Niclosamide in the treatment of tetagonimiasis

Original Article


Korean J Parasitol. 1978 Dec;16(2):65-68. English. Published online Mar 20, 1994. http://dx.doi.org/10.3347/kjp.1978.16.2.65
Copyright © 1978 by The Korean Society for Parasitology


Niclosamide in the treatment of tetagonimiasis
Yung-Kyum Ahn,Bong-Suck Chung and Chin-Thack Soh
Department of Parasitology, College of Medicine and Institute of Tropical Medicine, Yonsei University, Korea.


Abstract
Anthelmintic effect of niclosamide [N-(2-chloro-4-nitrophenyl)-5-chloro-salicylamide)] on Metagonimus infection was carried out to the cases in area of Seomjin-river. The drug, one tablet contains 0.5 g of niclosamide was supplied from Bu-gwang pharmaceutical company in Seoul. Sixty five cases were divided into three groups by the regimen: Group l given 2 g(4 tablets) for one day, Group II for two successive days and Group III for three successive days. Stool examination was done before and 2-3 weeks after the drug administration by formalin-ether concentration and Stoll's dilution egg counting techniques. The results were as follows: Egg negative conversion (cured) and egg reduction (more than 80% decrease) rates were 28.6%, 10.7% in group I, and 31.8%, 27.3% in group II. But of those in group III treated for three successive days, 73.3% was cured and 26.7% showed egg reduction, and the general egg reduction rate was 95.1%. The results in the present trial suggested that the niclosamide has anthelmintic efficacy when it is used in 2 g for more than three successive days.

Tables


	Table 1 Age distribution of the infected cases with Metagonimus yokogawai by group


	Table 2 E.P.G. ranges of the infected cases with Metagonimus yokogawai by group


	Table 3 Efficacy of niclosamide in Metagonimus yokogawai infectedf cases


	Table 4 Intensity of egg reduction after treatment with niclosamide

References


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