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Original Article

A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent

Camila Bárbara Cantalupo Lima1, Wagner Welber Arrais-Silva1, Rodrigo Luiz Oliveira Rodrigues Cunha2, Selma Giorgio2
The Korean Journal of Parasitology 2009;47(3):213-218.
Published online: August 28, 2009

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Corresponding author (sgiorgio@unicamp.br)
• Received: February 27, 2009   • Revised: April 2, 2009   • Accepted: April 4, 2009

Copyright © 2009 by The Korean Society for Parasitology

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A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent
Korean J Parasitol. 2009;47(3):213-218.   Published online August 28, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.3.213
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A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent
Korean J Parasitol. 2009;47(3):213-218.   Published online August 28, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.3.213
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A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent
Image Image Image Image
Fig. 1 Chemical structure of RT-01. The empirical formula is C13H22N+·C3H3Cl4OTe-.
Fig. 2 RT-01 toxicity for L. amazonensis. (A) Promastigotes were exposed to various concentrations of RT-01 for 24 hr at 26℃. The percentage control values were calculated by dividing promastigote numbers in the presence of RT-01 with promastigote numbers in the absence of RT-01 and multiplying by 100. (B) Extracellular amastigotes were exposed to various concentrations of RT-01 for 48 hr at 26℃. The transformation of amastigotes into promastigotes was estimated by counting promastigotes. The data shown represent the mean ± SEM. This experiment is representative of 5 independent repeats (*P < 0.01 in comparison to untreated parasites).
Fig. 3 Follow-up of BALB/c mice infected with L. amazonensis after intraperitoneal RT-01 treatment. Mice (7 per group) were infected with 105 amastigotes. RT-01 (180 µg/kg/day; ▴), (360 µg/kg/day; •) or (720 µg/kg/day; ▪) were administered by intraperitoneal injection 30 and 15 days before infection, and day 1, 15, and 30 post-infection (PI). Glucantime (100 mg/kg/day) were administered by peritoneal injection at day 20 PI (□). Untreated mice were injected with vehicles (DMSO and saline) without RT-01 (◇). (A) Lesion size is expressed as the difference in size between the infected and contralateral non-infected footpads. (B) Appearance of a typical footpad lesion of an untreated mouse at day 40 PI. (C) Appearance of a footpad lesion of a 360 µg/kg/day RT-01-treated mouse at day 40 PI. (D) Parasite burden in infected footpad lesions from untreated mice and RT-01-treated mice at day 40 PI. This experiment is representative of 3 independent repeats (*P < 0.05 in comparison to control mice).
Fig. 4 Follow-up of BALB/c mice infected with L. amazonensis after intralesional RT-01 treatment. Mice (7 per group) were infected with 105 amastigotes. RT-01 (180 µg/kg/day; ▴), (360 µg/kg/day; •) or (720 µg/kg/day; ▪) were administered 3 times at intervals of 10 days after infection. Untreated mice were injected with vehicles (DMSO and saline) without RT-01 (◇). (A) Lesion size is expressed as the difference in size between the infected and contralateral noninfected footpad. (B) Appearance of typical footpad lesion of untreated mouse at day 40 PI. (C) Appearance of footpad lesion of 720 µg/kg/day RT-01-treated mouse at day 40 PI. (D) Parasite burden in infected footpad lesion from untreated mice and RT-01-treated mice at day 40 PI. (E) Photomicrograph of the histological section of a footpad lesion from untreated mice at day 40 PI. (F) Photomicrograph of the histological section of a footpad lesion from 720 µg/kg/day RT-01-treated mouse at day 40 PI. Figs. (E) and (F) are hematoxylin and eosin stained. This experiment is representative of 3 independent repeats (*P < 0.05 in comparison to control mice).

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A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent
PHD : Parasites, Hosts and Diseases

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