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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Jong-Yil Chai, Bong-Kwang Jung, Sung-Jong Hong
Korean J Parasitol 2021;59(3):189-225.
Published online June 21, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.3.189
The use of albendazole and mebendazole, i.e., benzimidazole broad-spectrum anthelmintics, in treatment of parasitic infections, as well as cancers, is briefly reviewed. These drugs are known to block the microtubule systems of parasites and mammalian cells leading to inhibition of glucose uptake and transport and finally cell death. Eventually they exhibit ovicidal, larvicidal, and vermicidal effects on parasites, and tumoricidal effects on hosts. Albendazole and mebendazole are most frequently prescribed for treatment of intestinal nematode infections (ascariasis, hookworm infections, trichuriasis, strongyloidiasis, and enterobiasis) and can also be used for intestinal tapeworm infections (taeniases and hymenolepiasis). However, these drugs also exhibit considerable therapeutic effects against tissue nematode/cestode infections (visceral, ocular, neural, and cutaneous larva migrans, anisakiasis, trichinosis, hepatic and intestinal capillariasis, angiostrongyliasis, gnathostomiasis, gongylonemiasis, thelaziasis, dracunculiasis, cerebral and subcutaneous cysticercosis, and echinococcosis). Albendazole is also used for treatment of filarial infections (lymphatic filariasis, onchocerciasis, loiasis, mansonellosis, and dirofilariasis) alone or in combination with other drugs, such as ivermectin or diethylcarbamazine. Albendazole was tried even for treatment of trematode (fascioliasis, clonorchiasis, opisthorchiasis, and intestinal fluke infections) and protozoan infections (giardiasis, vaginal trichomoniasis, cryptosporidiosis, and microsporidiosis). These drugs are generally safe with few side effects; however, when they are used for prolonged time (>14-28 days) or even only 1 time, liver toxicity and other side reactions may occur. In hookworms, Trichuris trichiura, possibly Ascaris lumbricoides, Wuchereria bancrofti, and Giardia sp., there are emerging issues of drug resistance. It is of particular note that albendazole and mebendazole have been repositioned as promising anti-cancer drugs. These drugs have been shown to be active in vitro and in vivo (animals) against liver, lung, ovary, prostate, colorectal, breast, head and neck cancers, and melanoma. Two clinical reports for albendazole and 2 case reports for mebendazole have revealed promising effects of these drugs in human patients having variable types of cancers. However, because of the toxicity of albendazole, for example, neutropenia due to myelosuppression, if high doses are used for a prolonged time, mebendazole is currently more popularly used than albendazole in anti-cancer clinical trials.

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  • 10.1016/s1155-1968(23)45969-x

    CrossRef Listing of Deleted DOIs.2000;[Epub]     CrossRef
  • 55,422 View
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Serine Proteases of Parasitic Helminths
Yong Yang, Yun jun Wen, Ya Nan Cai, Isabelle Vall?e, Pascal Boireau, Ming Yuan Liu, Shi Peng Cheng
Korean J Parasitol 2015;53(1):1-11.
Published online February 27, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.1.1

Serine proteases form one of the most important families of enzymes and perform significant functions in a broad range of biological processes, such as intra- and extracellular protein metabolism, digestion, blood coagulation, regulation of development, and fertilization. A number of serine proteases have been identified in parasitic helminths that have putative roles in parasite development and nutrition, host tissues and cell invasion, anticoagulation, and immune evasion. In this review, we described the serine proteases that have been identified in parasitic helminths, including nematodes (Trichinella spiralis, T. pseudospiralis, Trichuris muris, Anisakis simplex, Ascaris suum, Onchocerca volvulus, O. lienalis, Brugia malayi, Ancylostoma caninum, and Steinernema carpocapsae), cestodes (Spirometra mansoni, Echinococcus granulosus, and Schistocephalus solidus), and trematodes (Fasciola hepatica, F. gigantica, and Schistosoma mansoni). Moreover, the possible biological functions of these serine proteases in the endogenous biological phenomena of these parasites and in the host-parasite interaction were also discussed.

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Case Reports

Clinical and Pathological Characteristics of Intraocular Cysticercosis
Juan-Juan Li, Li-Wei Zhang, Hua Li, Zhu-Lin Hu
Korean J Parasitol 2013;51(2):223-229.
Published online April 25, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.2.223

This study aimed to explore the clinical, radiological, and pathological characteristics of intraocular cysticercosis due to Taenia solium metacestode infection. Total 8 patients diagnosed with intraocular cysticercosis at the Red Cross Hospital of Yunnan Province, China were examined retrospectively. Patients with clear dioptic media had undergone fundus chromophotography. All patients underwent B ultrasonography of the ocular region (CT) successive scanning of the orbit and cerebral tissues. Parasites were extracted surgically and then examined pathologically. The fundus chromophotography showed a white and condensing scolex package in the vesicle. The B ultrasonic examination showed a vesicle-like echogenic mass in the vitreous chamber, in which the high-level echo spot was the cysticercus scolex. The pathological examinations showed that the vesicle wall exhibited hyaline degeneration, inflammatory cell infiltration, neuroglial fiber, and glial cell proliferation layers from the inside to the outside. The scolex is round and is composed of the outer tissue (the body wall) and the inner furrow tissue; these tissues migrated together. Primordially differentiated sucking discs were found in one case, but no hooklets were found. The inner scolex tissue was folded like a paper flower. The severity of intraocular disease is closely correlated with the pathophysiological processes of the cysticercus worm. Pathological examination of the intraocular lesions can help to evaluate the course of the disease as well as to provide a scientific basis for effective antiparasitic medication.

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A Human Case of Hymenolepis diminuta in a Child from Eastern Sicily
Ildebrando Patamia, Elisa Cappello, Donato Castellano-Chiodo, Filippo Greco, Luciano Nigro, Bruno Cacopardo
Korean J Parasitol 2010;48(2):167-169.
Published online June 17, 2010
DOI: https://doi.org/10.3347/kjp.2010.48.2.167

We report a case of Hymenolepis diminuta infection in a 2-year-old child living in a suburban area of Catania, Italy. This case was initially referred to us as Dipylidium caninum infection, which was not cured after being treated twice with mebendazole. However, by analyzing the clinical presentation and stool samples we arrived to the diagnosis of H. diminuta infection. The case presented with atypical allergic manifestations which had never been reported as clinical features of symptomatic H. diminuta infection; remittent fever with abdominal pain, diffuse cutaneous itching, transient thoracic rash, and arthromyalgias. The patient was treated with a 7-day cycle of oral niclosamide, which proved to be safe and effective. This case report emphasizes that a correct parasitological diagnosis requires adequate district laboratories and trained personnel. In addition, we recommend the importance of reporting all H. diminuta infection cases, in order to improve knowledge on epidemiology, clinical presentation, and treatment protocols.

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Brief Communication

Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes
Ji-Young Kim, Hyun-Jong Yang, Kwang-Sig Kim, Young-Bae Chung
Korean J Parasitol 2005;43(4):157-160.
Published online December 20, 2005
DOI: https://doi.org/10.3347/kjp.2005.43.4.157

A 29 kDa cysteine protease of Taenia solium metacestodes was purified by Mono Q anion-exchanger and Superose 6 HR gel filtration chromatography. The enzyme was effectively inhibited by cysteine protease inhibitors, such as iodoacetic acid (IAA) and trans-epoxy-succinyl-L-leucyl-amido (4-guanidino) butane (E-64) while inhibitors acting on serine- or metallo-proteases did not affect the enzyme activity. The purified enzyme degraded human immunoglobulin G (IgG), collagen and bovine serum albumin (BSA), but human IgG was more susceptible for proteolysis by the enzyme. To define the precise biological roles of the enzyme, more detailed biochemical and functional studies would be required.

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Original Article

A seroepidemiological survey of Taenia solium cysticercosis in Nabo, Guangxi Zhuang Autonomous Region, China
Joon-Yong Chung, Keeseon S. Eom, Yichao Yang, Xenming Li, Zheng Feng, Han-Jong Rim, Seung-Yull Cho, Yoon Kong
Korean J Parasitol 2005;43(4):135-139.
Published online December 20, 2005
DOI: https://doi.org/10.3347/kjp.2005.43.4.135

We have observed the seropositive rate of Taenia solium cysticercosis in residents at Nabo Village, Tiandong County, Guangxi Zhuang Autonomous Region, China by enzyme linked immunosorbent assay. The village had been found to be a relatively high endemic area of porcine cysticercosis among roaming pigs. Of 202 persons examined four males aged 15, 25, 35 and 41 year-old exhibited absorbance (abs) at 0.18, 0.20, 0.35 and 0.55, respectively. In addition, two females whose ages were 35 and 39 years revealed specific antibody levels of abs 0.26 and 0.41 in their sera. Overall positive rate among the people was 2.97%. All of these persons agreed that they had ingested the pork infected with T. solium metacestode (TsM), while history of proglottid discharge was not noticed from all of them. Three males and one female complained of intermittent headache. Our findings reinforced not only that the prevalence of cysticercosis might be related with roaming pigs infected with TsM but also that behavioral and environmental practices in local community constituted risk factors for transmission of the infection.

Citations

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  • What triggers seizures in neurocysticercosis? A MRI-based study in pig farming community from a district of North India
    Amit Prasad, Rakesh K. Gupta, Sunil Pradhan, Mukesh Tripathi, Chandra M. Pandey, Kashi N. Prasad
    Parasitology International.2008; 57(2): 166.     CrossRef
  • Tissue parasitic helminthiases are prevalent at Cheongjin, North Korea
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    The Korean Journal of Parasitology.2007; 45(2): 139.     CrossRef
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Brief Communications
Immunoblot findings of calcareous corpuscles binding proteins in cyst fluid of Taenia solium metacestodes
Hyun-Jong Yang
Korean J Parasitol 2004;42(3):141-143.
Published online September 20, 2004
DOI: https://doi.org/10.3347/kjp.2004.42.3.141

After collecting calcareous corpuscles from plerocercoid of Spirometra mansoni (sparganum), we evaluated the antigenic values of calcareous corpuscles binding proteins obtained from the cyst fluid of Taenia solium metacestodes. Immunoblot analysis revealed that cysticercosis patient sera strongly recognized 10 and 95 kDa calcareous corpuscles binding proteins. This result demonstrated that calcareous corpuscles are bound with major secretory antigenic proteins, which is possibly involved in the secretory pathways of the 10 and 95 kDa proteins presenting in the cyst fluid of T. solium metacestodes.

Citations

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  • Fasciclin-calcareous corpuscle binary complex mediated protein-protein interactions in Taenia solium metacestode
    Chun-Seob Ahn, Jeong-Geun Kim, Young-An Bae, Seon-Hee Kim, Joo-Ho Shin, Yichao Yang, Insug Kang, Yoon Kong
    Parasites & Vectors.2017;[Epub]     CrossRef
  • Morphometric characteristics of the metacestode Echinococcus vogeli Rausch & Bernstein, 1972 in human infections from the northern region of Brazil
    F. Almeida, F. Oliveira, R. Neves, N. Siqueira, R. Rodrigues-Silva, D. Daipert-Garcia, J.R. Machado-Silva
    Journal of Helminthology.2015; 89(4): 480.     CrossRef
  • Identification and functional characterization of alpha-enolase from Taenia pisiformis metacestode
    Shaohua Zhang, Aijiang Guo, Xueliang Zhu, Yanan You, Junling Hou, Qiuxia Wang, Xuenong Luo, Xuepeng Cai
    Acta Tropica.2015; 144: 31.     CrossRef
  • In vitro excystation of Echinostoma paraensei (Digenea: Echinostomatidae) metacercariae assessed by light microscopy, morphometry and confocal laser scanning microscopy
    Joyce Souza, Juberlan Garcia, Renata H. Neves, José Roberto Machado-Silva, Arnaldo Maldonado
    Experimental Parasitology.2013; 135(4): 701.     CrossRef
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Immunolocalization of the 150 kDa protein in cyst fluid of Taenia solium metacestodes
Hyun-Jong Yang, Young-Bae Chung
Korean J Parasitol 2004;42(2):81-84.
Published online June 20, 2004
DOI: https://doi.org/10.3347/kjp.2004.42.2.81

The 150 kDa protein of cyst fluid (CF) of Taenia solium metacestodes was purified by ammonium sulfate fractionation and Superose 6 HR gel filtration chromatography. The purified protein consisted of three subunits (15, 10 and 7 kDa proteins), which were analyzed with the use of a 7.5-15% gradient sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Immunofluorescence study was carried out by using immunize specific polyclonal antibody. Positive reactions were noticed at bladder walls, calcareous corpuscles, granules of cyst fluid and some host tissue surrounding the bladder wall of the metacestodes. These results suggest that the 150 kDa protein was secreted into host tissues, inducing immune responses in the host, and it may play important roles in the cellular physiology of the parasites.

Citations

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  • Taenia saginata: Production and characterization of monoclonal antibodies against Taenia saginata metacestode antigens
    Josy Campanhã Vicentini-Oliveira, Marjorie A. Golim, Silvana de Cássia Paulan, Germano Francisco Biondi, Rosana Rossi-Ferreira, Elenice Deffune, Cáris Maroni Nunes
    Experimental Parasitology.2010; 126(4): 621.     CrossRef
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The 10 kDa protein of Taenia solium metacestodes shows genus specific antigenicity
Seung-Kyu Park, Doo-Hee Yun, Joon-Yong Chung, Yoon Kong, Seung-Yull Cho
Korean J Parasitol 2000;38(3):191-194.
Published online September 30, 2000
DOI: https://doi.org/10.3347/kjp.2000.38.3.191

Genus specific antigenicity of the 10 kDa protein in cyst fluid (CF) of Taenia solium metacestodes was demonstrated by comparative immunoblot analysis. When CFs from taeniid metacestodes of T. saginata, T. solium, T. taeniaeformis and T. crassiceps were probed with specific monoclonal antibody (mAb) raised against 150 kDa protein of T. solium metacestodes, specific antibody reactions were observed in 7 and 10 kDa proteins of T. solium and in 7/8 kDa of T. saginata, T. taeniaeformis and T. crassiceps. The mAb did not react with any protein in hydatid fluid of Echinococcus granulosus and E. multilocularis. This result revealed that the 10 kDa peptide of T. solium metacestodes and its equivalent proteins of different Taenia metacestodes are genus specific antigens that are shared among different Taenia species.

Citations

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  • Echinococcus granulosus antigen B: A Hydrophobic Ligand Binding Protein at the host–parasite interface
    Valeria Silva-Álvarez, Ana Maite Folle, Ana Lía Ramos, Fernando Zamarreño, Marcelo D. Costabel, Eduardo García-Zepeda, Gustavo Salinas, Betina Córsico, Ana María Ferreira
    Prostaglandins, Leukotrienes and Essential Fatty Acids.2015; 93: 17.     CrossRef
  • Development of the S3Pvac Vaccine Against MurineTaenia crassicepsCysticercosis: A Historical Review
    Edda Sciutto, Gladis Fragoso, Marisela Hernández, Gabriela Rosas, José J. Martínez, Agnès Fleury, Jacquelynne Cervantes, Aline Aluja, Carlos Larralde
    Journal of Parasitology.2013; 99(4): 693.     CrossRef
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  • 70 Download
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PHD : Parasites, Hosts and Diseases