Parasites, Hosts and Diseases

"synthesis"

Brief Communication

Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin: Gab-Man Park, Hyun Park, Sangtae Oh, Seokjoon Lee; Korean J Parasitol 2017;55(6):661-665.
Published online December 31, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.6.661

Abstract
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We synthesized C-10 substituted triazolyl artemisinins by the Huisgen cycloaddition reaction between dihydroartemisinins (2) and variously substituted 1, 2, 3-triazoles (8a-8h). The antimalarial activities of 32 novel artemisinin derivatives were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin (9d-12d) showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate.

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Novel frontiers through nitrogen substitution at 6th, 10th and 11th position of artemisinin: Synthetic approaches and antimalarial activity
Priyanka Yadav, Varun Rawat, Shalini Kaushik Love, Ved Prakash Verma
European Journal of Medicinal Chemistry.2025; 281: 117032. CrossRef
Identification of potential bi-triazole based antimalarial compounds and their effects against asexual stages of Plasmodium isolates
Marcinete Latorre Almeida, Leandro do Nascimento Martinez, Welington da Silva Paula do Nascimento, Guilherme Matos Passarini, Daniel Sol Sol de Medeiros, Minelly Azevedo da Silva, Saara Neri Fialho, Amália do Santos Ferreira, Norton Rubens Diunior Lucas P
Caderno Pedagógico.2024; 21(13): e12709. CrossRef
In silico screening, synthesis, and antimalarial evaluation of PABA substituted 1,3,5-triazine derivatives as Pf-DHFR inhibitors
Ashmita Saha, Ayesha Aktar Khanam Choudhury, Nayana Adhikari, Surajit Kumar Ghosh, Anshul Shakya, Saurav Jyoti Patgiri, Udaya Pratap Singh, Hans Raj Bhat
Experimental Parasitology.2023; 250: 108546. CrossRef
Current development of 1,2,3-triazole derived potential antimalarial scaffolds: Structure- activity relationship (SAR) and bioactive compounds
S. Maheen Abdul Rahman, Jasvinder Singh Bhatti, Suresh Thareja, Vikramdeep Monga
European Journal of Medicinal Chemistry.2023; 259: 115699. CrossRef
Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research
Om P.S. Patel, Richard M. Beteck, Lesetja J. Legoabe
European Journal of Medicinal Chemistry.2021; 213: 113193. CrossRef

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Original Article

Draft Genome of Toxocara canis, a Pathogen Responsible for Visceral Larva Migrans: Jinhwa Kong, Jungim Won, Jeehee Yoon, UnJoo Lee, Jong-Il Kim, Sun Huh; Korean J Parasitol 2016;54(6):751-758.
Published online December 31, 2016; DOI: https://doi.org/10.3347/kjp.2016.54.6.751

Abstract
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This study aimed at constructing a draft genome of the adult female worm Toxocara canis using next-generation sequencing (NGS) and de novo assembly, as well as to find new genes after annotation using functional genomics tools. Using an NGS machine, we produced DNA read data of T. canis. The de novo assembly of the read data was performed using SOAPdenovo. RNA read data were assembled using Trinity. Structural annotation, homology search, functional annotation, classification of protein domains, and KEGG pathway analysis were carried out. Besides them, recently developed tools such as MAKER, PASA, Evidence Modeler, and Blast2GO were used. The scaffold DNA was obtained, the N50 was 108,950 bp, and the overall length was 341,776,187 bp. The N50 of the transcriptome was 940 bp, and its length was 53,046,952 bp. The GC content of the entire genome was 39.3%. The total number of genes was 20,178, and the total number of protein sequences was 22,358. Of the 22,358 protein sequences, 4,992 were newly observed in T. canis. Following proteins previously unknown were found: E3 ubiquitin-protein ligase cbl-b and antigen T-cell receptor, zeta chain for T-cell and B-cell regulation; endoprotease bli-4 for cuticle metabolism; mucin 12Ea and polymorphic mucin variant C6/1/40r2.1 for mucin production; tropomodulin-family protein and ryanodine receptor calcium release channels for muscle movement. We were able to find new hypothetical polypeptides sequences unique to T. canis, and the findings of this study are capable of serving as a basis for extending our biological understanding of T. canis.

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Parasites in Sewage: Legal Requirements and Diagnostic Tools
Oliwia Obuch-Woszczatyńska, Klaudia Bylińska, Małgorzata Krzyżowska, Karol Korzekwa, Piotr Bąska
Pathogens.2025; 14(1): 86. CrossRef
Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments
Ana C. Mengarda, Tais C. Silva, Aline S. Silva, Daniel B. Roquini, João Paulo S. Fernandes, Josué de Moraes
European Journal of Medicinal Chemistry.2023; 251: 115268. CrossRef
Antigenic Proteins from the Excretory–Secretory Products of Toxocara canis Larvae and Evaluation of Their Potential for Immunodiagnostics of Larval Toxocarosis
Kateřina Skulinová, Jan Novák, Libuše Kolářová, Martin Kašný
Acta Parasitologica.2022; 67(2): 705. CrossRef
GAAP: A Genome Assembly + Annotation Pipeline
Jinhwa Kong, Sun Huh, Jung-Im Won, Jeehee Yoon, Baeksop Kim, Kiyong Kim
BioMed Research International.2019; 2019: 1. CrossRef

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Brief Communication

Short-Cut Pathway to Synthesize Cellulose of Encysting Acanthamoeba: Eun-Kyung Moon, Hyun-Hee Kong; Korean J Parasitol 2012;50(4):361-364.
Published online November 26, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.4.361

Abstract
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The mature cyst of Acanthamoeba is highly resistant to various antibiotics and therapeutic agents. Cyst wall of Acanthamoeba are composed of cellulose, acid-resistant proteins, lipids, and unidentified materials. Because cellulose is one of the primary components of the inner cyst wall, cellulose synthesis is essential to the process of cyst formation in Acanthamoeba. In this study, we hypothesized the key and short-step process in synthesis of cellulose from glycogen in encysting Acanthamoeba castellanii, and confirmed it by comparing the expression pattern of enzymes involving glycogenolysis and cellulose synthesis. The genes of 3 enzymes, glycogen phosphorylase, UDP-glucose pyrophosphorylase, and cellulose synthase, which are involved in the cellulose synthesis, were expressed high at the 1st and 2nd day of encystation. However, the phosphoglucomutase that facilitates the interconversion of glucose 1-phosphate and glucose 6-phosphate expressed low during encystation. This report identified the short-cut pathway of cellulose synthesis required for construction of the cyst wall during the encystation process in Acanthamoeba. This study provides important information to understand cyst wall formation in encysting Acanthamoeba.

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Encystment and Excystment Processes in Acanthamoeba castellanii: An Emphasis on Cellulose Involvement
Mathew Choaji, Ascel Samba-Louaka, Zineb Fechtali-Moute, Willy Aucher, Sébastien Pomel
Pathogens.2025; 14(3): 268. CrossRef
Inhibition of GABA metabolism by β-lactam antibiotics affects encystation in Acanthamoeba
Chih-Ming Tsai, Yao-Tsung Chang, Yu-Jen Wang, Chun-Hsien Chen, Chuan-Yi Wang, Jian-Ming Huang
Biomedicine & Pharmacotherapy.2025; 193: 118841. CrossRef
Oxidase enzyme genes are differentially expressed during Acanthamoeba castellanii encystment
Christian Q. Scheckhuber, Rebeca Damián Ferrara, Jesús Gómez-Montalvo, Sutherland K. Maciver, Alvaro de Obeso Fernández del Valle
Parasitology Research.2024;[Epub] CrossRef
Biological characteristics and pathogenicity of Acanthamoeba
Yuehua Wang, Linzhe Jiang, Yitong Zhao, Xiaohong Ju, Le Wang, Liang Jin, Ryan D. Fine, Mingguang Li
Frontiers in Microbiology.2023;[Epub] CrossRef
Curcumin effect on Acanthamoeba triangularis encystation under nutrient starvation
Rachasak Boonhok, Suthinee Sangkanu, Suganya Phumjan, Ramita Jongboonjua, Nawarat Sangnopparat, Pattamaporn Kwankaew, Aman Tedasen, Chooi Ling Lim, Maria de Lourdes Pereira, Mohammed Rahmatullah, Polrat Wilairatana, Christophe Wiart, Karma G. Dolma, Alok
PeerJ.2022; 10: e13657. CrossRef
Stimulation of Acanthamoeba castellanii excystment by enzyme treatment and consequences on trophozoite growth
Zineb Fechtali-Moute, Philippe M. Loiseau, Sébastien Pomel
Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef
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Tshegofatso Ngwaga, Deepika Chauhan, Stephanie R. Shames
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Peganum harmala Extract Has Antiamoebic Activity to Acanthamoeba triangularis Trophozoites and Changes Expression of Autophagy-Related Genes
Rachasak Boonhok, Suthinee Sangkanu, Julalak Chuprom, Mayuna Srisuphanunt, Roghayeh Norouzi, Abolghasem Siyadatpanah, Farzaneh Mirzaei, Watcharapong Mitsuwan, Sueptrakool Wisessombat, Maria de Lourdes Pereira, Mohammed Rahmatullah, Polrat Wilairatana, Chr
Pathogens.2021; 10(7): 842. CrossRef
Evolution and function of carbohydrate reserve biosynthesis in parasitic protists
Julie E. Ralton, M. Fleur Sernee, Malcolm J. McConville
Trends in Parasitology.2021; 37(11): 988. CrossRef
The role of the Acanthamoeba castellanii Sir2-like protein in the growth and encystation of Acanthamoeba
So-Young Joo, Ja Moon Aung, Minsang Shin, Eun-Kyung Moon, Hyun-Hee Kong, Youn-Kyoung Goo, Dong-Il Chung, Yeonchul Hong
Parasites & Vectors.2020;[Epub] CrossRef
Encystation: the most prevalent and underinvestigated differentiation pathway of eukaryotes
Pauline Schaap, Christina Schilde
Microbiology.2018; 164(5): 727. CrossRef
Down-Regulation of Cellulose Synthase Inhibits the Formation of Endocysts in Acanthamoeba
Eun-Kyung Moon, Yeonchul Hong, Dong-Il Chung, Youn-Kyoung Goo, Hyun-Hee Kong
The Korean Journal of Parasitology.2014; 52(2): 131. CrossRef

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Mini Review

Trypanosome Glycosylphosphatidylinositol Biosynthesis: Yeonchul Hong, Taroh Kinoshita; Korean J Parasitol 2009;47(3):197-204.
Published online August 28, 2009; DOI: https://doi.org/10.3347/kjp.2009.47.3.197

Abstract
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Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known as variant surface glycoproteins and procyclins. GPI anchoring is suggested to be important for trypanosome survival and establishment of infection. Trypanosomes are not only pathogenically important, but also constitute a useful model for elucidating the GPI biosynthesis pathway. This review focuses on the trypanosome GPI biosynthesis pathway. Studies on GPI that will be described indicate the potential for the design of drugs that specifically inhibit trypanosome GPI biosynthesis.

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Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis
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Alyssa R. Borges, Fabian Link, Markus Engstler, Nicola G. Jones
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Original Article

Nucleolar translocalization of GRA10 of Toxoplasma gondii transfectionally expressed in HeLa cells: Hye-Jin Ahn, Sehra Kim, Ho-Woo Nam; Korean J Parasitol 2007;45(3):165-174.
Published online September 20, 2007; DOI: https://doi.org/10.3347/kjp.2007.45.3.165

Abstract
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Toxoplasma gondii GRA10 expressed as a GFP-GRA10 fusion protein in HeLa cells moved to the nucleoli within the nucleus rapidly and entirely. GRA10 was concentrated specifically in the dense fibrillar component of the nucleolus morphologically by the overlap of GFP-GRA10 transfection image with IFA images by monoclonal antibodies against GRA10 (Tg378), B23 (nucleophosmin) and C23 (nucleolin). The nucleolar translocalization of GRA10 was caused by a putative nucleolar localizing sequence (NoLS) of GRA10. Interaction of GRA10 with TATA-binding protein associated factor 1B (TAF1B) in the yeast two-hybrid technique was confirmed by GST pull-down assay and immunoprecipitation assay. GRA10 and TAF1B were also co-localized in the nucleolus after co-transfection. The nucleolar condensation of GRA10 was affected by actinomycin D. Expressed GFP-GRA10 was evenly distributed over the nucleoplasm and the nucleolar locations remained as hollows in the nucleoplasm under a low dose of actinomycin D. Nucleolar localizing and interacting of GRA10 with TAF1B suggested the participation of GRA10 in rRNA synthesis of host cells to favor the parasitism of T. gondii.

Citations

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Intracellular life of protozoan Toxoplasma gondii: Parasitophorous vacuole establishment and survival strategies
JULIANA A. PORTES, ROSSIANE C. VOMMARO, LUCIO AYRES CALDAS, ERICA S. MARTINS-DUARTE
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An in silico pipeline to filter the Toxoplasma gondii proteome for proteins that could traffic to the host cell nucleus and influence host cell epigenetic regulation
Genevieve Syn, Jenefer M Blackwell, Sarra E Jamieson, Richard W Francis
Memórias do Instituto Oswaldo Cruz.2018;[Epub] CrossRef
A novel dense granule protein NcGRA23 in Neospora caninum
Weirong Wang, Pengtao Gong, Pu Wang, Jingquan Dong, Xiaocen Wang, Zhengtao Yang, Jianhua Li, Xichen Zhang
Acta Biochimica et Biophysica Sinica.2018; 50(7): 727. CrossRef
How pathogens use linear motifs to perturb host cell networks
Allegra Via, Bora Uyar, Christine Brun, Andreas Zanzoni
Trends in Biochemical Sciences.2015; 40(1): 36. CrossRef
GRA 14, a novel dense granule protein from Neospora caninum
Gongzhen Liu, Xia Cui, Pan Hao, Daoyu Yang, Jing Liu, Qun Liu
Acta Biochimica et Biophysica Sinica.2013; 45(7): 607. CrossRef
Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21
Yuya Hirai, Emilie Louvet, Toshiyuki Oda, Masahiro Kumeta, Yuzo Watanabe, Tsuneyoshi Horigome, Kunio Takeyasu
Genes to Cells.2013; 18(9): 780. CrossRef
A Genome-Wide siRNA Screen to Identify Host Factors Necessary for Growth of the Parasite Toxoplasma gondii
Lindsey A. Moser, Angela M. Pollard, Laura J. Knoll, Mohamed Ali Hakimi
PLoS ONE.2013; 8(6): e68129. CrossRef
GRA Proteins of Toxoplasma gondii: Maintenance of Host-Parasite Interactions across the Parasitophorous Vacuolar Membrane
Ho-Woo Nam
The Korean Journal of Parasitology.2009; 47(Suppl): S29. CrossRef
Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection
Gretchen Hermes, James W Ajioka, Krystyna A Kelly, Ernest Mui, Fiona Roberts, Kristen Kasza, Thomas Mayr, Michael J Kirisits, Robert Wollmann, David JP Ferguson, Craig W Roberts, Jong-Hee Hwang, Toria Trendler, Richard P Kennan, Yasuhiro Suzuki, Catherine
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Brief Communication

Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin: Seokjoon Lee, Sangtae Oh, Gab-Man Park, Tong-Soo Kim, Jae-Sook Ryu, Han-Kyu Choi; Korean J Parasitol 2005;43(3):123-126.
Published online September 20, 2005; DOI: https://doi.org/10.3347/kjp.2005.43.3.123

Abstract
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Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10β-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.

Citations

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Chemical transformations of artemisinin
A. V. Semakov, S. V. Afanasyeva, S. A. Pukhov
Russian Chemical Bulletin.2024; 74(6): 1604. CrossRef
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Gisele E. Miana, Sergio R. Ribone, Domingo M.A. Vera, Manuel Sánchez-Moreno, María R. Mazzieri, Mario A. Quevedo
European Journal of Medicinal Chemistry.2019; 165: 1. CrossRef
Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin
Gab-Man Park, Hyun Park, Sangtae Oh, Seokjoon Lee
The Korean Journal of Parasitology.2017; 55(6): 661. CrossRef
TD-DFT calculations of UV absorption bands and their intensities in the spectra of some tetrahydroquinolines
María V. Cooke, Ivana Malvacio, Walter J. Peláez, Ana J. Pepino, María R. Mazzieri, Gustavo A. Argüello
RSC Advances.2015; 5(33): 26255. CrossRef
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Journal of Medicinal Chemistry.2012; 55(17): 7892. CrossRef
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Romina J. Pagliero, Sabrina Lusvarghi, Adriana B. Pierini, Reto Brun, María R. Mazzieri
Bioorganic & Medicinal Chemistry.2010; 18(1): 142. CrossRef