa, Rafal A. Alrawi, Mukhtar H. Ahmed
    Veterinary Immunology and Immunopathology.2024; 273: 110775.     CrossRef
  • Investigation of Echinococcus multilocularis in foxes and dogs in Pakistan by detection of copro-DNA
    Aisha Khan, Gérald Umhang, Zaib Ullah, Franck Boué, Vanessa Bastid, Ikram Ullah, Sajid Mahmood, Muhammad Sohail Afzal, Haroon Ahmed
    Parasitology Research.2021; 120(2): 731.     CrossRef
  • Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
    Sven Baumann, Rong Shi, Wenya Liu, Haihua Bao, Julian Schmidberger, Wolfgang Kratzer, Weixia Li, Thomas F. E. Barth, Sven Baumann, Johannes Bloehdorn, Iris Fischer, Tilmann Graeter, Natalja Graf, Beate Gruener, Doris Henne-Bruns, Andreas Hillenbrand, Tanj
    Infection.2019; 47(5): 703.     CrossRef
  • An Imported Case of Disseminated Echinococcosis in Korea
    Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
    The Korean Journal of Parasitology.2019; 57(4): 429.     CrossRef
  • The echinococcoses in Asia: The present situation
    Akira Ito, Christine M. Budke
    Acta Tropica.2017; 176: 11.     CrossRef
  • Alveolar Echinococcosis of the Liver: A Diagnostic Problem in a Nonendemic Area
    Kumble S. Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthruimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
    Current Problems in Diagnostic Radiology.2016; 45(1): 80.     CrossRef
  • Alveolar Echinococcosis of Liver: A Diagnostic Problem in a Nonendemic Area
    Kumble Seetharama Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthurimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
    Current Problems in Diagnostic Radiology.2015; 44(2): 221.     CrossRef
  • Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
    Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai
    The Korean Journal of Parasitology.2013; 51(5): 595.     CrossRef
  • Serodiagnosis of Echinococcosis by ELISA Using Cystic Fluid from Uzbekistan Sheep
    Yan Jin, Khikmat Anvarov, Abdukhakim Khajibaev, Samin Hong, Sung-Tae Hong
    The Korean Journal of Parasitology.2013; 51(3): 313.     CrossRef
  • In VitroandIn VivoActivities of Dicationic Diguanidino Compounds against Echinococcus multilocularis Metacestodes
    Tatiana Küster, Nadja Kriegel, David W. Boykin, Chad E. Stephens, Andrew Hemphill
    Antimicrobial Agents and Chemotherapy.2013; 57(8): 3829.     CrossRef
  • An Imported Case of Cystic Echinococcosis in the Liver
    Keun Soo Ahn, Sung-Tae Hong, Yu Na Kang, Jung Hyeok Kwon, Mi Jeong Kim, Tae Jun Park, Yong Hoon Kim, Tae Jin Lim, Koo Jeong Kang
    The Korean Journal of Parasitology.2012; 50(4): 357.     CrossRef
  • 10,352 View
  • 109 Download
  • Crossref