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"ocular toxoplasmosis"

Brief Communication

Elevated interleukin-10 levels in patients with ocular toxoplasmosis
Gee-Hyun Kim, Jae Hyuck Kwak, Young-Hoon Park
Parasites Hosts Dis 2023;61(3):310-316.
Published online August 21, 2023
DOI: https://doi.org/10.3347/PHD.22172
In elderly patients, ocular toxoplasmosis is one of the most common etiologies of uveitis, which should be differentially diagnosed from ocular lymphoma, another common pathology of uveitis in older adults. The high level of interleukin (IL)-10 and an IL-10/IL-6 ratio higher than 1 (>1.0) are helpful parameters to diagnose ocular lymphoma. In this study, we used aqueous humor samples to detect 4 cases of ocular toxoplasmosis in patients with high levels of IL-10 and an IL-10/IL-6 ratio higher than 1. Our results show that ocular toxoplasmosis may be associated with increased cytokine levels in aqueous humor.

Citations

Citations to this article as recorded by  Crossref logo
  • Toxoplasma gondii IST suppresses inflammatory and apoptotic responses by inhibiting STAT1-mediated signaling in IFN-γ/TNF-α-stimulated hepatocytes
    Seung-Hwan Seo, Ji-Eun Lee, Do-Won Ham, Eun-Hee Shin
    Parasites, Hosts and Diseases.2024; 62(1): 30.     CrossRef
  • Factors related to central nervous system involvement of primary vitreoretinal lymphoma
    Joo Young Kim, Jae Jung Kim, Rae Young Kim, Mirinae Kim, Young Gun Park, Young-Hoon Park
    Graefe's Archive for Clinical and Experimental Ophthalmology.2024; 262(8): 2421.     CrossRef
  • 7,928 View
  • 101 Download
  • 2 Web of Science
  • Crossref

Original Article

Serologic Tests of IgG and IgM Antibodies and IgG Avidity for Diagnosis of Ocular Toxoplasmosis
Bahman Rahimi-Esboei, Mohammad Zarei, Mehdi Mohebali, Hossein Keshavarz Valian, Saeedeh Shojaee, Raziyeh Mahmoudzadeh, Mirataollah Salabati
Korean J Parasitol 2018;56(2):147-152.
Published online April 30, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.2.147
This prospective study was aimed to detect acute and chronic ocular toxoplasmosis by comparison of anti-Toxoplasma gondii IgM and IgG antibody levels and IgG avidity test. One hundred and seventeen patients with ocular toxoplasmosis (OT) who referred to the Farabi Eye Hospital, Tehran, Iran were included in this study. Of the patients, 77 cases were positive for anti-T. gondii IgG, and 8 cases were positive for anti-T. gondii IgM. IgG avidity test revealed 11, 4, and 102 cases were low, intermediate, and high, respectively, and 6.8% and 9.4% of cases were positive for IgM and IgG avidity tests, respectively (P=0.632). Agreement (Kappa value) between paired tests IgG-IgM, IgG-IgG avidity, and IgM-IgG avidity was 0.080, 0.099, and 0.721, respectively (P<0.05). This study showed that conventional serologic tests (IgM and IgG levels) and IgG avidity correlate well each other and can be used to differentiate recent infections from old OT. It seems that reactivated old infections rather than recently acquired infections are majority of Iranian OT patients.

Citations

Citations to this article as recorded by  Crossref logo
  • Serum Concentrations of Th1, Th2 and Treg‐Associated Cytokines in Patients With Ocular Toxoplasmosis
    Ovi Sofia, Rahajeng Anugrahing Saldianovitta, I. Nyoman Surya Ari Wahyudi, Loeki Enggar Fitri, Hani Susianti, Seskoati Prayitnaningsih, Hidayat Sujuti
    Parasite Immunology.2025;[Epub]     CrossRef
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    Minh-Ngoc Nguyen, Seon-Ju Yeo, Hyun Park
    Frontiers in Microbiology.2024;[Epub]     CrossRef
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    Pratik Lakhmawar, Anup Kelgaonkar, Anamika Patel, Ashish Khalsa, Soumyava Basu
    Indian Journal of Ophthalmology.2024; 72(Suppl 4): S601.     CrossRef
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    BMC Pregnancy and Childbirth.2024;[Epub]     CrossRef
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  • Utility of blood as the clinical specimen for the diagnosis of ocular toxoplasmosis using uracil DNA glycosylase-supplemented loop-mediated isothermal amplification and real-time polymerase chain reaction assays based on REP-529 sequence and B1 gene
    Bahman Rahimi Esboei, Shirzad Fallahi, Mohammad Zarei, Bahram Kazemi, Mehdi Mohebali, Saeedeh Shojaee, Parisa Mousavi, Aref Teimouri, Raziyeh Mahmoudzadeh, Mirataollah Salabati, Hossein Keshavarz Valian
    BMC Infectious Diseases.2022;[Epub]     CrossRef
  • Ocular toxoplasmosis: phenotype differences between toxoplasma IgM positive and IgM negative patients in a large cohort
    Sofia Ajamil-Rodanes, Joshua Luis, Rabia Bourkiza, Benedict Girling, Angela Rees, Catherine Cosgrove, Carlos Pavesio, Mark Westcott
    British Journal of Ophthalmology.2021; 105(2): 210.     CrossRef
  • Study of toxoplasmosis and toxocariasis in patients suffering from ophthalmic disorders using serological and molecular methods
    Jasem Saki, Elham Eskandari, Mostafa Feghhi
    International Ophthalmology.2020; 40(9): 2151.     CrossRef
  • Duffy blood group system and ocular toxoplasmosis
    Ana Iara Costa Ferreira, Cinara Cássia Brandão de Mattos, Fábio Batista Frederico, Cássia Rúbia Bernardo, Gildásio Castelo de Almeida Junior, Rubens Camargo Siqueira, Cristina Silva Meira-Strejevitch, Vera Lucia Pereira-Chioccola, Luiz Carlos de Mattos
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  • Diagnostic significance of C-reactive protein and hematological parameters in acute toxoplasmosis
    Vanessa Sandri, Itamar Luís Gonçalves, Gustavo Machado das Neves, Marisa Lucia Romani Paraboni
    Journal of Parasitic Diseases.2020; 44(4): 785.     CrossRef
  • Evaluation of RE and B1 Genes as Targets for Detection of Toxoplasma gondii by Nested PCR in Blood Samples of Patients with Ocular Toxoplasmosis
    Bahman Rahimi Esboei, Bahram Kazemi, Mohammad Zarei, Mehdi Mohebali, Hossein Keshavarz Valian, Saeedeh Shojaee, Fatemeh Zahedipour, Shirzad Fallahi, Parisa Mousavi, Raziyeh Mahmoudzadeh, Mirataollah Salabati
    Acta Parasitologica.2019; 64(2): 384.     CrossRef
  • 12,813 View
  • 256 Download
  • 17 Web of Science
  • Crossref
Mini Review
Clinical Features and Treatment of Ocular Toxoplasmosis
Young-Hoon Park, Ho-Woo Nam
Korean J Parasitol 2013;51(4):393-399.
Published online August 30, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.4.393

Ocular toxoplasmosis is a disease caused by the infection with Toxoplasma gondii through congenital or acquired routes. Once the parasite reaches the retina, it proliferates within host cells followed by rupture of the host cells and invasion into neighboring cells to make primary lesions. Sometimes the restricted parasite by the host immunity in the first scar is activated to infect another lesion nearby the scar. Blurred vision is the main complaint of ocular toxoplasmic patients and can be diagnosed by detection of antibodies or parasite DNA. Ocular toxoplasmosis needs therapy with several combinations of drugs to eliminate the parasite and accompanying inflammation; if not treated it sometimes leads to loss of vision. We describe here clinical features and currently available chemotherapy of ocular toxoplasmosis.

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