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A clinical trial of oxantel and pyrantel against intestinal nematodes infections
Won-Young Choi,Ok-Ran Lee,Won-Koo Lee,Wun-Kyu Kim,Chang-Seng Chung and Byong-Ok Ough
Department of Parasitology, Catholic Medical College and Catholic Institute of Parasitic Diseases, Korea.
Institute for Tropical Endemic Diseases, Korea University Medical College, Korea.
Abstract
This study was conducted to determine the effect of oxantel/pyrantel tablets, oxantel suspension, pyrantel dry syrup and pyrantel tablets against T. trichiurus and A. lumbricoides infections.
Twenty-four cases of mixed infections of T. trichiurus and A. lumbricoides were treated with oxantel/pyrantel tablets at a single dose of 20 mg/kg of body weight, and 49 cases of single infection of T. trichiurus were administered oxantel suspension at a single dose of 15 mg/kg of body weight. On the other hand, single infection of A. lumbricoides in 18 cases was administered pyrantel dry syrup at a single dose of 5 mg/kg of body weight.
In the above 91 cases, the negative conversion rate and the egg reduction rate of egg out-put before and after the drug administration were examined by the cellophane thick smear method and Stoll's egg counting technique. A follow-up examination was carried out 3-4 weeks after the drug administration.
Other 59 cases of single and mixed infection of T. trichiurus and A. lumbricoides were examined by the cellophane thick smear method only and administered pyrantel tablets at a single dose of 2.5 mg/kg of body weight.
The results were summarized as follows:
1. The prevalence rates of T. trichiurus and A. lumbricoides infection in this study were 42.8% and 27.2% respectively by the cellophane thick smear method among 1,066 stool specimens.
2. The egg negative conversion rate and the egg reduction rate in the administration of oxantel/pyrantel tablets at a single dose of 20 mg/kg body weight were 75.0% and 97.8% respectively in T. trichiurus infection and 100% each in A. lumbricoides.
3. The egg negative conversion rate and the egg reduction rate in the administration of oxantel suspension at a single dose of 15 mg/kg body weight were 85.7% and 93.0% respectively in sinlge infection of T. trichiurus.
4. The egg negative conversion rate and the egg reduction rate in the administration of pyrantel dry syrup at a single dose of 5 mg/kg body weight were 100% each in single infection of A. lumbricoides.
5. The qualitative evaluation in cases of single and mixed infection of T. trichiurus and A. lumbricoides were by means of pyrantel tablets at a single dose of 2.5 mg/kg body weight, the cure being 100% against A. lumbricoides but 17.0% against T. trichiurus.
6. There were no undesirable side effects in this study and oxantel suspension and pyrantel dry syrup were well accepted and tolerated.
Tables
Table 1 Prevalence rates of intestinal parasites revealed by cellophane thick smear method in Nambu Women Guidance Agency, Hapcheon Girl School and Star of Sea Children's Home
Table 2 Analysis of multiple infections of intestinal parasites in Nambu Women Guidance Agency, Hapcheon Girl School and Star of the Sea Children's Home
Table 3 Egg negative conversion rates of A. lumbricodies and T. trichiurus after the administration with oxantel pamoate and/or pyrantel pamoate
Table 4 Egg reduction rates of A. lumbricodies and T. trichiurus after the administration with oxantel pamoate and/or pyrantel pamoate
References
1.
Bell WJ, Nassif S. Comparison of pyrantel pamoate and piperazine phosphate in the treatment of ascariasis. Am J Trop Med Hyg 1971;20(4):584–588.
2.
Cho SY. Korean J Pharmacol 1976;12(1):69.
3.
Desowitz RS, Bell T, Williams J, Cardines R, Tamarua M. Anthelmintic activity of pyrantel pamoate. Am J Trop Med Hyg 1970;19(5):775–778.
4.
Lee SH, Seo BS, Cho SY, Kang SY. Clinical Trial Of Oxantel Pamoate(Cp-14, 445) On Trichocephalus Trichiurus Infection. Korean J Parasitol 1976;14(1):25–31.
5.
Lee SH, Song CY, Lim JK. [Anthelmintic Effect Of Oxantel And Oxantel/pyrantel Tablets Against Intestinal Nematode Infections]. Korean J Parasitol 1977;15(2):121–126.
6.
Lim JK. Korean J Pharmacol 1974;10:97–101.
7.
Rim HJ, Ha JH, Lee JS, Hyun I, Uh KB. Pyrantel embonate in mass treatment of ascariasis and comparison with piperazine adipate and santonin-kainic acid complex. Korean J Parasitol 1974;12(2):141–146.
8.
Rim HJ, Won CY, Lee SI, Lim JK. Anthelmintic effect of oxantel pamoate and pyrantel pamoate suspension against intestinal nematode infestations. Korean J Parasitol 1975;13(2):97–101.
9.
Rim HJ, Lee SH, Lee SI, Chang DS, Lim JK. Effect Of Oxantel/pyrantel Pamoate Tablets Against Intestinal Nematodes In Korea. Korean J Parasitol 1978;16(1):14–20.
10.
Sargent RG, Savory AM, Mina A, Lee PR. A clinical evaluation of mebendazole in the treatment of trichuriasis. Am J Trop Med Hyg 1974;23(3):375–377.
11.
Seo BS, Rim HJ, Loh IK, Lee SH, Cho SY, Park SC, Bae JW, Kim JH, Lee JS, Koo BY, Kim KS. [Study On The Status Of Helminthic Infections In Koreans]. Korean J Parasitol 1969;7(1):53–70.
12.
Seo BS, et al. Korean Central J Medicine 1972;23:579–584.
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