Parasites, Hosts and Diseases

"coccidiosis"

Original Articles

Anticoccidial activities of a multicomplex mineral-based diet in broilers infected with Eimeria acervulina: Binh T. Nguyen, Rochelle A. Flores, Paula Leona T. Cammayo-Fletcher, Suk Kim, Woo H. Kim, Wongi Min; Parasites Hosts Dis 2025;63(2):135-146.
Published online May 26, 2025; DOI: https://doi.org/10.3347/PHD.24045

Poultry coccidiosis, caused by 7 Eimeria species, has a significant economic impact on the poultry industry and is managed mainly by chemotherapeutic drugs. However, alternative control measures are needed due to the emergence of drug-resistant strains. This study aimed to evaluate the anticoccidial effects of a multicomplex mineral-based diet in broilers infected with Eimeria acervulina. Broilers were fed a multicomplex mineral-based diet and infected with E. acervulina. Fecal oocyst shedding was 39.0% lower in the E. acervulina-infected broilers treated with the multicomplex mineral compared to that in untreated-infected broilers (365.7×10⁶±45.7 versus 599.8×10⁶±8.7, P<0.05). On day 6 post-infection, body weight gain was significantly higher in treated-infected chickens than untreated chickens (103.2±1.5% versus 94.1±1.7%, P<0.001). The lesion scores were similar between the 2 groups. Histopathological observations revealed that the width of the villi in the treated-infected chickens (286±9.5 μm) was significantly increased by 19.1% (240±10.8 μm, P<0.05) and 34.9% (212±7.3 μm, P<0.001) compared to those in the untreated-uninfected and untreated-infected groups, respectively. However, the villous height and crypt depth were similar between the untreated- and treated-infected groups. The positive effects of the dietary multicomplex mineral, including reduced fecal oocyst shedding, increased weight gain, and increased villi width, suggest its potential application in mitigating the adverse effects of Eimeria infection in both conventional and organic chicken industries.

Citations

Citations to this article as recorded by

Urban environmental drivers of eukaryotic microbiota and parasite prevalence in domestic pigeon faeces: a metabarcoding-based public health risk assessment in Seoul, South Korea
Singeun Oh, Jun Ho Choi, Xavier Chavarria, Myungjun Kim, Dongjun Kang, Myung-hee Yi, Yoon Hee Cho, In-Yong Lee, Tai-Soon Yong, Seongjun Choe, Ju Yeong Kim
Journal of The Royal Society Interface.2025;[Epub] CrossRef

1,996 View
57 Download
1 Web of Science
Crossref

Expression of Chicken NK-Lysin and Its Role in Chicken Coccidiosis Induced by Eimeria necatrix: Woo Hyun Kim, Wongi Min, Kwang Il Park, Hyun S. Lillehoj, Cherry P. Fernandez-Colorado, Rochelle A. Flores, Paula Leona T. Cammayo, Binh Thanh Nguyen; Korean J Parasitol 2021;59(5):439-445.
Published online October 22, 2021; DOI: https://doi.org/10.3347/kjp.2021.59.5.439

Abstract
PDF

Coccidiosis in chickens is an intestinal parasitic disease caused by protozoan parasites named Eimeria spp. In some Eimeria infections, intestinal lymphocytes are known to highly express chicken NK-lysin (cNK-lysin), an antimicrobial peptide with anticoccidial activity. Therefore, this study aims to investigate the expression of cNK-lysin in E. necatrix-infected chickens and its role in E. necatrix infection. The expression of cNK-lysin transcript was significantly increased in E. necatrix sporozoites-treated lymphocytes. In E. necatrix infection, cNK-lysin transcript was induced in intestinal lymphocytes but not in the spleen. The recombinant cNK-lysin exhibited anticoccidial activity against E. necatrix sporozoites as well as immunomodulatory activity on macrophages by inducing proinflammatory cytokines. These results indicated that E. necatrix infection induces high local expression of cNK-lysin and the secreted cNK-lysin helps protect coccidiosis.

Citations

Citations to this article as recorded by

Characterization of NK-lysin A, a potent antimicrobial peptide from the zebrafish Danio rerio
Marius Ortjohann, Matthias Leippe
Developmental & Comparative Immunology.2025; 162: 105266. CrossRef
Exploring the interplay between Eimeria spp. infection and the host: understanding the dynamics of gut barrier function
Pan Chen, Mujeeb Ur Rehman, Yanfeng He, Aoyun Li, Fuchun Jian, Longxian Zhang, Shucheng Huang
Veterinary Quarterly.2025; 45(1): 1. CrossRef
Development and immunological insights into recombinant/subunit vaccines against avian coccidiosis
Shagufta Iqbal, Syed Tanveer, Idrees Mehraj Allaie, Yasmeena Jan, Shahana Tramboo, Nazima Maqbool
Journal of Microbiological Methods.2025; 238: 107255. CrossRef
Orally delivered Bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens
Samiru S. Wickramasuriya, Inkyung Park, Youngsub Lee, Luciana M. Richer, Chris Przybyszewski, Cyril G. Gay, Jolieke G. van Oosterwijk, Hyun S. Lillehoj
Poultry Science.2023; 102(5): 102590. CrossRef
Research progress of the avian coccidiosis vaccine
Haiming Cai, Nanshan Qi, Juan Li, Minna Lv, Xuhui Lin, Junjing Hu, Jianfei Zhang, Shenquan Liao, Mingfei Sun
Veterinary Vaccine.2022; 1(1): 100002. CrossRef

5,020 View
157 Download
4 Web of Science
Crossref

Brief Communication

Epidemiological Survey on Eimeria spp. Associated with Diarrhea in Pre-weaned Native Korean Calves: Hyeon-Cheol Kim, Changyoung Choe, SuHee Kim, Joon-Seok Chae, Do-Hyeon Yu, Jinho Park, Bae-Keun Park, Kyoung-Seong Choi; Korean J Parasitol 2018;56(6):619-623.
Published online December 31, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.6.619

Abstract
PDF

Bovine coccidiosis is one of the most important parasitic diseases affecting calf productivity. Here, we investi- gated the prevalence of Eimeria spp. in pre-weaned native Korean calves and determined the correlation between diar- rhea and Eimeria spp. Fecal samples were collected from individual calves (288 normal and 191 diarrheic) in 6 different farms. Of the 479 samples, Eimeria oocysts were detected in 124 calves (25.9%). Five Eimeria spp. were identified; E. zuernii (18.8%) was the most prevalent, followed by E. auburnensis (12.5%), E. bovis (7.5%), E. subspherica (5.8%), and E. bukidnonensis (1.0%). A significant correlation was observed between diarrhea and mixed infection with more than 2 Eimeria spp. (odds ratio [OR]=2.21; 95% confidence interval [CI]: 1.09-4.49; P=0.03) compared to single infection (OR = 1.29; 95% CI: 0.77-2.15; P = 0.33). Of the 5 Eimeria spp. identified, E. subspherica (95% CI: 1.24-5.61; P = 0.01) and E. bukidnonensis (95% CI: 825.08-1,134.25; P = 0.00) strongly increased the risk of diarrhea by 2.64-fold and 967.39-fold, respectively, compared to other species. Moreover, mixed infection with E. auburnensis and E. bukidnonensis was significantly associated with diarrhea (OR = 2,388.48; 95% CI: 1,009.71-5,650.00; P < 0.00) in pre-weaned native Korean calves. This is the first report to demonstrate the importance of E. bukidnonensis associated with diarrhea in pre-weaned native Korean calves. Further epidemiological studies should investigate the prevalence of E. bukidnonensis and the association between E. bukidnonensis and diarrhea.

Citations

Citations to this article as recorded by

Status of Eimeria Infection in Dairy Calves in and Around Bishoftu, Central Ethiopia
Yihenew Getahun Ambaw, Gelan Tafesa, Ambachew Motbaynor Wubaye, Simachew Getaneh Endalamew, Simegnew Adugna Kallu, Satabdi Datta Choudhury
Journal of Parasitology Research.2025;[Epub] CrossRef
Molecular characterization of ten viral pathogens causing calf diarrhea in Hanwoo (Bos Taurus coreanae) by next generation sequencing
Jeong-Byoung Chae, Won Gyeong Kim, Shinae Song, Joon-Seok Chae
BMC Veterinary Research.2025;[Epub] CrossRef
Ecological Health and Freshwater Pathogen Using eDNA Metabarcoding: A Preliminary Assessment for Environmental Surveillance Development in Malaysia
Jiao Yang, Subha Bhassu, Ghazanfer Ali, Thenmoli Govindasamy, Muhamad Afiq Aziz, Arutchelvan Rajamanikam
Microorganisms.2025; 13(9): 2055. CrossRef
Current Insights into Neonatal Calf Diarrheal Etiology and the Therapeutic Role of Probiotics
Shuyao Zhu, Shuhao Bian, Liangliang Li, Mudassar Iqbal, Faisal Ayub Kiani, Abdul Asim Farooq, Haiju Dong, Xiangqian Zhang, Hongyu Dai, Fang Liu, Aoyun Li
Journal of Integrative Agriculture.2025;[Epub] CrossRef
CRYPTOSPORIDIOSIS: AN EXISTING PROBLEM
L. V. Nahorna, A. M. Tomik
Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology.2024; 25(2): 93. CrossRef
Eukaryotic Infections in Dairy Calves: Impacts, Diagnosis, and Strategies for Prevention and Control
Dereje Tulu Robi, Tesfa Mossie, Shiferaw Temteme
Veterinary Medicine: Research and Reports.2023; Volume 14: 195. CrossRef
Prevalence of Eimeria spp. with associated risk factors in dairy calves in Sylhet, Bangladesh
Liton Chandra Deb, Syed Sayeem Uddin Ahmed, Chandan Chandra Baidhya, Nirmalendu Deb Nath, Sumon Ghosh, Suman Paul
Veterinary Medicine and Science.2022; 8(3): 1250. CrossRef
Diversity of Eimeria (Apicomplexa: Eimeriidae) species and risk factors associated in natural infecting calves at the Southern Agreste Microregion in the State of Pernambuco, Brazil
Karlla Keyla Ferreira dos Santos, Lucia Oliveira de Macedo, Ângela Imperiano da Conceição, Lucas Azevedo dos Santos, Carla Lopes de Mendonça, Leucio Câmara Alves, Rafael Antonio Nascimento Ramos, Gílcia Aparecida de Carvalho
Revista Brasileira de Parasitologia Veterinária.2022;[Epub] CrossRef
Eimeria infections in domestic and wild ruminants with reference to control options in domestic ruminants
Berit Bangoura, Md Ashraful Islam Bhuiya, Michelle Kilpatrick
Parasitology Research.2022; 121(8): 2207. CrossRef
Dry Season Eimeria Infection in Dairy Cattle and Sheep in and Around Adama and Bishoftu Towns, Oromia, Ethiopia
Dinka Ayana, Kebene Temesgen, Bersissa Kumsa, Gebayehu Alkadir
Veterinary Medicine: Research and Reports.2022; Volume 13: 235. CrossRef
Changes in the blood electrolyte, BUN and glucose values in diarrheic Hanwoo neonatal calves
Mi-Jin Lee
Korean Journal of Veterinary Service.2022; 45(4): 337. CrossRef
Prevalence and infection risk factors of bovine Eimeria in China: a systematic review and meta-analysis
Dong-Li Li, Qing-Long Gong, Gui-Yang Ge, Qi Wang, Chen-Yan Sheng, Bao-Yi Ma, Zi-Yang Chen, Yang Yang, Jian-Ming Li, Kun Shi, Xue Leng, Rui Du
Parasite.2021; 28: 61. CrossRef
The prevalence of causative agents of calf diarrhea in Korean native calves
Jeong-Byoung Chae, Hyeon-Cheol Kim, Jun-Gu Kang, Kyoung-Seong Choi, Joon-Seok Chae, Do-Hyeon Yu, Bae-Keun Park, Yeon-su Oh, Hak-Jong Choi, Jinho Park
Journal of Animal Science and Technology.2021; 63(4): 864. CrossRef
Oxidant-antioxidants and trace mineral status in Coccidiosis affecting buffalo calves
Eman S. Ramadan, Shimaa G. Yehia, Noha Y. Salem
Comparative Clinical Pathology.2021; 30(6): 921. CrossRef

7,845 View
166 Download
11 Web of Science
Crossref

Original Articles

Dynamic Patterns of Systemic Innate Immunity and Inflammatory Associated Factors in Experimental Caprine Coccidiosis: Shabnam Tadayon, Seyed Mostafa Razavi, Saeed Nazifi; Korean J Parasitol 2016;54(6):719-724.
Published online December 31, 2016; DOI: https://doi.org/10.3347/kjp.2016.54.6.719

Abstract
PDF

The present study was designed to assess the dynamic patterns of pro-inflammatory cytokines, including IFN-γ, TNF-α, IL-4, IL-6, acute phase protein (α1-acid-glycoprotein, AGP), and an inflammation associated factor (adenosine deaminase; ADA) following experimental caprine coccidiosis. Ten kids aging from 2 to 4 months were infected orally with 5×10⁴ sporulated oocysts and 10 animals served as controls. Blood samples were collected in both groups before infection and at days 3, 7, 14, 21, 28, and 35 post-infection (PI), and the levels of above-mentioned factors were measured. IFN-γ, TNF-α, IL-4, IL-6, AGP, and ADA activities were significantly higher in infected animals from day 7 PI (P<0.05). In conclusion, the circulatory levels of most systemic inflammatory markers, including pro-inflammatory cytokines (IFN-γ, TNF-α, IL-4, IL-6), AGP, and ADA increased significantly starting from day 3 to day 7 PI in caprine coccidiosis.

Citations

Citations to this article as recorded by

Isolation of a Novel Caprine Eimeria christenseni Strain (GC) in Canary Islands and Analysis of Parasitological, Clinical, and Pathological Findings on Experimentally Infected Goat Kids
Emilio Barba, José Manuel Molina, Francisco Rodríguez, Otilia Ferrer, María Carmen Muñoz, Liliana M. R. Silva, María Cristina Del Río, José Adrián Molina, Anja Taubert, Carlos Hermosilla, Antonio Ruiz
Animals.2025; 15(2): 139. CrossRef
Acute phase response and oxidative stress in coccidiosis: A review in domestic animals
Seyed Mostafa Razavi, Mohammad Sajjad Soltan, Kiarash Abbasian, Ali Karami, Saeed Nazifi
Veterinary Parasitology.2024; 331: 110286. CrossRef
The role of genetics in determining resistance to coccidiosis in goats a review of current research and future directions
Tejswini Sontakke, Ashwini Biradar, Dinesh Nalage
Molecular Biology Reports.2023; 50(7): 6171. CrossRef
Effects of riboflavin and Bacillus subtilis on internal organ development and intestinal health of Ross 708 male broilers with or without coccidial challenge
Sabin Poudel, Li Zhang, George T. Tabler, Jun Lin, Wei Zhai
Poultry Science.2021; 100(4): 100973. CrossRef
Oxidative stress linked to changes of cholinesterase and adenosine deaminase activities in experimentally infected chicken chicks with Eimeria spp
Luiz Gustavo Griss, Gabriela M. Galli, Mateus Fracasso, Anielen D. Silva, Bruno Fortuoso, Maria Rosa C. Schetinger, Vera M. Morch, Marcel M. Boiago, Anderson Gris, Ricardo E. Mendes, Matheus D. Baldissera, Lenita M. Stefani, Aleksandro S. da Silva
Parasitology International.2019; 71: 11. CrossRef

8,192 View
118 Download
5 Web of Science
Crossref

Efficacy of a DNA Vaccine Carrying Eimeria maxima Gam56 Antigen Gene against Coccidiosis in Chickens: Jinjun Xu, Yan Zhang, Jianping Tao; Korean J Parasitol 2013;51(2):147-154.
Published online April 25, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.2.147

Abstract
PDF

To control coccidiosis without using prophylactic medications, a DNA vaccine targeting the gametophyte antigen Gam56 from Eimeria maxima in chickens was constructed, and the immunogenicity and protective effects were evaluated. The ORF of Gam56 gene was cloned into an eukaryotic expression vector pcDNA3.1(zeo)+. Expression of Gam56 protein in COS-7 cells transfected with recombinant plasmid pcDNA-Gam56 was confirmed by indirect immunofluorescence assay. The DNA vaccine was injected intramuscularly to yellow feathered broilers of 1-week old at 3 dosages (25, 50, and 100 ?g/chick). Injection was repeated once 1 week later. One week after the second injection, birds were challenged orally with 5×10⁴ sporulated oocysts of E. maxima, then weighed and killed at day 8 post challenge. Blood samples were collected and examined for specific peripheral blood lymphocyte proliferation activity and serum antibody levels. Compared with control groups, the administration of pcDNA-Gam56 vaccine markedly increased the lymphocyte proliferation activity (P<0.05) at day 7 and 14 after the first immunization. The level of lymphocyte proliferation started to decrease on day 21 after the first immunization. A similar trend was seen in specific antibody levels. Among the 3 pcDNA-Gam56 immunized groups, the median dosage group displayed the highest lymphocyte proliferation and antibody levels (P<0.05). The median dosage group had the greatest relative body weight gain (89.7%), and the greatest oocyst shedding reduction (53.7%). These results indicate that median dosage of DNA vaccine had good immunogenicity and immune protection effects, and may be used in field applications for coccidiosis control.

Citations

Citations to this article as recorded by

Alternatives to antibiotics against coccidiosis for poultry production: the relationship between immunity and coccidiosis management – a comprehensive review
Mohamed T. El-Saadony, Heba M. Salem, Marwa M. Attia, Nahed Yehia, Ahmed H. Abdelkader, Sara Abdel Mawgod, Nesma Mohamed Kamel, Samar Sami Alkafaas, Muslimah N. Alsulami, Ahmed Ezzat Ahmed, Dina Mostafa Mohammed, Ahmed M. Saad, Walid F.A. Mosa, Shaaban S.
Annals of Animal Science.2025;[Epub] CrossRef
Insight into poultry coccidiosis: a dual focus on anticoccidial drugs and herbal plants for pharmacological and prevention strategies
Pooja Bharti, Syed Tanveer, Zahoor Ahmad Wani, Shabir Ahmad Rather, Zahoor Ahmad Parray
Journal of Parasitic Diseases.2025; 49(3): 565. CrossRef
Development and immunological insights into recombinant/subunit vaccines against avian coccidiosis
Shagufta Iqbal, Syed Tanveer, Idrees Mehraj Allaie, Yasmeena Jan, Shahana Tramboo, Nazima Maqbool
Journal of Microbiological Methods.2025; 238: 107255. CrossRef
Innovative prevention and control of coccidiosis: targeting sporogony for new control agent development
Dan Zhao, Jingxia Suo, Lin Liang, Ruiying Liang, Rongqiong Zhou, Jiabo Ding, Xianyong Liu, Xun Suo, Sixin Zhang, Xinming Tang
Poultry Science.2024; 103(12): 104246. CrossRef
In vitro cultivation methods for coccidian parasite research
Anna Sophia Feix, Teresa Cruz-Bustos, Bärbel Ruttkowski, Anja Joachim
International Journal for Parasitology.2023; 53(9): 477. CrossRef
Recombinant GMA56 and ROP17 of Eimeria magna conferred protection against infection by homologous species
Jie Xiao, Hao Chen, Ruoyu Zheng, Jiayan Pu, Xiaobin Gu, Yue Xie, Ran He, Jing Xu, Bo Jing, Xuerong Peng, Guangyou Yang
Frontiers in Immunology.2023;[Epub] CrossRef
What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
Jesica Daiana Britez, Anabel Elisa Rodriguez, Lucía Di Ciaccio, Virginia Marugán-Hernandez, Mariela Luján Tomazic
Life.2023; 13(6): 1295. CrossRef
Cloning, expression and purification of Eimeria maxima gametocyte antigen-EmGam56 for control of poultry coccidiosis
Vijayashanthi Ramalingam, Raman Muthusamy, Kasthuri Bohra, Azhahianambi Palavesam, Dhinakarraj Gopal
Journal of Parasitic Diseases.2023; 47(4): 773. CrossRef
Vaccination Against Poultry Parasites
Ruediger Hauck, Kenneth S. Macklin
Avian Diseases.2023;[Epub] CrossRef
Coccidiosis: Recent Progress in Host Immunity and Alternatives to Antibiotic Strategies
Youngsub Lee, Mingmin Lu, Hyun S. Lillehoj
Vaccines.2022; 10(2): 215. CrossRef
A multiepitope vaccine encoding four Eimeria epitopes with PLGA nanospheres: a novel vaccine candidate against coccidiosis in laying chickens
ZhengQing Yu, SiYing Chen, JianMei Huang, WenXi Ding, YuFeng Chen, JunZhi Su, RuoFeng Yan, LiXin Xu, XiaoKai Song, XiangRui Li
Veterinary Research.2022;[Epub] CrossRef
Vaccines against chicken coccidiosis with particular reference to previous decade: progress, challenges, and opportunities
Tean Zaheer, Rao Zahid Abbas, Muhammad Imran, Asghar Abbas, Ali Butt, Sarfraz Aslam, Jameel Ahmad
Parasitology Research.2022; 121(10): 2749. CrossRef
Research progress of the avian coccidiosis vaccine
Haiming Cai, Nanshan Qi, Juan Li, Minna Lv, Xuhui Lin, Junjing Hu, Jianfei Zhang, Shenquan Liao, Mingfei Sun
Veterinary Vaccine.2022; 1(1): 100002. CrossRef
Protection of hatchlings against coccidiosis by maternal antibodies to four recombinant proteins of Eimeria tenella, Eimeria acervulina and Eimeria maxima
Xu Yang, Xingju Song, Jing Liu, Qingzhong Chen, Tongwei An, Qun Liu
Veterinary Parasitology.2022; 312: 109813. CrossRef
Veteriner protozoolojide aşı uygulamalarına güncel yaklaşım
Ahmet GÖKSU, Hatice ÇİÇEK
Journal of Advances in VetBio Science and Techniques.2021; 6(2): 179. CrossRef
Brief History and Advancements of Vaccination Against Avian Coccidiosis: A Review

Science Letters.2021; 9(2): 31. CrossRef
Sexual Development in Non-Human Parasitic Apicomplexa: Just Biology or Targets for Control?
Teresa Cruz-Bustos, Anna Sophia Feix, Bärbel Ruttkowski, Anja Joachim
Animals.2021; 11(10): 2891. CrossRef
Characterization of Cystoisospora suis sexual stages in vitro
Anna Sophia Feix, Teresa Cruz-Bustos, Bärbel Ruttkowski, Anja Joachim
Parasites & Vectors.2020;[Epub] CrossRef
Immunoprophylactic evaluation of recombinant gametocyte 22 antigen of Eimeria tenella in broiler chickens
Shafiya Imtiaz Rafiqi, Rajat Garg, Hira Ram, K. K. Reena, Mayurkumar Asari, Priyanka Kumari, V. R. Kundave, Mithilesh Singh, P. S. Banerjee
Parasitology Research.2019; 118(3): 945. CrossRef
A review of Eimeria antigen identification for the development of novel anticoccidial vaccines
J. Venkatas, M. A. Adeleke
Parasitology Research.2019; 118(6): 1701. CrossRef
Optimization of Immunization Procedure for Eimeria tenella DNA Vaccine pVAX1-pEtK2-IL-2 and Its Stability
Bucai Zhang, Cheng Yuan, Xiaokai Song, Lixin Xu, Ruofeng Yan, Muhammad Ali A. Shah, Changming Guo, Shanyuan Zhu, Xiangrui Li
Acta Parasitologica.2019; 64(4): 745. CrossRef
Recent advances in delivery of veterinary DNA vaccines against avian pathogens
Seyed Davoud Jazayeri, Chit Laa Poh
Veterinary Research.2019;[Epub] CrossRef
Passive immunization with Eimeria tenella gametocyte antigen 56 (EtGAM56) specific antibodies and active immunization trial with the epitope containing peptide
Stefanie Wiedmer, Alaa Aldin Alnassan, Beate Volke, Ahmed Thabet, Arwid Daugschies, Matthias Lendner, Michael Kurth
Veterinary Parasitology.2017; 247: 100. CrossRef
Recombinant anticoccidial vaccines - a cup half full?
Damer P. Blake, Iván Pastor-Fernández, Matthew J. Nolan, Fiona M. Tomley
Infection, Genetics and Evolution.2017; 55: 358. CrossRef
DNA vaccination of poultry: The current status in 2015
Marine Meunier, Marianne Chemaly, Daniel Dory
Vaccine.2016; 34(2): 202. CrossRef
Development of immunization trials against Eimeria spp.
Tarek A. Ahmad, Bassant A. El-Sayed, Laila H. El-Sayed
Trials in Vaccinology.2016; 5: 38. CrossRef
Construction of Eimeria tenella multi-epitope DNA vaccines and their protective efficacies against experimental infection
Xiaokai Song, Lixin Xu, Ruofeng Yan, Xinmei Huang, Xiangrui Li
Veterinary Immunology and Immunopathology.2015; 166(3-4): 79. CrossRef
Immunization with recombinant 3-1E protein in AbISCO®-300 adjuvant induced protective immunity against Eimeria acervulina infection in chickens
Ying Zhang, Lixia Wang, Wenke Ruan, Jianjun Zhang, Peng Yao, Sai Zhou, Jian An
Experimental Parasitology.2014; 141: 75. CrossRef
Securing poultry production from the ever-present Eimeria challenge
Damer P. Blake, Fiona M. Tomley
Trends in Parasitology.2014; 30(1): 12. CrossRef
Strategies for anti-coccidial prophylaxis
DAVID M. WITCOMBE, NICHOLAS C. SMITH
Parasitology.2014; 141(11): 1379. CrossRef

9,864 View
107 Download
Crossref

Changing Patterns of Acute Phase Proteins and Inflammatory Mediators in Experimental Caprine Coccidiosis: Mohammad Hashemnia, Azizollah Khodakaram-Tafti, Seyed Mostafa Razavi, Saeed Nazifi; Korean J Parasitol 2011;49(3):213-219.
Published online September 30, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.3.213

Abstract
PDF

This experiment was conducted to assess the changing patterns and relative values of acute phase proteins and inflammatory cytokines in experimental caprine coccidiosis. Eighteen newborn kids were allocated to 3 equal groups. Two groups, A and B, were inoculated with a single dose of 1×10³ and1×10⁵ sporulated oocysts of Eimeria arloingi, respectively. The third group, C, received distilled water as the control. Blood samples were collected from the jugular vein of each kid in both groups before inoculation and at days 7, 14, 21, 28, 35, and 42 post-inoculation (PI), and the levels of haptoglobin (Hp), serum amyloid A (SAA), TNF-α, and IFN-γ were measured. For histopathological examinations, 2 kids were selected from each group, euthanized, and necropsied on day 42 PI. Mean Hp concentrations in groups A and B (0.34 and 0.68 g/L) at day 7 PI were 3.2 and 6.3 times higher than the levels before inoculation. The mean SAA concentrations in groups A and B (25.6 and 83.5 ?g/ml) at day 7 PI were 4.2 and 13.7 times higher than the levels before inoculation. The magnitude and duration of the Hp and SAA responses correlated well with the inoculation doses and the severity of the clinical signs and diarrhea in kids. These results were consistent with the histopathological features, which showed advanced widespread lesions in group B. In both groups, significant correlations were observed for TNF-α and IFN-γ with SAA and Hp, respectively. In conclusion, Hp and SAA can be useful non-specific diagnostic indicators in caprine coccidiosis.

Citations

Citations to this article as recorded by

Global prevalence of Eimeria species in goats: a systematic review and meta-analysis
Endris A. Ali, Abdul Ghafar, Juan C. Angeles-Hernandez, Muhammad Yaseen, Charles G. Gauci, Ian Beveridge, Sandra Baxendell, Abdul Jabbar
Frontiers in Veterinary Science.2025;[Epub] CrossRef
Acute phase response and oxidative stress in coccidiosis: A review in domestic animals
Seyed Mostafa Razavi, Mohammad Sajjad Soltan, Kiarash Abbasian, Ali Karami, Saeed Nazifi
Veterinary Parasitology.2024; 331: 110286. CrossRef
DEVELOPMENT OF A QUANTITATIVE IMMUNOASSAY FOR SERUM HAPTOGLOBIN AS A PUTATIVE DISEASE MARKER IN THE SOUTHERN WHITE RHINOCEROS (CERATOTHERIUM SIMUM SIMUM)
Henrik H. Petersen, Rikke Stenbak, Camilla Blaabjerg, Anne K.H. Krogh, Mads F. Bertelsen, Peter Buss, Peter M.H. Heegaard
Journal of Zoo and Wildlife Medicine.2022;[Epub] CrossRef
Assessment of the Immune Response of Clinically Infected Calves to Cryptosporidium parvum Infection
Wael El-Deeb, Olimpia Iacob, Mahmoud Fayez, Ibrahim Elsohaby, Abdulrahman Alhaider, Hermine V. Mkrtchyan, Abdelazim Ibrahim, Naser Alhumam
Agriculture.2022; 12(8): 1151. CrossRef
Comparative study on plasma fibrinogen and ceruloplasmin concentrations during pregnancy and postpartum period in Bulgarian native goats
I. Fasulkov, M. Karadaev, D. Zapryanova, T. Mircheva, N. Vasilev, F. Ceciliani
BULGARIAN JOURNAL OF VETERINARY MEDICINE.2022; 25(4): 603. CrossRef
Acute phase biomarkers of diseases in small ruminants: an overview
P.T. Iliev, T.M. Georgieva
BULGARIAN JOURNAL OF VETERINARY MEDICINE.2019; 22(1): 1. CrossRef
Haptoglobin and serum amyloid A in goats with clinical form of caprine arthritis-encephalitis
Michał Czopowicz, Olga Szaluś-Jordanow, Marcin Mickiewicz, Agata Moroz, Lucjan Witkowski, Iwona Markowska-Daniel, Tadeusz Stefaniak, Emilia Bagnicka, Jarosław Kaba
Small Ruminant Research.2017; 156: 73. CrossRef
Agreement between commercial assays for haptoglobin and serum amyloid A in goats
Michał Czopowicz, Olga Szaluś-Jordanow, Marcin Mickiewicz, Agata Moroz, Lucjan Witkowski, Iwona Markowska-Daniel, Daria Reczyńska, Emilia Bagnicka, Jarosław Kaba
Acta Veterinaria Scandinavica.2017;[Epub] CrossRef
Effect of Ketoprofen on acute phase protein concentrations in goats undergoing castration
Umit Karademir, Ibrahim Akin, Hasan Erdogan, Kerem Ural, Gamze Sevri Ekren Asici
BMC Veterinary Research.2016;[Epub] CrossRef
Dynamic Patterns of Systemic Innate Immunity and Inflammatory Associated Factors in Experimental Caprine Coccidiosis
Shabnam Tadayon, Seyed Mostafa Razavi, Saeed Nazifi
The Korean Journal of Parasitology.2016; 54(6): 719. CrossRef
Intestinal pathogens, diarrhoea and acute phase proteins in naturally infected dairy calves
Leena Seppä-Lassila, Toomas Orro, Brian Lassen, Riikka Lasonen, Tiina Autio, Sinikka Pelkonen, Timo Soveri
Comparative Immunology, Microbiology and Infectious Diseases.2015; 41: 10. CrossRef
Systemic acute phase proteins response in calves experimentally infected with Eimeria zuernii
Brian Lassen, Berit Bangoura, Triin Lepik, Toomas Orro
Veterinary Parasitology.2015; 212(3-4): 140. CrossRef
Acute phase proteins and their use in the diagnosis of diseases in ruminants: a review
C. Tothova, O. Nagy, G. Kovac
Veterinární medicína.2014; 59(4): 163. CrossRef