There is renewed interest in natural products as a starting point for discovery of drugs for schistosomiasis. Recent studies have shown that phytol reveals interesting in vivo and in vitro antischistosomal properties against Schistosoma mansoni adult worms. Here, we report the in vitro antischistosomal activity of phytol against Schistosoma haematobium juvenile and adult worms and alterations on the tegumental surface of the worms by means of scanning electron microscopy. The assay, which was carried out with 6 concentrations (25, 50, 75, 100, 125, and 150 μg/ml) of phytol, has shown a promising activity in a dose and time-dependent manner. There was a significant decline in the motility of the worms and a mortality rate of 100% was found at 48 hr after they had been exposed to phytol in the concentration of 150 μg/ml. Male worms were more susceptible. On the ultrastructural level, phytol also induced tegumental peeling, disintegration of tubercles and spines in addition to morphological disfiguring of the oral and ventral suckers. This report provides the first evidence that phytol is able to kill S. haematobium of different ages, and emphasizes that it is a promising natural product that could be used for development of a new schistosomicidal agent.
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Water knotweed is an important candidate for preclinical trials with its high photoprotection and remarkable bioactive properties Emine Bagdatli, Aliye Gediz Erturk European Journal of Integrative Medicine.2024; 66: 102340. CrossRef
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Biomedical Activities of Florasol Paramasivam Selvakumar Journal of Preventive, Diagnostic and Treatment Strategies in Medicine.2022; 1(3): 158. CrossRef
Phytochemical Analysis of the Essential Oils From Aerial Parts of Four Scutellaria “Skullcap” Species Cultivated in South Alabama: Scutellaria baicalensis Georgi, S. Barbata D. Don, S. Incana Biehler, and S. Lateriflora L Sims K. Lawson, Prabodh Satyal, William N. Setzer Natural Product Communications.2021;[Epub] CrossRef
Barbatic acid from Cladia aggregata (lichen): Cytotoxicity and in vitro schistosomicidal evaluation and ultrastructural analysis against adult worms of Schistosoma mansoni H.A.M.F. Silva, A.L. Aires, C.L.R. Soares, J.L.F. Sá, M.C.B. Martins, M.C.P.A. Albuquerque, T.G. Silva, F.A. Brayner, L.C. Alves, A.M.M.A. Melo, N.H. Silva Toxicology in Vitro.2020; 65: 104771. CrossRef
Anti‐Schistosoma mansoni effects of essential oils and their components Muhammad Torequl Islam, Miquel Martorell, Bahare Salehi, William N. Setzer, Javad Sharifi‐Rad Phytotherapy Research.2020; 34(8): 1761. CrossRef
Characteristics and function of cathepsin L3 from Schistosoma japonicum Wenling Huang, Mengjie Gu, Wenjun Cheng, Qin Ping Zhao, Zhenping Ming, Huifen Dong Parasitology Research.2020; 119(5): 1619. CrossRef
Efficacy of artemisinin–naphthoquine phosphate against Schistosoma haematobium adult flukes: dose–effect relationship and tegumental alterations S.N. El-Beshbishi, S. El Bardicy, M. Tadros, M. Ayoub, A. Taman Journal of Helminthology.2019; 93(04): 513. CrossRef
Antischistosomal Agents: State of Art and Perspectives Eloi M Lago, Rogério P Xavier, Thaina R Teixeira, Lívia M Silva, Ademar A da Silva Filho, Josué de Moraes Future Medicinal Chemistry.2018; 10(1): 89. CrossRef
Toxin-Pathogen Synergy Reshaping Detoxification and Antioxidant Defense Mechanism of Oligonychus afrasiaticus (McGregor) Ahmed Mohammed AlJabr, Abid Hussain, Muhammad Rizwan-ul-haq Molecules.2018; 23(8): 1978. CrossRef
Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy Valentin Buchter, Jeannine Hess, Gilles Gasser, Jennifer Keiser Parasites & Vectors.2018;[Epub] CrossRef
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