Parasites, Hosts and Diseases

"artemisinin"

Mini Review

Emerging Plasmodium falciparum K13 gene mutation to artemisinin-based combination therapies and partner drugs among malaria-infected population in sub-Saharan Africa: Samuel Adeniyi Oyegbade, Emmanuel Ojochegbe Mameh, Daniel Oluwatobiloba Balogun, Victoria-Grace Onyekachi Aririguzoh, Paul Akinniyi Akinduti; Parasites Hosts Dis 2025;63(2):109-122.
Published online May 26, 2025; DOI: https://doi.org/10.3347/PHD.24053

Abstract
PDF

The continuous Plasmodium falciparum kelch13 (PfK13) genetic alterations conferring resistance to artemisinin-based combination therapies and partner drugs pose a significant threat to effective treatment and control of P. falciparum infection in developing countries. This review evaluates the emergence and epidemiology of the PfK13 mutation associated with artemisinin resistance in the sub-Saharan Africa (SSA) population. Despite empirical control and artemisinin combination therapy, the PfK13 gene mutation, previously described in Southeast Asia, has been reported in the SSA. Eight of these validated markers, including P553L, M476I, C580Y, A675V, P574L, R561H, R622I, and F446I, were reported among the SSA population. Novel and unvalidated markers, such as P615S, M472I, F434S, A578S, P570L, Y558C, K563R, A569T, I684N, M472I, and C473F spread among the population with low frequency. We provide insight into the emergence and spread of validated and unvalidated PfK13 mutations among the SSA population, which could lead to high artemisinin resistance. Investigating the verified PfK13 mutations will improve prophylactic strategies, prognostic diagnosis and guide effective population-based surveillance for effective P. falciparum malaria control in SSA.

Citations

Citations to this article as recorded by

Emergence of chloroquine-sensitive Plasmodium falciparum and rising resistance to first-line artemisinin partner drugs in Malawi
Ernest Mazigo, Hojong Jun, Wang-Jong Lee, Johnsy Mary Louis, Jadidan Hada Syahada, Fadhila Fitriana, Fauzi Muh, Md Atique Ahmed, Feng Lu, Joon-Hee Han, Tae-Hyung Kwon, Se Jin Lee, Sunghun Na, Wanjoo Chun, Won Sun Park, Eun-Taek Han, Winifrida Kidima, Jin-
Emerging Microbes & Infections.2025;[Epub] CrossRef
A scoping review of antimalarial drug resistance markers in Kenya (1987–2022): toward a National Surveillance Framework and Data Repository
Kevin Wamae, John Magudha, Emmanuel Asiimwe, Kariuki Kimani, Regina Kandie, Kibor Keitany, Robert W. Snow, L. Isabella Ochola-Oyier
Malaria Journal.2025;[Epub] CrossRef
Imidazolopiperazines as next-generation antimalarial agents: a scoping review of efficacy, mechanisms of action and resistance; prospects for future development
Fatoumata Ousmane Maiga, Laurent Dembele, Mohamed Maiga, Abdoulaye A. Djimde
Therapeutic Advances in Infectious Disease.2025;[Epub] CrossRef

5,806 View
96 Download
3 Web of Science
Crossref

Original Articles

Antimalarial Efficacy of Aqueous Extract of Strychnos ligustrina and Its Combination with Dihydroartemisinin and Piperaquine Phosphate (DHP) against Plasmodium berghei Infection: Umi Cahyaningsih, Siti Sa’diah, Wasrin Syafii, Rita Kartika Sari, Abdul Jafar Maring, Arifin Budiman Nugraha; Korean J Parasitol 2022;60(5):339-344.
Published online October 21, 2022; DOI: https://doi.org/10.3347/kjp.2022.60.5.339

The development of drug resistance is one of the most severe concerns of malaria control because it increases the risk of malaria morbidity and death. A new candidate drug with antiplasmodial activity is urgently needed. This study evaluated the efficacy of different dosages of aqueous extract of Strychnos ligustrina combined with dihydroartemisinin and piperaquine phosphate (DHP) against murine Plasmodium berghei infection. The BALB/c mice aged 6-8 weeks were divided into 6 groups, each consisting of 10 mice. The growth inhibition of compounds against P. berghei was monitored by calculating the percentage of parasitemia. The results showed that the mice receiving aqueous extract and combination treatment showed growth inhibition of P. berghei in 74% and 94%, respectively. S. ligustrina extract, which consisted of brucine and strychnine, effectively inhibited the multiplication of P. berghei. The treated mice showed improved hematology profiles, body weight, and temperature, as compared to control mice. Co-treatment with S. ligustrina extract and DHP revealed significant antimalarial and antipyretic effects. Our results provide prospects for further discovery of antimalarial drugs that may show more successful chemotherapeutic treatment.

Citations

Citations to this article as recorded by

In Vitro and Molecular Docking Studies of the Antimalarial Activities of Strychnos ligustrina Extracts from Different Parts of the Woody Stem
Rita Kartika SARI, Wasrin SYAFII, Yanico Hadi PRAYOGO, Anne CAROLINA, Sri FAMILASARI, Umi CAHYANINGSIH, Siti SA’DIAH, Setyanto Tri WAHYUDI, Muhammad Adly Rahandi LUBIS
Journal of the Korean Wood Science and Technology.2025; 53(1): 89. CrossRef
Antimalarial drug resistance and drug discovery: learning from the past to innovate the future
Liana Theodoridis, Teresa G. Carvalho
International Journal for Parasitology: Drugs and Drug Resistance.2025; 28: 100602. CrossRef
Chemical constituents, pharmacological action, antitumor application, and toxicity of Strychnine Semen from Strychnons pierriana A.W.Hill.: A review
Weiran Liu, Xintian Tang, Chengyu Fan, Guannan He, Xiaoxin Wang, Xiaodong Liang, Xia Bao
Journal of Ethnopharmacology.2023; 317: 116748. CrossRef

3,667 View
179 Download
3 Web of Science
Crossref

A LAMP-SNP Assay Detecting C580Y Mutation in Pfkelch13 Gene from Clinically Dried Blood Spot Samples: Thunchanok Khammanee, Nongyao Sawangjaroen, Hansuk Buncherd, Aung Win Tun, Supinya Thanapongpichat; Korean J Parasitol 2021;59(1):15-22.
Published online February 19, 2021; DOI: https://doi.org/10.3347/kjp.2021.59.1.15

Artemisinin resistance (ART) has been confirmed in Greater Mekong Sub-region countries. Currently, C580Y mutation on Pfkelch13 gene is known as the molecular marker for the detection of ART. Rapid and accurate detection of ART in field study is essential to guide malaria containment and elimination interventions. A simple method for collection of malaria-infected blood is to spot the blood on filter paper and is fast and easy for transportation and storage in the field study. This study aims to evaluate LAMP-SNP assay for C580Y mutation detection by introducing an extra mismatched nucleotide at the 3’ end of the FIP primer. The LAMP-SNP assay was performed in a water bath held at a temperature of 56°C for 45 min. LAMP-SNP products were interpreted by both gel-electrophoresis and HNB-visualized changes in color. The method was then tested with 120 P. falciparum DNA from dried blood spot samples. In comparing the LAMP-SNP assay results with those from DNA sequencing of the clinical samples, the 2 results fully agreed to detect C580Y. The sensitivity and specificity of the LAMP-SNP assay showed 100%. There were no cross-reactions with other Plasmodium species and other Pfkelch13 mutations. The LAMP-SNP assay performed in this study was rapid, reliable, and useful in detecting artemisinin resistance in the field study.

Citations

Citations to this article as recorded by

Colorimetric loop-mediated isothermal amplification (cLAMP) assay for the genotyping of a thrombophilia genetic risk factor, MTHFR (C677T)
Reham Altwayan, Huseyin Tombuloglu, Moneerah Alsaeed, Abdulrahman Alhusil
Analytical Methods.2025; 17(21): 4432. CrossRef
Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia
Suttipat Srisutham, Aungkana Saejeng, Nardlada Khantikul, Rungniran Sugaram, Raweewan Sangsri, Arjen M. Dondorp, Nicholas P. J. Day, Mallika Imwong
Scientific Reports.2025;[Epub] CrossRef
Loop-mediated isothermal amplification (LAMP): A promising tool for rapid, point-of-care diagnosis of parasitic diseases in low-income countries
Kevin Polpitiya, Madhavi Hewadikaram
Molecular and Biochemical Parasitology.2025; 264: 111704. CrossRef
A Biotinylated cpFIT-PNA Platform for the Facile Detection of Drug Resistance to Artemisinin in Plasmodium falciparum
Odelia Tepper, Daniel H. Appella, Hongchao Zheng, Ron Dzikowski, Eylon Yavin
ACS Sensors.2024; 9(3): 1458. CrossRef
Interference reduction isothermal nucleic acid amplification strategy for COVID-19 variant detection
Guodong Li, Chung-Nga Ko, Zikang Wang, Feng Chen, Wanhe Wang, Dik-Lung Ma, Chung-Hang Leung
Sensors and Actuators B: Chemical.2023; 377: 133006. CrossRef
Super-assembly of integrated gold magnetic assay with loop-mediated isothermal amplification for point-of-care testing
Jianping Liang, Jie Zeng, Xiaojuan Huang, Tengteng Zhu, Yonglong Gong, Chen Dong, Xiangrong Wang, Lingzhi Zhao, Lei Xie, Kang Liang, Qiongxiang Tan, Yali Cui, Biao Kong, Wenli Hui
Nano Research.2023; 16(1): 1242. CrossRef
Engineered Biosensors for Diagnosing Multidrug Resistance in Microbial and Malignant Cells
Niharika G. Jha, Daphika S. Dkhar, Sumit K. Singh, Shweta J. Malode, Nagaraj P. Shetti, Pranjal Chandra
Biosensors.2023; 13(2): 235. CrossRef
Application of loop-mediated isothermal amplification combined with lateral flow assay visualization of Plasmodium falciparum kelch 13 C580Y mutation for artemisinin resistance detection in clinical samples
Wannida Sanmoung, Nongyao Sawangjaroen, Suwannee Jitueakul, Hansuk Buncherd, Aung Win Tun, Supinya Thanapongpichat, Mallika Imwong
Acta Tropica.2023; 246: 106998. CrossRef
Visual single nucleotide polymorphism (SNP) detection for ALDH2 genotyping based on multiplex ligation probe amplification (MLPA) and lateral flow assay
Dan Yin, Xiaolan Li, Li Mai, Ruxin Wang, Sitian Tang, Liyi Hu
Microchemical Journal.2023; 194: 109329. CrossRef
Application of multiple binding sites for LAMP primers across P. falciparum genome improves detection of the parasite from whole blood samples
Cavin Mgawe, Clement Shilluli, Steven Nyanjom, Eddy Odari, Jacqueline C. Linnes, Bernard N. Kanoi, Jesse Gitaka, Lucy Ochola
Frontiers in Malaria.2023;[Epub] CrossRef
Single nucleotide polymorphism genotyping of ALDH2 gene based on asymmetric PCR and fluorescent probe-mediated melting curves
Limei Zhang, Dan Liu, Baolin Li, Jingling Xie, Jinbo Liu, Zhang Zhang
Analytical Biochemistry.2022; 642: 114509. CrossRef
Prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency among Malaria Patients in Southern Thailand: 8 Years Retrospective Study
Thunchanok Khammanee, Nongyao Sawangjaroen, Hansuk Buncherd, Aung Win Tun, Supinya Thanapongpichat
The Korean Journal of Parasitology.2022; 60(1): 15. CrossRef
Current Epidemiological Characteristics of Imported Malaria, Vector Control Status and Malaria Elimination Prospects in the Gulf Cooperation Council (GCC) Countries
Jamshaid Iqbal, Suhail Ahmad, Ali Sher, Mohammad Al-Awadhi
Microorganisms.2021; 9(7): 1431. CrossRef

6,255 View
183 Download
13 Web of Science
Crossref

Molecular Surveillance of Pfkelch13 and Pfmdr1 Mutations in Plasmodium falciparum Isolates from Southern Thailand: Thunchanok Khammanee, Nongyao Sawangjaroen, Hansuk Buncherd, Aung Win Tun, Supinya Thanapongpichat; Korean J Parasitol 2019;57(4):369-377.
Published online August 31, 2019; DOI: https://doi.org/10.3347/kjp.2019.57.4.369

Abstract
PDF

Artemisinin-based combination therapy (ACT) resistance is widespread throughout the Greater Mekong Subregion. This raises concern over the antimalarial treatment in Thailand since it shares borders with Cambodia, Laos, and Myanmar where high ACT failure rates were reported. It is crucial to have information about the spread of ACT resistance for efficient planning and treatment. This study was to identify the molecular markers for antimalarial drug resistance: Pfkelch13 and Pfmdr1 mutations from 5 provinces of southern Thailand, from 2012 to 2017, of which 2 provinces on the Thai- Myanmar border (Chumphon and Ranong), one on Thai-Malaysia border (Yala) and 2 from non-border provinces (Phang Nga and Surat Thani). The results showed that C580Y mutation of Pfkelch13 was found mainly in the province on the Thai-Myanmar border. No mutations in the PfKelch13 gene were found in Surat Thani and Yala. The Pfmdr1 gene isolated from the Thai-Malaysia border was a different pattern from those found in other areas (100% N86Y) whereas wild type strain was present in Phang Nga. Our study indicated that the molecular markers of artemisinin resistance were spread in the provinces bordering along the Thai-Myanmar, and the pattern of Pfmdr1 mutations from the areas along the international border of Thailand differed from those of the non-border provinces. The information of the molecular markers from this study highlighted the recent spread of artemisinin resistant parasites from the endemic area, and the data will be useful for optimizing antimalarial treatment based on regional differences.

Citations

Citations to this article as recorded by

Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia
Suttipat Srisutham, Aungkana Saejeng, Nardlada Khantikul, Rungniran Sugaram, Raweewan Sangsri, Arjen M. Dondorp, Nicholas P. J. Day, Mallika Imwong
Scientific Reports.2025;[Epub] CrossRef
Tracking Drug Resistance in Plasmodium falciparum: Genetic Diversity of Key Resistance Markers in Brazilian Malaria Hotspots
Rebecca de Abreu-Fernandes, Lucas Tavares de Queiroz, Natália Ketrin Almeida-de-Oliveira, Aline Rosa de Lavigne Mello, Jacqueline de Aguiar Barros, Lilian Rose Pratt-Riccio, Gisely Cardoso de Melo, Patrícia Brasil, Cláudio Tadeu Daniel-Ribeiro, Didier Men
International Journal of Molecular Sciences.2025; 26(13): 5977. CrossRef
Preliminary analysis of the conserved Plasmodium falciparum k13 gene in Arbaminch and Mirab Abaya, Ethiopia
Kefiyalew Jote, Yirgalem Gebrehiwot, Abnet Abebe, Canelle Kipayko, Cheikh Cambel Dieng, Eugenia Lo, Lemu Golassa, Bayissa Chala
Malaria Journal.2025;[Epub] CrossRef
Antimalarial Mechanisms and Resistance Status of Artemisinin and Its Derivatives
Dan Zheng, Tingting Liu, Shasha Yu, Zhilong Liu, Jing Wang, Ying Wang
Tropical Medicine and Infectious Disease.2024; 9(9): 223. CrossRef
Molecular insights into artemisinin resistance in Plasmodium falciparum: An updated review
Wihda Aisarul Azmi, Andita Fitri Mutiara Rizki, Yenny Djuardi, I. Made Artika, Josephine Elizabeth Siregar
Infection, Genetics and Evolution.2023; 112: 105460. CrossRef
Application of loop-mediated isothermal amplification combined with lateral flow assay visualization of Plasmodium falciparum kelch 13 C580Y mutation for artemisinin resistance detection in clinical samples
Wannida Sanmoung, Nongyao Sawangjaroen, Suwannee Jitueakul, Hansuk Buncherd, Aung Win Tun, Supinya Thanapongpichat, Mallika Imwong
Acta Tropica.2023; 246: 106998. CrossRef
Prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency among Malaria Patients in Southern Thailand: 8 Years Retrospective Study
Thunchanok Khammanee, Nongyao Sawangjaroen, Hansuk Buncherd, Aung Win Tun, Supinya Thanapongpichat
The Korean Journal of Parasitology.2022; 60(1): 15. CrossRef
An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins
Hari Madhav, Nasimul Hoda
European Journal of Medicinal Chemistry.2021; 210: 112955. CrossRef
Diagnosing the drug resistance signature in Plasmodium falciparum: a review from contemporary methods to novel approaches
Laxman Kumar Murmu, Arpita Arsmika Sahu, Tapan Kumar Barik
Journal of Parasitic Diseases.2021; 45(3): 869. CrossRef
A resistant mutant of Plasmodium falciparum purine nucleoside phosphorylase uses wild-type neighbors to maintain parasite survival
Yacoba V.T. Minnow, Rajesh K. Harijan, Vern L. Schramm
Journal of Biological Chemistry.2021; 296: 100342. CrossRef
A LAMP-SNP Assay Detecting C580Y Mutation in Pfkelch13 Gene from Clinically Dried Blood Spot Samples
Thunchanok Khammanee, Nongyao Sawangjaroen, Hansuk Buncherd, Aung Win Tun, Supinya Thanapongpichat
The Korean Journal of Parasitology.2021; 59(1): 15. CrossRef
New insights into the spread of resistance to artemisinin and its analogues
Noreen Noreen, Asad Ullah, Syed Muhammad Salman, Yahia Mabkhot, Abdulrhman Alsayari, Syed Lal Badshah
Journal of Global Antimicrobial Resistance.2021; 27: 142. CrossRef
Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria and prevalence of molecular markers associated with artemisinin and partner drug resistance in Uganda
Chris Ebong, Asadu Sserwanga, Jane Frances Namuganga, James Kapisi, Arthur Mpimbaza, Samuel Gonahasa, Victor Asua, Sam Gudoi, Ruth Kigozi, James Tibenderana, John Bosco Bwanika, Agaba Bosco, Denis Rubahika, Daniel Kyabayinze, Jimmy Opigo, Damian Rutazana,
Malaria Journal.2021;[Epub] CrossRef

7,873 View
222 Download
14 Web of Science
Crossref

Brief Communications

Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin: Gab-Man Park, Hyun Park, Sangtae Oh, Seokjoon Lee; Korean J Parasitol 2017;55(6):661-665.
Published online December 31, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.6.661

Abstract
PDF

We synthesized C-10 substituted triazolyl artemisinins by the Huisgen cycloaddition reaction between dihydroartemisinins (2) and variously substituted 1, 2, 3-triazoles (8a-8h). The antimalarial activities of 32 novel artemisinin derivatives were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin (9d-12d) showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate.

Citations

Citations to this article as recorded by

Novel frontiers through nitrogen substitution at 6th, 10th and 11th position of artemisinin: Synthetic approaches and antimalarial activity
Priyanka Yadav, Varun Rawat, Shalini Kaushik Love, Ved Prakash Verma
European Journal of Medicinal Chemistry.2025; 281: 117032. CrossRef
Identification of potential bi-triazole based antimalarial compounds and their effects against asexual stages of Plasmodium isolates
Marcinete Latorre Almeida, Leandro do Nascimento Martinez, Welington da Silva Paula do Nascimento, Guilherme Matos Passarini, Daniel Sol Sol de Medeiros, Minelly Azevedo da Silva, Saara Neri Fialho, Amália do Santos Ferreira, Norton Rubens Diunior Lucas P
Caderno Pedagógico.2024; 21(13): e12709. CrossRef
In silico screening, synthesis, and antimalarial evaluation of PABA substituted 1,3,5-triazine derivatives as Pf-DHFR inhibitors
Ashmita Saha, Ayesha Aktar Khanam Choudhury, Nayana Adhikari, Surajit Kumar Ghosh, Anshul Shakya, Saurav Jyoti Patgiri, Udaya Pratap Singh, Hans Raj Bhat
Experimental Parasitology.2023; 250: 108546. CrossRef
Current development of 1,2,3-triazole derived potential antimalarial scaffolds: Structure- activity relationship (SAR) and bioactive compounds
S. Maheen Abdul Rahman, Jasvinder Singh Bhatti, Suresh Thareja, Vikramdeep Monga
European Journal of Medicinal Chemistry.2023; 259: 115699. CrossRef
Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research
Om P.S. Patel, Richard M. Beteck, Lesetja J. Legoabe
European Journal of Medicinal Chemistry.2021; 213: 113193. CrossRef

7,729 View
174 Download
6 Web of Science
Crossref

Appropriate Time for Primaquine Treatment to Reduce Plasmodium falciparum Transmission in Hypoendemic Areas: Polrat Wilairatana, Srivicha Krudsood, Noppadon Tangpukdee; Korean J Parasitol 2010;48(2):179-182.
Published online June 17, 2010; DOI: https://doi.org/10.3347/kjp.2010.48.2.179

Abstract
PDF

Artemesinin-combination therapies (ACT) for falciparum malaria reduce gametocyte carriage, and therefore reduce transmission. Artemisinin derivatives will act against only young gametocytes whereas primaquine acts on mature gametocytes which are present usually in the circulation at the time when the patient presents for treatment. Both artemisinin derivatives and primaquine have short half-lives, less than 1 hr and 7 hr, respectively. Therefore, asexual parasites or young gametocytes remain after completed ACT. A single dose of primaquine (0.50-0.75 mg base/kg) at the end of ACT can kill only mature gametocytes but cannot kill young gametocytes (if present). Remaining asexual forms after completion of ACT course, e.g., artesunate-mefloquine for 3 days, may develop to mature gametocytes 7-15 days later. Thus, an additional dose of primaquine (0.50-0.75 mg base/kg) given 2 weeks after ACT completion may be beneficial for killing remaining mature gametocytes and contribute to more interruption of Plasmodium falciparum transmission than giving only 1 single dose of primaquine just after completing ACT.

Citations

Citations to this article as recorded by

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review
Wesley C. Van Voorhis, J. Stone Doggett, Marilyn Parsons, Matthew A. Hulverson, Ryan Choi, Samuel L.M. Arnold, Michael W. Riggs, Andrew Hemphill, Daniel K. Howe, Robert H. Mealey, Audrey O.T. Lau, Ethan A. Merritt, Dustin J. Maly, Erkang Fan, Kayode K. Oj
Experimental Parasitology.2017; 180: 71. CrossRef
Transmission-blocking strategies: the roadmap from laboratory bench to the community
Daniel Gonçalves, Patrick Hunziker
Malaria Journal.2016;[Epub] CrossRef
Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds
Solomon M Abay, Leonardo Lucantoni, Nisha Dahiya, Geme Dori, Edson G Dembo, Fulvio Esposito, Guilio Lupidi, Sonny Ogboi, Robert K Ouédraogo, Annamaria Sinisi, Orazio Taglialatela-Scafati, R Serge Yerbanga, Massimo Bramucci, Luana Quassinti, Jean Bosco Oué
Malaria Journal.2015;[Epub] CrossRef
Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes
Rama Subba Rao Vidadala, Kayode K. Ojo, Steven M. Johnson, Zhongsheng Zhang, Stephen E. Leonard, Arinjay Mitra, Ryan Choi, Molly C. Reid, Katelyn R. Keyloun, Anna M.W. Fox, Mark Kennedy, Tiffany Silver-Brace, Jen C.C. Hume, Stefan Kappe, Christophe L.M.J.
European Journal of Medicinal Chemistry.2014; 74: 562. CrossRef
Strategic use of antimalarial drugs that block falciparum malaria parasite transmission to mosquitoes to achieve local malaria elimination
Rashad Abdul-Ghani, John C. Beier
Parasitology Research.2014; 113(10): 3535. CrossRef
Blocking malaria transmission to Anopheles mosquitoes using artemisinin derivatives and primaquine: a systematic review and meta-analysis
Solomon Mequanente Abay
Parasites & Vectors.2013;[Epub] CrossRef
Plasmodium Cell Biology Should Inform Strategies Used In The Development Of Antimalarial Transmission-Blocking Drugs
Michael J Delves
Future Medicinal Chemistry.2012; 4(18): 2251. CrossRef
Efficacy of different primaquine-based antimalarial regimens against Plasmodium falciparum gametocytemia
Eliana M. Arango, Yulieth A. Upegui, Jaime Carmona-Fonseca
Acta Tropica.2012; 122(2): 177. CrossRef
Primaquina, gametocitemia de Plasmodium falciparum y bloqueo de transmisión: ineficacia del actual régimen de dosificación
Jaime Carmona-Fonseca, Eliana María Arango Flórez
MedUNAB.2012; 15(1): 14. CrossRef
Methodology and application of flow cytometry for investigation of human malaria parasites
Brian T. Grimberg
Journal of Immunological Methods.2011; 367(1-2): 1. CrossRef
Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials
Anthony E. Kiszewski
Pharmaceuticals.2010; 4(1): 44. CrossRef

9,191 View
129 Download
Crossref

Original Articles

Gametocyte Clearance in Uncomplicated and Severe Plasmodium falciparum Malaria after Artesunate-Mefloquine Treatment in Thailand: Noppadon Tangpukdee, Srivicha Krudsood, Sriripun Srivilairit, Nanthaporn Phophak, Putza Chonsawat, Wimon Yanpanich, Shigeyuki Kano, Polrat Wilairatana; Korean J Parasitol 2008;46(2):65-70.
Published online June 20, 2008; DOI: https://doi.org/10.3347/kjp.2008.46.2.65

Abstract
PDF

Artemisinin-based combination therapy (ACT) is currently promoted as a strategy for treating both uncomplicated and severe falciparum malaria, targeting asexual blood-stage Plasmodium falciparum parasites. However, the effect of ACT on sexual-stage parasites remains controversial. To determine the clearance of sexual-stage P. falciparum parasites from 342 uncomplicated, and 217 severe, adult malaria cases, we reviewed and followed peripheral blood sexual-stage parasites for 4 wk after starting ACT. All patients presented with both asexual and sexual stage parasites on admission, and were treated with artesunate-mefloquine as the standard regimen. The results showed that all patients were asymptomatic and negative for asexual forms before discharge from hospital. The percentages of uncomplicated malaria patients positive for gametocytes on days 3, 7, 14, 21, and 28 were 41.5, 13.1, 3.8, 2.0, and 2.0%, while the percentages of gametocyte positive severe malaria patients on days 3, 7, 14, 21, and 28 were 33.6, 8.2, 2.7, 0.9, and 0.9%, respectively. Although all patients were negative for asexual parasites by day 7 after completion of the artesunate-mefloquine course, gametocytemia persisted in some patients. Thus, a gametocytocidal drug, e.g., primaquine, may be useful in combination with an artesunate-mefloquine regimen to clear gametocytes, so blocking transmission more effectively than artesunate alone, in malaria transmission areas.

Citations

Citations to this article as recorded by

Knowledge about Asymptomatic Malaria and Acceptability of Using Artemisia afra Tea among Health Care Workers (HCWs) in Yaoundé, Cameroon: A Cross-Sectional Survey
Abenwie Suh Nchang, Lahngong Shinyuy, Sandra Noukimi, Sylvia Njong, Sylvie Bambara, Edgar Kalimba, Joseph Kamga, Stephen Ghogomu, Michel Frederich, Jean Talom, Jacob Souopgui, Annie Robert
International Journal of Environmental Research and Public Health.2023; 20(13): 6309. CrossRef
Parasite clearance dynamics in children hospitalised with severe malaria in the Ho Teaching Hospital, Volta Region, Ghana
Laura Paris, Richmond G. Tackie, Khalid B. Beshir, John Tampuori, Gordon A. Awandare, Fred N. Binka, Britta C. Urban, Bismarck Dinko, Colin J. Sutherland
Parasite Epidemiology and Control.2022; 19: e00276. CrossRef
NPC1161B, an 8-Aminoquinoline Analog, Is Metabolized in the Mosquito and Inhibits Plasmodium falciparum Oocyst Maturation
Timothy Hamerly, Rebecca E. Tweedell, Bernadette Hritzo, Vincent O. Nyasembe, Babu L. Tekwani, N. P. Dhammika Nanayakkara, Larry A. Walker, Rhoel R. Dinglasan
Frontiers in Pharmacology.2019;[Epub] CrossRef
Recent Advances in Transmission-Blocking Drugs for Malaria Elimination
Ishan Wadi, Mahendra Nath, Anupkumar R Anvikar, Pargat Singh, Abhinav Sinha
Future Medicinal Chemistry.2019; 11(23): 3047. CrossRef
Comprehensive review on various strategies for antimalarial drug discovery
Mitali Mishra, Vikash K. Mishra, Varsha Kashaw, Arun K. Iyer, Sushil Kumar Kashaw
European Journal of Medicinal Chemistry.2017; 125: 1300. CrossRef
Plasmodium falciparum genotype and gametocyte prevalence in children with uncomplicated malaria in coastal Ghana
Ruth Ayanful-Torgby, Akua Oppong, Joana Abankwa, Festus Acquah, Kimberly C. Williamson, Linda Eva Amoah
Malaria Journal.2016;[Epub] CrossRef
The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission
Jared N. Balaich, Derrick K. Mathias, Baldwyn Torto, Bryan T. Jackson, Dingyin Tao, Babak Ebrahimi, Brian B. Tarimo, Xavier Cheseto, Woodbridge A. Foster, Rhoel R. Dinglasan
Antimicrobial Agents and Chemotherapy.2016; 60(4): 2108. CrossRef
Sexual development in Plasmodium parasites: knowing when it's time to commit
Gabrielle A. Josling, Manuel Llinás
Nature Reviews Microbiology.2015; 13(9): 573. CrossRef
Gametocyte Clearance Kinetics Determined by Quantitative Magnetic Fractionation in Melanesian Children with Uncomplicated Malaria Treated with Artemisinin Combination Therapy
Stephan Karl, Moses Laman, Brioni R. Moore, John Benjamin, Tamarah Koleala, Clemencia Ibam, Bernadine Kasian, Peter M. Siba, Andreea Waltmann, Ivo Mueller, Robert C. Woodward, Timothy G. St. Pierre, Timothy M. E. Davis
Antimicrobial Agents and Chemotherapy.2015; 59(8): 4489. CrossRef
Strategic use of antimalarial drugs that block falciparum malaria parasite transmission to mosquitoes to achieve local malaria elimination
Rashad Abdul-Ghani, John C. Beier
Parasitology Research.2014; 113(10): 3535. CrossRef
A Male and Female Gametocyte Functional Viability Assay To Identify Biologically Relevant Malaria Transmission-Blocking Drugs
A. Ruecker, D. K. Mathias, U. Straschil, T. S. Churcher, R. R. Dinglasan, D. Leroy, R. E. Sinden, M. J. Delves
Antimicrobial Agents and Chemotherapy.2014; 58(12): 7292. CrossRef
Comparison of three methods for detection of gametocytes in Melanesian children treated for uncomplicated malaria
Stephan Karl, Moses Laman, Tamarah Koleala, Clemencia Ibam, Bernadine Kasian, Nola N’Drewei, Anna Rosanas-Urgell, Brioni R Moore, Andreea Waltmann, Cristian Koepfli, Peter M Siba, Inoni Betuela, Robert C Woodward, Timothy G St Pierre, Ivo Mueller, Timothy
Malaria Journal.2014;[Epub] CrossRef
The Effect of Primaquine on Gametocyte Development and Clearance in the Treatment of Uncomplicated Falciparum Malaria With Dihydroartemisinin-Piperaquine in South Sumatra, Western Indonesia: An Open-Label, Randomized, Controlled Trial
Inge Sutanto, Sri Suprijanto, Ayleen Kosasih, Muhamad S. Dahlan, Din Syafruddin, Rita Kusriastuti, William A. Hawley, Neil F. Lobo, Feiko O. ter Kuile
Clinical Infectious Diseases.2013; 56(5): 685. CrossRef
Fitness components and natural selection: why are there different patterns on the emergence of drug resistance in Plasmodium falciparum and Plasmodium vivax?
Kristan A Schneider, Ananias A Escalante
Malaria Journal.2013;[Epub] CrossRef
Effects of Antimalarial Molecules on the Gametocyte Stage of Plasmodium falciparum: The Debate
Odile Dechy-Cabaret, Françoise Benoit-Vical
Journal of Medicinal Chemistry.2012; 55(23): 10328. CrossRef
Efficacy of different primaquine-based antimalarial regimens against Plasmodium falciparum gametocytemia
Eliana M. Arango, Yulieth A. Upegui, Jaime Carmona-Fonseca
Acta Tropica.2012; 122(2): 177. CrossRef
A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines
Michael J. Delves, Chandra Ramakrishnan, Andrew M. Blagborough, Didier Leroy, Timothy N.C. Wells, Robert E. Sinden
International Journal for Parasitology.2012; 42(11): 999. CrossRef
Plasmodium Cell Biology Should Inform Strategies Used In The Development Of Antimalarial Transmission-Blocking Drugs
Michael J Delves
Future Medicinal Chemistry.2012; 4(18): 2251. CrossRef
Laboratory Diagnosis of Tropical Infections
Bryan H. Schmitt, Jon E. Rosenblatt, Bobbi S. Pritt
Infectious Disease Clinics of North America.2012; 26(2): 513. CrossRef
Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study
Rashid A Khatib, Jacek Skarbinski, Joseph D Njau, Catherine A Goodman, Berty F Elling, Elizeus Kahigwa, Jacquelin M Roberts, John R MacArthur, Julie R Gutman, Abdunoor M Kabanywanyi, Ernest E Smith, Masha F Somi, Thomas Lyimo, Alex Mwita, Blaise Genton, M
Malaria Journal.2012;[Epub] CrossRef
Primaquina, gametocitemia de Plasmodium falciparum y bloqueo de transmisión: ineficacia del actual régimen de dosificación
Jaime Carmona-Fonseca, Eliana María Arango Flórez
MedUNAB.2012; 15(1): 14. CrossRef
A Sub-Microscopic Gametocyte Reservoir Can Sustain Malaria Transmission
Stephan Karl, David Gurarie, Peter A. Zimmerman, Charles H. King, Tim G. St. Pierre, Timothy M. E. Davis, Steffen Borrmann
PLoS ONE.2011; 6(6): e20805. CrossRef
Appropriate Time for Primaquine Treatment to Reduce Plasmodium falciparum Transmission in Hypoendemic Areas
Polrat Wilairatana, Srivicha Krudsood, Noppadon Tangpukdee
The Korean Journal of Parasitology.2010; 48(2): 179. CrossRef
Artemisinin-based combination therapies and their introduction in Japan
Shigeyuki Kano
Journal of Infection and Chemotherapy.2010; 16(6): 375. CrossRef
Transmission blocking activity of a standardized neem (Azadirachta indica) seed extract on the rodent malaria parasite Plasmodium berghei in its vector Anopheles stephensi
Leonardo Lucantoni, Rakiswendé S Yerbanga, Giulio Lupidi, Luciano Pasqualini, Fulvio Esposito, Annette Habluetzel
Malaria Journal.2010;[Epub] CrossRef
A Lethal Case of Plasmodium falciparum Infection in a Young Patient with End-stage Renal Failure Who Underwent Regular Hemodialysis
Anggoro Budi Hartopo, Doni Priambodo Wijisaksono
Internal Medicine.2010; 49(17): 1867. CrossRef
The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border
Saranath Lawpoolsri, Irwin F Chavez, Surapon Yimsamran, Supalap Puangsa-art, Nipon Thanyavanich, Wanchai Maneeboonyang, Wuthichai Chaimungkun, Pratap Singhasivanon, James H Maguire, Laura L Hungerford
Malaria Journal.2010;[Epub] CrossRef
Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin
Bénédicte Pacorel, Suet C. Leung, Andrew V. Stachulski, Jill Davies, Livia Vivas, Hollie Lander, Stephen A. Ward, Marcel Kaiser, Reto Brun, Paul M. O’Neill
Journal of Medicinal Chemistry.2010; 53(2): 633. CrossRef
Optimally timing primaquine treatment to reduce Plasmodium falciparum transmission in low endemicity Thai-Myanmar border populations
Saranath Lawpoolsri, Eili Y Klein, Pratap Singhasivanon, Surapon Yimsamran, Nipon Thanyavanich, Wanchai Maneeboonyang, Laura L Hungerford, James H Maguire, David L Smith
Malaria Journal.2009;[Epub] CrossRef
Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children
Akintunde Sowunmi, Oluchi O Nkogho, Titilope M Okuboyejo, Grace O Gbotosho, Christian T Happi, Elsie O Adewoye
Malaria Journal.2009;[Epub] CrossRef

9,691 View
110 Download
Crossref

Minor liver profile dysfunctions in Plasmodium vivax, P. malariae and P. ovale patients and normalization after treatment: Noppadon Tangpukdee, Vipa Thanachartwet, Srivicha Krudsood, Nutthanej Luplertlop, Karnchana Pornpininworakij, Kobsiri Chalermrut, Sasikarn Phokham, Shigeyuki Kano, Sornchai Looareesuwan, Polrat Wilairatana; Korean J Parasitol 2006;44(4):295-302.
Published online December 20, 2006; DOI: https://doi.org/10.3347/kjp.2006.44.4.295

Abstract
PDF

Liver function tests were performed in 61 vivax, 54 malariae and 15 ovale malaria patients who were admitted to Bangkok Hospital for Tropical Diseases between 2001 and 2004. The
objective
of the study was to evaluate changes in hepatic biochemical indices before and after treatment with artemisinin derivatives. On admission and prior to treatment, hepatic dysfunction was found among the 3 groups. Serum liver function tests and physical examinations were performed weekly during the 28-day follow-up period. Initially elevated serum bilirubin and diminished albumin returned to normal within 2 weeks of treatment. Serum alkaline phosphatase and aminotransferases returned to within normal limits within 3 weeks. We conclude that patients with Plasmodium vivax, P. malariae and P. ovale infections had slightly elevated serum bilirubin, aminotransferase and alkaline phosphatase levels, and hypoalbuminemia. These minor abnormalities returned to normal within a few weeks after treatment with therapies based on artemisinin derivatives.

Citations

Citations to this article as recorded by

The Dynamics of Liver Function Test Abnormalities after Malaria Infection: A Retrospective Observational Study
John Woodford, G. Dennis Shanks, Paul Griffin, Stephan Chalon, James S. McCarthy
The American Journal of Tropical Medicine and Hygiene.2018; 98(4): 1113. CrossRef
Liver injury in uncomplicated malaria: an overlooked phenomenon
Brioni R. Moore
EBioMedicine.2018; 37: 15. CrossRef
Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection
Sandipan Ray, Sandip K. Patel, Apoorva Venkatesh, Gangadhar Chatterjee, Naziya N. Ansari, Nithya J. Gogtay, Urmila M. Thatte, Prajakta Gandhe, Santosh G. Varma, Swati Patankar, Sanjeeva Srivastava
Scientific Reports.2017;[Epub] CrossRef
Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission
Paul Griffin, Cielo Pasay, Suzanne Elliott, Silvana Sekuloski, Maggy Sikulu, Leon Hugo, David Khoury, Deborah Cromer, Miles Davenport, Jetsumon Sattabongkot, Karen Ivinson, Christian Ockenhouse, James McCarthy, Photini Sinnis
PLOS Neglected Tropical Diseases.2016; 10(12): e0005139. CrossRef
Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax — malaria in India and Saudi Arabia
Wajihullah Khan, Haytham Zakai, Umm-e-Asma
Acta Parasitologica.2014;[Epub] CrossRef
Association of Heme Oxygenase 1 with the Restoration of Liver Function after Damage in Murine Malaria by Plasmodium yoelii
Sumanta Dey, Somnath Mazumder, Asim Azhar Siddiqui, M. Shameel Iqbal, Chinmoy Banerjee, Souvik Sarkar, Rudranil De, Manish Goyal, Samik Bindu, Uday Bandyopadhyay, J. H. Adams
Infection and Immunity.2014; 82(8): 3113. CrossRef
A STUDY OF CLINICAL PROFILE IN PATIENTS WITH P.VIVAX MALARIA
Apte S., Jain J., Parmar A., Apte A., Sinha U, Chanchlani R
Journal of Evolution of Medical and Dental Sciences.2014; 03(03): 575. CrossRef
Mice lacking inducible nitric oxide synthase develop exacerbated hepatic inflammatory responses induced by Plasmodium berghei NK65 infection
Onésia Cristina Oliveira-Lima, Danielle Bernardes, Mauro Cunha Xavier Pinto, Rosa Maria Esteves Arantes, Juliana Carvalho-Tavares
Microbes and Infection.2013; 15(13): 903. CrossRef
Clinico-laboratory profile of severe Plasmodium vivax malaria in a tertiary care centre in Kolkata
Sayantan Ray, Manjari Saha, Debojyoti Sarkar, Arunansu Talukdar, Amitava Chakraborty
Tropical Parasitology.2013; 3(1): 53. CrossRef
Effect of artesunate based combination therapy with homeopathic medicine china on liver and kidney of Plasmodium berghei infected mice
A. Rajan, U. Bagai, S. Chandel
Journal of Parasitic Diseases.2012;[Epub] CrossRef
A Case of Plasmodium ovale Malaria Imported from West Africa
SeJin Moon, Baek-Nam Kim, Eun-Young Kuak, Tae Hee Han
Laboratory Medicine Online.2012; 2(1): 51. CrossRef
Retrospective analysis of vivax malaria patients presenting to tertiary referral centre of Uttarakhand
Saurabh Srivastava, Sohaib Ahmad, Nadia Shirazi, Sanjiv Kumar Verma, Prashant Puri
Acta Tropica.2011; 117(2): 82. CrossRef
Ictericia y hepatopatía en el paciente con malaria
Ana del Mar Cortina, Alberto Tobón
Infectio.2010; 14(4): 277. CrossRef
Clinical Features of Children Hospitalized with Malaria—A Study from Bikaner, Northwest India
Dhanpat Kumar Kochar, Ashish Das, Shilpi Garg, Sanjay Kumar Kochar, Ghanshyam Singh Sengar, Gajanand Singh Tanwar, Anjana Gupta, Abhishek Kochar, Deepak Pakalapati, Vishal Saxena, Poonam Chand Khatri, Sheetal Middha, Jyoti Acharya
The American Journal of Tropical Medicine and Hygiene.2010; 83(5): 981. CrossRef
Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria
Sue Jean Lee, Rose McGready, Christine Fernandez, Kasia Stepniewska, Moo Koo Paw, Samuel Jacher Viladpai-nguen, Kyaw Lay Thwai, Leopoldo Villegas, Pratap Singhasivanon, Brian M. Greenwood, Nicholas J. White, François Nosten
European Journal of Clinical Pharmacology.2008; 64(10): 987. CrossRef
Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species
Sanjay Kumar, Mithu Guha, Vinay Choubey, Pallab Maity, Kumkum Srivastava, Sunil K. Puri, Uday Bandyopadhyay
Free Radical Biology and Medicine.2008; 44(4): 602. CrossRef

8,644 View
133 Download
Crossref

Brief Communication

Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin: Seokjoon Lee, Sangtae Oh, Gab-Man Park, Tong-Soo Kim, Jae-Sook Ryu, Han-Kyu Choi; Korean J Parasitol 2005;43(3):123-126.
Published online September 20, 2005; DOI: https://doi.org/10.3347/kjp.2005.43.3.123

Abstract
PDF

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10β-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.

Citations

Citations to this article as recorded by

Chemical transformations of artemisinin
A. V. Semakov, S. V. Afanasyeva, S. A. Pukhov
Russian Chemical Bulletin.2024; 74(6): 1604. CrossRef
Design, synthesis and molecular docking studies of novel N-arylsulfonyl-benzimidazoles with anti Trypanosoma cruzi activity
Gisele E. Miana, Sergio R. Ribone, Domingo M.A. Vera, Manuel Sánchez-Moreno, María R. Mazzieri, Mario A. Quevedo
European Journal of Medicinal Chemistry.2019; 165: 1. CrossRef
Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin
Gab-Man Park, Hyun Park, Sangtae Oh, Seokjoon Lee
The Korean Journal of Parasitology.2017; 55(6): 661. CrossRef
TD-DFT calculations of UV absorption bands and their intensities in the spectra of some tetrahydroquinolines
María V. Cooke, Ivana Malvacio, Walter J. Peláez, Ana J. Pepino, María R. Mazzieri, Gustavo A. Argüello
RSC Advances.2015; 5(33): 26255. CrossRef
Malaria-Infected Mice Live Until at Least Day 30 after a New Artemisinin-Derived Thioacetal Thiocarbonate Combined with Mefloquine Are Administered Together in a Single, Low, Oral Dose
Alexander M. Jacobine, Jennifer R. Mazzone, Rachel D. Slack, Abhai K. Tripathi, David J. Sullivan, Gary H. Posner
Journal of Medicinal Chemistry.2012; 55(17): 7892. CrossRef
Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines
Romina J. Pagliero, Sabrina Lusvarghi, Adriana B. Pierini, Reto Brun, María R. Mazzieri
Bioorganic & Medicinal Chemistry.2010; 18(1): 142. CrossRef

7,958 View
100 Download
Crossref

Original Article

Molecular cloning and characterization of peroxiredoxin from Toxoplasma gondii: Eui-Sun Son, Kyoung-Ju Song, Jong-Chul Shin, Ho-Woo Nam; Korean J Parasitol 2001;39(2):133-141.
Published online June 30, 2001; DOI: https://doi.org/10.3347/kjp.2001.39.2.133

Abstract
PDF

A cDNA of 1.1 kb comprising the gene encoding the peroxiredoxin of Toxoplasma gondii (TgPrx) has been cloned. The open reading frame of 591 bp was translated into a protein of 196 amino acids with a molecular mass of 25 kDa. Conserved 2 cysteine domains of Phe-Val-Cys-Pro and Glu-Val-Cys-Pro indicated TgPrx belonged to 2-Cys Prx families. TgPrx showed the highest homology with that of Arabidopsis thaliana by 53.9% followed by Entamoeba histolytica with 39.5% by the amino acid sequence alignment. Polyclonal antibody against recombinant TgPrx detected 25 kDa band in T. gondii without binding to host cell proteins. TgPrx was located in the cytoplasm of T. gondii extracellularly or intracellularly by immunofluorescence assay. The expression of TgPrx was increased as early as 30 min after the treatment with artemisinin in the intracellular stage, while no changes in those of host Prx I and TgSOD. This result implies that TgPrx may function as an antioxidant protecting the cell from the attack of reactive oxygen intermediates. It is also suggested that TgPrx is a possible target of chemotherapy.

Citations

Citations to this article as recorded by

Toxoplasma survives the loss of key enzymes of peroxide and glutathione metabolism
Qinghong Guo, Jiajia Pan, Xuefang Guo, Meng Zhao, Huiyu Du, Mengting Wang, Marcel Deponte, Xinhua Zhong, Lihua Xiao, Yaoyu Feng, Ningbo Xia
The FASEB Journal.2025;[Epub] CrossRef
Neospora caninum peroxiredoxin 1 is an essential virulence effector with antioxidant function
Yutao Shao, Xiaodan Yuan, Boya Du, Xuancheng Zhang, Xin Li, Xu Zhang, Pengtao Gong, Nan Zhang, Xiaocen Wang, Jianhua Li
Veterinary Parasitology.2024; 327: 110117. CrossRef
Genetic Disruption of Toxoplasma gondii peroxiredoxin (TgPrx) 1 and 3 Reveals the Essential Role of TgPrx3 in Protecting Mice from Fatal Consequences of Toxoplasmosis
Ragab M. Fereig, Yoshifumi Nishikawa
International Journal of Molecular Sciences.2022; 23(6): 3076. CrossRef
Characterization of the Neospora caninum peroxiredoxin: a novel peroxidase and antioxidant enzyme
Jade Cabestre Venancio-Brochi, Luiz Miguel Pereira, Luciana Baroni, Péricles Gama Abreu-Filho, Ana Patrícia Yatsuda
Parasitology Research.2022; 121(6): 1735. CrossRef
Mining the Proteome of Toxoplasma Parasites Seeking Vaccine and Diagnostic Candidates
Sajad Rashidi, Javier Sánchez-Montejo, Reza Mansouri, Mohammad Ali-Hassanzadeh, Amir Savardashtaki, Mohammad Saleh Bahreini, Mohammadreza Karimazar, Raúl Manzano-Román, Paul Nguewa
Animals.2022; 12(9): 1098. CrossRef
Inhibition of Toxoplasma gondii Growth by Dihydroquinine and Its Mechanisms of Action
Aarin M. Huffman, Joseph A. Ayariga, Audrey Napier, Boakai K. Robertson, Daniel A. Abugri
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Evaluation of the Combined Effect of Artemisinin and Ferroptosis Inducer RSL3 against Toxoplasma gondii
Mao Huang, Xinru Cao, Yucong Jiang, Yuehong Shi, Yazhen Ma, Dandan Hu, Xingju Song
International Journal of Molecular Sciences.2022; 24(1): 229. CrossRef
The Cataleptic, Asymmetric, Analgesic, and Brain Biochemical Effects of Parkinson’s Disease Can Be Affected by Toxoplasma gondii Infection
Mahnaz Taherianfard, Moslem Riyahi, Mostafa Razavi, Zahedeh Bavandi, Narges Eskandari Roozbahani, Mohammad Mehdi Namavari, Moustafa Gabr
BioMed Research International.2020;[Epub] CrossRef
Artemisinin and its derivatives in treating protozoan infections beyond malaria
Cecilia Shi Ni Loo, Nelson Siu Kei Lam, Deying Yu, Xin-zhuan Su, Fangli Lu
Pharmacological Research.2017; 117: 192. CrossRef
Parasite excretory‐secretory products and their effects on metabolic syndrome
J. Crowe, F. E. Lumb, M. M. Harnett, W. Harnett
Parasite Immunology.2017;[Epub] CrossRef
Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice
Ragab M. Fereig, Yasuhiro Kuroda, Mohamad Alaa Terkawi, Motamed Elsayed Mahmoud, Yoshifumi Nishikawa, Gordon Langsley
PLOS ONE.2017; 12(4): e0176324. CrossRef
Peroxiredoxin 3 promotes IL-12 production from macrophages and partially protects mice against infection with Toxoplasma gondii
Ragab M. Fereig, Yoshifumi Nishikawa
Parasitology International.2016; 65(6): 741. CrossRef
Oxidative Stress Control by Apicomplexan Parasites
Soraya S. Bosch, Thales Kronenberger, Kamila A. Meissner, Flávia M. Zimbres, Dirk Stegehake, Natália M. Izui, Isolmar Schettert, Eva Liebau, Carsten Wrenger
BioMed Research International.2015; 2015: 1. CrossRef
Comparison of protein expression profiles between three Perkinsus spp., protozoan parasites of molluscs, through 2D electrophoresis and mass spectrometry
S. Fernández-Boo, E. Chicano-Gálvez, J. Alhama, J.L. Barea, A. Villalba, A. Cao
Journal of Invertebrate Pathology.2014; 118: 47. CrossRef
Peroxiredoxins as multifunctional enzymes
M. G. Sharapov, V. K. Ravin, V. I. Novoselov
Molecular Biology.2014; 48(4): 520. CrossRef
Cloning and Characterization of a 2-Cys Peroxiredoxin from Babesia gibsoni
Tatsunori MASATANI, Masahito ASADA, Madoka ICHIKAWA-SEKI, Miho USUI, Mohamad A. TERKAWI, Kei HAYASHI, Shin-ichiro KAWAZU, Xuenan XUAN
Journal of Veterinary Medical Science.2014; 76(1): 139. CrossRef
Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1β secretion enhances parasite replication
Edward S Marshall, Hany M Elshekiha, Mohamed-Ali Hakimi, Robin J Flynn
Veterinary Research.2011;[Epub] CrossRef
The histone methylase KMTox interacts with the redox‐sensor peroxiredoxin‐1 and targets genes involved in Toxoplasma gondii antioxidant defences
Céline F. Sautel, Philippe Ortet, Nehmé Saksouk, Sylvie Kieffer, Jérôme Garin, Olivier Bastien, Mohamed‐Ali Hakimi
Molecular Microbiology.2009; 71(1): 212. CrossRef
Identification of conoidin A as a covalent inhibitor of peroxiredoxin II
Jeralyn D. Haraldsen, Gu Liu, Catherine H. Botting, Jeffrey G. A. Walton, Janet Storm, Timothy J. Phalen, Lai Yu Kwok, Dominique Soldati-Favre, Nicholas H. Heintz, Sylke Müller, Nicholas J. Westwood, Gary E. Ward
Organic & Biomolecular Chemistry.2009; 7(15): 3040. CrossRef
Toxoplasma gondii: Proteomic analysis of antigenicity of soluble tachyzoite antigen
Guang-Yuan Ma, Jian-Zhong Zhang, Guo-Rong Yin, Jian-Hong Zhang, Xiao-Li Meng, Fei Zhao
Experimental Parasitology.2009; 122(1): 41. CrossRef
Dual Targeting of Antioxidant and Metabolic Enzymes to the Mitochondrion and the Apicoplast of Toxoplasma gondii
Paco Pino, Bernardo Javier Foth, Lai-Yu Kwok, Lilach Sheiner, Rebecca Schepers, Thierry Soldati, Dominique Soldati-Favre, Daniel Eliot Goldberg
PLoS Pathogens.2007; 3(8): e115. CrossRef
Plasmodium falciparum: Discovery of peroxidase active organelles
Michael T. McIntosh, David A. Elliott, Keith A. Joiner
Experimental Parasitology.2005; 111(2): 133. CrossRef
Host persistence: exploitation of anti-inflammatory pathways by Toxoplasma GONDII
Julio Aliberti
Nature Reviews Immunology.2005; 5(2): 162. CrossRef
The Opportunistic Pathogen Toxoplasma gondii Deploys a Diverse Legion of Invasion and Survival Proteins
Xing W. Zhou, Björn F.C. Kafsack, Robert N. Cole, Phil Beckett, Rong F. Shen, Vern B. Carruthers
Journal of Biological Chemistry.2005; 280(40): 34233. CrossRef
The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury
Lai Yu Kwok, Dirk Schlüter, Christine Clayton, Dominique Soldati
Molecular Microbiology.2004; 51(1): 47. CrossRef