Santonin-kainic acid complex was evaluated as a chemotherapeutic of the mass treatment of the Ascaris lumbricoides infection in Korea. The results could be summarized as follows: The negative conversion rate was 82.9% in average in 4 treated groups. Some variations of negative conversion rate among the treated groups were noticed. The egg reduciton rate was 97.7% in average and the results were rather uniform among the three evaluated groups. By the analysis of egg reduction, it seems that the lightly infected cases whose E.P.G. were under 5,000 were resistant to treatment with the less reduced egg output.
After the treatment with this complex, the number of egg discharged cases were reduced to 1.84% and the average number of discharge eggs per incompletely treated or untreated cases were reduced to 12.5% compared with the level of before-treatment egg output. The successive observations of the pattern of worm expulsion after drug intake was made. The worms were mostly expelled in the stool within 3 days, and 58.9% of total expelled worms were collected within 24-hour stool. The minimum length of the immature worms expelled was 7.6cm. Among the 659 Ascaris collected in the first-day stool from 91 rural people, 8.5% were in the range of 7.6-12.2 cm-long, immature worms. The sex ratio, male: female= 0.69: 1.
Citations
Citations to this article as recorded by
Microorganism-mediated algal biomass processing for clean products manufacturing: Current status, challenges and future outlook Fady Abd El-Malek, Marian Rofeal, Hossain M. Zabed, Abdul-Sattar Nizami, Mohammad Rehan, Xianghui Qi Fuel.2022; 311: 122612. CrossRef
Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an
N
-prenyltransferase
Jonathan R. Chekan, Shaun M. K. McKinnie, Joseph P. Noel, Bradley S. Moore Proceedings of the National Academy of Sciences.2020; 117(23): 12799. CrossRef
Biosynthesis of marine toxins Jonathan R. Chekan, Timothy R. Fallon, Bradley S. Moore Current Opinion in Chemical Biology.2020; 59: 119. CrossRef
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid Jonathan R. Chekan, Shaun M. K. McKinnie, Malia L. Moore, Shane G. Poplawski, Todd P. Michael, Bradley S. Moore Angewandte Chemie International Edition.2019; 58(25): 8454. CrossRef
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid Jonathan R. Chekan, Shaun M. K. McKinnie, Malia L. Moore, Shane G. Poplawski, Todd P. Michael, Bradley S. Moore Angewandte Chemie.2019; 131(25): 8542. CrossRef
War on Two Fronts: The Fight against Parasites in Korea and Vietnam Mark Harrison, Sung Vin Yim Medical History.2017; 61(3): 401. CrossRef
Combination therapy in the treatment of helminth diseases Vijai K. Agrawal, Satyavan Sharma Medicinal Research Reviews.1985; 5(3): 333. CrossRef
Pyrantel embonate in mass treatment of ascariasis and comparison with piperazine adipate and santonin-kainic acid complex Han Jong Rim, Joung Hwan Ha, Joon Sang Lee, Il Hyun, Kwang Bon Uh The Korean Journal of Parasitology.1974; 12(2): 141. CrossRef
