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Reduced single dose of mebendazole in treatment of Ascaris lumbricoides infection
Byong-Seol Seo,Seung-Yull Cho and Jong-Yil Chai
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.
Abstract
The efficacy of reduced single doses of mebendazole against Ascaris lumbricoides infection was evaluated by cellophane thick smear and egg counting techinques, in two rural populations from December 1977 to March 1978.
Total 191 infected cases were divided into five dose groups; 100 mg single dose, 200 mg single dose, 300 mg single dose, 400 mg and 600 mg in repeated doses.
The cure rate of mebendazole in the treatment of Ascaris infection was remarkably high and satisfactory in every dose groups. The egg reduction rates were all over 98 percent in every dose groups.
Side effects were observed during the treatment, mainly mild and transient gastrointestinal troubles, and not exacerbated by the increase of doses upto 300 mg in single dose.
Above results confirmed that in case of mass chemotherapy of Ascaris infection, 100 mg or 200 mg of single dose treatment is sufficient to achieve the economic and acceptable method of treatment.
Tables
Table 1 Results of stool examination in two surveyed inhabitants revealed by cellophane thick smear method
Table 2 Cure rate of Ascaris lumbricoides infection by dosage schedules of mebendazole
Table 3 Distribution of failed cases in complete cure according to the age band of subjected cases by doses
Table 4 Egg reduction rates Ascaris lumbricoides according to doses of mebendazole
Table 5 Distribution of failed cases in complete cure according to the pre-treatment E.P.G.
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